Indian Journal of Surgical Oncology最新文献

{"title":"A Prospective Comparative Study on Assessment of Outcomes of Axillary Lymph Node Dissection for Carcinoma of Breast Using Electrocautery, Harmonic Focus, and Ligasure.","authors":"Kawadu Jawade, Rahul Gupta, A K Dewan","doi":"10.1007/s13193-025-02498-z","DOIUrl":"10.1007/s13193-025-02498-z","url":null,"abstract":"<p><p>Axillary lymph node dissection (ALND) is an essential component of surgical management in breast cancer. Electrocautery (EC), Harmonic Scalpel (HS), and LigaSure™ (LS) are commonly used surgical devices, but limited studies have directly compared their outcomes in ALND. This study aimed to prospectively compare Electrocautery (EC), Harmonic Scalpel (HS), and LigaSure™ (LS) for axillary lymph node dissection (ALND) in breast cancer surgery. The primary objective was to evaluate differences in operative time, intraoperative blood loss, postoperative drain output, drain removal time, seroma formation, and lymph node yield across the three techniques. Secondary objectives included assessing early postoperative complications and long-term lymphedema. A prospective observational study was conducted from June 2020 to March 2023 at a single center, including 150 operable breast cancer patients undergoing ALND. Patients were sequentially allocated into three groups (<i>n</i> = 50 each): EC, HS, and LS. Standardized surgical techniques and postoperative protocols were followed. Data on perioperative outcomes and complications were collected and statistically analyzed. LigaSure had the longest operative time (43.2 ± 2.98 min) but the least blood loss (48.6 ± 3.67 ml). Both HS and LS showed significantly reduced postoperative drain output (428.0 ± 61.7 ml and 416.1 ± 68.5 ml) and earlier drain removal (10.67 ± 2.34 and 10.27 ± 2.49 days) compared to EC (510.8 ± 79.9 ml; 13.69 ± 2.90 days) (<i>p</i> < 0.0001). Seroma formation was more frequent in the EC group (28%) than HS (12%) and LS (8%), though not statistically significant. Lymph node yield and complication rates were comparable. No lymphedema was reported during follow-up. Both Harmonic Scalpel and LigaSure significantly reduced intraoperative and postoperative morbidity compared to Electrocautery, while maintaining equivalent oncological outcomes. These advanced energy devices are safe and efficient alternatives for ALND in breast cancer surgery.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1759-1764"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioguided Occult Lesion Localization (ROLL) and Radioactive Seed Localization (RSL) versus Wire-guided Localization (WGL) in Breast-conserving Surgery for Non-Palpable Breast Cancer: a Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"Victor Arthur Ohannesian, Bruno Marçola Ishizuka, Isabelle Rodrigues Menezes, Paweł Łajczak, Matheus Almeida Cabral, Henrique Busch Vaqueiro, Lucas da Silva Costa, Pedro Henrique Machado Carani, Yasmin Picanco Silva, Miguel José Francisco Neto, Akemi Osawa, Jairo Wagner, Solange Amorim Nogueira","doi":"10.1007/s13193-025-02481-8","DOIUrl":"10.1007/s13193-025-02481-8","url":null,"abstract":"<p><p>Non-palpable breast cancers require precise localization techniques for surgical excision. Wire-guided localization (WGL) has been the standard, but newer methods like Radioguided Occult Lesion Localization (ROLL) and Radioactive Seed Localization (RSL) offer potential benefits. This study compares the efficacy and safety of these techniques in breast-conserving surgery. A systematic review and meta-analysis of randomized controlled trials (RCTs) compared ROLL, RSL, and WGL in patients undergoing breast-conserving surgery for non-palpable breast cancer. Primary outcomes included surgical margin status, re-excision rates, and operative time. Secondary outcomes were patient satisfaction and adverse events. From 8,300 articles, 2,081 were screened, and 15 RCTs were included. Seven studies compared WGL vs. ROLL (1,441 patients), and eight compared WGL vs. RSL (2,376 patients). RSL associated with a modest reduction compared with WGL for positive surgical margins (RR: 0.71, 95% CI: 0.52-0.98, I² = 42%) and reoperations (RR: 0.71, 95% CI: 0.54-0.95, I² = 0%), both statistically significant. ROLL showed a modest advantage over WGL (RR: 0.66, 95% CI: 0.45-0.96, I² = 0%). Other comparisons, including complications related to marker implantation and sentinel lymph node identification failures, showed no significant differences. Across analyses, effect sizes were small, and heterogeneity among included studies was moderate. RSL and ROLL appear to offer modest advantages over WGL for localizing non-palpable breast cancers in breast-conserving surgery. Both techniques demonstrated favorable outcomes in margin clearance and re-excision rates, though overall differences remain limited. Further research directly comparing ROLL and RSL is needed.