Indian Journal of Surgical Oncology最新文献_第2页

Our Experience of 500 Chemo Port Placements with Cephalic Vein Cut Down Technique-A Saviour for Cancer Treatment. 头静脉切开技术--癌症治疗的救星，我们的 500 例化疗端口置入经验

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-06-24 DOI: 10.1007/s13193-024-02000-1

Vijay Kumar, Raxith Sringeri

{"title":"Our Experience of 500 Chemo Port Placements with Cephalic Vein Cut Down Technique-A Saviour for Cancer Treatment.","authors":"Vijay Kumar, Raxith Sringeri","doi":"10.1007/s13193-024-02000-1","DOIUrl":"10.1007/s13193-024-02000-1","url":null,"abstract":"Implantable chemoport is a very useful device for long-term venous access for infusion of chemotherapeutic drugs and other agents. Niederhuber et al. (Surgery 92:706-712, 1982) reported on the first use of the totally implantable central venous port system (TICVPS) in 1982. Five hundred patients undergoing surgical implantation of chemoports in Bharath Cancer Hospital, Mysore, India, between September 2020 and June 2022 were included in this prospective observational cohort study. Five hundred chemoport implantations were available for analysis. The cephalic vein cut down technique was attempted in 500 patients and successful in 410 patients (82.2%). There were no intraoperative complications. Venous access device systems are nowadays widely used in cancer patients to facilitate frequent perfusions of chemotherapy (Vescia et al. in Ann Oncol 19(1):9-15, 2008). The placement of totally implanted venous access devices started 30 years ago. Since then, different techniques were established to reduce complications and to make the implantation safe and comfortable for patients (Teichgraber et al. in Cardiovasc Intervent Radiol 32(5):975-979, 2009). The cephalic vein cutdown approach for CICVAD placement appears to be a safe and better alternative to the percutaneous subclavian vein approach in cancer patients. Cephalic vein cut down approach is LESS with More benefits.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"784-788"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SENOMAC Trial: The Devil is in the Details. SENOMAC 审判：细节决定成败。

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-05-29 DOI: 10.1007/s13193-024-01972-4

Mayank Tripathi, Kumar Vineet

引用次数: 0

Single-Tracer Methylene Blue-Guided Sentinel Lymph Node Biopsy in Early-Stage Squamous Cell Carcinoma of the Buccal Mucosa: A Prospective Study. 单示踪剂亚甲蓝引导的前哨淋巴结活检在早期口腔黏膜鳞状细胞癌中的应用：一项前瞻性研究。

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-05-28 DOI: 10.1007/s13193-024-01962-6

Joseph Mathew, B C Rajani, Deeksha Thakur, R Krishnappa, K S Sabitha, Rajshekar Halkud

{"title":"Single-Tracer Methylene Blue-Guided Sentinel Lymph Node Biopsy in Early-Stage Squamous Cell Carcinoma of the Buccal Mucosa: A Prospective Study.","authors":"Joseph Mathew, B C Rajani, Deeksha Thakur, R Krishnappa, K S Sabitha, Rajshekar Halkud","doi":"10.1007/s13193-024-01962-6","DOIUrl":"10.1007/s13193-024-01962-6","url":null,"abstract":"Background: Subsite and tumor stage-related heterogeneity in studies on optical tracer-guided sentinel lymph node biopsy (SLNB) in oral squamous cell carcinoma (SCC) has led to inconsistent results, limiting the applicability and wider adoption of this technique.Methodology: This single-center, prospective validation study conducted in January and February 2022, included 29 consecutive patients with early-stage, node-negative SCC of the buccal mucosa undergoing methylene blue-guided SLNB followed by modified radical neck dissection (considered the reference standard) to determine the identification rate and test validity of SLNB, and secondarily, the clinicopathological factors associated with node-positivity using binary logistic regression.Results: SLN identification rate with methylene blue was 93.1% with 66 SLNs retrieved in 27 patients, at a median 2 (IQR 2-3) nodes per procedure. Additionally, 644 nodes were grossed in the neck dissection specimens of 29 patients (median yield 24; IQR 17.5-26 per procedure). Overall accuracy of SLNB was 96.3% (95%CI 81.03-99.91%), with sensitivity and negative predictive value of 83.3% (95%CI 35.88-99.58%) and 95.5% (95%CI 77.16-99.88%), respectively. The only factor independently predictive of occult nodal involvement was pathological depth of infiltration (hazard ratio 3.312; 95%CI 1.040-10.546, p = 0.043) which at 6.5 mm was 100% sensitive and 91.3% specific (area under curve 0.975; 95%CI 0.925-1.000).Conclusion: Methylene blue-guided SLNB may be considered a viable alternative to evaluate the neck in early-stage buccal mucosal SCC with acceptable test validity and reliability. [Registered with the Clinical Trials Registry of India (CTRI/2022/01/039523 dated 18th January 2022)].","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"661-670"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Clinico-Pathological Relationship Between Stromal Tumor-Infiltrating Lymphocytes and Androgen Receptor Expression Across Molecular Subtypes of Invasive Breast Carcinoma. 评估浸润性乳腺癌不同分子亚型的基质瘤浸润淋巴细胞与雄激素受体表达之间的临床病理关系

