Indian Journal of Surgical Oncology最新文献

{"title":"Comparative Study of Conventional Care Vs. Enhanced Recovery After Surgery (ERAS) in Colorectal Surgery : a Retrospective Observational Study in a Tertiary Care Setting.","authors":"Sean S Jacob, Shabnam S Aboobacker, Kushal Agarwal, Ashwin Kr, Darshan Patil, Neha Shekhar, Sanjana Mahesh, Rohit C Kumar, Nagarjuna Reddy, Maria Reddy","doi":"10.1007/s13193-026-02570-2","DOIUrl":"https://doi.org/10.1007/s13193-026-02570-2","url":null,"abstract":"<p><strong>Background: </strong>Enhanced Recovery After Surgery (ERAS) protocols aim to reduce surgical stress, postoperative morbidity, and length of hospital stay following colorectal surgery. While ERAS has been widely adopted in high-income countries, evidence from low- and middle-income tertiary care settings remains limited. This study compares perioperative outcomes of ERAS versus conventional care in patients undergoing colorectal cancer surgery.</p><p><strong>Methods: </strong>This retrospective observational study analyzed a prospectively maintained database of 153 patients who underwent elective colorectal cancer resections at a tertiary oncology center between July 2023 and July 2025. Patients were divided into a pre-ERAS group (Group I, n = 85) and a post-ERAS group (Group II, n = 68). Primary endpoints included length of hospital stay, postoperative complications, protocol compliance, and 30-day readmissions. Secondary outcomes assessed specific complication categories. Descriptive and comparative statistical analyses were performed.</p><p><strong>Results: </strong>Baseline demographic, clinical, and tumor characteristics were comparable between groups. Implementation of ERAS resulted in a significant reduction in median length of hospital stay from 7.8 to 5.6 days (28.2% reduction). Overall ERAS compliance improved markedly from 32.5% in the pre-ERAS period to 86.0% post-implementation, with substantial gains across preoperative, intraoperative, and postoperative components. Major postoperative complications, including anastomotic leak and surgical site infections, remained low and comparable between groups. Pulmonary outcomes improved, and no increase in cardiovascular complications was observed. Gastrointestinal complications such as postoperative ileus and nausea were more frequent in the post-ERAS group but did not translate into increased morbidity or readmission rates.</p><p><strong>Conclusion: </strong>Implementation of ERAS protocols in colorectal cancer surgery is feasible and safe in a tertiary care setting and is associated with significantly reduced hospital stay and improved protocol adherence without increasing major postoperative morbidity. High compliance with ERAS pathways plays a crucial role in optimizing short-term surgical outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"755-763"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Role of Epithelial-Mesenchymal Transition Markers in Oral Squamous Cell Carcinoma: An Observational Study.","authors":"Pratik Solanki, Manu Malhotra, Ashok Singh, S K S Mareshwari, Rahul Kumar, Ritu Thakur, Amit Gupta","doi":"10.1007/s13193-026-02587-7","DOIUrl":"https://doi.org/10.1007/s13193-026-02587-7","url":null,"abstract":"<p><strong>Introduction: </strong>Epithelial-mesenchymal transition (EMT) has evolved as a possible pathway in the pathophysiology of tumor formation and progression; however, the contribution of this phenomenon in human cancers, especially oral malignancy, lacks sufficient evidence. This study aimed to evaluate the expression of EMT markers E-cadherin and N-cadherin and their correlation with clinicopathological factors in Oral Cavity Squamous Cell Cancer (OSCC).</p><p><strong>Methods: </strong>This prospective observational study was conducted on a hundred histologically proven cases of OSCC based on inclusion and exclusion criteria. In these cases, the expression level of Epithelial-Mesenchymal Transition markers (E-cadherin, N-cadherin) was evaluated using Immunohistochemistry (IHC) staining. Expression of E-cadherin and N-cadherin was analyzed and correlated with clinical and histopathological factors using appropriate statistical methods.