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02481-8.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1747-1758"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Treatment Patterns, and Survival Outcomes in Patients With Uterine Cancer in a Real-World Setting in India.","authors":"Shalini Bose, Kavita Khoiwal, Shalini Rajaram, Amrita Gaurav, Rajlaxmi Mundhra, Anupama Bahadur, Nilotpal Chowdhury, Ashok Singh, Sweety Gupta, Deepa Joseph, Amit Sehrawat, Deepak Sundriyal, Parish Kamdi, Jaya Chaturvedi","doi":"10.1007/s13193-025-02519-x","DOIUrl":"10.1007/s13193-025-02519-x","url":null,"abstract":"<p><p>Uterine cancer is one of the most common gynecological malignancies globally, with increasing incidence in developing countries. This study evaluates epidemiology, clinical and surgico-pathological characteristics, treatment patterns, and survival outcomes in patients with uterine cancer from a tertiary care center in India. This ambispective observational study included 111 patients diagnosed with uterine cancer who had undergone primary treatment between January 2018 and December 2024. Data on demographic parameters, clinical presentation, imaging, histopathology, treatment modalities, and survival were analyzed using SPSS v25. Kaplan-Meier analysis was used to estimate overall survival (OS) and progression-free survival (PFS). The median age was 57 years, with the majority being postmenopausal (83.78%). The most common presenting symptom was postmenopausal bleeding (69.37%). Endometrioid adenocarcinoma was the predominant histological subtype (68.93%) in endometrial biopsy. Surgery was performed in 91.89% of cases. FIGO 2023 staging classified 55.85% as stage I. 10.81% of cases were upstaged with FIGO 2023 staging when compared to FIGO 2009 staging distribution. Low-grade endometrioid carcinoma was the most predominant (66.67%) histopathological type in the final histopathology. The median OS was highest (59.667 months) for low-grade endometrioid carcinoma. Node positivity was associated with significantly poorer OS (<i>p</i> = 0.002). Histological subtype significantly influenced PFS (<i>p</i> = 0.006), with sarcomas having the worst outcomes. Uterine cancer predominantly presents in postmenopausal women and is often diagnosed at an early stage. Endometrioid histology is the most common subtype. Overall survival is favorable in early-stage and non-aggressive histologies. Node positivity and aggressive histology significantly affect prognosis.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02519-x.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1985-1994"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Outcomes of Sleeve Resection Lung - Observational Study.","authors":"Vijayraj S Patil, Nandhini Vigneshwar, Harish Kumar H, Ramachandra C, Ravi Arjunan, Syed Altaf, C Srinivas, Mahesh Bandemegal","doi":"10.1007/s13193-026-02554-2","DOIUrl":"10.1007/s13193-026-02554-2","url":null,"abstract":"<p><strong>Background: </strong>For patients who are unable to tolerate pneumonectomy with inadequate pulmonary reserve, pulmonary sleeve resection is an effective alternative. Due to advancements in perioperative care and oncologic benefits for central lung cancers, sleeve resection is a preferred approach, even in patients with good pre-operative pulmonary reserve.</p><p><strong>Methods: </strong>Patients with resectable intrabronchial tumors - Non small cell carcinoma (NSCLC) like squamous cell carcinoma, carcinoid tumors, mucoepidermoid carcinoma, and other histologies who underwent sleeve resection surgery from January 2020 to January 2025, were included.