Indian Journal of Surgical Oncology最新文献

{"title":"From Statistics to Stories: Unveiling the Epidemiology of Breast Carcinoma in Northwestern India.","authors":"Naina Kumar, Kriti Gera, Pinakin Patel, Kamal Kishore Lakhera, Suresh Singh, Bhairulal Gurjar, Arjun Kumar, Pranav Singhal, Bhoopendra Gora, Raj Govind Sharma","doi":"10.1007/s13193-024-02104-8","DOIUrl":"https://doi.org/10.1007/s13193-024-02104-8","url":null,"abstract":"<p><p>After receiving the pathology report for breast cancer, the first question most patients ask their doctor is about their journey ahead. The type of cancer and how it spreads can give us an idea of what to expect during follow-up. Unfortunately, there is a lack of reporting, management, and documentation of breast cancer cases in India, resulting in a shortage of information on the different types of breast cancer. To address this issue, a study was conducted to gain a better understanding of the pattern of breast carcinoma in Northwestern India. A total of 2619 breast cancer pathology reports were gathered from four major diagnostic centres in Northwest India. Out of all breast cancer patients, 97.74% (2560) were women, while men accounted for only 2.25% (59) of the sample. At the time of diagnosis, 72% of patients were in stages III and IV, while only 28% of patients were in the early stages of cancer (stages I and II). The most common type of breast cancer was infiltrating duct carcinoma (IDC), which constituted 80.71% (2114/2619) of all malignant lesions. infiltrating lobular carcinoma was the second most common pathology, accounting for 5.38% (141/2619) of all cases. The rarer pathologies had a presentation rate below 10%. Our study revealed the most common symptom as a painless lump. Significant majority presented in advanced stages. An alarming 20% presented with foul-smelling ulceration or fungation of the skin. Varied presentations of breast cancer subtypes were evident. As the age-old saying goes-the 'most common' is often ignored as a large portion of the researcher's attention is focused on 'rarer stuff'. Similarly, IDC being the commonest deserves most of our attention. Not just the histology but its grades too. The lack of awareness regarding the risk factors and early detection methods of breast cancer is unfortunately even prevalent in 49% of healthcare workers. What India needs are more data reporting, timely diagnostic strategies, standardized reporting for pathology, and guideline-based management strategies. Increasing data collection electronically in the coming years will help India in displaying more data.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"543-549"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Platelet/Albumin Ratio Predicts Morbidity and Mortality in Patients with Retroperitoneal Liposarcoma.","authors":"Dorian Yarih Garcia-Ortega, Julián Diaz-Rico, Ana Paulina Melendez-Fernandez, Constanza Palma-Rebollar, Kuauhyama Luna-Ortiz","doi":"10.1007/s13193-024-02106-6","DOIUrl":"https://doi.org/10.1007/s13193-024-02106-6","url":null,"abstract":"<p><p>Retroperitoneal sarcomas are a rare and heterogeneous group of malignant neoplasms. The most frequent sarcoma in this location is liposarcoma; complete resection is the gold standard of treatment. To achieve this, a multivisceral resection is often necessary to reduce local recurrence. However, this approach must be balanced by the potential for added morbidity. This study aims to evaluate the platelet-albumin ratio as a predictor of morbidity risk. A retrospective review of the medical records of patients with retroperitoneal liposarcomas operated with curative intent at our institution between January 2010 and December 2020 was performed. The platelet-albumin ratio was calculated, and a cutoff point of 78.86 was determined to predict morbidity by receiver operating characteristic (ROC) curve analysis, divided into high-risk and low-risk groups with a sensitivity of 83% and a specificity of 71.6%. These risk groups were contrasted with the different demographic and evolution variables. One hundred thirty-six patients were analyzed, and 91 met the inclusion criteria; age at presentation was 52.55 years (SD 12.96), tumor size was 29.31 (SD 12.43), and 40.7% underwent multivisceral resections, identifying a difference between the presence of a high platelet/albumin ratio and the appearance of complications at 30 days with an OR of 8 (CI 1.0052 to 63.6698, <i>p</i> 0.0494). The platelet-albumin ratio is an easy-to-use test that could help clarify the group of patients who require preoperative prehabilitation to reduce significant complications.