Indian Journal of Surgical Oncology最新文献

{"title":"Expression of Peroxisome Proliferator-Activated Receptor γ in Human Colorectal Carcinoma and Its Correlation with Clinicopathological Characteristics.","authors":"Deepsikha Dharamsaktu, Jyotsna Naresh Bharti, Poonam Elhence, Meenakshi Rao, Jeewan Ram Vishnoi, Subash Chandra Soni, Neeti Rustagi","doi":"10.1007/s13193-024-02122-6","DOIUrl":"https://doi.org/10.1007/s13193-024-02122-6","url":null,"abstract":"<p><p>Peroxisome proliferator activator receptor γ (PPAR γ) activation may be responsible for inhibiting the growth of cancer cell lines, and drugs that activate PPAR γ may have therapeutic benefits. Therefore, a mutation in peroxisome proliferator activator receptor γ can produce carcinogenesis. This present study aims to assess the expression of PPAR γ by immunohistochemistry in colorectal carcinoma and its correlation with clinicopathological characteristics. Most of the cases were elderly males, and pelvic pain and bleeding were the predominant symptoms. Colon carcinoma was more common than rectal carcinoma. The adenocarcinoma NOS and mucinous carcinoma were the common histological types, and 40% cases showed lymph node metastasis. The PPAR γ expression was present in 61.8% of the patients, and it showed a significant correlation with lymph node metastasis and tumor location (<i>p</i> = 0.05 and <i>p</i> = 0.04). The overall survival was slightly higher but non-significant in patients with positive PPAR γ expression than negative ones (<i>p</i> = 0.7). The multivariate analysis revealed that nodal metastasis, lymphovascular invasion, and tumor-infiltrating lymphocytes were the independent prognostic factors for colorectal carcinoma. The PPAR γ expression showed a significant correlation with lymph node metastasis and tumor location. Thus, we hypothesized that the PPAR γ expression might affect the overall survival in colorectal cancer. However, more studies with larger sample size are required to understand the nature of colorectal cancer expressing PPAR γ which might benefit the patient therapeutically in future.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"685-690"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes and Survival in Pancreatic and Periampullary Cancers: A Single Centre Experience.","authors":"Suresh Kumar, Navin Noushad, M P Viswanathan, Arvind Raj","doi":"10.1007/s13193-024-02116-4","DOIUrl":"https://doi.org/10.1007/s13193-024-02116-4","url":null,"abstract":"<p><p>Pancreatic cancer is an aggressive malignancy with many cases diagnosed at locally advanced stages making pancreaticoduodenectomy a technically challenging surgery with significant mortality and morbidity. This study analyses the surgical outcomes and survival after surgery for pancreatic cancers from a single centre in south India. This is a retrospective analysis of pancreatic and periampullary cancer patients who were treated in our institute between January 2014 and November 2022 (<i>n</i> = 71). The median age at diagnosis was 55 years. In about 2/3rd of cases, tumour was located in periampullary region and 62 out of 71 patients underwent curative resection. The most common histopathological diagnosis was adenocarcinoma (87%). Nodal metastasis were detected in 13% of specimens. The predominant morbidity was delayed gastric emptying (DGE 12.7%) and clinically relevant postoperative pancreatic fistula (CR-POPF 11%) with a combined overall morbidity of 35.2% and 30-day mortality of 7.3%. Pre-op nutritional status had a strong association with postoperative morbidity. The median time of survival was 20 months, with a median follow-up of 22 months. Age less than 60 years (<i>P</i> value = 0.0264) and receiving all 6 or more cycles of chemo were significantly associated with improved survival (<i>P</i> value = 0.0297). Lower-stage cancers (T1, T2, and N0) were associated with better survival. The patient characteristics, histological factors, and perioperative outcomes were similar to the reports from other Indian studies. The 3-year survival rate was 30%. There was an increasing trend of survival in patients with age less than 60 years and in patients who received 6 or more cycles of chemotherapy.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"621-626"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Indocyanine Green Angiography to Assess Intra-operative Bowel Vascularity and its Association with Post-operative Outcome in Robot-assisted Rectal Resection: a Prospective Indian Cohort Study.","authors":"Shrivastava Neelesh, Balasubramanian A, Penumadu Prasanth, Ramanan Sinduja, Subramani Pradeep","doi":"10.1007/s13193-024-02126-2","DOIUrl":"https://doi.org/10.1007/s13193-024-02126-2","url":null,"abstract":"<p><p>Adequate intestinal perfusion is one of the critical factors influencing anastomotic leak (AL) in colorectal surgery. The use of indocyanine green fluoroscence angiography (ICG-FA) intra-operatively to ensure optimal perfusion is being increasingly used. This prospective study aimed to assess the role of ICG-FA in robot-assisted surgery for rectal cancer. This was a prospective cohort study carried out between July 2019 and July 2023, comprising patients