Indian Journal of Surgical Oncology最新文献

{"title":"Health-Related Quality of Life Among Thyroid Cancer Survivors in India: Insights from the Modified City of Hope-QOL Thyroid Version Questionnaire.","authors":"Sushil Raj Shrestha, Madhu Priya, G Vetrivel, Manu Malhotra, Abhishek Bhardwaj, Saurabh Varshney, Amit Kumar, Amit Kumar Tyagi, Gaurav Kumar Goldar","doi":"10.1007/s13193-025-02329-1","DOIUrl":"https://doi.org/10.1007/s13193-025-02329-1","url":null,"abstract":"<p><p>The purpose of this study is to assess the HRQOL and identify the potential risk factors for its deterioration in thyroid cancer (TC) survivors in India. We also aim to strengthen the existing COH-QOL (thyroid) Questionnaire by adding two missing items of tingling or numbness and scar on the neck in the physical and psychological domains, respectively. TC survivors were recruited from the ENT OPD and the Uttarakhand Thyroid Surgeries Registry System from a period of 2017 to 2022. Participants completed a Hindi-validated modified version of the COH-QOL (thyroid) Questionnaire to assess QOL domains. The correlation of QOL scores with different health conditions was done. QOL is affected after the initial TC diagnosis and treatment, with poorer scores in all domains. Quality of work is the most affected item in the social domain. The potential risk factors for deterioration in QOL scores are age, gender, employment, educational status, stage of disease, comorbidities, extent of surgery, hypocalcemia, RAI therapy, and thyroid hormone withdrawal. Given the rapidly increasing number of TC survivors, mostly of the middle age group, and the fact that it grossly affects the work performance scale, our study will help to develop robust monitoring tools, awareness programs, intervention strategies, and TC-specific survivorship plans.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02329-1.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"420-429"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Tumour Volume as a Prognostic Factor for Organ Preservation in Locally Advanced Laryngeal Cancers.","authors":"Siva Priya, Christopher John, Lakshmi Narasimhan Parasuraman, Hemavathi Masilamani, Satish Srinivas Kondavetti","doi":"10.1007/s13193-025-02320-w","DOIUrl":"https://doi.org/10.1007/s13193-025-02320-w","url":null,"abstract":"<p><p>Tumour volume is considered as one of the prognostic factor in determining outcomes after chemoradiation in head and neck cancer. In our study, we sought to analyse the use of tumour volume as a predictor of laryngeal preservation outcomes in locally advanced laryngeal carcinoma treated with chemoradiation. A total of 37 patients with locally advanced laryngeal carcinoma (stages III and IV) who underwent chemoradiation for the period of 2017 to 2024 were included. The pre-treatment tumour volumes were obtained from planning computed tomography images. The tumour volumes were compared to various treatment outcomes like overall survival (OS), disease free survival (DFS) and laryngeal preservation rates (LPR). Statistical analysis was done by testing hypotheses (chi-square test and independent sample <i>t</i>-test) to identify significant relationships or differences, evaluating diagnostic tests with ROC curves and estimating survival probabilities with the Kaplan-Meier method. The ideal cut-off for tumour volume was 13.04 cm³ which was obtained using receiver operating characteristic (ROC) curve. The 3-year OS was 75.91% (95% <i>CI</i> 62.789-89.642) vs. 59.47% (95% <i>CI</i> 43.985-74.937) (<i>p</i> = 0.187) and the 3-year DFS was 81.39% (95% <i>CI</i> 71.962-90.822) vs. 77.39% (95% <i>CI</i> 65.722-88.999) (<i>p</i> = 0.829). On univariate analysis, the tumour volume is statically significant when compared with laryngeal preservation rates [88.9% vs. 11.1% (<i>p</i> = 0.001)]. The pre-treatment tumour volume of laryngeal carcinoma has significant impact on the LPR. The use of pre-treatment volumes obtained from modern day imaging modalities may supplement the TNM staging system and can help identify patients who would benefit from laryngeal preservation approach and thereby significantly improving the quality of life in these patients.