Indian Journal of Surgical Oncology最新文献

{"title":"Adjuvant Chemotherapy Does Not Compensate for an Inadequate Right Colon Cancer Surgery: High Peritoneal Recurrence Rates Indicate Need for Altered Treatment Paradigms.","authors":"Swapnil Patel, Mufaddal Kazi, Anand Mohan, Vivek Sukumar, Ashwin L deSouza, Avanish Saklani","doi":"10.1007/s13193-024-02099-2","DOIUrl":"https://doi.org/10.1007/s13193-024-02099-2","url":null,"abstract":"<p><p>There is a lack of evidence for optimal management of patients with right colon cancers upon referral to the oncology care centre, following an inadequate index surgery elsewhere. A prospectively maintained database of patients with right colon cancers managed between 2013 and 2019 was screened to identify those patients who underwent index surgery in a non-oncological setup. They were managed with adjuvant chemotherapy followed by observation, with surgery being reserved for recurrent disease. Of the 155 patients identified after the screening, 97 were included in the study. They were stratified depending upon the number of lymph nodes harvested at primary surgery-Group A (less than 12 nodes) (<i>n</i> = 49), Group B (12 to 27 nodes) (<i>n</i> = 39) and Group C (28 and more nodes) (<i>n</i> = 9). Patients with lymph node metastases had inferior survival at 2 years than node-negative patients and this survival difference increased progressively from Group A towards Group C. Patients who had radiological locoregional residual disease upon restaging (at presentation) had significantly inferior survival. At the end of 2 years, overall survival and disease-free survival of the cohort were 71.5% and 45.8%, respectively. Fifty-eight patients had disease relapse, with peritoneal recurrence seen in 37 patients (63.8%). Of these, only 15.5% recurrences were surgically salvageable. Treatment of patients who have undergone inadequate index colectomy with chemotherapy alone has shown inferior survival outcomes with high rates of peritoneal relapse in comparison to historical cohorts. The treatment strategy for such patients needs to be revisited in a prospective study design.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"528-535"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Outcomes After McKeown and Ivor Lewis Esophagectomy for Lower Third Esophageal Cancer.","authors":"Naveen Kumar, Amitabha Mandal, Sandeep Bhoriwal, S V S Deo, Sachidanand Jee Bharati, Sunil Kumar","doi":"10.1007/s13193-023-01770-4","DOIUrl":"10.1007/s13193-023-01770-4","url":null,"abstract":"<p><p>The commonly performed surgical procedures for esophageal cancer are McKeown and Ivor Lewis esophagectomy. The Ivor Lewis esophagectomy is mainly performed for lower esophageal cancer. Herein, we analyzed both procedures performed for lower esophageal cancer to look for perioperative and survival outcomes. The surgical data was retrieved from the computerized database, and the patients operated on for lower esophageal cancer from 2014 to 2019 were included. Both procedures were analyzed for demographic details, perioperative outcomes, complication rate, and overall and disease-free survivals. A total of 90 patients undergoing esophagectomy for lower esophageal cancer. RLN palsy and anastomotic leak rate were higher in the McKeown group. The estimated 5-year OS was 49% and 58.3% in the McKeown and Ivor Lewis groups, respectively, whereas the estimated 5-year DFS was 41% and 63.9%. In the Ivor Lewis group, on comparing both histological subtypes, the estimated 5-year OS was 74% and 26.3% (<i>p</i> < 0.05) whereas the DFS was 74.5% and 42% (<i>p</i> = 0.07) for SCC and adenocarcinoma, respectively. This study did not find a significant difference in the perioperative as well as survival outcomes comparing McKeown esophagectomy with the Ivor Lewis procedure for lower third esophageal cancer. A prospective trial is warranted to see the difference.