undergoing elective robot-assisted rectal resection. The primary objective was to determine the role of ICG-FA in assessing bowel vascularity and in deciding the transection point of the bowel. The secondary objective was to assess the effect of ICG-FA on the post-operative outcomes, and also the effect of the various variables on the ICG staining grade. A total of 50 patients were included. Sixty percent of the patients received pre-operative radiotherapy, including short-course radiotherapy (SCRT) and long-course concurrent chemoradiation (LCRT). A change in transection line based on a less than normal ICG-FA grade was done in 11 patients (22%). Post-operatively, AL was present in 8 patients, out of whom 5 underwent re-operation. Administration of pre-operative RT was the only factor significantly associated with post-operative AL (<i>p</i> < 0.05). The present study showed that a change in the transection point based on the intra-operative ICG-FA was made in 22% of the patients. ICG-FA could hence be used as a potential adjunct to the operative surgeon in assessing the bowel vascularity in a minimally invasive approach like robotic or laparoscopic surgery.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"676-684"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and Prognostic Accuracy of MMPs and TIMPs in Oral Cancer Patients on Enzyme-Linked Immunosorbent Assay (ELISA) as Compared to Immunohistochemistry (IHC).","authors":"Jyoti Saini, Jaimanti Bakshi, Naresh Kumar Panda, Maryada Sharma, Ashok Kumar Yadav, Suruthy Narayansami, Atul Kumar Goyal","doi":"10.1007/s13193-024-02113-7","DOIUrl":"https://doi.org/10.1007/s13193-024-02113-7","url":null,"abstract":"<p><p>Oral cancer is one of most common noncommunicable diseases that imposed significant burden on healthcare around the globe including India. Several molecular markers have been extensively researched for their potential as diagnostic and prognostic biomarkers for oral cancer. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) found to play a crucial role in cytoskeleton dynamics and thus tumor growth and metastasis. The present study aims to analyze the MMP (MMP-1, MMP-3, MMP-9, and MMP-13) and TIMP (TIMP-1 and TIMP-3) expression in the oral cancer patients as compared to healthy controls. We also aim to compare the diagnostic accuracy of MMPs and TIMPs on enzyme-linked immunosorbent assay (ELISA) with respect to the immunohistochemistry (IHC). A total of 15 oral cancer patients and 14 healthy controls were enrolled in this study. Blood sample from oral cancer patients and healthy controls was obtained to analyze the MMP and TIMP expression levels in serum sample using ELISA. Tumor tissue sample from patients for IHC analysis was obtained by biopsy under local anesthesia. Data were compared between ELISA and IHC for sensitivity and specificity analysis. The mean age of the patients was 47.07 ± 15.74 years with the highest incidence of disease found in male gender (86.7%). MMPs and TIMPs exhibited higher expression in oral cancer patients as compared to healthy controls and the difference was statistically significant in case of MMP-13. MMPs and TIMPs showed stronger expression at advanced stages of cancer on IHC with MMP-9 exhibiting the highest expression level. The highest sensitivity and specificity on ELISA with respect to IHC were exhibited by the MMP-3 followed by MMP-13, TIMP-1, TIMP-3, and MMP-1. MMP-3 and MMP-13 were found to be reliable in terms of diagnostic marker for oral cancer as they found to have the highest sensitivity and specificity on ELISA with respect to IHC. MMP-9 was found to be reliable as a prognostic marker as it expresses highest on IHC at advanced stages of oral cancer.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"601-610"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The INDEPSO-ISPSM Consensus on Peritoneal Malignancies-Methodology.","authors":"Swapnil Patel, Vivek Sukumar, Somashekhar S P, Geetu Bhandoria, Ambarish Chatterjee, Suryanarayana V S Deo, Niharika Garach, Arvind Guru, Neha Kumar, Rohit Kumar, Ashwin K Rajagopal, Sanjeev Kumar, Sanket Mehta, Deepti Mishra, Ajinkya Pawar, Aruna Prabhu, Snita Sinukumar, Sohan Solanki, Vivekanand Sharma, Ramakrishnan Ayaloor Sheshadri, Aditi Bhatt","doi":"10.1007/s13193-024-02118-2","DOIUrl":"https://doi.org/10.1007/s13193-024-02118-2","url":null,"abstract":"<p><p>The numerous international guidelines on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) do not cover many clinically relevant issues for which evidence is limited and some regional issues (HIPEC in limited resource settings, age-limit for CRS, etc.). We describe the methodology of a consensus CRS and HIPEC for peritoneal malignancies carried out under the aegis of the two national societies for peritoneal oncology-INDEPSO and ISPSM. The modified Delphi technique was used with two rounds of voting. Eight key topics were selected by a working group of 29 members. Questionnaires comprising of closed-ended questions were disseminated through the online SurveyMonkey (http://www.surveymonkey.com) platform. A panel of 56 surgical, gastrointestinal, and gynecologic oncologists with a minimum of 5 years