</p><p><strong>Results: </strong>A total of 51 intrabronchial tumors were operated, of which 25 cases underwent sleeve resection, and the rest underwent lobectomy or pneumonectomy.Right lung sleeve resections were done for 13 cases, and in left lung 12 cases sleeve resection was done. Postoperative complications were noted in 6 patients. Clavien Dindo grade >3 in 4 patients and grade<3 in 2 patients. None of them has anastomosis related complications like leak, fistula, or stricture. Postoperative pulmonary function test was done in 18 out of 25 patients at 12th month to date. A positive trend of improvement was noted in postoperative FEV1 compared to predicted postoperative FEV1 in 10 out of 18 patients. 24 patients are alive and without recurrence. No 30-day mortality.</p><p><strong>Conclusion: </strong>Sleeve resection of the lung is a good option for endobronchial tumors with acceptable perioperative and short-term outcomes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-026-02554-2.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1995-2003"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations on \"McKeown Versus Ivor Lewis Esophagectomy for Lower Esophageal Squamous Cell Carcinoma: a Prospective Comparison of Surgical and Survival Outcomes\".","authors":"Ankur Sharma, Sushma Narsing Katkuri, Varshini Vadhithala","doi":"10.1007/s13193-025-02524-0","DOIUrl":"10.1007/s13193-025-02524-0","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"2006-2007"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Stathmin and p-16 as Diagnostic Immunohistochemical Marker to Differentiate Benign from Dysplastic or Invasive Malignant Oral Mucosal Epithelial Lesions and their Correlation with Histological Grading in Oral Squamous Cell Carcinoma.","authors":"Aparajita Samaddar, Manas Talukdar, Ipsita Saha, Santanu Sen, Bijan Adhikary","doi":"10.1007/s13193-025-02489-0","DOIUrl":"10.1007/s13193-025-02489-0","url":null,"abstract":"<p><p>Oral Squamous cell carcinoma (OSCC) is one of the most common head-neck cancers with significant morbidity and mortality. Previous studies showed stathmin over-expression in different poorly differentiated carcinomas including stomach, ovary and prostate. HR-HPV infection is an independent risk factor for OSCC and p16 is a surrogate marker. The aim of this study was to determine proportion of hyperplasia, dysplasia and OSCC cases in suspected oral squamous epithelial lesions and to evaluate the role of Stathmin and P16 in differentiating hyperplastic from dysplastic/OSCC cases along with their association with tumour grading. Biopsied specimens from suspected oral lesions were evaluated by routine histopathology and same blocks were used for immunohistochemistry with Stathmin and p16. This study included total 41 cases and showed 58.53% of the lesions are OSCC with male preponderance and buccal mucosa as the most common site.70.8% cases of OSCC showed p16 over expression. Both stathmin and p16 positivity have significant association with dysplastic and OSCC cases compared to hyperplasia with sensitivity of 75% for Stathmin and specificity of 92.31% for p16 to differentiate benign from premalignant/malignant cases. However there were no association with tumour grading. Hence Stathmin and p16 expression may be utilized in difficult cases to differentiate premalignant/malignant lesions from benign ones and targeted therapy may be developed in future. Higher proportions of p16 positive cases indicate the positive association between HR-HPV and OSCC. Further HPV-DNA based study may confirm the association and preventive measures can be implemented accordingly.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1789-1795"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Versatility of Modified Martius Flap in Pelvic Reconstructive Surgeries.","authors":"Rahulkumar Chavan, Avanish Saklani, Devendra Pal, Ganapathy Kini, Tushar L Pawar, Shraddha Bhone, Nandkishor Narwade, Sameer Kadam, Vivekanand Sharma","doi":"10.1007/s13193-025-02499-y","DOIUrl":"10.1007/s13193-025-02499-y","url":null,"abstract":"<p><p>Fistulas among pelvic organs are common complications after surgery or radiation, which profoundly affect the physical and mental wellbeing of a patient. Martius flap has been used as a vascularized pedicled interposition graft in the treatment of pelvic fistulas. Hereby we are describing 3 different utilities of this flap. 1st we will describe the utility of a <b><i>transposed de-epithelized flap, plugged in to the bladder lumen after laparotomy</i></b> for repair of vesicovaginal fistula ( <b><i>VVF</i></b> ) located in trigone. Next reconstruction of the  <b><i>posterior vaginal wall (PVW),</i></b> after it's an en bloc resection in rectal cancer, is elaborated. Use of a de-epithelized transposed flap and re construction of PVW with martius flap, are two innovative techniques , not described before. Next we will describe the utility of this flap in repair of rectovaginal fistula <b><i>(RVF).