Indian Journal of Surgical Oncology最新文献

{"title":"Analysis of the Efficacy of Surgical Excision Combined with Electron Beam Therapy for Keloids.","authors":"Jiaqi Zhang, Dongjun Jeon, Zheng Su, Xiaolian Xiao, Jinming Zhang, Weiqiang Liang","doi":"10.1007/s13193-024-02048-z","DOIUrl":"https://doi.org/10.1007/s13193-024-02048-z","url":null,"abstract":"<p><p>This study aimed to investigate the incidence and impact of patient characteristics and timing of postoperative electron beam therapy on the treatment efficacy of keloids. A total of 66 patients with keloids underwent surgical treatment and postoperative electron beam therapy. Follow-up was conducted for 43 patients, and treatment efficacy was analyzed for 39 patients. Statistical analysis was used to analyze incidence characteristics and effects of patient characteristics and timing of electron beam therapy on treatment efficacy. The study included 66 patients with 133 keloids. The timing of electron beam therapy significantly impacted treatment efficacy, with higher efficacy observed when performed 0-2 days after surgery compared to 3-5 days after surgery. Keloids are more common in women aged 20-40 years. The timing of electron beam therapy significantly impacted treatment efficacy, with higher efficacy observed when performed 0-2 days after surgery compared to 3-5 days after surgery.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"550-557"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary Carcinoma of Thyroglossal Duct Cyst-A Case Series.","authors":"Sakshi Negi, Naresh Kumar Panda, Sourabha Kumar Patro, Rijuneeta Gupta, Monil Parsana, Shivam Saxena, Debajyoti Chatterjee, Elgiva Khristie Iangngap","doi":"10.1007/s13193-024-02111-9","DOIUrl":"https://doi.org/10.1007/s13193-024-02111-9","url":null,"abstract":"<p><p>Carcinoma arising from the thyroglossal duct cysts is a rare entity which results from metaplastic changes in the persistent thyroglossal duct. This study highlights five cases of thyroglossal duct carcinoma accompanied by thyroid malignancy in three cases. Papillary carcinoma is the predominant subtype, observed in all five cases. Sistrunk surgery, combined with total thyroidectomy, was performed on all patients, with one patient undergoing additional neck dissection. Thyroglossal duct papillary carcinoma is relatively uncommon condition and its co-occurrence with thyroid gland carcinoma further adds to its rarity which required surgical management followed by radioactive iodine ablation therapy with thyroid hormone suppression. Timely identification, coupled with appropriate surgical intervention, is necessary for favourable patient's outcomes. Additional procedures, such as total thyroidectomy when necessary and neck dissection, should be considered.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"633-638"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Mandibulectomy in Oral Cavity Cancers - Classification and Indications.","authors":"Sudhir Nair, Hitesh R Singhavi, Vidula Mestry, Rathan Shetty, Poonam Joshi, Pankaj Chaturvedi","doi":"10.1007/s13193-024-02102-w","DOIUrl":"https://doi.org/10.1007/s13193-024-02102-w","url":null,"abstract":"<p><p>Squamous cell carcinoma of the lip and oral cavity (OSCC) is a significant global health issue, particularly in low-income countries, with an estimated 390,000 cases detected annually. Although surgery remains the primary treatment option, complex resections are frequently required to attain clear margins. Traditionally, a part of the jaw bone close to the tumour is resected (segmental mandibulectomy) during the surgery. However, marginal mandibulectomy (MM), involving the resection of the mandibular rim while preserving its continuity, offers a less debilitating alternative to segmental mandibulectomy (SM) in selected cases. This review examines marginal mandibulectomy's oncological safety and efficacy and its current role in managing oral cavity cancers, as indicated by the most recent literature. MM is an effective treatment for tumours, which abut the mandible without bone invasion and provides comparable oncological outcomes to SM, with fewer functional and cosmetic deficits. The authors also propose a classification based on the plane of resection and location within the mandible. We believe this classification will be helpful in reporting the MM series done in various centres in a uniform fashion. However, there is a need for precise surgical planning before doing an MM for obtaining the optimal results.