Indian Journal of Surgical Oncology最新文献

{"title":"Metastasis to Thyroid from Recurrent Head and Neck Squamous Cell Carcinoma: A Case Series and Review of Literature.","authors":"Avneet Kaur, Rohit Nayyar, Harit Kumar Chaturvedi, Akshat Malik","doi":"10.1007/s13193-024-02054-1","DOIUrl":"10.1007/s13193-024-02054-1","url":null,"abstract":"<p><p>Metastasis to the thyroid gland from a squamous head and neck primary is extremely rare. We present three cases of recurrent head and neck squamous cell carcinoma with squamous metastasis to the thyroid gland. The surgery was done in two cases where the disease was resectable and limited, whereas due to extensive disease, the third case was managed with palliative chemotherapy. There was an early disease progression in all patients, including those treated surgically. Due to the limited number of reported cases of head and neck squamous cell cancers metastasizing to the thyroid gland, data regarding their prognosis and management is insufficient. We still need further data to identify patients who can benefit from surgical resection in such scenarios.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 1","pages":"122-126"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Institutional Insights into the Management and Surgical Resection of Tracheobronchial Lesions: Experience with 11 Patients.","authors":"Naveen Kumar Kushwaha, Pradeep Jaiswal, Vijay Pratap Singh, S Harish, Prashant Gupta","doi":"10.1007/s13193-024-02101-x","DOIUrl":"10.1007/s13193-024-02101-x","url":null,"abstract":"<p><p>Pathologic conditions affecting the central airways encompass a wide array of focal alterations. The diagnosis of central airway lesions poses considerable challenges due to their varied presentations, resulting in delayed recognition and management. However, advances in bronchoscopy and multidetector computed tomography (MDCT) aid in early detection. Management depends both on the pathology and the obstructive potential of the process. We present our experience with the comprehensive evaluation and management of 11 cases of focal tracheobronchial lesions surgically treated at our institution, with an emphasis on lung parenchyma preservation. This is a retrospective analysis of prospectively maintained data of 11 patients who were surgically treated for focal tracheobronchial lesions between January 2021 and December 2023 at a tertiary care hospital in India. Their demographic data, clinical presentation, and perioperative details were recorded. All patients underwent MDCT chest, bronchoscopy, and pulmonary function tests as part of the workup for diagnosis and assessment. The study included nine male and two female patients with a mean age of 36.4 years (range 9-64 years). Surgical procedures included main bronchus sleeve resection (3 patients), sleeve lobectomies (3 patients), sleeve bi-lobectomy (1 patient), and tracheal resection with end-to-end anastomosis (4 patients). Postoperatively, one patient died due to acute respiratory distress syndrome (ARDS). Pathological evaluation revealed malignant causes in 9 patients and non-neoplastic causes in 2 patients. The mean hospital stay was 6.5 days, with chest tube removal at 5.6 days. The average follow-up period was 8.2 months, ranging from 6 to 15 months. Based on our series, we ascertain that a complete resection, whenever feasible, offers optimal potential benefits and symptom alleviation for individuals with focal tracheobronchial lesions. Enhanced recognition of these lesions, coupled with a heightened level of suspicion and prompt diagnosis, stands pivotal in ensuring the safe and efficacious management of such cases.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 1","pages":"364-375"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Anesthesia Techniques for Breast Cancer Surgeries-A Narrative Review.","authors":"Raghuraman M Sethuraman","doi":"10.1007/s13193-024-02043-4","DOIUrl":"10.1007/s13193-024-02043-4","url":null,"abstract":"<p><p>Postoperative pain of breast cancer procedures can be debilitating and if not treated properly can lead to acute and chronic complications. Regional anesthesia techniques are very useful in providing adequate pain relief and can be applied either as a supplement to general anesthesia or surgical anesthesia in these surgeries. The application of ultrasound has revolutionized the field of regional anesthesia for breast cancer procedures, especially in the last decade. A thorough understanding of the application of each technique with precise knowledge of the sensory supply of the breast and axilla and the types of breast cancer surgeries can help us to choose the proper technique(s). In this article, the commonly used regional anesthesia techniques for breast cancer surgeries are discussed.