Indian Journal of Surgical Oncology最新文献

{"title":"Impact of Bile Spill During Index Cholecystectomy on the Outcomes of Incidental Gallbladder Cancer.","authors":"Murugappan Nachiappan, Yoji Kishi, Anand Nagar, Nalini Kanta Ghosh, Spiros G Delis, Tseten Yonjen Tamang, Vinay K Kapoor","doi":"10.1007/s13193-026-02539-1","DOIUrl":"10.1007/s13193-026-02539-1","url":null,"abstract":"<p><p>Incidental gallbladder cancer (iGBC) is discovered unexpectedly during histopathological examination after cholecystectomy, with the surgeon typically unaware of the malignancy at the time of surgery. Malignant cells have been demonstrated in the bile of patients with gallbladder cancer. Bile spillage during laparoscopic cholecystectomy is a common concern because it may lead to the dissemination of malignant cells, potentially resulting in widespread disease and poor oncological outcomes. The prognostic implications of bile spillage in iGBC patients remain uncertain, particularly regarding whether these patients should be staged as having metastatic disease and treated with palliative chemotherapy, or if curative resection should be pursued when the local pathology is resectable. To clarify this uncertainty, we conducted a systematic literature review to assess the impact of bile spillage on disease outcomes in iGBC patients. This review aims to shed light on the oncological consequences of bile spillage during cholecystectomy and guide clinical decision-making in the management of iGBC. A comprehensive search of the PubMed database, focusing on articles published up until September 2023 was made with the following search query: (\"gallbladder neoplasms\"[MeSH Terms] OR \"neoplasm, residual\"[MeSH Terms] OR \"gallbladder diseases\"[MeSH Terms] OR \"carcinoma gallbladder\"[Text Word] OR \"gallbladder neoplasm*\"[Text Word]) AND (\"Incidental Findings\"[MeSH Terms] OR \"incidental\"[Text Word] OR \"incidentally detected\"[Text Word] OR \"incidental gallbladder carcinoma*\"[Text Word] OR \"incidental gallbladder cancer*\"[Text Word]). Survival differences were our primary outcome. Secondary outcomes included the incidence of metastatic disease during staging prior to re-exploration, the occurrence of peritoneal carcinomatosis during re-exploration, success in achieving complete resection, the presence of residual disease identified through histopathology, and disease recurrence. Seven studies were analysed to study the impact of bile spillage on survival. The survival outcomes consistently indicated a poorer prognosis for patients with bile spillage compared with those without. Bile spillage led to higher incidence of peritoneal metastases and decreased possibility of curative re-resections. Bile spillage during the initial laparoscopic cholecystectomy has been shown to significantly worsen the prognosis of iGBC, consistently leading to poorer outcomes. Although the conclusions drawn from this review are limited by the retrospective design, potential confounders and biases, and inconsistent reporting in the available studies, they underscore the critical need for meticulous surgical techniques to prevent bile spillage in every laparoscopic cholecystectomy.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2031-2038"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Pitfalls of Squamous Cell Carcinoma Arising from an Epidermal Cyst.","authors":"Jiro Ichikawa, Tomohiro Inoue, Kojiro Onohara, Masanori Wako","doi":"10.1007/s13193-026-02532-8","DOIUrl":"10.1007/s13193-026-02532-8","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2228-2231"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Phase II Randomised Controlled Trial Comparing Pulmonary Complications in Retrosternal vs. Posterior Mediastinal Gastric Conduit Placement in Patients Undergoing McKeown Minimally Invasive Esophagectomy.","authors":"Amit Kumar, Sandeep Kumar Bhoriwal, Sunil Kumar, Svs Deo, Amitabha Mandal, Jyoti Sharma, Naveen Kumar, Jyoutishman Saikia, Bittu Bhukkal, Bhawani Pathak, Seema Mishra, RaghuRam K, Praveen Royal Mokkapati, Paramesh S, Sushmita Pathy, Chethan R","doi":"10.1007/s13193-026-02555-1","DOIUrl":"10.1007/s13193-026-02555-1","url":null,"abstract":"<p><strong>Introduction: </strong>Pulmonary complications are the commonest morbidity after esophageal resection for malignancy. Gastric conduit is commonly used for restoration of the continuity, and can be placed through either posterior mediastinal(PM) or retrosternal route(RS). The choice of the route can have significant effect on the incidence of post operative complication. The current study is a randomised controlled trial comparing post operative pulmonary complications(PPC) in patients undergoing conduit placement among these two routes.</p><p><strong>Material and methods: </strong>Phase II RCT conducted in a tertiary care canter from August 2023 to January 2025. Thirty patients were included and randomised in two groups of 15 patients each, based upon the placement of the conduit i.e. either posterior mediastinal or retrosternal. Post-operative complications were studied and compared.