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":" ","pages":"465-471"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48897774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The INDEPSO-ISPSM Consensus on Peritoneal Malignancies-Methodology.","authors":"Swapnil Patel, Vivek Sukumar, Somashekhar S P, Geetu Bhandoria, Ambarish Chatterjee, Suryanarayana V S Deo, Niharika Garach, Arvind Guru, Neha Kumar, Rohit Kumar, Ashwin K Rajagopal, Sanjeev Kumar, Sanket Mehta, Deepti Mishra, Ajinkya Pawar, Aruna Prabhu, Snita Sinukumar, Sohan Solanki, Vivekanand Sharma, Ramakrishnan Ayaloor Sheshadri, Aditi Bhatt","doi":"10.1007/s13193-024-02118-2","DOIUrl":"10.1007/s13193-024-02118-2","url":null,"abstract":"<p><p>The numerous international guidelines on cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) do not cover many clinically relevant issues for which evidence is limited and some regional issues (HIPEC in limited resource settings, age-limit for CRS, etc.). We describe the methodology of a consensus CRS and HIPEC for peritoneal malignancies carried out under the aegis of the two national societies for peritoneal oncology-INDEPSO and ISPSM. The modified Delphi technique was used with two rounds of voting. Eight key topics were selected by a working group of 29 members. Questionnaires comprising of closed-ended questions were disseminated through the online SurveyMonkey (http://www.surveymonkey.com) platform. A panel of 56 surgical, gastrointestinal, and gynecologic oncologists with a minimum of 5 years of experience with CRS-HIPEC voted on 260 questions. A consensus was reached if any of the options received 70% or more votes (> 90% = strong consensus). The response rate was 98.2% in round I and 94.6% in round II. A consensus was achieved on 80.7% questions after two rounds (43.0% after round I; 36.9% after round II). It was the highest in the enhanced recovery after surgery (ERAS) section (93.3%) and the lowest (68.0%) for ovarian cancer. A strong consensus was reached on 59 (22.6%) questions (highest for  the technical section (34.2%); lowest in the ERAS section (16.6%)). This consensus which had a high rate of participation should be a useful clinical resource for surgeons treating peritoneal malignancies in India and other regions with a similar demographic and socioeconomic background.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-02118-2.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"651-659"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary Carcinoma of Thyroglossal Duct Cyst-A Case Series.","authors":"Sakshi Negi, Naresh Kumar Panda, Sourabha Kumar Patro, Rijuneeta Gupta, Monil Parsana, Shivam Saxena, Debajyoti Chatterjee, Elgiva Khristie Iangngap","doi":"10.1007/s13193-024-02111-9","DOIUrl":"10.1007/s13193-024-02111-9","url":null,"abstract":"<p><p>Carcinoma arising from the thyroglossal duct cysts is a rare entity which results from metaplastic changes in the persistent thyroglossal duct. This study highlights five cases of thyroglossal duct carcinoma accompanied by thyroid malignancy in three cases. Papillary carcinoma is the predominant subtype, observed in all five cases. Sistrunk surgery, combined with total thyroidectomy, was performed on all patients, with one patient undergoing additional neck dissection. Thyroglossal duct papillary carcinoma is relatively uncommon condition and its co-occurrence with thyroid gland carcinoma further adds to its rarity which required surgical management followed by radioactive iodine ablation therapy with thyroid hormone suppression. Timely identification, coupled with appropriate surgical intervention, is necessary for favourable patient's outcomes. Additional procedures, such as total thyroidectomy when necessary and neck dissection, should be considered.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"633-638"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Baseline Endogenous Testosterone Levels on Risk Stratification in Pathological Organ-Confined Prostate Cancer: Results in 460 Patients Treated with Robot-Assisted Radical Prostatectomy.","authors":"Antonio Benito Porcaro, Andrea Panunzio, Alberto Bianchi, Sebastian Gallina, Emanuele Serafin, Riccardo Rizzetto, Giovanni Mazzucato, Stefano Vidiri, Damiano D'Aietti, Giulia Fassio, Rossella Orlando, Francesco Ditonno, Alberto Baielli, Francesco Artoni, Francesca Montanaro, Giulia Marafioti Patuzzo, Filippo Migliorini, Alessandro Veccia, Matteo Brunelli, Salvatore Siracusano, Maria Angela Cerruto, Alessandro Tafuri, Alessandro Antonelli","doi":"10.1007/s13193-024-02109-3","DOIUrl":"10.1007/s13193-024-02109-3","url":null,"abstract":"<p><p>The objective is to test the role of baseline endogenous testosterone (ET) in discriminating adverse tumor grades and predicting disease progression in