of experience with CRS-HIPEC voted on 260 questions. A consensus was reached if any of the options received 70% or more votes (> 90% = strong consensus). The response rate was 98.2% in round I and 94.6% in round II. A consensus was achieved on 80.7% questions after two rounds (43.0% after round I; 36.9% after round II). It was the highest in the enhanced recovery after surgery (ERAS) section (93.3%) and the lowest (68.0%) for ovarian cancer. A strong consensus was reached on 59 (22.6%) questions (highest for  the technical section (34.2%); lowest in the ERAS section (16.6%)). This consensus which had a high rate of participation should be a useful clinical resource for surgeons treating peritoneal malignancies in India and other regions with a similar demographic and socioeconomic background.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-02118-2.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"651-659"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant Chemotherapy Does Not Compensate for an Inadequate Right Colon Cancer Surgery: High Peritoneal Recurrence Rates Indicate Need for Altered Treatment Paradigms.","authors":"Swapnil Patel, Mufaddal Kazi, Anand Mohan, Vivek Sukumar, Ashwin L deSouza, Avanish Saklani","doi":"10.1007/s13193-024-02099-2","DOIUrl":"https://doi.org/10.1007/s13193-024-02099-2","url":null,"abstract":"<p><p>There is a lack of evidence for optimal management of patients with right colon cancers upon referral to the oncology care centre, following an inadequate index surgery elsewhere. A prospectively maintained database of patients with right colon cancers managed between 2013 and 2019 was screened to identify those patients who underwent index surgery in a non-oncological setup. They were managed with adjuvant chemotherapy followed by observation, with surgery being reserved for recurrent disease. Of the 155 patients identified after the screening, 97 were included in the study. They were stratified depending upon the number of lymph nodes harvested at primary surgery-Group A (less than 12 nodes) (<i>n</i> = 49), Group B (12 to 27 nodes) (<i>n</i> = 39) and Group C (28 and more nodes) (<i>n</i> = 9). Patients with lymph node metastases had inferior survival at 2 years than node-negative patients and this survival difference increased progressively from Group A towards Group C. Patients who had radiological locoregional residual disease upon restaging (at presentation) had significantly inferior survival. At the end of 2 years, overall survival and disease-free survival of the cohort were 71.5% and 45.8%, respectively. Fifty-eight patients had disease relapse, with peritoneal recurrence seen in 37 patients (63.8%). Of these, only 15.5% recurrences were surgically salvageable. Treatment of patients who have undergone inadequate index colectomy with chemotherapy alone has shown inferior survival outcomes with high rates of peritoneal relapse in comparison to historical cohorts. The treatment strategy for such patients needs to be revisited in a prospective study design.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"528-535"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Outcomes After McKeown and Ivor Lewis Esophagectomy for Lower Third Esophageal Cancer.","authors":"Naveen Kumar, Amitabha Mandal, Sandeep Bhoriwal, S V S Deo, Sachidanand Jee Bharati, Sunil Kumar","doi":"10.1007/s13193-023-01770-4","DOIUrl":"10.1007/s13193-023-01770-4","url":null,"abstract":"<p><p>The commonly performed surgical procedures for esophageal cancer are McKeown and Ivor Lewis esophagectomy. The Ivor Lewis esophagectomy is mainly performed for lower esophageal cancer. Herein, we analyzed both procedures performed for lower esophageal cancer to look for perioperative and survival outcomes. The surgical data was retrieved from the computerized database, and the patients operated on for lower esophageal cancer from 2014 to 2019 were included. Both procedures were analyzed for demographic details, perioperative outcomes, complication rate, and overall and disease-free survivals. A total of 90 patients undergoing esophagectomy for lower esophageal cancer. RLN palsy and anastomotic leak rate were higher in the McKeown group. The estimated 5-year OS was 49% and 58.3% in the McKeown and Ivor Lewis groups, respectively, whereas the estimated 5-year DFS was 41% and 63.9%. In the Ivor Lewis group, on comparing both histological subtypes, the estimated 5-year OS was 74% and 26.3% (<i>p</i> < 0.05) whereas the DFS was 74.5% and 42% (<i>p</i> = 0.07) for SCC and adenocarcinoma, respectively. This study did not find a significant difference in the perioperative as well as survival outcomes comparing McKeown esophagectomy with the Ivor Lewis procedure for lower third esophageal cancer. A prospective trial is warranted to see the difference.