</p><p><strong>Result: </strong>Minor complications, classified as Clavien-Dindo grade I-II, were similar in both groups. Pulmonary complications were significantly more frequent in PM (p = 0.021), Anastomotic leaks did not differ among two groups (p = 0.465).FEV₁ and FVC values at 1 and 6 months were significantly reduced among patients with complications; however, the magnitude of decline was less pronounced in the RS group (p = 0.01,0.03). Subgroup analysis showed that patients with anastomotic leaks had longer conduit lengths than those without leaks, (p = 0.020). Univariate and multivariate analyses were performed and among the evaluated parameters, only the route of gastric conduit reconstruction showed a significant association, with complications occurring more frequently in the PM group than in the RS group (77.8% vs. 38.1%; p = 0.014). On multivariate logistic regression, the PM route emerged as an independent determinant of pulmonary complications (adjusted odds ratio 2.40; 95% CI, 1.05-5.80; p = 0.038).</p><p><strong>Conclusion: </strong>RS gastric conduit reconstruction offers a safe and effective alternative to the PM route, reducing PPCs without significantly increasing anastomotic leak risk. Persistent pulmonary function decline remains linked to PPCs. Although limited by a small, single-centre cohort, these findings support RS reconstruction for patients at higher risk of pulmonary morbidity, warranting validation in larger multicentre studies.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at https://doi.org/10.1007/s13193-026-02555-1.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2187-2194"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteral Resections in Non-urological Cancer Surgeries: Experience from a Tertiary Cancer Center.","authors":"Abhiram Gatty, Prasanth Poolakkil, Nizamuddeen Pareekkutty, Bonny Alloissius, Satheesan Balasubramanian","doi":"10.1007/s13193-026-02553-3","DOIUrl":"10.1007/s13193-026-02553-3","url":null,"abstract":"<p><p>Radical surgeries for abdominopelvic and retroperitoneal malignancies sometimes necessitate Ureteral resections due to tumor involvement. Preservation of renal function is crucial in such cases, especially considering the systemic therapy needs of oncology patients. The objectives were to study the indications, the common reconstructive methods, surgical complications, ureteral patency rates, and postoperative complications. This retrospective study included 20 patients who underwent Ureteral resection and reconstruction between 2013 and 2023 at a tertiary cancer institute. Among 1800 patients undergoing major abdominal surgeries for non-urologic malignancies, 20 required Ureteral resections. The most common malignancy was colorectal adenocarcinoma (65%). The distal ureter was most frequently involved (85%). Ureteroureterostomy(35%) and ureteroneocystostomy(45%) were the predominant reconstruction techniques. Histopathologically tumor infiltration of the ureter was noted in 20% of patients. Acute complications included anastomotic leak (20%), septic shock (20%), and urinary fistulae (5%). Of the 16 survivors, 25% developed renal function derangement, 25% had urinary incontinence, and one had a Ureteral stricture requiring intervention. Ureteralresection and reconstruction, makes surgical resection of the prmary lesionpossible along with multivisceral resections for non-urological malignancies,but with a potential for morbidity. Ureteroureterostomy is the most commonprocedure of choice for upper and mid ureter injuries, whileureteroneocystostomy for lower zone or pelvic ureter. Most individualsrequiring a ureteral resection and reconstruction for non-urothelial tumors hadpreserved renal function over long-term.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2118-2124"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prepectoral Implant for Immediate Breast Reconstruction after Mastectomy: A Review Article.","authors":"Menna Allah Khalid Megahed, Mohamed Attia Elfadali","doi":"10.1007/s13193-025-02512-4","DOIUrl":"10.1007/s13193-025-02512-4","url":null,"abstract":"<p><p>Breast cancer is the most common malignancy among women, with 2.3 million new cases diagnosed annually. Immediate breast reconstruction has become integral to patient-centered care. Prepectoral implant placement is re-emerging as a promising alternative to submuscular techniques, offering reduced postoperative pain, quicker recovery, and improved aesthetics. A narrative review of published literature was conducted, focusing on the evolution of implant placement, patient selection, surgical technique, outcomes, and complications. Special attention was given to the role of acellular dermal matrix (ADM) and the practical challenges faced in low- and middle-income countries (LMICs). Prepectoral reconstruction avoids muscle dissection, reducing pain, dysfunction, and animation deformity. Use of ADM lowers capsular contracture but increases costs and infection risk. Reported complications include seroma, rippling, and flap necrosis. While long-term comparative studies remain limited, evidence supports safe outcomes in selected patients. In LMICs, alternatives to ADM and reliance on clinical flap assessment make the approach feasible despite resource constraints. Prepectoral implant-based reconstruction is an evolving technique with clear functional and aesthetic benefits. Adaptation to local resources allows wider applicability, though further long-term data are needed to optimize oncologic safety and patient satisfaction.