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"558-566"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Desk of Editors: Surgical Oncology-Embracing Change and Enduring Relevance.","authors":"Pankaj Kumar Garg, S P Somashekhar","doi":"10.1007/s13193-025-02309-5","DOIUrl":"https://doi.org/10.1007/s13193-025-02309-5","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"377-381"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Hodgkin Lymphoma Presenting as an Ulcerated Soft Tissue Mass on Left Thigh: A Rare Case Report.","authors":"Arshi Khan, Ruquiya Afrose, Sadia Afreen, Karthik Dasari, Mohammad Akram, Sayeedul Hasan Arif, Mohammad Jaseem Hassan","doi":"10.1007/s13193-024-02105-7","DOIUrl":"https://doi.org/10.1007/s13193-024-02105-7","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"712-716"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of Solid Pseudopapillary Neoplasm of the Pancreas-an Experience from Tertiary Care Centre.","authors":"Rohit Bhatta, Santosh Irrinki, Vikas Gupta, Thakur Deen Yadav, Yashwant Raj Sakaray, Hemanth Kumar, Ritambhra Nada, Harjeet Singh","doi":"10.1007/s13193-023-01805-w","DOIUrl":"10.1007/s13193-023-01805-w","url":null,"abstract":"<p><p>Solid pseudopapillary neoplasm (SPN) is uncommon and constitutes to 1-2% of pancreatic tumours. Owing to its rarity, literature is sparse on its clinicopathological characteristics and surgical outcomes. Our study is a retrospective analysis of prospectively maintained data of patients with histologically proven SPN between January 2012 and December 2019. Patients' demography, clinical presentation, preoperative imaging, operative details, perioperative outcomes, and long-term follow-up were recorded and analyzed. A total of 14 patients were included in the study, all were females with a median age of 19.5 years (range 15-35 years). All presented with pain abdomen. Eight (57.1%) out of 14 patients were correctly diagnosed with contrast-enhanced computed tomography (CECT) abdomen. CECT revealed solid cystic well-encapsulated lesions in 12(85.7%) and homogenous mass lesions without cystic changes in 2 (14.2%) patients. The most common tumour location was head/uncinate process (57.1%). Eight (57.1%) underwent pancreaticoduodenectomy and 6 (42.8%) had undergone distal pancreatectomy. The median size of tumour was 10 cm (4.5-14 cm). The median postoperative stay was 9 days (range 4-20 days). Seven patients (50%) developed postoperative pancreatic fistula (Grade-A-6/7, Grade-B-1/7) and delayed gastric emptying (DGE) was noted in two (14.2%). R0 resection could be achieved in 13 patients (92.8%). Median follow-up period was 49.5 months. One patient had postoperative recurrence after 48 months of surgery. SPN is a rare tumour of pancreas. Surgical resection is associated with acceptable morbidity and is required for potential cure.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":" ","pages":"502-507"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47371903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cancer Care-Post‑Independence Evolution in West Bengal and Eastern India.","authors":"Arnab Gupta","doi":"10.1007/s13193-022-01650-3","DOIUrl":"https://doi.org/10.1007/s13193-022-01650-3","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s13193-022-01603-w.].</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"722"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chemotherapy on Fertility and Fertility Preservation Strategies for the Women of Childbearing Potential Undergoing Chemotherapy: A Comprehensive Review.","authors":"Mayank Kapoor, Anusha Mruthyunjaya Swamy, Deepak Sundriyal, Mridul Khanna, Nishant Sinha, Karthik J, Shalini Rajaram, Amit Sehrawat","doi":"10.1007/s13193-024-02103-9","DOIUrl":"https://doi.org/10.1007/s13193-024-02103-9","url":null,"abstract":"<p><p>Cancer incidence among women of childbearing potential (WCBP) underscores the need for effective fertility preservation strategies. Advances