Indian Journal of Surgical Oncology最新文献

{"title":"A Short Course of Preoperative Denosumab Injection Followed by Surgery in High-Risk Giant Cell Tumors of the Extremities: A Retrospective Study.","authors":"Sujit Kumar Tripathy, Saroj Das Majumdar, Siddharth Satyakam Pradhan, Paulson Varghese, Hrudeswar Behera, Anand Srinivasan","doi":"10.1007/s13193-024-01990-2","DOIUrl":"10.1007/s13193-024-01990-2","url":null,"abstract":"<p><p>Despite early promising results with denosumab treatment in giant cell tumor of bone (GCTB), recent studies have raised concerns about a high local recurrence rate following preoperative denosumab administration and joint preservation surgery. This retrospective study evaluated data from 25 high-risk GCT patients (Campanacci grade II or III with features like soft tissue extension, pathological fracture, minimal periarticular or subarticular bone) treated with five doses of neoadjuvant denosumab injection followed by either curettage and cementing (<i>n</i> = 13) or joint reconstruction with fibular graft/endoprosthesis (<i>n</i> = 12) between 2014 and 2019. With an average follow-up of 40 months, the study found only one patient of local recurrence. All patients were independently ambulant, with a mean MSTS score of 26.32. Subgroup analysis revealed an MSTS score of 27.76 in the joint preservation group, and 24.75 in the excision with reconstruction/prosthetic replacement group (unpaired <i>t</i>-test, <i>p</i>-value < 0.001). Five patients experienced postoperative complications, including two infections, one recurrence, one mediolateral instability in the prosthetic component, and one restriction of wrist movement. A short course of neoadjuvant denosumab, followed by curettage and cementing or wide excision with joint reconstruction/prosthetic replacement, appears to be an effective strategy for high-risk GCTB patients. This approach not only minimizes surgical morbidity but also does not increase the local recurrence rate. The short course regimen may present a cost-effective and practical option in clinical practice.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"825-836"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Androgen Receptor Expression in Breast Cancer: Insights into Histopathological Parameters and Hormone Receptor Status Among Indian Women.","authors":"Nidhiben Harshadkumar Thakkar, Md Ali Osama, Shashi Dhawan","doi":"10.1007/s13193-024-01997-9","DOIUrl":"10.1007/s13193-024-01997-9","url":null,"abstract":"<p><p>Breast cancer, an exceptionally hormone-dependent tumor, exhibits a diverse clinical profile. Its therapeutic categorization relies on the expression of key receptors, namely, estrogen receptor (ER), progesterone receptor (PR), and Her2neu. The androgen receptor (AR), a member of the nuclear receptor superfamily, is a biomarker gaining attention in breast cancer research, particularly for triple-negative breast cancers. We conducted an analysis of AR expression in 113 primary breast cancer cases, using a cutoff criterion of ≥ 10% tumor cell positivity. ER, PR, and Her2neu statuses were determined based on the 2023 ASCO-CAP criteria. AR expression was then correlated with various clinicopathological factors, including age, menopausal status, centricity, histological type, grade, tumor size, nodal status, lymphovascular and perineural invasion, and ER, PR, and HER2neu statuses. Among the 113 cases, 57 (50.4%) showed positive AR expression. No statistically significant associations were found between AR expression and age, menopausal status, histological type, histological grade, nodal status, or ER and PR expression. Notably, all multicentric tumors (<i>n</i> = 7, 100%) were AR negative. AR expression was linked to smaller tumor sizes. Positive AR cases exhibited an association with Her2neu overexpression, particularly in ER and PR-negative tumors. Of note, 35% of triple-negative tumors displayed AR positivity. AR emerges as a promising marker in breast cancers, particularly in triple-negative cases. Larger-scale studies are warranted to comprehensively assess the relationship between AR expression and histopathological parameters, as well as other immunohistochemical markers.