Indian Journal of Surgical Oncology最新文献

{"title":"Non-Hodgkin Lymphoma Presenting as an Ulcerated Soft Tissue Mass on Left Thigh: A Rare Case Report.","authors":"Arshi Khan, Ruquiya Afrose, Sadia Afreen, Karthik Dasari, Mohammad Akram, Sayeedul Hasan Arif, Mohammad Jaseem Hassan","doi":"10.1007/s13193-024-02105-7","DOIUrl":"10.1007/s13193-024-02105-7","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"712-716"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cancer Care-Post‑Independence Evolution in West Bengal and Eastern India.","authors":"Arnab Gupta","doi":"10.1007/s13193-022-01650-3","DOIUrl":"https://doi.org/10.1007/s13193-022-01650-3","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s13193-022-01603-w.].</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"722"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Distant Metastases in High-Risk Operable Breast Cancer (HROBC) pT1-2 N2a or Higher at Diagnosis.","authors":"Vani Parmar, Naveena Kumar An, Nita S Nair, Shalaka Joshi, Purvi Thakkar, Garvit Chitkara, Basila Ali, Varsha Gaikwad, Shabina Siddique, Vaibhav Vanmali, Palak Popat, Sneha Shah, Sangeeta Desai, Tanuja Shet, Meenakshi Thakur, Venkatesh Rangarajan, Rajendra Achyut Badwe","doi":"10.1007/s13193-024-02098-3","DOIUrl":"https://doi.org/10.1007/s13193-024-02098-3","url":null,"abstract":"<p><p>Current standard guidelines do not recommend a routine staging workup in early operable breast cancer (OBC) as the incidence of de novo metastasis is only 1-2%. Some of these patients are at high risk for relapse based on the higher axillary nodal burden. This prospective study evaluated the presence of de novo asymptomatic distant metastases in HROBC with pT1/2 N2a/N3 on upfront surgery. A single-centre study was carried out in upfront operated OBC patients with four or more axillary nodes positive after definitive surgery. Comprehensive metastatic workup was carried out, including an ultrasound abdomen, bone scan, and CT scan (thorax-abdomen-pelvis) or PET scan before initiating adjuvant treatment. If a distant disease was detected, the adjuvant treatment intent was tailored accordingly. The study accrued a prospective consecutive cohort of 97 women with pT1-2 N2a-3 during 2015-2018 operated upfront for OBC with cT1-2 N0-1. Forty percent of women were premenopausal, 54 (55.6%) had pN2a, and 43 (44.3%) had pN3 disease. Distant disease was seen in 8 of 97 women (8.24%) of these high-risk early cancers, 5 had oligometastatic denovo disease (5.15%), and 3 had polymetastatic (3.09%). Between the 2 groups, the pickup rate of distant disease was higher in pN3 (11.4%) as against pN2a (5.6%), <i>p</i> = NS. Only 3.09% of patients with extensive metastases were treated with palliative intent. The study shows potential to optimize the management of HROBC with heavy nodal disease identified post-primary surgery by selective staging investigations, adequate resource stratification, and thereby improved management, including modifying treatment plans early.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"576-580"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Number of Negative Lymph Nodes Removed on the Survival and Recurrence Rate After Primary Surgery in Patients with Ovarian Cancer: A Multi-Center Retrospective Cohort Study.","authors":"Elham Rahimpour, Behnaz Niroomand, Maryam Kalatehjari, Fatemeh Shahbakhti, Mansour Bahardoust, Babak Goodarzy, Fatemeh Majdolashrafi, Sara Ghorbanzade, Adnan Tizmaghz","doi":"10.1007/s13193-024-02077-8","DOIUrl":"10.1007/s13193-024-02077-8","url":null,"abstract":"<p><p>The effect of the number of negative lymph nodes (NLNs) removed on the overall survival (OS) and recurrence rate of ovarian cancer (OC) patients has not been investigated. This study aimed to investigate the effect of the number of NLNs removed on OC patients' survival and recurrence rate after primary surgery. In this multi-center cohort study, the medical profile of 504 OC patients (mean age 55.21 years and mean follow-up 78.5 ± 28.4 months) who underwent primary surgery between 2011 and 2021 in gynecological tumor surgery centers affiliated with Iran and Shahid Beheshti Universities of Medical Sciences, Tehran, Iran, was retrospectively examined. Based on the number of NLNs removed, patients