in cancer treatment have significantly improved survival rates, highlighting survivorship issues, particularly fertility concerns in younger patients. Chemotherapy, while a crucial treatment for cancer, often brings with it unintended consequences, particularly regarding fertility. Chemotherapy induces gonadotoxicity through mechanisms such as DNA damage, follicular apoptosis, and hormonal disruption, compromising ovarian function and fertility. The risk of infertility may be low, intermediate, or high depending upon the drug used, the dose, and the duration of use. Quantifying chemotherapy's impact is challenging due to diverse agents and variable effects. Guidelines recommend discussing fertility preservation options with WCBP before treatment, using biomarkers like anti-Mullerian hormone (AMH) to assess ovarian reserve. Strategies include cryopreservation of ovarian tissue, embryos, and oocytes, each with distinct advantages and considerations. Pharmacological interventions like GnRH agonists aim to mitigate gonadotoxic effects, although their efficacy is debated. Surgical approaches like oophoropexy protect ovaries during pelvic radiation but pose logistical challenges. Fertility preservation involves ethical and psychosocial dimensions, including informed consent, financial considerations, and ethical dilemmas, necessitating comprehensive patient counselling. Future research focuses on enhancing techniques such as in vitro maturation, developing artificial ovaries, and refining cryopreservation methods to optimize outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"401-407"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Distant Metastases in High-Risk Operable Breast Cancer (HROBC) pT1-2 N2a or Higher at Diagnosis.","authors":"Vani Parmar, Naveena Kumar An, Nita S Nair, Shalaka Joshi, Purvi Thakkar, Garvit Chitkara, Basila Ali, Varsha Gaikwad, Shabina Siddique, Vaibhav Vanmali, Palak Popat, Sneha Shah, Sangeeta Desai, Tanuja Shet, Meenakshi Thakur, Venkatesh Rangarajan, Rajendra Achyut Badwe","doi":"10.1007/s13193-024-02098-3","DOIUrl":"https://doi.org/10.1007/s13193-024-02098-3","url":null,"abstract":"<p><p>Current standard guidelines do not recommend a routine staging workup in early operable breast cancer (OBC) as the incidence of de novo metastasis is only 1-2%. Some of these patients are at high risk for relapse based on the higher axillary nodal burden. This prospective study evaluated the presence of de novo asymptomatic distant metastases in HROBC with pT1/2 N2a/N3 on upfront surgery. A single-centre study was carried out in upfront operated OBC patients with four or more axillary nodes positive after definitive surgery. Comprehensive metastatic workup was carried out, including an ultrasound abdomen, bone scan, and CT scan (thorax-abdomen-pelvis) or PET scan before initiating adjuvant treatment. If a distant disease was detected, the adjuvant treatment intent was tailored accordingly. The study accrued a prospective consecutive cohort of 97 women with pT1-2 N2a-3 during 2015-2018 operated upfront for OBC with cT1-2 N0-1. Forty percent of women were premenopausal, 54 (55.6%) had pN2a, and 43 (44.3%) had pN3 disease. Distant disease was seen in 8 of 97 women (8.24%) of these high-risk early cancers, 5 had oligometastatic denovo disease (5.15%), and 3 had polymetastatic (3.09%). Between the 2 groups, the pickup rate of distant disease was higher in pN3 (11.4%) as against pN2a (5.6%), <i>p</i> = NS. Only 3.09% of patients with extensive metastases were treated with palliative intent. The study shows potential to optimize the management of HROBC with heavy nodal disease identified post-primary surgery by selective staging investigations, adequate resource stratification, and thereby improved management, including modifying treatment plans early.