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-06-27 DOI: 10.1007/s13193-024-02001-0

Adil Aziz Khan, Sana Ahuja, Kiruthikasri G, Sufian Zaheer

{"title":"Evaluating the Clinico-Pathological Relationship Between Stromal Tumor-Infiltrating Lymphocytes and Androgen Receptor Expression Across Molecular Subtypes of Invasive Breast Carcinoma.","authors":"Adil Aziz Khan, Sana Ahuja, Kiruthikasri G, Sufian Zaheer","doi":"10.1007/s13193-024-02001-0","DOIUrl":"10.1007/s13193-024-02001-0","url":null,"abstract":"Breast cancer remains a significant cause of mortality globally, necessitating effective treatment strategies. Neoadjuvant chemotherapy (NAC) is widely employed to minimize tumor burden and prevent local spread, with treatment efficacy varying based on molecular subtypes. Despite advancements, resistance to conventional therapies persists, prompting the exploration of alternative approaches, including immune cell therapy. Tumor-infiltrating lymphocytes (TILs) have emerged as immunological biomarkers in breast cancer, exhibiting associations with molecular subtypes and treatment response. This retrospective study assessed the clinico-pathological relationship between stromal TILs and AR expression across molecular subtypes of invasive breast carcinoma in an Indian cohort. Thirty-seven patients receiving NAC followed by modified radical mastectomy were analyzed for TILs and molecular subtyping. Immunohistochemistry was used to determine hormone receptor status and AR expression. A higher AR positivity was observed in hormone receptor-positive/Her2neu-negative and hormone receptor-positive/Her2neu-positive tumors compared to triple-negative breast cancers (TNBCs). Significant associations were observed between AR expression and tumor grade, but not with age or Her2neu status. Although no significant correlation was found between AR and complete response to NAC, a weak negative correlation between AR and TILs was noted. Notably, TNBCs with negative AR and Ki67 index exhibited poorer responses to NAC, emphasizing the need for adjuvant therapy. These findings underscore the complex interplay between AR, TILs, and treatment response in breast cancer, highlighting the potential of personalized therapeutic approaches. Further research is warranted to elucidate the prognostic significance of AR and its implications for tailored treatment strategies in breast cancer management.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"802-808"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological Risk Factors for Occult Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Oral Cavity. 早期口腔鳞状细胞癌隐匿性结节转移的病理学风险因素

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-06-29 DOI: 10.1007/s13193-024-01993-z

Mansi Dey, Kriti Grover, Siddharth Arora, Arjun Agarwal, Cheena Garg, Rashmi Katyal

