Role of Intraoperative Bone Dust Cytology for Assessing Bone Margins: A Novel Technique.

IF 0.6 Q4 ONCOLOGY
Indian Journal of Surgical Oncology Pub Date : 2025-02-01 Epub Date: 2024-09-18 DOI:10.1007/s13193-024-02069-8
Lakshminarasimman Parasuraman, Nikhilesh Borkar, Neelam Prabhudesai, Kintan Sanghvi, Shubhada Kane, Dinesh Shah, Prathamesh Pai
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引用次数: 0

Abstract

Surgical margin influences the outcome of oral squamous cell carcinoma (OSCC). There are few techniques described in the literature for assessing intraoperative bone margins which are cumbersome. We present a novel technique for rapid intraoperative analysis of cortical bone. Fifty untreated patients with OSCC had their margins analysed with bone dust cytology during surgery. This was compared with standard final histopathology in terms of sensitivity and specificity. A total of 227 sites were analysed. A total of 152 sites (66.9%) were true negative while 54 sites (23.8%) were true positive in comparison to final histology following bone decalcification. Overall, 15 sites (6.6%) were false negative while 6 sites (2.6%) were false positive giving a sensitivity of 78.26%, specificity of 96.20%, positive predictive value of 90%, and a negative predictive value of 91.02%. The overall accuracy rate for bone dust cytology was 90.75%. Bone dust cytology is a simple, feasible and less time-consuming with an accuracy rate of 90.75%.

术中骨尘细胞学在评估骨缘中的作用:一项新技术。
手术切缘影响口腔鳞状细胞癌(OSCC)的预后。文献中很少有技术描述术中骨缘的评估,这很麻烦。我们提出一种术中快速分析皮质骨的新技术。50例未经治疗的OSCC患者在手术期间用骨尘细胞学分析了他们的边缘。在敏感性和特异性方面,将其与标准的最终组织病理学进行比较。总共分析了227个地点。与骨脱钙后的最终组织学比较,152个位点(66.9%)为真阴性,54个位点(23.8%)为真阳性。假阴性15处(6.6%),假阳性6处(2.6%),敏感性78.26%,特异性96.20%,阳性预测值90%,阴性预测值91.02%。骨粉细胞学检查总体准确率为90.75%。骨尘细胞学是一种简单、可行、省时的方法,准确率可达90.75%。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
190
期刊介绍: The Indian Journal of Surgical Oncology aims to encourage and promote clinical and research activities pertaining to Surgical Oncology. It also aims to bring in the concept of multidisciplinary team approach in management of various cancers. The Journal would publish original article, point of technique, review article, case report, letter to editor, profiles of eminent teachers, surgeons and instititions - a short (up to 500 words) of the Cancer Institutions, departments, and oncologist, who founded new departments.
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