</i></b>  Study was prospective observational, total of 10 patients were included in the study between January 2021 and June 2023. 4 patients had VVF involving trigone, 4 underwent reconstruction of PVW following ELAPE (Extralevator abdomino perineal excision) and 3 patients had RVF. In all cases modified Martius flap was used to achieve epithelial integrity. All patients reported <b><i>successful clinical and radiological closure of fistula</i></b> . Patients underwent diversion stoma closure after healing of RVF. Patients with <b><i>posterior vaginal wall reconstruction also</i></b> reported resumption of <b><i>sexual activity</i></b> . Modified Martius flap technique is simple and reproducible in pelvis fistulas repair and PVW reconstruction to create neovagina.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1899-1908"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pectoralis Major Myocutaneous Flap in Reconstruction of Defects after Head and Neck Oncological Resections - Gender wise Comparison of Profile and Outcome.","authors":"Balamurugan G, Madhumitha Mythili, Senthilkumar N, Ganesh Vijaykumar G, Ramkumar P","doi":"10.1007/s13193-025-02515-1","DOIUrl":"10.1007/s13193-025-02515-1","url":null,"abstract":"<p><p>Head and neck malignancies significantly contribute to the cancer burden among women in South India mainly due to the tobacco chewing pattern prevalent in them.The use of pectoralis major myocutaneous flap for post surgical defect reconstruction is more challenging in them owing to their donor area anatomy. We aimed to analyse and compare the clinical profile and post operative outcome of male and female patients undergoing pectoralis major myocutaneous flap reconstruction for oncological head and neck resections. We retrospectively analysed the records of male and female patients who underwent PMMC flap reconstruction in our institution during 2022-24 and assessed their outcome perioperatively and after 6 months of follow up and drew comparisons. Sixty six patients underwent PMMC flap reconstruction during the two year period. Out of them, 37 (56.1%) were women and 29 (43.9%) were men. Median age among females and males were 58 y and 54.8 years respectively. Buccal mucosa was the predominant primary site in both but constituted a higher proportion in female patients. (46% vs. 34%), followed by lower alveolus. Overall, 26 inlay, 5 overlay and 35 bipaddled flaps were done.54% of defects in female patients required bipaddled flaps for closure. Mean operating time was 219 min & 196 min for female and male patients respectively. All female patients had their donor sites closed primarily ; 30% of males required split skin grafts. In the early post operative period, minor complications ( wound infection, partial necrosis ) occured in 30% patients overall. (32% among females, 27% among males) which were successfully managed conservatively. Flap loss necessitating alternate cover occured in 6% - 4 patients( 2 males, 2 females). On follow up at 6th month, both subgroups had satisfactory functional shoulder outcomes as determined by range of movements. The pectoralis major myocutaneous flap provides reliable results in both gender groups inspite of technical difficulties in female patients.