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":" ","pages":"465-471"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48897774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Recent Overview of Molecular Pathways in Synthetic Lethality as a Proposed Valid Target in Oncology: Current Insights and Future Directions.","authors":"Sangeetha Raja, Akash Rahangan, Indumathi Prabath, Jamuna Rani","doi":"10.1007/s13193-024-02088-5","DOIUrl":"https://doi.org/10.1007/s13193-024-02088-5","url":null,"abstract":"<p><p>Earlier conducted systematic reviews have focused on the important impact of synthetic lethality (SL) application in managing various types of tumors, classifying SL, methods for assessment, and technological advances in SL inhibitions and examining the preclinical and clinical landscape of SL cancer biology, and neither of those investigations presented the molecular pathway description of the recommended lethal target of SL in cancer. Out of 36 gene expression omnibus (GEO) database sets selected from 343 retrieved (2023 to 2024), 11 were excluded, and 25 were included in the study and presented in the review. Beyond the search, few interesting database sets comprising interesting molecular pathway were included in minority. Molecular pathways pictures of the proposed SL targets for the cancer condition were prepared for lucid understanding of the oncology disease fundamental mechanism behind the SL concept. SL approach benefits have been demonstrated in cancer. Thus, the current exploration suggests that SL approach of molecular investigations should be expanded to include other specialists including cardiovascular and nephrology to fully explore the benefits of society.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"408-420"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Baseline Endogenous Testosterone Levels on Risk Stratification in Pathological Organ-Confined Prostate Cancer: Results in 460 Patients Treated with Robot-Assisted Radical Prostatectomy.","authors":"Antonio Benito Porcaro, Andrea Panunzio, Alberto Bianchi, Sebastian Gallina, Emanuele Serafin, Riccardo Rizzetto, Giovanni Mazzucato, Stefano Vidiri, Damiano D'Aietti, Giulia Fassio, Rossella Orlando, Francesco Ditonno, Alberto Baielli, Francesco Artoni, Francesca Montanaro, Giulia Marafioti Patuzzo, Filippo Migliorini, Alessandro Veccia, Matteo Brunelli, Salvatore Siracusano, Maria Angela Cerruto, Alessandro Tafuri, Alessandro Antonelli","doi":"10.1007/s13193-024-02109-3","DOIUrl":"https://doi.org/10.1007/s13193-024-02109-3","url":null,"abstract":"<p><p>The objective is to test the role of baseline endogenous testosterone (ET) in discriminating adverse tumor grades and predicting disease progression in prostate cancer (PCa) patients, who harbored organ-confined disease at radical prostatectomy (RP). Between November 2014 and December 2019, data on PCa patients treated with robot-assisted RP at a single tertiary referral center were retrospectively analyzed. Baseline ET levels were coded as abnormal (≤ 350 ng/dL) vs. normal (> 350 ng/dL) according to a standard consensus. In the surgical specimen, the International Society of Urological Pathology (ISUP) grade groups 3 and 4/5 were classified as unfavorable tumor grades. Disease progression was defined as biochemical recurrence/persistence and/or local recurrence and/or distant metastases. Multivariable logistic and Cox regression models were used. Overall, 460 patients were included. In the surgical specimen, adverse tumor grades were detected in 198 (43.0%) patients of whom 60 (13.0%) harbored ISUP grade group 4/5. Disease progression occurred in 62 (13.5%) patients. In multivariable regression models that adjusted for other available clinical and pathological factors, patients with abnormal baseline ET levels were less likely to associate with unfavorable tumor grades, as well as to experience PCa progression (hazard ratio: 0.49; 95% CI: 0.26-0.92; <i>p</i> = 0.026). In pathological organ-confined PCa, baseline ET levels predicted disease progression after discriminating unfavorable tumor grades. Accordingly, baseline ET is a risk factor that might further stratify patients diagnosed with PCa.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"587-594"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Thoracic Diseases (Benign and Malignant) in North Western India: A Study of 2527 Cases.","authors":"Manish Sahni, Suresh Singh, Rajgovind Sharma, Pinakin Patel, Kamal Kishor Lakhera","doi":"10.1007/s13193-024-02124-4","DOIUrl":"https://doi.org/10.1007/s13193-024-02124-4","url":null,"abstract":"<p><p>Thoracic cancers especially lung cancer form a huge burden of morbidity and mortality around the world. The first question most patients ask after receiving the biopsy report is on the type of cancer and how it spreads which gives an idea of what to expect during follow-up. Unfortunately, due to a lack of reporting, management, and documentation of thoracic neoplasms in India, there is a shortage of information on various types of thoracic neoplasms and their distribution. What we need is more data reporting, timely diagnostic strategies, and standardized reporting for pathology leading to evidence-based management strategies. To address this issue, we conducted a study to gain insights into patterns and relative frequencies of thoracic neoplasms in North Western India.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-02124-4.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"660-666"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}