were divided into four groups, including 0-9, 10-19, 20-30, and > 30 NLNs, including 152, 169, 124, and 59 OC patients, respectively. The 5-year survival was 49.1%. The median survival was 61 months. The RFS and OS were significantly better in patients with more than 30 NLNs removed compared to other groups. The multivariable analysis showed that the OS rate was significantly better in patients with the number of NLNs removed ≥ 20 compared to < 20 (HR, 1.88; 95% CI 1.15-2.62; <i>p</i>, 0.001). Also, age, FIGO stage, presence of metastasis, adjuvant therapy, and tumor pathological differentiation were significantly related to the OS of OC patients (<i>p</i> < 0.05). Paying attention to the number of NLNs removed during primary surgery can be a key factor in improving the OS rate of OC patients.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"536-542"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Define Inflammatory Breast Cancer: A Systematic Review.","authors":"Sadaf Alipour, Ramesh Omranipour, Mohammadreza Zafarghandi, Abdolali Assarian, Ali Mir","doi":"10.1007/s13193-024-02094-7","DOIUrl":"10.1007/s13193-024-02094-7","url":null,"abstract":"<p><p>The diagnosis of IBC is clinical and mainly based upon skin changes. This definition may vary from one clinician to another and one patient to another. Due to the obscure criteria available for diagnosing IBC, in this review, we gathered all the reliable information in the literature about the definition of IBC in the last decade to identify important features that should be considered in the diagnosis. We conducted this systematic review on MEDLINE and PUBMED by searching for the keywords \"inflammatory breast cancer,\" \"diagnosis,\" \"criteria,\" or \"definition.\" The time limit of this study was 13 years, from 2010 to 2023. Our basic search revealed 158 articles and finally 24 studies were approved and evaluated. The prevalence of clinical signs and symptoms and imaging and pathologic features were analyzed. The clinical criteria for the definition and diagnosis of IBC were mentioned in 100% of the studies, with the most common being skin changes (erythema, edema, and peau d'orange) in all 24 articles, rapid onset (< 6 months) in 66.6% of the studies, and involvement of at least one-third of the breasts in 41.6% of the studies. The imaging criteria for IBC diagnosis were discussed in 11 studies (45.8%), with the most common imaging sign being diffuse involvement of the breast and skin thickening (72.7%). Five studies (20.8%) evaluated the role of magnetic resonance imaging (MRI) in the diagnosis of IBC and reported the following findings: heterogeneous enhancement, edema on T2-weighted images, asymmetrical enhancement, diffuse non-mass enhancement, skin enhancement, and Cooper's ligament enhancement. Pathology-specific findings were common in 10 articles (41.6%), which included dermal/non-dermal lymphatic tumor emboli. This study suggested that IBC should be suspected in the presence of rapid-onset (at least less than 6 months) erythema and edema, regardless of its extent, and when suspected, mammography and ultrasound should be performed to search for diffuse skin or parenchymal involvement, multicentric disease, and suspicious regional lymph nodes. MRI and skin biopsy could be helpful when the diagnosis is not clear (e.g., no underlying mass).</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"393-400"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chemotherapy on Fertility and Fertility Preservation Strategies for the Women of Childbearing Potential Undergoing Chemotherapy: A Comprehensive Review.","authors":"Mayank Kapoor, Anusha Mruthyunjaya Swamy, Deepak Sundriyal, Mridul Khanna, Nishant Sinha, Karthik J, Shalini Rajaram, Amit Sehrawat","doi":"10.1007/s13193-024-02103-9","DOIUrl":"10.1007/s13193-024-02103-9","url":null,"abstract":"<p><p>Cancer incidence among women of childbearing potential (WCBP) underscores the need for effective fertility preservation strategies. Advances in cancer treatment have significantly improved survival rates, highlighting survivorship issues, particularly fertility concerns in younger patients. Chemotherapy, while a crucial treatment for cancer, often brings with it unintended consequences, particularly