prostate cancer (PCa) patients, who harbored organ-confined disease at radical prostatectomy (RP). Between November 2014 and December 2019, data on PCa patients treated with robot-assisted RP at a single tertiary referral center were retrospectively analyzed. Baseline ET levels were coded as abnormal (≤ 350 ng/dL) vs. normal (> 350 ng/dL) according to a standard consensus. In the surgical specimen, the International Society of Urological Pathology (ISUP) grade groups 3 and 4/5 were classified as unfavorable tumor grades. Disease progression was defined as biochemical recurrence/persistence and/or local recurrence and/or distant metastases. Multivariable logistic and Cox regression models were used. Overall, 460 patients were included. In the surgical specimen, adverse tumor grades were detected in 198 (43.0%) patients of whom 60 (13.0%) harbored ISUP grade group 4/5. Disease progression occurred in 62 (13.5%) patients. In multivariable regression models that adjusted for other available clinical and pathological factors, patients with abnormal baseline ET levels were less likely to associate with unfavorable tumor grades, as well as to experience PCa progression (hazard ratio: 0.49; 95% CI: 0.26-0.92; <i>p</i> = 0.026). In pathological organ-confined PCa, baseline ET levels predicted disease progression after discriminating unfavorable tumor grades. Accordingly, baseline ET is a risk factor that might further stratify patients diagnosed with PCa.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"587-594"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Efficacy of Surgical Excision Combined with Electron Beam Therapy for Keloids.","authors":"Jiaqi Zhang, Dongjun Jeon, Zheng Su, Xiaolian Xiao, Jinming Zhang, Weiqiang Liang","doi":"10.1007/s13193-024-02048-z","DOIUrl":"10.1007/s13193-024-02048-z","url":null,"abstract":"<p><p>This study aimed to investigate the incidence and impact of patient characteristics and timing of postoperative electron beam therapy on the treatment efficacy of keloids. A total of 66 patients with keloids underwent surgical treatment and postoperative electron beam therapy. Follow-up was conducted for 43 patients, and treatment efficacy was analyzed for 39 patients. Statistical analysis was used to analyze incidence characteristics and effects of patient characteristics and timing of electron beam therapy on treatment efficacy. The study included 66 patients with 133 keloids. The timing of electron beam therapy significantly impacted treatment efficacy, with higher efficacy observed when performed 0-2 days after surgery compared to 3-5 days after surgery. Keloids are more common in women aged 20-40 years. The timing of electron beam therapy significantly impacted treatment efficacy, with higher efficacy observed when performed 0-2 days after surgery compared to 3-5 days after surgery.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"550-557"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of Thoracic Diseases (Benign and Malignant) in North Western India: A Study of 2527 Cases.","authors":"Manish Sahni, Suresh Singh, Rajgovind Sharma, Pinakin Patel, Kamal Kishor Lakhera","doi":"10.1007/s13193-024-02124-4","DOIUrl":"10.1007/s13193-024-02124-4","url":null,"abstract":"<p><p>Thoracic cancers especially lung cancer form a huge burden of morbidity and mortality around the world. The first question most patients ask after receiving the biopsy report is on the type of cancer and how it spreads which gives an idea of what to expect during follow-up. Unfortunately, due to a lack of reporting, management, and documentation of thoracic neoplasms in India, there is a shortage of information on various types of thoracic neoplasms and their distribution. What we need is more data reporting, timely diagnostic strategies, and standardized reporting for pathology leading to evidence-based management strategies. To address this issue, we conducted a study to gain insights into patterns and relative frequencies of thoracic neoplasms in North Western India.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-02124-4.