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"321-327"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Surgical Outcomes of Curative Colorectal Resections from an Evolving Low-Volume Cancer Center in a Tier-2 City in India.","authors":"Vishnu S Menon, Amita Sekhar Padhy, Rigved Nittala, Mounika Basani, Sidaksingh R Arora","doi":"10.1007/s13193-025-02339-z","DOIUrl":"https://doi.org/10.1007/s13193-025-02339-z","url":null,"abstract":"<p><p>Colorectal cancers (CRC) are the fourth most prevalent cancer in India. Treatment modalities range from surgery, chemotherapy, radiotherapy, targeted treatment, and immunotherapy, with surgery forming the cornerstone of curative treatment in combination with any of the above. We sought to explore the short-term surgical outcomes of curative colorectal resections from our center and compare them with the published outcomes elsewhere. This is a retrospective study of all colorectal cancers that underwent curative resections at our center, from 1st January 2017 to 31st October 2024. Patients were identified from a prospectively maintained surgical database and electronic medical records. The clinical, radiological, histopathological features, and 30-day surgical outcomes were evaluated. We identified 207 patients for the said duration, with the majority of them being males (60.9%, 126/207), left-sided tumors (70%, 145/207) and clinic-radiologically stage III cancers (66.2%, 137/207). Preoperative treatment was employed in 38.7% (80/207) patients who were mostly rectal primaries (78/80). A minimally invasive surgical (MIS) approach was attempted in 36 patients with a conversion rate of 16.7%. Extended resections were performed in 33 patients (15.9%). The median length of hospital stay was 7 days (range 5 to 34 days). We observed re-exploration rates of 7.2%, a readmission rate of 3.4%, major perioperative morbidity (Clavien-Dindo 3a or above) of 13%, and 30-day perioperative mortality of 2.9%. Margin-negative resections were achievable in almost all cases (99.5%, 206/207), and optimal nodal yield (12 or more) was attained in 90.8% (188/207). Our study provides preliminary evidence that safe colorectal resections, including extended resections, can be performed in low-volume and resource-constrained centers with acceptable perioperative morbidity.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"436-446"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of Facial Defects with Prosthesis as a Salvage Option After Flap Failure-A Study of 13 Cases.","authors":"Aishwarya Chatterjee, Manish Sahni, Suresh Singh, Pinakin Patel, Kalpesh Chhajer, Kamal Kishor Lakhera, Raj Govind Sharma","doi":"10.1007/s13193-025-02336-2","DOIUrl":"https://doi.org/10.1007/s13193-025-02336-2","url":null,"abstract":"<p><p>Surgical removal of cancerous lesion may sometimes lead to large defects that connect the oral cavity with the exterior. The loss of a microvascular flap used to reconstruct the defect sometimes complicates the matter. A second surgery is at times refused or not amenable due to unavoidable reasons. In these situations, a facial prosthesis serves as a salvage treatment option, thus improving the quality of life (QOL) of the patients. The purpose of this clinical study is to document the non-invasive retentive aids used for the facial prosthesis and assess the improvement in QOL after rehabilitation with facial prosthesis for participants with facial defects. Data of 13 head and neck cancer patients rehabilitated with facial prosthesis was collected retrospectively. The relevant sociodemographic, clinical, surgical, histopathological, TNM staging, reconstructive flap, prosthesis, material used for prosthesis, and retentive aids related data was collected. The psychosocial perception scale (PSP) questionnaire was administered to the patient at baseline and 6 months of follow-up to evaluate the quality of life. QOL data pre and post prosthesis was subjected to statistical analysis. Wilcoxon signed rank test and paired <i>t</i>-test was used to analyze pre and post assessment of QOL. A total of 13 patients (10 males and 3 females) who underwent surgical resection for oral cavity cancer received facial prosthesis. Majority of the lesions occurred in the buccal mucosa followed by the maxilla. All participants had T4 lesions and had received adjuvant radiation (60 Gy, 30 fractions). Reconstruction by pectoralis major myocutaneous flap in 6 participants, free anterolateral thigh flap in 4, free fibular flap in 1, vascularized iliac crest in 1 and split thickness skin graft in 1 participant was done. Twelve prosthesis were retained with magnetic attachments and favorable undercut was used to retain 1 prosthesis. The pre and post-prosthesis scores showed statistical significant values in the domains of functions (<i>p</i> = 0.05) and positive emotions (<i>p</i> = 0.04). Given the psychosocial impact a facial defect has on a head and neck cancer patient, considerable improvement was noted in the QOL. The PSP scale is a very specific questionnaire aimed at addressing patients with extraoral prosthesis, and this study drives that point succinctly. Retaining extraoral prosthesis is challenging; careful selection of retentive undercuts or choice of retentive aids is necessary to make the prosthesis a success.