regarding fertility. Chemotherapy induces gonadotoxicity through mechanisms such as DNA damage, follicular apoptosis, and hormonal disruption, compromising ovarian function and fertility. The risk of infertility may be low, intermediate, or high depending upon the drug used, the dose, and the duration of use. Quantifying chemotherapy's impact is challenging due to diverse agents and variable effects. Guidelines recommend discussing fertility preservation options with WCBP before treatment, using biomarkers like anti-Mullerian hormone (AMH) to assess ovarian reserve. Strategies include cryopreservation of ovarian tissue, embryos, and oocytes, each with distinct advantages and considerations. Pharmacological interventions like GnRH agonists aim to mitigate gonadotoxic effects, although their efficacy is debated. Surgical approaches like oophoropexy protect ovaries during pelvic radiation but pose logistical challenges. Fertility preservation involves ethical and psychosocial dimensions, including informed consent, financial considerations, and ethical dilemmas, necessitating comprehensive patient counselling. Future research focuses on enhancing techniques such as in vitro maturation, developing artificial ovaries, and refining cryopreservation methods to optimize outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"401-407"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposal for Orocutaneous Fistula Grading Following Oral Cancer Surgery.","authors":"Shivakumar Thiagarajan, Nithyanand Chidambaranathan, B Gurukeerthi, Devendra Chaukar","doi":"10.1007/s13193-023-01786-w","DOIUrl":"10.1007/s13193-023-01786-w","url":null,"abstract":"<p><p>Orocutaneous fistula (OCF) is a common postoperative complication encountered following surgery for oral cancers with multiple implications. There is no grading system available for this complication which has so many implications that would help in its uniform reporting and management. In this study, we have included patients with oral squamous cell carcinoma operated on between January 2021 and December 2021 and tested a proposed three-tier grading system (grades 1-3) for OCF. Out of the 284 patients at risk of OCF, 37 (13%) patients developed OCF in this cohort. Six patients had grade 1 OCF, 20 patients had grade 2 OCF, and 11 patients had grade 3 OCF. Patients with a higher grade of OCF had prolonged hospital stays and required multiple surgical debridements and/or resuturings, and a few needed another flap, which was statistically significant. The proposed grading system for OCF appears to be useful in grading this complication. However, this needs to be validated in a prospective study across multiple centres.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":" ","pages":"496-501"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44147930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between the Devil and the Deep Sea-The Cardiac Conundrum: Report of a Contiguous Cavo-Atrial Tumor Thrombus in NSGCT Testis.","authors":"Shrinivas Venkatesh, Dakshinamurthy Suresh Kumar, Shalini Shree Krishnamurthy, Krishna Muralidharan, Navin Noushad, Kanuj Malik, Anand Raja","doi":"10.1007/s13193-024-02119-1","DOIUrl":"10.1007/s13193-024-02119-1","url":null,"abstract":"<p><p>Testicular cancer is notorious for its myriad presentations. In this case report, we present a 28-year-old gentleman diagnosed with metastatic non-seminomatous germ cell tumor (NSGCT). After receiving neoadjuvant chemotherapy, he was found to have a large paracaval conglomerate nodal mass infiltrating the inferior vena cava (IVC), with a contiguous thrombus extending from the vena cava to the right atrium. The pre-operative imaging was ambiguous, with the cavo-atrial thrombus appearing to float within the vascular lumen at some places and infiltrating the caval wall at others. Hence, arrangements were made for cardiopulmonary bypass, sternotomy, and vascular surgeon backup. Intraoperatively, the vena cava was palpated in its entirety up to the mediastinum, and the thrombus was found to be freely floating. Hence, the thrombus was milked out in its entirety from the right atrium up to the vena cava, and the paracaval mass was resected en bloc with the tumor thrombus. The IVC was reconstructed