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 1","pages":"127-133"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early vs. Late Stoma Reversal After Open Low Anterior Resection Post-Neoadjuvant Chemoradiotherapy.","authors":"Fahad Bin Abdul Majeed, Madhu Muralee, Chandramohan","doi":"10.1007/s13193-024-02036-3","DOIUrl":"10.1007/s13193-024-02036-3","url":null,"abstract":"<p><p>Diversion stomas are done to protect the patients from anastomosis-related complications after low anterior resection, particularly after neoadjuvant chemoradiotherapy. Problems with these temporary stomas are the significant deterioration in quality of life along with medical and surgical complications. Diversion ileostomy is the most commonly performed diversion procedure. Reversal of stoma is usually done after completion of adjuvant chemotherapy. Studies looking into the safety of early stoma reversal have shown conflicting results. The objective of this work is to study the advantages, disadvantages, and complications associated with early ileostomy reversal when compared to late ileostomy reversal in patients undergoing stoma reversal that was done as part of open low anterior resection for rectal cancer. Total of 92 patients were recruited for the study during the time period March, 2018, to June, 2019; 12 patients did not fulfill the inclusion criteria. A total of 80 patients were analyzed, 39 of whom underwent early reversal and 41 underwent late reversal. All of whom were prospectively followed up to assess the quality of life and complications associated with early and late stoma reversals. Both groups of patients were similar in the baseline characteristics. Perioperative complications were found to be significantly increased in the late reversal group when compared to early reversal group (7 vs. 0 with <i>P</i> 0.043). Quality-of-life assessment showed significant improvement in patients who underwent early stoma reversal with significant improvement in raw score, functional score, and symptoms score (<i>P</i> < 0.001). Adjuvant chemotherapy was also not significantly delayed in the early reversal group. Early stoma reversal should be offered to patients after open low anterior resection post-NACTRT, as it is safer and associated with improvement in quality of life.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 1","pages":"94-99"},"PeriodicalIF":0.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study.","authors":"Sujit Kumar Tripathy, Saroj Das Majumdar, Siddharth Satyakam Pradhan, Paulson Varghese, Hrudeswar Behera, Anand Srinivasan","doi":"10.1007/s13193-024-01990-2","DOIUrl":"10.1007/s13193-024-01990-2","url":null,"abstract":"<p><p>Despite early promising results with denosumab treatment in giant cell tumor of bone (GCTB), recent studies have raised concerns about a high local recurrence rate following preoperative denosumab administration and joint preservation surgery. This retrospective study evaluated data from 25 high-risk GCT patients (Campanacci grade II or III with features like soft tissue extension, pathological fracture, minimal periarticular or subarticular bone) treated with five doses of neoadjuvant denosumab injection followed by either curettage and cementing (<i>n</i> = 13) or joint reconstruction with fibular graft/endoprosthesis (<i>n</i> = 12) between 2014 and 2019. With an average follow-up of 40 months, the study found only one patient of local recurrence. All patients were independently ambulant, with a mean MSTS score of 26.32. Subgroup analysis revealed an MSTS score of 27.76 in the joint preservation group, and 24.75 in the excision with reconstruction/prosthetic replacement group (unpaired <i>t</i>-test, <i>p</i>-value < 0.001). Five patients experienced postoperative complications, including two infections, one recurrence, one mediolateral instability in the prosthetic component, and one restriction of wrist movement. A short course of neoadjuvant denosumab, followed by curettage and cementing or wide excision with joint reconstruction/prosthetic replacement, appears to be an effective strategy for high-risk GCTB patients. This approach not only minimizes surgical morbidity but also does not increase the local recurrence rate. The short course regimen may present a cost-effective and practical option in clinical practice.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"825-836"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Androgen Receptor Expression in Breast Cancer: Insights into Histopathological Parameters and Hormone Receptor Status Among Indian Women.","authors":"Nidhiben Harshadkumar Thakkar, Md Ali Osama, Shashi Dhawan","doi":"10.1007/s13193-024-01997-9","DOIUrl":"10.1007/s13193-024-01997-9","url":null,"abstract":"<p><p>Breast cancer, an exceptionally hormone-dependent tumor, exhibits a diverse clinical profile. Its therapeutic categorization relies on the expression of key receptors, namely, estrogen receptor (ER), progesterone receptor (PR), and Her2neu. The androgen receptor (AR), a member of the nuclear receptor superfamily, is a biomarker gaining attention in breast cancer research, particularly for triple-negative breast cancers. We conducted an analysis of AR expression in 113 primary breast cancer cases, using a cutoff criterion of ≥ 10% tumor cell positivity. ER, PR, and Her2neu statuses were determined based on the 2023 ASCO-CAP criteria. AR expression was then correlated with various clinicopathological factors, including age, menopausal status, centricity, histological type, grade, tumor size, nodal status, lymphovascular and perineural invasion, and ER, PR, and HER2neu statuses. Among the 113 cases, 57 (50.4%) showed positive AR expression. No statistically significant associations were found between AR expression and age, menopausal status, histological type, histological grade, nodal status, or ER and PR expression. Notably, all multicentric tumors (<i>n</i> = 7, 100%) were AR negative. AR expression was linked to smaller tumor sizes. Positive AR cases exhibited an association with Her2neu overexpression, particularly in ER and PR-negative tumors. Of note, 35% of triple-negative tumors displayed AR positivity. AR emerges as a promising marker in breast cancers, particularly in triple-negative cases. Larger-scale studies are warranted to comprehensively assess the relationship between AR expression and histopathological parameters, as well as other immunohistochemical markers.