{"title":"Pathological Risk Factors for Occult Nodal Metastasis in Early-Stage Squamous Cell Carcinoma of the Oral Cavity.","authors":"Mansi Dey, Kriti Grover, Siddharth Arora, Arjun Agarwal, Cheena Garg, Rashmi Katyal","doi":"10.1007/s13193-024-01993-z","DOIUrl":"10.1007/s13193-024-01993-z","url":null,"abstract":"Occult neck metastasis is the presence of metastasis in the cervical lymph nodes that cannot be radiologically or clinically identified. Presence of metastasis in any neck node can have a significant impact on overall survival of patients with oral squamous cell carcinoma (OSCC). Our aim was to analyze the correlation of various histopathological parameters with occult nodal metastasis in early-stage OSCC and to obtain an optimal DOI cut-off value for predicting its increased risk. We conducted a retrospective study on patients who reported to our institute with clinical stage I and II OSCC. The patients having well-differentiated and moderately differentiated OSCC were included. Association of various histopathological parameters with occult nodal metastasis was assessed using statistical analysis. A total of 102 patients of early-stage well-differentiated and moderately differentiated OSCC with clinically negative necks who underwent elective neck dissection at our institute from the year 2018 to 2023 were enrolled in the study. Depth of invasion (DOI), perineural invasion (PNI), worst pattern of invasion (WPOI), and grade of tumor differentiation were the histopathological parameters entered into the univariate regression analysis as predictive variables, and they were found to be predictors of occult nodal metastasis. An optimal DOI cut-off value of 5.5 mm was obtained for predicting the increase in the risk of occult nodal metastasis. DOI, PNI, WPOI, and grade of tumor differentiation are predictors of occult nodal metastasis. There is a need for searching methods for preoperative and intraoperative detection of all these histopathological factors so that unnecessary elective neck treatment can be avoided.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"837-843"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Incidence of Head and Neck Cancers in Dibrugarh District, Assam, India; During the Period 2003-2016. 2003-2016 年间印度阿萨姆邦迪布勒加区头颈部癌症发病率趋势。

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI: 10.1007/s13193-024-01968-0

Adity Sharma, Utpal Dutta, Chandopal Saikia, Dimpal Pathak, Moirangthem Kameshwor Singh

{"title":"Trends in Incidence of Head and Neck Cancers in Dibrugarh District, Assam, India; During the Period 2003-2016.","authors":"Adity Sharma, Utpal Dutta, Chandopal Saikia, Dimpal Pathak, Moirangthem Kameshwor Singh","doi":"10.1007/s13193-024-01968-0","DOIUrl":"10.1007/s13193-024-01968-0","url":null,"abstract":"Head and neck cancers are considered to be the most common cancers in developing countries, especially in Southeast Asia. In India, it accounts for one-fourth of male cancers and one-tenth of female cancers. An attempt was made to study head and neck cancer trends in the Dibrugarh district of Assam, North-East India, India. All sites viz., oral cavity and mobile tongue, oropharynx, hypopharynx, larynx, nasopharynx and others were considered separately for both the sexes to carry out the present analysis. Using the data from the Population-Based Cancer Registry, Upper Assam, Dibrugarh, annual crude incidence rate and age-specific rate were calculated for the period from 2003 to 2016. Mann-Kendall and Sen's Slope non-parametric analysis were applied to examine the trend in the percentages of Head and Neck cancers. The most frequent incidence site for HN cancers was the hypopharynx (33.50%). The disease was common among the males (78.87%) compared to the female (21.13%) population in Dibrugarh district. HN cancers are more prone to the age group 50-70 years (60.93%) compared to the individuals with less than 50 years (26.51%). Combining all the sites of HN cancers in male showed a significant decrease in incidence, whereas in female increasing trend was noted over a period of time. A slight decline in the percentage of head and neck cancer was documented in Dibrugarh when we combined both sexes. The results obtained from the current investigation will laid the scientific framework for proper planning and organization of prevention, diagnosis and treatment of HN cancers in Dibrugarh district, Assam.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"671-676"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Bioinformatic Analysis Identifies a Tumor Suppressor Landscape of the MEG3 lncRNA in Breast Cancer. 综合生物信息学分析确定了乳腺癌中 MEG3 lncRNA 的肿瘤抑制因子图谱

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-06-27 DOI: 10.1007/s13193-024-01992-0