</p><p><strong>Results: </strong>The mean age of the patients was 47.96 ± 11.15 years (range: 24-70 years) with male predominance (92%). E-cadherin and N-cadherin expression were observed in 18 (18%) and 58 (58%) cases, respectively. Reduced expression of E-cadherin was observed in 82% of cases, while N-cadherin positivity was seen in 58% of tumors. N-cadherin expression showed a statistically significant association with clinical T stage (<i>p</i> = 0.001), clinical N stage (<i>p</i> = 0.041), tumor size (<i>p</i> = 0.016), depth of invasion (<i>p</i> = 0.001), pathological T stage (<i>p</i> = 0.005), and AJCC stage (<i>p</i> = 0.017). No significant association was observed between E-cadherin expression and clinicopathological parameters.</p><p><strong>Conclusion: </strong>This study demonstrated frequent loss of E-cadherin and increased N-cadherin expression in oral squamous cell carcinoma. N-cadherin positivity showed significant association with indicators of tumor aggressiveness such as higher T stage, nodal involvement, tumor size, depth of invasion, and AJCC stage, suggesting a possible role of cadherin switching in OSCC progression.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-026-02587-7.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"819-826"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Critical Role of Intra-Operative Frozen Section Biopsy in Recurrent and Previously Treated Oral Cavity Cancers: Institutional Experience from 510 Cases.","authors":"Mohsina Hussain, Viren Nagarkar, H Sonal, Sucheta Gandhe, Yogesh Pawar, Sirshendu Roy, Raj Nagarkar","doi":"10.1007/s13193-026-02547-1","DOIUrl":"https://doi.org/10.1007/s13193-026-02547-1","url":null,"abstract":"<p><strong>Background: </strong>Frozen section (FS) is commonly used for intraoperative margin assessment in oral cavity squamous cell carcinoma (OCSCC). Its value in recurrent or previously treated cases, however, remains uncertain.</p><p><strong>Methods: </strong>We retrospectively analyzed prospectively collected data from 510 patients with histologically confirmed OCSCC treated between April 2018 and August 2022. Patients were divided into Group A (recurrent/second primaries/previously treated, n = 247) and Group B (treatment-naïve, n = 263). A 1-cm gross margin was targeted for all resections. FS and permanent sections were reviewed by three institutional pathologists. Margins were defined as positive (tumor/ moderate to severe dysplasia at the cut edge or < 1 mm), close (1-5 mm), and free (> 5 mm). Primary outcomes included initial FS margin status, number of additional resections (recuts), and final histopathology margin status.</p><p><strong>Results: </strong>On initial FS, a significantly higher proportion of patients in Group A had close or positive margins (34.41%, 85/247) compared to Group B (1.52%, 4/263), with the difference being highly statistically significant (p < 0.0001). After intraoperative revision, 72 of the 85 patients (84.70%) in Group A achieved negative margins on a second margin revision, and an additional 9 patients (10.58%) required a third margin revision to achieve negative margins. Overall, only 4 of the 510 patients (0.78%) in the entire cohort had close or positive margins on final histopathology, and all four were from Group A. On final HPE, 3 patients had close margins and 1 had a persistent positive margin.</p><p><strong>Conclusion: </strong>Gross examination with an adequate margin may be sufficient for treatment-naïve OCSCC. However, for previously treated cases, FS significantly aids in achieving intraoperative margin clearance and reduces final positive margins. The study's primary aim was not to assess oncologic outcomes, but rather to emphasize the necessity of FS in complex cases who had undergone multiple prior treatments where gross inspection is unreliable.