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"789-795"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Ventricular Extrinsic Compression Tamponade Caused by Dilation/Necrosis of a Coloplasty Performed for Esophageal Squamous Cell Carcinoma.","authors":"Sébastien Tanaka, Tigran Poghosyan, Philippe Montravers","doi":"10.1007/s13193-024-02044-3","DOIUrl":"10.1007/s13193-024-02044-3","url":null,"abstract":"<p><p>In the context of dysphagia, an infiltrating squamous cell carcinoma of the esophagus was diagnosed in a 43-year-old woman with a history of two liver and one kidney transplants as a result of Alagille syndrome. An esophagectomy with retrosternal left coloplasty (esocolic, gastrocolic, and colocolic anastomoses) was performed. On postoperative day 2, her hemodynamic status deteriorated resulting in significant increases in norepinephrine doses (from 0.33 to 2 micg/kg/min). Transthoracic echocardiography was difficult to perform because the patient had limited imaging windows. Transesophageal echocardiography was contraindicated due to the nature of her surgery. An emergency thoraco-abdominal CT scan showed that the coloplasty was dilated, ischemic, and compressing the right ventricle anteriorly. Emergency surgery revealed mediastinitis with necrosis of the coloplasty. Surgical decompression of the coloplasty led to rapid improvement in hemodynamics, requiring only reduced doses of norepinephrine.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"746-747"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Mole with Rare Ovarian Metastasis: Successful Treatment with Hysterectomy and Chemotherapy-A Case Report.","authors":"Geet Bhuyan, Manish Das","doi":"10.1007/s13193-024-02086-7","DOIUrl":"10.1007/s13193-024-02086-7","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 Suppl 4","pages":"622-626"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Presentation of Epidermal Inclusion Cyst of Gluteal Region: Case Report.","authors":"Kapilnath Muralimanohar, Kaushal G Vira","doi":"10.1007/s13193-024-02062-1","DOIUrl":"10.1007/s13193-024-02062-1","url":null,"abstract":"<p><p>Epidermal inclusion cysts are common, benign, intradermal, or subcutaneous lesions typically asymptomatic ranging from 1 to 4 cm in size. Transformation to squamous cell carcinoma is rare. Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. We present a case of a 70-year-old male, with a giant gluteal swelling masquerading as soft tissue sarcoma. The clinical, radiological, and histopathologic findings are described. We present this case because it is rare for a benign epidermal inclusion cyst to be unusually large and malignant transformation in such cysts is rarely reported. We also recommend that the entire cyst wall is to be removed without disruption and to be subjected for a thorough histopathological evaluation.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 Suppl 4","pages":"611-615"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Flap Necrosis in Inguinal Lymph Node Dissection.","authors":"Shiv Rajan, Naseem Akhtar, Sugandha Arya, Sameer Gupta, Puneet Prakash, Vijay Kumar, Sanjeev Misra, Arun Chaturvedi, Abhilasha Tripathi, Prabhakar Mishra","doi":"10.1007/s13193-024-01985-z","DOIUrl":"10.1007/s13193-024-01985-z","url":null,"abstract":"<p><p>Inguinal skin flap necrosis (SFN) is a significant clinical problem associated with inguinal lymph node dissection (ILND). The aetiology of SFN is multifactorial, and its manifestations vary widely. Thermal damage caused by electrocautery during the elevation of the skin flap may contribute to this problem, which has not been studied previously. This prospective, observational study included patients undergoing ILND from January 2020 to July 2022. Based on the technique of raising the inguinal skin flaps, the patients were divided into two groups (cold knife or electrocautery). The remaining part of the procedure was the same. The inguinal wound was examined and photographed to assess the SFN. A total of 42 patients were included (21 in each group). Age, gender, body mass index (BMI), alcohol or tobacco consumption, immune compromised status, and serum albumin were comparable (<i>p</i> > 0.05). The average time required to elevate flaps was 13.14 vs. 11.47 min (<i>p</i> = 0.0231), and gauze soakage was 2.05 vs. 1.52 (<i>p</i> < 0.0001) with a cold knife compared to electrocautery. The incidence of SFN and surgical site infection (SSI) was significantly lower with the use of a cold knife [4.8% vs. 33.3% (<i>p</i> = 0.045) and 0% vs. 19% (<i>p</i> = 0.0378)]. Grade 3 necrosis was observed only with electrocautery use. Compared to conventional electrocautery, the cold knife technique lowers the incidence of SFN and SSI. Further research with a larger sample size and a standardized definition is needed to validate these results.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"762-767"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}