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"581-586"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mucinous Cystic Neoplasm of Gall Bladder Lacking the Usual Ovarian-Like Mesenchymal Stroma.","authors":"Shikhar Chohan, Sufian Zaheer","doi":"10.1007/s13193-024-02128-0","DOIUrl":"https://doi.org/10.1007/s13193-024-02128-0","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"717-721"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Extra-adrenal Myelolipoma: A Rare Case with Literature Review.","authors":"Snehasis Pradhan, Sujan Kumar Voni, Sudam Sadangi, Jubraj Kalita, Adya Kinkar Panda, Sunil Kumar Agarwal, Debahuti Mohapatra, Sangram Keshari Panda, Subhashree Subhasmita Dash","doi":"10.1007/s13193-024-02121-7","DOIUrl":"https://doi.org/10.1007/s13193-024-02121-7","url":null,"abstract":"<p><p>Myelolipoma is a benign tumour comprising both hematopoietic tissue and normal adipose tissue. It is a rare tumour found incidentally in adrenal glands on imaging, rarely reported in the extra-adrenal/perirenal region with less than 50 cases being reported in the literature. Even rarely, it presents bilaterally. We report a case of a 65-year-old male with bilateral extra-adrenal myelolipoma who underwent en bloc excision of bilateral tumours diagnosed preoperatively by radiological imaging. We reviewed the literature to look into the incidence, aetiology, imaging characteristics, diagnosis, treatment and follow-up in patients with extra-adrenal myelolipomas.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"427-431"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Role of Tumor-Infiltrating Lymphocytes, Tumor Budding, Tumor Border Configuration, and Tumor Stroma Ratio in Colorectal Carcinoma.","authors":"Mukta Pujani, Kanika Singh, Charu Agarwal, Varsha Chauhan, Sneha Prasad, Mitasha Singh, Ruchira Wadhwa, Alka Yadav","doi":"10.1007/s13193-024-02127-1","DOIUrl":"https://doi.org/10.1007/s13193-024-02127-1","url":null,"abstract":"<p><p>Histomorphological features like tumor-infiltrating lymphocytes (TIL), tumor budding (TB), tumor stroma ratio (TSR), and tumor border configuration (TBC) may provide important prognostic information for more accurate stratification and personalized therapeutic approach in colorectal cancer (CRC). The objective of the current study was to investigate the prognostic impact of novel histopathological features (TIL, TB, TBC, TSR) and a new combined risk score (CRS) in primary CRC. This cross-sectional observational study was conducted on hematoxylin and eosin (H&E)-stained slides of 65 primary CRC cases. Stromal TIL was categorized into 3 groups: low (0 to 10%), intermediate (15 to 50%), and high (55 to 100%). Tumor budding was counted in 10 HPFs and graded as follows: 0-4 buds-low TB, 5-9 buds-intermediate TB, and 10 or more buds-high TB. TBC was labeled as either pushing or infiltrative. TSR was scored into two groups as high TSR (low stroma as ≤ 50%) and low TSR (high stroma > 50%). A novel CRS was constructed based on TBC, TB, and TSR: Infiltrating TBC, TB score > 5 (median), and low TSR were categorized as risk items. Final categories were as follows: low-risk tumors with ≤ 1 risk item and high-risk tumors with > 1 risk items. TIL showed a significant correlation with histological tumor type; TB was significantly associated with tumor location, grade, T stage, and perineural invasion, while TBC significantly correlated with tumor location only. TSR showed significant association with tumor location and perineural invasion, while the combined risk score significantly correlated with tumor location and grade. Tumor border configuration, tumor budding, tumor stroma ratio, and the newly formed combined risk score are simple, cost-effective, potential markers in colorectal cancer patients, suggesting that their incorporation in the routine histopathological evaluation could be useful in determining the prognosis of colorectal cancer cases.