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"744-748"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pd-L1 Expression in Oral Cavity Squamous Cell Carcinomas.","authors":"Aasma Nalwa, Aarathi Visakhan, Poonam Abhay Elhence, Meenakshi Rao, Vikarn Vishwajeet, Akhil Dhanesh Goel","doi":"10.1007/s13193-026-02565-z","DOIUrl":"https://doi.org/10.1007/s13193-026-02565-z","url":null,"abstract":"<p><p>Programmed cell death ligand-1 (PD-L1) is involved in T-cell regulation by acting as an immune checkpoint inhibitor, and its expression is being widely studied in various malignancies. The following study was designed to examine the role of PD-L1 and its association with HPV in oral squamous cell carcinomas in the Indian population. Immunohistochemistry for PD-L1 and p16 was done on the resection specimens. Combined positive score (CPS) was evaluated for PD-L1; a CPS <i>≥</i> 1and < 20 was considered low-positive, and a CPS <i>≥</i> 20 was considered strong positive. Diffuse and strong nuclear and cytoplasmic expression of p16 in <i>≥</i> 70% tumor cells was considered positive (block) expression. A total of 188 cases were included in the study. PD-L1 expression was seen in a total of 86.1% (162 cases); of these, 67.02% (126 cases) showed strong expression of PD-L1 with a CPS <i>≥</i> 20. A significant correlation was observed between PD-L1 expression and tumor stage, with higher PD-L1 expression in advanced stages T2-4 compared to T1 (p-value = 0.014). No significant correlation of PD-L1 with p16 positivity, lymph node metastases, or tumor grade was observed. High PD-L1 expression was observed in more than 80% of cases, regardless of HPV status, suggesting that targeted immunotherapy with PD-L1 inhibitors can be an effective treatment in the Indian subpopulation, especially in those with advanced-stage tumors.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"764-769"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Oncologists as Clinical Leaders in Multidisciplinary Cancer Care.","authors":"Pankaj Kumar Garg, Andreas Brandl","doi":"10.1007/s13193-026-02599-3","DOIUrl":"https://doi.org/10.1007/s13193-026-02599-3","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"709-710"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Surgical Management of Retroperitoneal Paragangliomas: A Single Centre Experience.","authors":"Yalini Devi, Tanvi M Shah, Mufaddal Kazi, Shraddha Patkar, Rajiv Kumar Kaushal, Kunal Gala, Mahesh Goel","doi":"10.1007/s13193-026-02538-2","DOIUrl":"https://doi.org/10.1007/s13193-026-02538-2","url":null,"abstract":"<p><p>Retroperitoneal paragangliomas (RP-PGLs) are rare extra-adrenal neuroendocrine tumors representing ~ 1-3% of retroperitoneal masses. They may secrete catecholamines, causing hypertension and life-threatening complications if untreated. Surgical resection is the mainstay of therapy, yet data-particularly from the Indian subcontinent-are scarce. To evaluate clinical presentation, diagnostic workup, perioperative management and long-term outcomes of RP-PGL resections at a tertiary oncology center. A retrospective analysis of 30 patients who underwent RP-PGL resection from 2005 to 2023 was done. Preoperative evaluation was based on standard institutional protocols after a multidisciplinary discussion. Data collected included operative time, blood loss, histopathology (tumor size, stage, margins, SDH/MEN mutations) and Clavien-Dindo morbidity. Overall survival (OS) and disease-free survival (DFS) were estimated via Kaplan-Meier analysis. Median age was 44 years (range 22-66); 40% were male. Presentations: pain (56.7%), incidental mass (23.3%), classical symptoms (6.7%). Half had secretory tumors; 40% of these exhibited uncontrolled hypertensions. R0 resection was achieved in 73.3%, including 13.3% multivisceral/vascular resections. SDH and MEN mutations were found 16.7%, and 3.3% respectively. Postoperative morbidity ≥Clavien-Dindo IIIa occurred in 16.7%, with no 90-day mortality. At a median follow-up of the 36.9 months (95% C.I: 10.9 to 62.8 months), median OS and DFS were not reached and the 3-year Overall survival (OS) and 3-year disease free survival (DFS) was 95.5% (91.1 to 99.9%) and 89.1% (81.6 to 96.6%) respectively. Three recurrences occurred; two responded to peptide receptor radionuclide therapy. Surgical management of RP-PGLs is safe and