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2019-2030"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality Risk in Mucinous Appendiceal Neoplasms: Insights from a National Database.","authors":"Samantha L Sherman, Tony Boualoy, Alexandra Helbing, Ambria S Moten","doi":"10.1007/s13193-026-02536-4","DOIUrl":"10.1007/s13193-026-02536-4","url":null,"abstract":"<p><p>We sought to identify mortality predictors among patients with mucinous appendiceal adenocarcinoma (MAA) and high-grade appendiceal mucinous neoplasm (HAMN). Cases of HAMN and MAA in the National Cancer Database years 2007-2021 were analyzed. Cox regression models identified mortality risk factors. Among 3,738 cases, 1.9% had HAMN, 49.1% low-grade MAA, 6.8% high-grade MAA, and 42.3% MAA grade unknown. Patients with HAMN often underwent partial colectomy, whereas patients with MAA more frequently received hemicolectomy or total colectomy. Chemotherapy was utilized in 4.4% HAMN, 54.0% low-grade MAA, 65.8% high-grade MAA, and 61.3% MAA grade unknown (<i>p</i> < 0.001). Patients with high-grade MAA had a greater risk of death than low-grade MAA (HR 2.04, 95%CI 1.71-2.44) but there was no difference in the risk of death between HAMN and low-grade MAA (HR 1.00, 95%CI 0.39-2.54). Surgery lowered mortality risk, while positive margins (HR 1.87, 95%CI 1.61-2.13) and lymphovascular invasion (LVI) (HR 2.01, 95%CI 1.66-2.45) increased it, and chemotherapy showed no effect (HR 0.91, 95%CI 0.80-1.04). Mortality risk is similar for HAMN and low-grade MAA. Key mortality predictors include age, sex, margins, and LVI. The minimal effect of chemotherapy highlights the crucial role of surgery in improving survival.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2167-2173"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Lymph Node Yield Per Neck Level as a Predictor of Recurrence in Oral Tongue Squamous Cell Carcinoma: A Retrospective Observational Study\".","authors":"Shiva Shiva, Akshay Anand, Abhinav Arun Sonkar","doi":"10.1007/s13193-026-02562-2","DOIUrl":"10.1007/s13193-026-02562-2","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2244-2245"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Neoadjuvant Concurrent Chemoradiation in Locally Advanced Breast Cancer- Short-term Results of a Randomized Controlled Trial.","authors":"Ganesh Bhat, Ashwinee Rahalkar, Mrinalini Verma, Kul Ranjan Singh, Pooja Ramakant, Anand Kumar Mishra","doi":"10.1007/s13193-025-02526-y","DOIUrl":"10.1007/s13193-025-02526-y","url":null,"abstract":"<p><p>Neoadjuvant chemotherapy (NACT) is the standard treatment for locally advanced breast cancer (LABC) to make tumors operable and facilitate breast conservation surgery (BCS). While pathological complete response (PCR) following NACT is expected to improve outcomes, PCR rates are relatively low except in HER2-positive or triple negative tumors. Radiotherapy (RT), conventionally is administered post-surgery. Concurrent chemoradiotherapy (CCRT), a strategy widely used in other cancers, combines the benefits of chemotherapy and radiotherapy, potentially improving tumor control and better PCR rates. This study aimed to evaluate the safety and efficacy of neoadjuvant CCRT compared to conventional NACT in LABC patients, focusing on PCR, adverse events, locoregional control, and survival outcomes. This randomized controlled trial enrolled non-metastatic LABC patients from a tertiary hospital in North India between September 2020 and January 2024. Patients were randomized into two groups: Group 1 received CCRT (chemotherapy concurrent with RT), and Group 2 received conventional NACT. Outcomes measured included PCR, adverse events, surgical metrics, progression-free survival (PFS), disease-free survival (DFS), and overall survival (OS). Among 126 participants, 66 were allocated to CCRT and 60 to NACT. PCR was significantly higher in the CCRT group (67.8%) compared to the NACT group (40%, <i>p</i> = 0.011). Locoregional recurrence was lower in the CCRT group (3.3% vs. 10.9%, <i>p</i> = 0.383), though not statistically significant. Adverse events such as skin reactions were more frequent in the CCRT group (31.8% vs. 13.3%, <i>p</i> = 0.02), with most being mild and manageable. Kaplan-Meier analysis showed no significant differences in PFS, DFS, or OS between the two groups during a mean follow-up of 17.43 months. Neoadjuvant CCRT in LABC has higher PCR rates, manageable toxicity profiles, without difference in survival. It offers a promising alternative to conventional therapy, particularly in resource-limited settings. Long-term survival data are awaited to establish its definitive role.