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"379-386"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum CA 242 as a Potential Diagnostic Tool for Gallbladder Cancer: A Clinical Evaluation.","authors":"Jaydeep Jain, Amit Gupta, Sarath Krishnan M P, Sweety Gupta, Bela Goyal, Monisha S, Satish Ammapalem, Arunkumar V, Rahul Dev","doi":"10.1007/s13193-025-02332-6","DOIUrl":"https://doi.org/10.1007/s13193-025-02332-6","url":null,"abstract":"<p><p>Gallbladder cancer (GBC) is a prevalent form of biliary cancer with a dismal prognosis. Most patients present in late stages of disease when surgery is not a viable option. Hence, biomarkers for early detection of GBC are desperately needed. Routine serum tumor markers have shown variable predictability in different populations. CA 242 is emerging as a promising biomarker in gastrointestinal cancers. This study explored diagnostic potential of serum CA 242 and its correlation with other tumor markers in gallbladder cancer. In this prospective cross-sectional study, 50 GBC patients, 20 benign gallbladder disease (chronic calculous cholecystitis) patients, and 10 healthy controls were included. Serum CA 242 concentration was determined using the high-sensitivity ELISA method. Serum CEA, CA 125, and CA19-9 levels were analyzed using chemiluminescence. Receiver operating characteristic (ROC) was plotted to determine diagnostic potential of CA 242. The Mann-Whitney <i>U</i> test was used to compare CA 242 levels among different subgroups. Spearman's correlation was done to correlate CA 242 with other tumor markers. The median level of CA 242 in the GBC group was significantly higher (29.29 [1.40-171.50]) pg/ml compared to the non-GBC group (1.60 [1.2-2.00]) pg/ml. ROC analysis revealed that area under the curve for serum CA 242 was 0.756 (95% CI, 0.651-0.862), with a sensitivity of 64.0%, specificity of 93.3%, and diagnostic accuracy of 75.0% at an appropriate cut-off value of 6.6 pg/ml. There was significant positive correlation between CA 242 and serum CEA (<i>r</i> = 0.487, <i>P</i> = 0.000) and CA19-9 (<i>r</i> = 0.472, <i>P</i> = 0.001). No difference was observed in different subgroups like abdominal pain, obstructive jaundice, liver infiltration, lymph node involvement, metastasis, TNM staging, and resectability with serum CA 242. Serum CA 242 showed a promising potential as a diagnostic biomarker in GBC more so as a confirmatory biomarker in conjunction with other tumor markers. No association was however observed in terms of clinicopathological characteristics.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13193-025-02332-6.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"447-453"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend of Serum CEA in Recurrent Signet Cell Colorectal Adenocarcinomas.","authors":"Preeti Vijayakumaran, Mufaddal Kazi, Ashwin Desouza, Avanish Saklani","doi":"10.1007/s13193-025-02340-6","DOIUrl":"https://doi.org/10.1007/s13193-025-02340-6","url":null,"abstract":"<p><p>Colorectal cancer (CRC) represents a major global health burden, with signet cell adenocarcinoma constituting a rare but aggressive subtype. Despite multimodality treatment with curative intent, recurrence rates remain significant, and outcomes are poor. Carcinoembryonic antigen (CEA) is a widely used biomarker for CRC follow-up; however, its role in signet cell CRC remains inadequately defined. This study aimed to evaluate the trends in serum CEA among baseline CEA secretors and non-secretors presenting with recurrence after curative treatment and assess its value in postoperative surveillance. This retrospective study analyzed data from a prospectively maintained database at a tertiary cancer center between June 2011 and October 2021. Inclusion criteria were patients with recurrent signet cell colorectal adenocarcinoma, treated with curative intent, and with available CEA values at baseline, treatment completion, and recurrence. Variables included demographic data, baseline CEA levels, recurrence patterns, and CEA status at recurrence. Baseline CEA secretors were defined as those with preoperative CEA > 5 ng/ml. Statistical analysis employed chi-square and Fisher's exact tests for categorical data, with significance set at <i>p</i> < 0.05. Out of 263 signet cell colorectal adenocarcinoma patients, 100 recurrent cases were analyzed. Baseline CEA secretors accounted for 35%, while 65% were non-secretors. Elevated CEA levels at recurrence were observed in 94.3% of baseline secretors and 67.7% of non-secretors. Among