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"660-666"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Recent Overview of Molecular Pathways in Synthetic Lethality as a Proposed Valid Target in Oncology: Current Insights and Future Directions.","authors":"Sangeetha Raja, Akash Rahangan, Indumathi Prabath, Jamuna Rani","doi":"10.1007/s13193-024-02088-5","DOIUrl":"10.1007/s13193-024-02088-5","url":null,"abstract":"<p><p>Earlier conducted systematic reviews have focused on the important impact of synthetic lethality (SL) application in managing various types of tumors, classifying SL, methods for assessment, and technological advances in SL inhibitions and examining the preclinical and clinical landscape of SL cancer biology, and neither of those investigations presented the molecular pathway description of the recommended lethal target of SL in cancer. Out of 36 gene expression omnibus (GEO) database sets selected from 343 retrieved (2023 to 2024), 11 were excluded, and 25 were included in the study and presented in the review. Beyond the search, few interesting database sets comprising interesting molecular pathway were included in minority. Molecular pathways pictures of the proposed SL targets for the cancer condition were prepared for lucid understanding of the oncology disease fundamental mechanism behind the SL concept. SL approach benefits have been demonstrated in cancer. Thus, the current exploration suggests that SL approach of molecular investigations should be expanded to include other specialists including cardiovascular and nephrology to fully explore the benefits of society.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"408-420"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Mandibulectomy in Oral Cavity Cancers - Classification and Indications.","authors":"Sudhir Nair, Hitesh R Singhavi, Vidula Mestry, Rathan Shetty, Poonam Joshi, Pankaj Chaturvedi","doi":"10.1007/s13193-024-02102-w","DOIUrl":"https://doi.org/10.1007/s13193-024-02102-w","url":null,"abstract":"<p><p>Squamous cell carcinoma of the lip and oral cavity (OSCC) is a significant global health issue, particularly in low-income countries, with an estimated 390,000 cases detected annually. Although surgery remains the primary treatment option, complex resections are frequently required to attain clear margins. Traditionally, a part of the jaw bone close to the tumour is resected (segmental mandibulectomy) during the surgery. However, marginal mandibulectomy (MM), involving the resection of the mandibular rim while preserving its continuity, offers a less debilitating alternative to segmental mandibulectomy (SM) in selected cases. This review examines marginal mandibulectomy's oncological safety and efficacy and its current role in managing oral cavity cancers, as indicated by the most recent literature. MM is an effective treatment for tumours, which abut the mandible without bone invasion and provides comparable oncological outcomes to SM, with fewer functional and cosmetic deficits. The authors also propose a classification based on the plane of resection and location within the mandible. We believe this classification will be helpful in reporting the MM series done in various centres in a uniform fashion. However, there is a need for precise surgical planning before doing an MM for obtaining the optimal results.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"581-586"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Extra-adrenal Myelolipoma: A Rare Case with Literature Review.","authors":"Snehasis Pradhan, Sujan Kumar Voni, Sudam Sadangi, Jubraj Kalita, Adya Kinkar Panda, Sunil Kumar Agarwal, Debahuti Mohapatra, Sangram Keshari Panda, Subhashree Subhasmita Dash","doi":"10.1007/s13193-024-02121-7","DOIUrl":"10.1007/s13193-024-02121-7","url":null,"abstract":"<p><p>Myelolipoma is a benign tumour comprising both hematopoietic tissue and normal adipose tissue. It is a rare tumour found incidentally in adrenal glands on imaging, rarely reported in the extra-adrenal/perirenal region with less than 50 cases being reported in the literature. Even rarely, it presents bilaterally. We report a case of a 65-year-old male with bilateral extra-adrenal myelolipoma who underwent en bloc excision of bilateral tumours diagnosed preoperatively by radiological imaging. We reviewed the literature to look into the incidence, aetiology, imaging characteristics, diagnosis, treatment and follow-up in patients with extra-adrenal myelolipomas.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"427-431"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}