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at https://doi.org/10.1007/s13193-025-02526-y.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2048-2054"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Cardiac Dose Sparing in Lung Cancer SBRT Through 4D-CT-Based Respiratory Phase Selection.","authors":"Mariem Trabelsi, Lotfi Ben Salem, Hamida Romdhan, Dorra Ben-Sellem","doi":"10.1007/s13193-026-02534-6","DOIUrl":"10.1007/s13193-026-02534-6","url":null,"abstract":"<p><p>Cardiac toxicity remains a significant concern in stereotactic body radiotherapy (SBRT) for lung cancer, particularly when tumors are adjacent to the heart. This study aimed to assess the dosimetric impact of different respiratory phases on heart dose using four-dimensional computed tomography (4D-CT), and to determine the optimal phase for gated SBRT planning. We retrospectively analyzed lung cancer patients treated with SBRT who had 10-phase 4D-CT scans. Cardiac dose metrics, including mean heart dose (Dmean), V30 (volume receiving ≥30 Gy), and V25 (volume receiving ≥25 Gy), were evaluated across all respiratory phases. The heart was delineated on each phase, and the internal target volume (ITV) and displacement were also recorded. Tumor location was considered to assess its influence on heart exposure. Statistical comparisons were performed using paired t-tests. All cardiac dose metrics showed a decreasing trend from inspiration (0-20%) to expiration (80- 90%). The lowest Dmean (19.2 Gy), V30 (38.1%), and V25 (25.6%) were observed during the end-expiratory phase (90%). This phase also demonstrated minimal heart displacement (2.1 mm) and the smallest ITV (60 cm³), suggesting enhanced stability. Tumors located in the lower lobes or central regions exhibited greater sensitivity to respiratory phase, especially during inspiration. Expiratory gating significantly reduced heart dose in these cases. End-expiration appears to be the most favorable respiratory phase for cardiac sparing in SBRT for lung cancer. The integration of 4D-CT-based respiratory gating into clinical workflows enables individualized treatment planning, reduced target margins, and improved delivery safety. Tumor location should also be considered when selecting the optimal respiratory phase to optimize dosimetric outcomes. Although the present analysis focused primarily on cardiac dosimetry, this emphasis is clinically justified, as the heart is a critical and dose-limiting organ at risk with a well-established impact on long-term survival in lung cancer patients. Optimizing cardiac dose through respiratory phase selection therefore represents a clinically meaningful step toward safer SBRT delivery. Nevertheless, comprehensive evaluation of additional organs at risk is required before these findings can be generalized to broader clinical practice.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2151-2158"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphadenectomy During Staging Laparotomy in Early-Stage Ovarian Cancer: a Critical Analysis of Retrospective Data.","authors":"Mahendra Kumar, Upasana Baruah, Debabrata Barmon, Dimpy Begum","doi":"10.1007/s13193-025-02487-2","DOIUrl":"10.1007/s13193-025-02487-2","url":null,"abstract":"<p><p>Comprehensive pelvic and para-aortic lymphadenectomy (CLD) is traditionally considered essential for accurate staging of early-stage epithelial ovarian cancer (ESOC). However, its impact on survival outcomes compared to limited nodal sampling (LNS) during staging laparotomy remains uncertain, particularly in the context of adjuvant chemotherapy. This retrospective study included patients with histologically confirmed ESOC who underwent staging laparotomy between January 2017 and December 2021. Patients with borderline, benign, germ cell, or metastatic tumours were excluded. PFS and OS were analysed using Kaplan-Meier and log-rank tests. Hazard ratios (HR) were calculated using Cox regression. A total of 144 patients were included in our study: 117 underwent LNS and 27 underwent CLD. High-grade serous ovarian carcinoma (HGSOC) accounted for 70% of cases. All patients with HGSOC received adjuvant chemotherapy. After a median follow-up of 45 months, no statistically significant difference in PFS (<i>p</i> = 0.5) or OS (<i>p</i> = 0.7) was observed between groups. Mean OS was 83.3 months (LNS) vs. 86.7 months (CLD). HRs for PFS and OS across all histologies were 0.94 and 0.95, respectively. In the HGSOC subgroup, OS HR was lower at 0.63, suggesting a potential trend toward improved survival with CLD. However, CLD was associated with higher postoperative morbidity, including lymphocyst formation and lymphedema. Limited nodal sampling did not compromise survival outcomes in patients with ESOC, including HGSOC. In the context of universal adjuvant chemotherapy, LNS may be an acceptable alternative to CLD in select patients. Prospective trials are warranted to validate these findings.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 9","pages":"2159-2166"},"PeriodicalIF":0.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149082420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}