secretors, only 5.7% showed normal CEA at recurrence. Recurrence patterns revealed no significant correlation with baseline secretor status, though peritoneal recurrences were more frequent among secretors. Most recurrence cases, irrespective of baseline CEA levels, exhibited elevated CEA levels, emphasizing its relevance in surveillance. This study highlights the importance of CEA monitoring in the follow-up of recurrent signet cell colorectal adenocarcinoma. Elevated CEA levels are a reliable marker for recurrence, even in baseline non-secretors. Conversely, normal CEA in secretory patients offers a reassuring prognostic indicator. The study highlights the non-site-specific nature of CEA elevation at recurrence. The study's findings support the continued use of serial CEA measurements in the postoperative surveillance of signet cell CRC.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"398-403"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatofibrosarcoma Protuberans: A Diagnostic and Management Conundrum-A Retrospective Study from a Tertiary Care Center in South India.","authors":"Samuel Paul Dhinakar Arelly, Titus Devabalan Koil, Beaulah Roopavathana, Paul Trinity Stephen, Anne Jennifer Prabhu, Sabbavarapu Padmasree, Suchita Chase","doi":"10.1007/s13193-025-02335-3","DOIUrl":"https://doi.org/10.1007/s13193-025-02335-3","url":null,"abstract":"<p><p>Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor with low metastatic potential with high local recurrence rates, arising in the dermis and often mimics other benign skin conditions. FS-DFSP is a more aggressive variant, associated with higher metastatic potential. While wide local excision is considered the primary modality of treatment, patients with high risk features would necessitate adjuvant therapy. Our study looked at challenges in diagnosing and managing DFSP. This retrospective analysis involved 50 patients who had surgical management of DFSP at a tertiary care center in South India from April 2012 to September 2024. In a study of 50 patients, most were male, with a median age of 40 years. Tumors had a median size of 4 cm, primarily located in the anterior abdominal wall. Eight four percent underwent wide local excision with a 3 cm margin; 33 patients had primary closure, while eight required flap coverage. Post-operative complications occurred in 11 patients, mainly surgical site infections. FS-DFSP was observed in 14 cases, and 24 patients received adjuvant radiation therapy due to close margins or recurrence. Only two patients were treated with adjuvant imatinib. We had only one recurrence in our study. Pre-operative biopsy and imaging can help prevent inadequate excisions, reducing recurrences and the need for re-excision and adjuvant therapy. Accepted surgical margins range from 2 to 3 cm, but wider margins necessitate flap covers and wound complications. Adjuvant therapy in select patients with local recurrence, close surgical margins, and aggressive histological types can improve outcomes.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"404-411"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Presence of Th2 Response Through GATA-3 and IL-4 Expression in Oral Tongue and Lower Lip Squamous Cell Carcinomas.","authors":"Afonso Nóbrega Dantas, Joabe Dos Santos Pereira, Lélia Maria Guedes Queiroz, Lélia Batista de Souza, Patrícia Teixeira de Oliveira, Pedro Paulo de Andrade Santos","doi":"10.1007/s13193-025-02334-4","DOIUrl":"https://doi.org/10.1007/s13193-025-02334-4","url":null,"abstract":"<p><p>This study aimed to assess the expression of <i>Gata-3</i> and <i>Il-4</i> by verifying the presence of Th2 responses in carcinoma lesions under different clinical conditions. Sixty specimens comprising 30 oral tongue squamous cell carcinomas (OTSCCs) and 30 lower lip squamous cell carcinomas (LLSCCs) were randomly selected for the study. <i>Gata-3</i> was quantified in parenchymal and stromal cells and <i>Il-4</i> was semi-quantitatively analyzed. The highest <i>Gata-3</i> ⁺ expressions in LLSCC cases were detected in the total parenchyma (<i>p</i>: 0.000), total stroma (<i>p</i>: 0.000), and total parenchyma/stroma (<i>p</i>: 0.000). Concerning <i>Il-4</i>, higher concentrations were detected in the parenchyma (<i>p</i>: 0.000) in LLSCC cases, while higher concentrations were observed in the stroma (<i>p</i>: 0.000) and in the parenchyma/stroma (<i>p</i>: 0.004) in OTSCC cases. Significant associations between <i>Gata-3</i> and <i>Il-4</i> were detected according to the OTSCC region in comparison with LLSCC cases. A higher number of immunolabelled cells for <i>Gata-3</i> was observed in LLSCCs, suggesting greater <i>Gata-3</i> expression in less aggressive lesions, potentially reducing the likelihood of tumor invasion and metastasis. Furthermore, higher <i>Il-4</i> expressions were noted in OTSCC stroma, evidencing not only a higher response (Th2) in this tumor microenvironment but also suggesting that the lower amounts of <i>Il-4</i> detected in LLSCCs may be associated with a neoplastic growth inhibition mechanism. These findings corroborate the more aggressive OTSCC behavior in comparison with LLSCCs and emphasize the important role of this cytokine and its application in the fight against cancer.