Alireza Ahmadi, Abedeh Rezaei, Mohammad Khalaj-Kondori, Mina Khajehdehi

{"title":"A Comprehensive Bioinformatic Analysis Identifies a Tumor Suppressor Landscape of the MEG3 lncRNA in Breast Cancer.","authors":"Alireza Ahmadi, Abedeh Rezaei, Mohammad Khalaj-Kondori, Mina Khajehdehi","doi":"10.1007/s13193-024-01992-0","DOIUrl":"10.1007/s13193-024-01992-0","url":null,"abstract":"Breast cancer (BC) is the leading cause of cancer mortality in women and a major risk to world health. Therefore, effective strategies are required for prompt diagnosis and treatment. Nowadays, non-coding RNAs (ncRNAs), particularly long ncRNAs (lncRNAs), have assumed a significant role in the prognosis and diagnosis of diseases, including cancer. In the present study, surveying the bioinformatic tools, including the lncRNADisease v2.0, OncoDB, InteractiVenn, GEPIA, RAID, COXPRESdb, DAVID v6.8, GEO2R, and LncSEA, we proposed the Maternally Expressed Gene (MEG3) as a potential biomarker in BC. This lncRNA significantly downregulates in BC and is associated with tumor size, metastasis, and pathological stage. MEG3 expression is downregulated in several types of primary human cancers and tumor cell lines, which raises the possibility that it could act as a tumor suppressor. The results suggest that MEG3 may play a crucial role in fundamental pathways, including apoptosis, and interact with essential genes and proteins such as P53. It may also be associated with the prognosis, proliferation, migration, invasion, and metastasis of BC.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"752-761"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Breast Cancer Subtypes and Clinicopathological Factors with Axillary Lymph Node Positivity Amongst Women with Breast Cancer in Rajasthan: An Observational Analytical Study. 拉贾斯坦邦乳腺癌亚型和临床病理因素与腋窝淋巴结阳性的关系：观察性分析研究

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-06-19 DOI: 10.1007/s13193-024-01987-x

Pinakin Patel, Naina Kumar, Agil Babu, Ajay Gupta, Kamal Kishore Lakhera, Suresh Singh, Arjun Kumar, Mansi Faujdar, Pranav Singhal, Bhoopendra Singh Gora

{"title":"Association of Breast Cancer Subtypes and Clinicopathological Factors with Axillary Lymph Node Positivity Amongst Women with Breast Cancer in Rajasthan: An Observational Analytical Study.","authors":"Pinakin Patel, Naina Kumar, Agil Babu, Ajay Gupta, Kamal Kishore Lakhera, Suresh Singh, Arjun Kumar, Mansi Faujdar, Pranav Singhal, Bhoopendra Singh Gora","doi":"10.1007/s13193-024-01987-x","DOIUrl":"10.1007/s13193-024-01987-x","url":null,"abstract":"Prognostic factors by definition, are capable of providing information on clinical outcomes at the time of diagnosis, independent of therapy. The number of positive lymph nodes (number of ipsilateral axillary nodes with metastatic tumour deposits) is a strong and independent prognostic factor in breast cancer. In a meta-analysis (New England Journal of Medicine, 2017) of over 62,000 patients, the risk of distant recurrence over years 5 to 20 for those with T1 tumours was 13% in the absence of lymph node involvement, 20% among those with one to three involved lymph nodes, and 34% among those with four to nine involved nodes. In this study, we analyzed the association of clinicopathological factors and breast cancer subtypes with axillary lymph node (ALN) positivity in women with breast cancer in Rajasthan. A multivariate Logistic (Ordinal) Regression Model was used to predict the number of positive lymph nodes based on independent variables that showed 90% significance in bivariate analysis, such as total number of lymph nodes dissected, tumour necrosis, and lymphovascular invasion. The Wald criterion indicated that only LVI had a significant impact on the prediction (p < 0.05), while tumour necrosis and the total number of lymph nodes dissected were not significant predictors (p > 0.05). Patients with LVI had a 43.47 times higher risk of having positive lymph nodes (p < 0.05). Early prediction of lymph node metastasis through LVI testing can help in prognostication. Breast cancer subtypes should not be a criterion while deciding lymph nodal management.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"768-776"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Twofold Expression of Receptor Tyrosine Kinase 2 (ROR2) in Giant Cell Tumors of Bone: Outcome of a Case‒Control Study. 骨巨细胞瘤中受体酪氨酸激酶 2 (ROR2) 的双倍表达：一项病例对照研究的结果。