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"576-580"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Define Inflammatory Breast Cancer: A Systematic Review.","authors":"Sadaf Alipour, Ramesh Omranipour, Mohammadreza Zafarghandi, Abdolali Assarian, Ali Mir","doi":"10.1007/s13193-024-02094-7","DOIUrl":"https://doi.org/10.1007/s13193-024-02094-7","url":null,"abstract":"<p><p>The diagnosis of IBC is clinical and mainly based upon skin changes. This definition may vary from one clinician to another and one patient to another. Due to the obscure criteria available for diagnosing IBC, in this review, we gathered all the reliable information in the literature about the definition of IBC in the last decade to identify important features that should be considered in the diagnosis. We conducted this systematic review on MEDLINE and PUBMED by searching for the keywords \"inflammatory breast cancer,\" \"diagnosis,\" \"criteria,\" or \"definition.\" The time limit of this study was 13 years, from 2010 to 2023. Our basic search revealed 158 articles and finally 24 studies were approved and evaluated. The prevalence of clinical signs and symptoms and imaging and pathologic features were analyzed. The clinical criteria for the definition and diagnosis of IBC were mentioned in 100% of the studies, with the most common being skin changes (erythema, edema, and peau d'orange) in all 24 articles, rapid onset (< 6 months) in 66.6% of the studies, and involvement of at least one-third of the breasts in 41.6% of the studies. The imaging criteria for IBC diagnosis were discussed in 11 studies (45.8%), with the most common imaging sign being diffuse involvement of the breast and skin thickening (72.7%). Five studies (20.8%) evaluated the role of magnetic resonance imaging (MRI) in the diagnosis of IBC and reported the following findings: heterogeneous enhancement, edema on T2-weighted images, asymmetrical enhancement, diffuse non-mass enhancement, skin enhancement, and Cooper's ligament enhancement. Pathology-specific findings were common in 10 articles (41.6%), which included dermal/non-dermal lymphatic tumor emboli. This study suggested that IBC should be suspected in the presence of rapid-onset (at least less than 6 months) erythema and edema, regardless of its extent, and when suspected, mammography and ultrasound should be performed to search for diffuse skin or parenchymal involvement, multicentric disease, and suspicious regional lymph nodes. MRI and skin biopsy could be helpful when the diagnosis is not clear (e.g., no underlying mass).</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"393-400"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Number of Negative Lymph Nodes Removed on the Survival and Recurrence Rate After Primary Surgery in Patients with Ovarian Cancer: A Multi-Center Retrospective Cohort Study.","authors":"Elham Rahimpour, Behnaz Niroomand, Maryam Kalatehjari, Fatemeh Shahbakhti, Mansour Bahardoust, Babak Goodarzy, Fatemeh Majdolashrafi, Sara Ghorbanzade, Adnan Tizmaghz","doi":"10.1007/s13193-024-02077-8","DOIUrl":"https://doi.org/10.1007/s13193-024-02077-8","url":null,"abstract":"<p><p>The effect of the number of negative lymph nodes (NLNs) removed on the overall survival (OS) and recurrence rate of ovarian cancer (OC) patients has not been investigated. This study aimed to investigate the effect of the number of NLNs removed on OC patients' survival and recurrence rate after primary surgery. In this multi-center cohort study, the medical profile of 504 OC patients (mean age 55.21 years and mean follow-up 78.5 ± 28.4 months) who underwent primary surgery between 2011 and 2021 in gynecological tumor surgery centers affiliated with Iran and Shahid Beheshti Universities of Medical Sciences, Tehran, Iran, was retrospectively examined. Based on the number of NLNs removed, patients were divided into four groups, including 0-9, 10-19, 20-30, and > 30 NLNs, including 152, 169, 124, and 59 OC patients, respectively. The 5-year survival was 49.1%. The median survival was 61 months. The RFS and OS were significantly better in patients with more than 30 NLNs removed compared to other groups. The multivariable analysis showed that the OS rate was significantly better in patients with the number of NLNs removed ≥ 20 compared to < 20 (HR, 1.88; 95% CI 1.15-2.62; <i>p</i>, 0.001). Also, age, FIGO stage, presence of metastasis, adjuvant therapy, and tumor pathological differentiation were significantly related to the OS of OC patients (<i>p</i> < 0.05). Paying attention to the number of NLNs removed during primary surgery can be a key factor in improving the OS rate of OC patients.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"536-542"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}