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"789-795"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Mole with Rare Ovarian Metastasis: Successful Treatment with Hysterectomy and Chemotherapy-A Case Report.","authors":"Geet Bhuyan, Manish Das","doi":"10.1007/s13193-024-02086-7","DOIUrl":"10.1007/s13193-024-02086-7","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 Suppl 4","pages":"622-626"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Presentation of Epidermal Inclusion Cyst of Gluteal Region: Case Report.","authors":"Kapilnath Muralimanohar, Kaushal G Vira","doi":"10.1007/s13193-024-02062-1","DOIUrl":"10.1007/s13193-024-02062-1","url":null,"abstract":"<p><p>Epidermal inclusion cysts are common, benign, intradermal, or subcutaneous lesions typically asymptomatic ranging from 1 to 4 cm in size. Transformation to squamous cell carcinoma is rare. Neoplastic change in these cysts can be associated with prominent symptoms such as pain, rapid growth, or ulceration. We present a case of a 70-year-old male, with a giant gluteal swelling masquerading as soft tissue sarcoma. The clinical, radiological, and histopathologic findings are described. We present this case because it is rare for a benign epidermal inclusion cyst to be unusually large and malignant transformation in such cysts is rarely reported. We also recommend that the entire cyst wall is to be removed without disruption and to be subjected for a thorough histopathological evaluation.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 Suppl 4","pages":"611-615"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Flap Necrosis in Inguinal Lymph Node Dissection.","authors":"Shiv Rajan, Naseem Akhtar, Sugandha Arya, Sameer Gupta, Puneet Prakash, Vijay Kumar, Sanjeev Misra, Arun Chaturvedi, Abhilasha Tripathi, Prabhakar Mishra","doi":"10.1007/s13193-024-01985-z","DOIUrl":"10.1007/s13193-024-01985-z","url":null,"abstract":"<p><p>Inguinal skin flap necrosis (SFN) is a significant clinical problem associated with inguinal lymph node dissection (ILND). The aetiology of SFN is multifactorial, and its manifestations vary widely. Thermal damage caused by electrocautery during the elevation of the skin flap may contribute to this problem, which has not been studied previously. This prospective, observational study included patients undergoing ILND from January 2020 to July 2022. Based on the technique of raising the inguinal skin flaps, the patients were divided into two groups (cold knife or electrocautery). The remaining part of the procedure was the same. The inguinal wound was examined and photographed to assess the SFN. A total of 42 patients were included (21 in each group). Age, gender, body mass index (BMI), alcohol or tobacco consumption, immune compromised status, and serum albumin were comparable (<i>p</i> > 0.05). The average time required to elevate flaps was 13.14 vs. 11.47 min (<i>p</i> = 0.0231), and gauze soakage was 2.05 vs. 1.52 (<i>p</i> < 0.0001) with a cold knife compared to electrocautery. The incidence of SFN and surgical site infection (SSI) was significantly lower with the use of a cold knife [4.8% vs. 33.3% (<i>p</i> = 0.045) and 0% vs. 19% (<i>p</i> = 0.0378)]. Grade 3 necrosis was observed only with electrocautery use. Compared to conventional electrocautery, the cold knife technique lowers the incidence of SFN and SSI. Further research with a larger sample size and a standardized definition is needed to validate these results.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"762-767"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Thyroidectomy Versus Partial Thyroidectomy for Non-Toxic Multinodular Goiter: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Hadi A Al-Hakami, Dania A Kouther, Jawaher F Alsharef, Meshaal A Kouther, Amal H Abualola, Abdullah A Ghaddaf, Baraa Awad, Mohammed Al Garni","doi":"10.1007/s13193-024-02057-y","DOIUrl":"10.1007/s13193-024-02057-y","url":null,"abstract":"<p><p>Thyroid follicular nodular disease (non-toxic multinodular goiter), the commonest thyroid disorder, can be managed with different surgical methods, including total thyroidectomy (TT), near-total thyroidectomy (NTT), subtotal thyroidectomy (STT), and Dunhill operation (DO). This systematic review and meta-analysis aimed to provide an update on the role of TT versus NTT, STT, or DO in MNG concerning goiter recurrence, thyroid cancer incidence, and reported complications. We conducted a systematic literature search in Medline, EMBASE, and CENTRAL. We included randomized controlled trials (RCTs) that compared TT to partial thyroidectomy (NTT, STT, or DO) in the management of multinodular goiter (MNG). The following outcomes, goiter recurrence, cancer incidence, and adverse events (hypoparathyroidism and recurrent laryngeal nerve injury), were evaluated. We used the risk ratio (RR) to represent the dichotomous outcome. Subgroup analysis was performed based on the different types of partial thyroidectomy (NTT, STT, and DO). A total of 7 RCTs that included 1909 individuals were deemed eligible. TT showed significantly better results compared to PT in terms of goiter recurrence (RR = 0.05, 95% CI 0.02 to 0.13, <i>P</i> = 0.001; <i>I</i> ^<i>2</i>  = 0%), whereas it showed similar results compared to PT in terms of thyroid cancer incidence (RR = 1.09, 95% CI 0.76 to 1.57, <i>P</i> = 0.63; <i>I</i> ^<i>2</i>  = 0%). PT was significantly better than TT concerning transient adverse events (RR = 2.18, 95% CI 1.64 to 2.89, <i>P</i> = 0.001: <i>I</i> ^<i>2</i>  = 63%). This meta-analysis showed that TT has a lower risk of goiter recurrence. TT is comparable to PT in terms of persistent adverse events but has a higher risk for transient adverse events.