achieves excellent long-term survival. A standardized diagnostic algorithm, multidisciplinary perioperative optimization and readiness for complex resections are key to favorable outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"813-818"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very Late Spontaneous Rupture of a Studer Orthotopic Neobladder Fifteen Years After Radical Cystoprostatectomy.","authors":"Huber Díaz-Fuentes, Andrés Martínez-Cornelio, David A Nájera","doi":"10.1007/s13193-026-02574-y","DOIUrl":"https://doi.org/10.1007/s13193-026-02574-y","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"717-718"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience Based Procedure Guide for Robotic Bilateral Axillo-breast Approach (BABA) Thyroidectomy Using the SSI MANTRA Robotic System: Feasibility, Safety, and Early Outcomes from a Prospective Case Series.","authors":"Kushal Agrawal, Ashwin Kr, Rohitkuma C, Narayana Subramaniam, Elvis Joseph, Esha Shanbhag, Chintan Safi, Omkar Sahindrakar, Jyotsana Goyal, Somashekhar Sp","doi":"10.1007/s13193-026-02563-1","DOIUrl":"https://doi.org/10.1007/s13193-026-02563-1","url":null,"abstract":"<p><p>Open thyroidectomy remains the standard treatment for most thyroid disorders; however, concerns regarding permanent cervical scarring have led to increasing adoption of remote-access techniques. The bilateral axillo-breast approach (BABA) provides symmetric access and familiar anatomy while avoiding a neck incision. Robotic assistance further enhances precision and ergonomics. The SSI MANTRA robotic system is a newer, indigenously developed platform, but procedural standardization for robotic BABA thyroidectomy using this system is limited. To present an experience-based procedural roadmap for robotic BABA thyroidectomy using the SSI MANTRA robotic system and to evaluate its feasibility, safety, and early outcomes. This prospective case series included 32 patients who underwent robotic BABA thyroidectomy using the SSI MANTRA system. A standardized procedural guide encompassing preoperative optimization, operating room setup, patient positioning, port placement, docking strategy, instrumentation, and stepwise surgical technique was developed. Demographic characteristics, intraoperative variables, and early postoperative outcomes were analyzed. The mean age was 29 years, with a female predominance (87.5%). The mean total operative time was 189.4 ± 41.9 min, with a mean docking time of 31.2 ± 11.3 min and a mean console time of 121.3 ± 38.4 min. Mean blood loss was 24 ml. No intraoperative recurrent laryngeal nerve or tracheal injuries occurred. Transient vocal cord palsy was observed in 2 patients (6.25%) and transient hypoparathyroidism in 3 patients (9.37%), with no permanent complications. Other postoperative events were infrequent and managed conservatively. Robotic BABA thyroidectomy using the SSI MANTRA robotic system is a safe and feasible remote-access technique with acceptable operative efficiency and low early morbidity. The standardized procedural roadmap may enhance reproducibility and facilitate wider adoption. Larger studies with long-term follow-up are warranted.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"770-777"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Gamma-Glutamyl Transferase as an Adjunctive Marker for Liver Metastasis in Gallbladder Carcinoma-An Observational Study.","authors":"Manish Kulshrestha, Sarath Krishnan, Deepak Rajput, Bela Goyal, Amit Gupta, Sweety Gupta, Vatsala Singh, Adarsh Jha","doi":"10.1007/s13193-026-02593-9","DOIUrl":"https://doi.org/10.1007/s13193-026-02593-9","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between serum gamma-glutamyl transferase (GGT) levels and liver metastasis in gallbladder carcinoma (GBC) and assess its potential as an adjunctive biomarker for staging and surgical planning.