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"691-697"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinico-Demographic Profile of Carcinoma Rectum-Experience from a Tertiary Care Centre of Eastern India.","authors":"Linkon Biswas, Firdoushi Khatun, Tanmoy Basak, Bidyut Biswas, Koustav Biswas, Sumitava De, Srikrishna Mandal","doi":"10.1007/s13193-024-02114-6","DOIUrl":"https://doi.org/10.1007/s13193-024-02114-6","url":null,"abstract":"<p><p>Carcinoma rectum is a major health issue in India as well as the rest of the world. Cases of rectal cancers are often diagnosed late because of mimicking symptoms with haemorrhoids/fissures and lack of awareness. In this study, we analysed the clinico-demographic profile of patients with carcinoma rectum, attending a tertiary care centre of Eastern India over the last 2 years. We analysed the database of radiotherapy OPD of a tertiary care centre of Eastern India, and collected the demographic, clinical and treatment data of rectal carcinoma patients who attended our OPD between 2021 and 2023. The objective was to assess the demographic and clinical profile of these patients and compare with those reported from other parts of the India as well as rest of the world. Data of total 76 patients were analysed in this study. The mean age of the study population was 50.7 (± 13.59) years. A striking 40% of patients were below 50 years of age. Stage III was the most common (43%) TNM stage at presentation. 15.7% presented with metastatic disease with the liver being the most common site of metastasis. 15.7% of patients underwent upfront surgery either as trans-anal resection or trans-abdominal resection of tumour. Most of the patients (56.5%) had gone through surgery after neo-adjuvant therapy (either total neo-adjuvant therapy or neo-adjuvant radiotherapy). Around 64.4% (<i>n</i> = 49) of patients received radiation as part of total neo-adjuvant therapy (TNT). Eight (10.5%) patients received adjuvant therapy after definitive surgery. To conclude, it can be said that this study revealed involvement of younger population, emergence of poor prognostic histologies and presence of disease at an advanced stage, all of which should be counted as warning signs for the picture rectal carcinoma of India. More researches are required in this field for detection of risk factors, prevention and treatment.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"595-600"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the Planning Target Volume Correlate with Toxicity for Head and Neck Cancer Patients Undergoing Radiation? A Prospective Observational Study.","authors":"Sneha Ujjayani, Manur Gururajachar Janaki","doi":"10.1007/s13193-024-01905-1","DOIUrl":"https://doi.org/10.1007/s13193-024-01905-1","url":null,"abstract":"<p><p>Tolerance to radiation depends on the tumor volume; the greater the volume, the higher the toxicities. In this study, we aimed to study the impact of planning target volume (PTV) on toxicities in head and neck cancer (HNC) patients assigned to receive radiation with or without chemotherapy. Planning target volume (PTV) of 35 histologically proven non-nasopharyngeal head and neck cancer patients undergoing radiation with or without chemotherapy was recorded in cubic centimeters (cc). Their PTV high risk (PTVH) and PTV low risk (PTVL) were correlated with mucositis and dermatitis assessed weekly during treatment and at 2 weeks and 6 weeks post treatment. Thirty-five patients were treated with chemoradiation. Their mean PTVH was 278.08 cc (83-812 cc). The mean PTVL was 505.5 (44-1173 cc). Grade II and above mucositis was seen around fourth week and dermatitis and dysphagia by the end of fifth week which persisted till 2 weeks post follow-up in majority of patients. A cutoff of PTVH > 220 cc and PTVL > 550 cc correlated with grade 2 and above toxicities. Head and neck cancer patients with PTV 66 Gy > 220 cc need to be monitored closely during chemoradiation as they are likely to develop severe grades of toxicities.