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1929-1934"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Esophagectomy for Esophageal Cancer: A 14-Year Experience of Over 1000 Consecutive Cases from a High-Volume Center in India.","authors":"Subramanyeshwar Rao Thammineedi, Kalidindi Venkata Vijaya Narsimha Raju, Sujith Chyau Patnaik, Pratap Reddy, Srijan Sandesh Shukla, Basanth Kumar Rayani, Vibhavari Milind Naik, Syed Nusrath","doi":"10.1007/s13193-025-02495-2","DOIUrl":"10.1007/s13193-025-02495-2","url":null,"abstract":"<p><p>Esophagectomy remains the cornerstone of curative treatment for esophageal and gastroesophageal junction (GEJ) cancers. This study presents a comprehensive analysis of perioperative outcomes, complications, and survival over a 14-year period at a high-volume tertiary cancer center in India. A retrospective review was conducted of 992 patients who underwent esophagectomy for esophageal or GEJ carcinoma at a Tertiary cancer care hospital in South India, from January 2010 to September 2024. Patients with upper esophageal malignancies, total/proximal gastrectomy, and palliative procedures were excluded. Data were extracted from a prospectively maintained database and analyzed for demographics, operative details, histopathology, complications, and survival outcomes. The cohort included 992 patients (56.8% female), with squamous cell carcinoma being the most common histology (66.8%). Neoadjuvant chemoradiotherapy (NACRT) was administered to 57.9% of patients. Transthoracic esophagectomy (TTE) was performed in 594 patients (59.8%), and transhiatal esophagectomy (THE) in 395 patients (39.8%). Overall, 64 patients (6.4%) required conversion to open surgery. This included 11 thoracic conversions and 53 abdominal conversions. Median operative time was 375 min, with a median blood loss of 100 mL. R0 resection was achieved in 94.3% of patients, with a median of 20 lymph nodes harvested. Postoperative pneumonia occurred in 14.4%, and anastomotic complications in 12.2%. Thirty-day and ninety-day mortality rates were 3.5% and 4.5%, respectively. Five-year disease-free survival (DFS) was 78% in the NACRT group compared to 49% in the upfront surgery group. Five-year overall survival (OS) was 62% in the NACRT group versus 35% in the upfront surgery group. This large series demonstrates the feasibility, safety, and oncologic efficacy of MIE in a high-volume Indian center with acceptable morbidity and R0 resection rates. Neoadjuvant therapy, especially NACRT, is associated with superior survival outcomes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02495-2.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1838-1851"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic Features of Metaplastic Breast Carcinoma: Experience from A Cancer Research Centre in India.","authors":"Anish Chowdhury, Ketul Puj, Mohit Sharma, Poojitha Yalla, Arpit Bandi, Gautami Joshi, Shailesh Patel, Ishan Arora, Harsha Panchal, Rujuta Shah, Shashank J Pandya","doi":"10.1007/s13193-025-02525-z","DOIUrl":"10.1007/s13193-025-02525-z","url":null,"abstract":"<p><p>Metaplastic Breast Carcinoma (MpBC) is a rare, aggressive form of breast cancer, comprising 1.4-5% of all breast malignancies. Typically classified as Triple Negative Breast Cancer (TNBC), MpBC behaves more aggressively than most TNBC cases, often presenting with worse outcomes despite node-negative stages. Given its rarity, knowledge is scarce regarding its natural history and optimum treatment. This study aims to evaluate the clinicopathological characteristics, therapeutic responses, and outcomes of MpBC patients at a tertiary cancer center in India. This retrospective study included MpBC patients treated at our institution from January 2016 to May 2023. Data collected included epidemiological, clinical, histopathological records and survival outcomes. Kaplan-Meier survival analysis was conducted using IBM SPSS ver 25. A total of 37 MpBC cases were identified. The median age at presentation was 51 years, with metastatic disease being more common in older patients. Most cases presented at Stage II (54.1%), average tumor size of 5.1 cm. Node-positive disease was found in 40.5% of patients. Surprisingly only 56.8% of patients had TNBC. The most common histological subtype was MpBC with squamous cell component (29.3%). The median overall survival was 56 months for the study cohort. MpBC is a rare and aggressive breast cancer subtype, often diagnosed post-surgery. Despite presenting with large tumors, it shows paradoxically low lymph node metastasis. Surgical management is the primary treatment, with chemotherapy showing limited efficacy.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02525-z.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 8","pages":"1962-1968"},"PeriodicalIF":0.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}