</p><p><strong>Materials and methods: </strong>This observational, cross-sectional study was conducted over 18 months at a tertiary care centre and included 109 histologically confirmed GBC patients. Biochemical parameters, including serum GGT, alkaline phosphatase (ALP), bilirubin fractions, and tumor markers (CEA, CA 19 - 9, CA 125), were analyzed. The association between GGT and clinicopathological variables was assessed using appropriate statistical methods, and the diagnostic performance of GGT was evaluated using receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>Based on contrast-enhanced CT imaging, patients were categorized into two groups: those with liver metastasis (<i>n</i> = 50) and those without (<i>n</i> = 59). Serum GGT levels were significantly elevated in the liver metastasis group (130.00[59.50-340.25]U/L) compared to those without metastasis (73.00[33.00-168.00]U/L; <i>p</i> = 0.0034). GGT showed strong correlations with ALP (ρ = 0.68, <i>p</i> < 0.001), direct bilirubin, and total bilirubin. ROC analysis yielded an AUC of 0.666, with a GGT cutoff of 203 U/L showing 44.0% sensitivity and 81.4% specificity. Elevated GGT was also significantly associated with distant lymphadenopathy, unresectability, higher TNM stage, and poorly differentiated tumors.</p><p><strong>Conclusion: </strong>GGT is a readily available, low-cost biomarker significantly associated with advanced disease in GBC and liver metastases. Its integration into preoperative assessment may enhance staging accuracy and guide surgical decision-making. Prospective validation in larger cohorts is warranted.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-026-02593-9.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"921-927"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Value of Sentinel Lymph Node in Stomach Cancer Patients Using Blue Dye in Suez Canal University Hospital.","authors":"Ahmed Abobakr Nasr Ramadan, Kerolos Antonious Abdelmassieh, Soliman Hamed El Kamash Abdelfatah, Sherif Hussein Farrag, Ahmed Mohamed Mahmoud Gomaa, Haidi AbdelZaher Mohamed Zenelden","doi":"10.1007/s13193-026-02557-z","DOIUrl":"https://doi.org/10.1007/s13193-026-02557-z","url":null,"abstract":"<p><strong>Background: </strong>Lymph node metastases is the principal predictive determinant following curative resection in gastric carcinoma. The incorporation of sentinel lymph node (SLN) mapping into surgical techniques may facilitate limited stomach resections while maintaining oncological safety. This study evaluated the practicality and diagnostic effectiveness of patent blue dye for sentinel lymph node mapping in gastric cancer surgery.</p><p><strong>Patients and methods: </strong>A prospective intraoperative diagnostic accuracy study was conducted with 37 patients diagnosed with operable gastric cancer at Suez Canal University Hospital, spanning from December 2021 to December 2023. A subserosal injection of 2 mL of patent blue dye was performed around the tumor using a four-quadrant technique. Sentinel nodes along with their associated lymphatic basins were removed and analyzed histopathologically. The assessment of detection rate and sensitivity was conducted based on the distribution of nodal metastasis.</p><p><strong>Results: </strong>The mean age of the patients was 62 years. The median number of recovered lymph nodes was 22, and for collected sentinel nodes the median number was 4. The identification rate of sentinel lymph nodes was found to be 94.59%. The sensitivity of sentinel node identification using the pick-up method alone was recorded at 73.91%. However, this number increased to 95.65% with the adoption of the sentinel lymph node basin concept. In one instance, skip metastasis outside the sentinel basinwas noted, representing 2.7% of the total cases.</p><p><strong>Conclusion: </strong>The use of patent blue dye for sentinel lymph node mapping in gastric cancer surgery proves to be a viable technique, demonstrating high detection rates and enhanced sensitivity when employing the sentinel basin approach. Further extensive studies are necessary to confirm these results and evaluate their influence on long-term cancer-related outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 4","pages":"807-812"},"PeriodicalIF":0.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147785270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}