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"516-520"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation of Briganti and Memorial Sloan-Kettering Cancer Centre Nomograms for Predicting Lymph Node Invasion in the Indian Cohort of Patients with Prostate Cancer.","authors":"Mayank Agrawal, Milap Shah, Danny Darlington Carbin, Puneet Ahluwalia, Gagan Gautam, Gopal Sharma","doi":"10.1007/s13193-023-01732-w","DOIUrl":"10.1007/s13193-023-01732-w","url":null,"abstract":"<p><p>Briganti and Memorial Sloan-Kettering Cancer Centre (MSKCC) nomograms are the two commonly used models for predicting lymph node invasion (LNI) in patients with prostate cancer. However, they have never been validated in the Indian cohort of patients with prostate cancer. Hence, with this study, we aimed to externally validate Briganti (2012) and MSKCC nomograms in our dataset of patients who underwent robot-assisted radical prostatectomy (RARP). We reviewed our prospectively maintained RARP data to predict the probability of LNI using Briganti (2012) and MSKCC nomograms. The two models were validated by receiver operating characteristic (ROC) curve analysis, calibration plots, and decision curve analysis (DCA). Of the 482 patients included in this study, 127 (26.3%) had lymph nodal metastasis. ROC analysis revealed an area under the curve of 0.75 (0.70-0.80) and 0.76 (0.71-0.80) for the Briganti and MSKCC nomograms, respectively, in predicting LNI. Calibration plots for both Briganti and MSKCC nomograms showed under or overestimation at different predicted probabilities. DCA showed a net clinical benefit of both models at a threshold probability of 10%. Using 5% cut-off for threshold for lymph node dissection, Briganti nomogram would have sensitivity, specificity, PPV, and NPV of (126/127) 99.2%, (14/355) 3.9%, (126/467) 26.9%, and (14/15) 93.3%, respectively. Using the same cut-off, MSKCC nomogram would have sensitivity, specificity, PPV, and NPV of (126/127) 99.2%, (56/355) 15.7%, (126/425) 29%, and (56/57) 98%, respectively. With this study, we independently validated Briganti and MSKCC nomograms for predicting LNI in the Indian cohort of patients with prostate cancer.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":" ","pages":"450-455"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44275502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Worth Performing Intersphincteric Resection in Patients Having Rectal Adenocarcinoma with Oligometastasis.","authors":"Abdeali Saif Arif Kaderi, Sanjay Singh, Ankit Sharma, Mufaddal Kazi, Ashwin Desouza, Avanish Saklani","doi":"10.1007/s13193-024-02117-3","DOIUrl":"https://doi.org/10.1007/s13193-024-02117-3","url":null,"abstract":"<p><p>Intersphincteric resection (ISR) is being increasingly performed in metastatic rectal adenocarcinoma (with oligometastasis) patients. There has been a trend towards worse prognosis in this group. This study compares the oncological and surgical outcomes of patients with and without pre-operative oligometastasis who underwent ISR. The outcomes compared include prognostic factors like margin positivity, recurrence rates, stoma reversal rate, and surgical failure rate (defined as a combination of one or more of the aforestated factors). The demographic pattern, American Society of Anaesthesia grade (ASA), treatment received, clinical and histopathological T and N stage, grade, type of minimally invasive surgery (MIS) approach, neoadjuvant therapy, and pathological high-risk features are also studied. Patients who underwent minimally invasive ISR over 10 years at a high-volume tertiary cancer center were selected for the study. Factors used for the assessment of oncological outcomes were margin positivity (circumferential resection and distal margin), recurrence (both local and systemic), and stoma reversal rate. A descriptive and comparative analyses were performed. Four hundred and eight patients underwent minimally invasive ISR of which 25 (6.12%) patients were oligometastatic. While R0 resection was similar in both groups, higher overall recurrence (24% versus 18.5%) and low stoma reversal rate (36.8% versus 67.3%) were observed in the oligometastatic group with statistically significant differences. No local recurrence was seen in the oligometastatic group, and the difference compared to non-metastatic group was not statistically different. This study indicates that oligometastatic patients who underwent ISR experienced lower stoma reversal rates, maintaining similar local control but facing higher rates of systemic recurrence.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-02117-3.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"645-650"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}