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-02057-y.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"920-930"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Axillary Fibroadenoma in Accessory Breast Masquerading Malignancy.","authors":"Arushi, Sana Ahuja, Sufian Zaheer","doi":"10.1007/s13193-024-02110-w","DOIUrl":"10.1007/s13193-024-02110-w","url":null,"abstract":"<p><p>Fibroadenoma presenting in the axilla is a rare occurrence often associated with ectopic breast tissue. Accessory breast(s) are characterized by the existence of additional breasts, exceeding the typical count of two, accompanied by or without a nipple and areola, in human anatomy. It can manifest at any point along the primitive embryonic milk lines, which extend from the armpit to the groin region. This case report describes a 39-year-old female presenting with right axillary swelling and a history of fibroadenoma excision from the contralateral breast. Emphasizing the importance of considering this condition in the axillary differential diagnosis, it highlights the diagnostic challenge of distinguishing it from metastatic lymphadenopathy. Fine needle aspiration cytology (FNAC) plays a crucial role in early diagnosis, leading to a favorable prognosis following excision. Management strategies for fibroadenomas vary based on symptoms and concerns, ranging from observation to surgical excision. This case underscores the rarity of axillary fibroadenoma, necessitating individualized management approaches and emphasizing the pivotal role of cytological evaluation in guiding appropriate interventions for optimal patient outcomes. The case also underscores the importance of considering accessory breast masses in the differential diagnosis of axillary lumps, given their potential for malignant transformation and clinical implications.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 Suppl 4","pages":"650-653"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Urothelial Carcinoma of the Bladder and Renal Cell Carcinoma of the Kidney: A Diagnostic and Therapeutic Challenge.","authors":"Adil Aziz Khan, Rohan Nautiyal, Sachin Kolte, Pawan Vasudeva","doi":"10.1007/s13193-024-02097-4","DOIUrl":"10.1007/s13193-024-02097-4","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 Suppl 4","pages":"637-641"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Depth of Invasion on Contrast-Enhanced Computed Tomography in Tumours of the Gingivobuccal Complex-A Retrospective Analysis.","authors":"Mainak Ghosh, Adarsh Ishwar Hegde, Aparna Ganesan, Saurabh Badgurjar","doi":"10.1007/s13193-024-01998-8","DOIUrl":"10.1007/s13193-024-01998-8","url":null,"abstract":"<p><p>Depth of invasion (DOI) is an established independent prognostic factor in oral squamous cell carcinoma (OSCC) and also predicts cervical nodal metastasis. Preoperative determination of DOI based on imaging can aid in decision-making regarding neck dissection or determining the prognosis of the disease. This study aimed to correlate the DOI measured on contrast enhanced computed tomography (rDOI) with the pathologically measured DOI (pDOI). Retrospective data of patients with OSCC of the gingivobuccal complex from January 2023 to July 2023 was collected. Two radiologists independently measured the DOI on axial and coronal planes of CECT. The correlation between rDOI and pDOI was determined. Stepwise multiple linear regression analysis was performed to predict the pDOI using rDOI. ROC curve analysis was performed for the rDOI as measured on both axial and coronal sections in predicting the nodal metastasis. A total of 59 patients were included in the study. The mean rDOI was 11.06 mm on axial section and 10.9 mm on coronal section, and pDOI was 9.7 mm. Spearman's correlation coefficient between pDOI and rDOI measured on axial (rho = 0.61; <i>p</i> value = 0.001) and coronal (rho = 0.62; <i>p</i> value = 0.001) sections implied strong correlation which was statistically significant. The present study attempted to establish the correlation and accuracy of CECT-determined rDOI in axial and coronal planes in gingivobuccal complex tumours. Multicentric studies with a larger sample size are mandated to augment the results obtained in this study.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-024-01998-8.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"796-801"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shoulder Reconstruction Using a 3D Printed 'Gigaprosthesis' Following Resection of Massive Primary Bone Tumour.","authors":"Suraj Hindiskere, Prashant Puranik, Muralikrishna Nekkanti, Pramod S Chinder","doi":"10.1007/s13193-024-02042-5","DOIUrl":"10.1007/s13193-024-02042-5","url":null,"abstract":"","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"15 4","pages":"738-745"},"PeriodicalIF":0.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}