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-05-28 DOI: 10.1007/s13193-024-01965-3

Shiva S, Sandeep Kumar Nema, Shyam Kumar Tripathi, Kirubakaran Saraswathy P

{"title":"Twofold Expression of Receptor Tyrosine Kinase 2 (ROR2) in Giant Cell Tumors of Bone: Outcome of a Case‒Control Study.","authors":"Shiva S, Sandeep Kumar Nema, Shyam Kumar Tripathi, Kirubakaran Saraswathy P","doi":"10.1007/s13193-024-01965-3","DOIUrl":"10.1007/s13193-024-01965-3","url":null,"abstract":"Suppression or overexpression of transmembrane proteins of the Wnt family and receptor tyrosine kinases (ROR1 and ROR2) is implicated in the causation of cancer. The objective of this study was to determine the expression of ROR2 in patients with giant cell tumor of bone (GCT) by quantitative PCR (qPCR). In this case‒control study, samples of tumor tissue (patients) and bone from the tumor-free margin (controls) were subjected to qPCR in patients who underwent definitive treatment. The GCTs were classified per radiologic classification and histologic grading. Eleven cases and controls, consisting of six men and five women with a mean age of 33.18 ± 12.35 (20-50) years, were included over the study period of 2 years. The median duration since diagnosis was 12 (IQR 9) months. There was a 2.51-fold change (upregulation of ROR2 expression) in cases compared with controls, which was significant (0.00). There was an increase in the expression of ROR2 with tumor grade. However, these differences were not significant (Campanacci (P 0.05 cases and 0.84 controls), Jaffe (P 0.07 cases and 0.44 controls), or Enneking (0.07 cases and 0.44 controls)). Treatment with bisphosphonates (P = 0.17) or denosumab (P = 0.75) had no significant effect on ROR2 expression. Patients with GCT exhibit more than twofold upregulation of ROR2 expression, confirming its role in causing osteoclast-mediated bone destruction. Therefore, ROR2 may be a target for drug development in the treatment of GCT.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"694-698"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adamantinoma: A SEER-based Epidemiological Analysis. 金刚腺瘤：基于 SEER 的流行病学分析。

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Indian Journal of Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-06-26 DOI: 10.1007/s13193-024-02002-z

Kevin E Agner, Michael C Larkins

{"title":"Adamantinoma: A SEER-based Epidemiological Analysis.","authors":"Kevin E Agner, Michael C Larkins","doi":"10.1007/s13193-024-02002-z","DOIUrl":"10.1007/s13193-024-02002-z","url":null,"abstract":"Adamantinoma (AD) is a rare bone cancer accounting for less than 0.1-0.5% of all primary bone tumors. No consensus guidelines exist for the treatment of this disease and long-term (twenty-year) survival has yet to be explored. The Surveillance, Epidemiology, and End Results (SEER) Program was queried for patients with a diagnosis of primary AD (ICD-O-3 code 9261/3). Demographic and treatment variables were analyzed via Fisher's Exact Test and 20-year overall survival (20y OS) was assessed via log-rank analysis. Seventy-four patients with AD were identified; median age was 20-24 years. Multivariate analysis demonstrated that patients < 25 years of age at diagnosis with AD had increased 20y OS compared to those > 24 years (HR = 0.28; p = 0.028), while no other variables influenced survival. Subanalysis demonstrated patients > 40 years saw decreased survival (46% [11%, 81%]) compared to those ≤ 40 years (96% [89%, 104%]; p = 0.005). Patients ≤ 40 years of age at diagnosis were more likely to have local disease (78% of all 49 local cases) and less likely to have distant disease (0% of two cases) compared to patients > 40 years (p = 0.017). Stratifying by surgical procedure, no difference in 20y OS was appreciated (p = 0.12). Younger age at diagnosis provides mortality benefit and increased proportion of localized disease for those diagnosed with AD. No other demographic or treatment variables were found to influence 20y OS. Population-based analysis of AD is limited both by disease rarity and incomplete coding within SEER.","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"809-815"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0