with a Dacron graft. A review of the literature revealed no previously documented cases of contiguous cavo-atrial tumor thrombus. Approaching cases requires an assessment of the nature of the thrombus and the need to prepare for the worst. It is worth remembering that going the extra mile concerning obtaining a complete tumor clearance is worth it in NSGCTs, given the highly gratifying outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"639-644"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Progression on Neoadjuvant Chemotherapy: An Indicator of Poor Outcomes in Extremity Osteosarcoma.","authors":"Chandra Kumar Krishnan, Madhusudan Reddy Karagiri, Venkatraman Radhakrishnan, Anand Raja","doi":"10.1007/s13193-024-02087-6","DOIUrl":"10.1007/s13193-024-02087-6","url":null,"abstract":"<p><p>Osteosarcoma is a matrix-producing neoplasm. Most patients are treated with neoadjuvant chemotherapy (NACT. Various parameters are available for response assessment which include radiological and histological criteria. Data on clinical responses such as pain response and size assessment is meagre. In this study, we aimed to analyze if clinical assessment used for response evaluation can predict prognosis in patients receiving neoadjuvant chemotherapy for extremity osteosarcoma. All patients diagnosed with osteosarcoma and who underwent treatment with curative intent between January 2000 and December 2018 were identified. Patients who had progression were identified and whether clinical progression impacted overall survival (OS) and disease-free survival (DFS) was analyzed. Forty-three patients who had progression on NACT were identified. When compared to patients who did not have clinical progression, more patients in the clinical progression group had large tumors (<i>p</i> = 0.025), the majority underwent amputation (<i>p</i> = <0.001), and most were poor responders to chemotherapy (<i>p</i> = 0.011). Clinical progression on NACT predicted poor OS and DFS on univariate analysis but not on multivariate analysis. Although patients with clinical progression had poor oncological outcomes, it was not a statistically significant factor affecting oncological outcomes. The role of continuing the same chemotherapy regimen in the adjuvant setting in this subset of patients is doubtful. Large multicentric studies are needed to know the prognostic impact of clinical progression during NACT on oncological outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"567-575"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Outcomes of Oesophagectomy in a Real-World Scenario from a Tier II City in India.","authors":"Amita Sekhar Padhy, Rigved Nittala, Srikarthik Voleti, Chaitanya Raju Chalapaka","doi":"10.1007/s13193-024-01924-y","DOIUrl":"10.1007/s13193-024-01924-y","url":null,"abstract":"<p><p>This study evaluates short-term outcomes of oesophagectomy at a low-volume cancer hospital in Visakhapatnam, India. Fifteen patients who underwent oesophagectomy from 2020 to 2023 were analysed. The most common histology was squamous cell carcinoma. The mean age was 55 years and the majority were male. The common approaches used were open transhiatal and transthoracic oesophagectomy. The mean operative time was 9.5 h, and the mean hospital stay was 15.92 days. There were no perioperative deaths, but complications included pulmonary issues, vocal cord paralysis, anastomotic leaks, chyle leaks and wound infections. Higher volume centres tend to have better outcomes after oesophagectomy. However, factors other than volume like patient selection, ERAS (Enhanced Recovery After Surgery) protocols, specialized critical care and trained multidisciplinary teams also impact outcomes. At our centre, though a low-volume hospital, proper patient selection, prehabilitation and a collaborative team approach helped achieve acceptable results. We recommend developing consensus on defining low- and high-volume centres for oesophagectomy in the Indian context, based on disease burden, resources and constraints. Overall, there is a lack of Indian data comparing outcomes between low and high-volume centres for oesophagectomy.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"16 2","pages":"521-527"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}