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"412-419"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of FDG-PET/CT in Determining DOI and PNI in OSCC-A Retrospective Study from Eastern India.","authors":"Jyoti Ranjan Swain, Tushar Mohapatra, Nitya Nutan Misra, Resham Chandra Majhi, Pradyuspita Sahoo, Tushar Kant Sahoo, Bharat Bhusan Sathpathy, Subrat Kumar Samantara, Kunal Goutam, Swodeep Mohanty","doi":"10.1007/s13193-025-02307-7","DOIUrl":"https://doi.org/10.1007/s13193-025-02307-7","url":null,"abstract":"<p><p>Oral squamous cell carcinoma is the most common malignancy in the head and neck region. The DOI and PNI are important prognostic factors. DOI greater than 4 mm is also used as an indication for elective neck node dissection. FDG-PET/CT is now used in head and neck cancers for the delineation of the primary tumor, detection of regional nodal metastases, distant metastases, and second primary tumors. In our study, we have tried to show the correlation between preoperative FDG uptake values and postoperative histopathological parameters such as DOI and PNI. Two hundred eighty-four patients with OSCC who presented to us underwent whole-body FDG-PET/CT in addition to the routine evaluation. The patients underwent surgeries for the primary lesion and neck dissection. DOI data was segregated into ≤ 4 mm and > 4 mm. PNI was segregated into positive and negative. ROC was plotted to know the cutoff point of SUVmax in predicting DOI and PNI. For predicting the DOI > 4 mm, the cutoff point for SUVmax was 8.88 with a specificity of 76.4 and sensitivity of 69.8 (Youden's index - .660), area under the curve 0.771, and <i>p</i> value of 0.001. For predicting the presence of PNI, the cutoff point for SUVmax was 13.33 with sensitivity of 49.4 and specificity of 70.8. Preoperative FDG PET/CT can predict the depth of invasion in lesions that appear to be less than 4 mm clinically and help in decisions regarding elective neck dissections. Although the sensitivity and specificity of FDG PET/CT in predicting PNI are low but SUVmax above 13.33 can be considered a poor prognostic factor, considering the possibility of PNI positivity. FDG-PET/CT should not only be used for the diagnosis of distant metastases and identification of second primary. It can also be used for the identification of poor prognostic factors such as DOI and PNI.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"328-333"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Difference Has No Effect on Survival in Pancreatic Cancer.","authors":"Faruk Tas, Kayhan Erturk","doi":"10.1007/s13193-025-02321-9","DOIUrl":"https://doi.org/10.1007/s13193-025-02321-9","url":null,"abstract":"<p><p>Due to controversial results, the clinical impact of sex in pancreatic cancer has not been fully clarified. We aimed to investigate the clinical significance of sex in patients with pancreatic cancer in this study. A total of 334 pancreatic cancer patients were assessed retrospectively. Of 334 patients, 109 (32.6%) were women. The distribution of sex according to stages was identical: 52 of 154 patients (33.8%) had metastatic disease, 39 of 122 patients (32.0%) had locally advanced disease, and 18 of 58 patients (31.0%) had local disease (<i>p</i> = 0.9). No significant effect of any clinical variable on sex was observed in all stages, but women had higher serum LDH levels than men in metastatic disease (57.1 vs 20.5%, <i>p</i> = 0.009). Overall survival rates of patients in all stages were similar between sexes; the median overall survival rates in women vs. men were 5.5 vs. 4.35 months, respectively, in patients with metastatic disease (<i>p</i> = 0.2); 9.9 vs. 8.9 months, respectively in patients with locally advanced disease (<i>p</i> = 0.6); and 20.05 vs 17.8 months, respectively, in patients with local disease (<i>p</i> = 0.09). In conclusion, no effect of sex on survival was found in pancreatic cancer patients.</p>","PeriodicalId":46707,"journal":{"name":"Indian Journal of Surgical Oncology","volume":"17 2","pages":"334-339"},"PeriodicalIF":0.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}