Analytical and Bioanalytical Chemistry最新文献

{"title":"Durable, recyclable, and stretchable plasmonic film for grapefruit decay detection.","authors":"Limei Liu, Tingfeng Dai, Taimin Sun, Binghao Wang","doi":"10.1007/s00216-025-06077-7","DOIUrl":"https://doi.org/10.1007/s00216-025-06077-7","url":null,"abstract":"<p><p>Flexible surface-enhanced Raman scattering (SERS) sensors show promise for non-destructive, on-site fruit quality monitoring; however, current SERS substrates frequently fail to meet the extended operational stability demands of cross-seasonal agricultural storage systems. This study presents a durable, recyclable, and stretchable plasmonic film (Au@AgNWs/PDMS) for decay detection in grapefruits. By partially embedding silver nanowires (AgNWs) in PDMS and functionalizing surfaces with gold nanoparticles via galvanic replacement, the composite film achieves high sensitivity (10⁻⁹ M rhodamine 6G), mechanical resilience (85% tensile strain tolerance), and long-term stability (49 days). The substrate retains stable SERS performance through 1000 stretching cycles and supports five regeneration cycles without degradation. Practical validation demonstrated its capacity for in situ fungal biomarker tracking on grapefruit surfaces, correlating quinone accumulation with decay progression. Combining conformal adhesion, environmental resistance, and reusability, this technology offers a scalable solution for enhancing food security during storage.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of polychlorinated alkanes in food by liquid chromatography-tandem mass spectrometry.","authors":"Ingus Perkons, Laura Lazdina, Dzintars Zacs","doi":"10.1007/s00216-025-06070-0","DOIUrl":"https://doi.org/10.1007/s00216-025-06070-0","url":null,"abstract":"<p><p>Polychlorinated alkanes (PCAs), the principal constituents of chlorinated-paraffin technical mixtures, are persistent, bioaccumulative pollutants that raise growing toxicological concern. Due to their complexity, PCA analysis in food remains analytically challenging, predominantly relying on high-resolution mass spectrometry applications. This study aimed to develop and validate a more accessible liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying PCA-C_10-17 in food commodities. Six reversed-phase columns were evaluated during the study, and phenyl-hexyl and biphenyl stationary phases provided superior separation of critical isobaric PCA homologues. Ammonium acetate (5 mM) was used as a mobile phase additive to promote the formation of acetate adducts, enhancing selectivity in MS/MS settings by minimizing the impact of deprotonated species on product-ion spectra. Validation experiments conducted using fortified samples demonstrated satisfactory recoveries (PCA-C_10-13, 88%; PCA-C_14-17, 121%; and PCA-C_10-17, 103%). Comparative analyses using six interlaboratory test materials and a certified fish matrix reference material confirmed the method's accuracy. All z-scores for PCA-C_10-13 were ≤|2|, and only 2 results for PCA-C_14-17 were in the questionable range (|z|= 2-3). In the certified reference material, measured values for PCA-C_10-13 were within the certified range, while those for PCA-C_14-17 were near its lower boundary. The developed method was compared to the conventional high-resolution mass spectrometry, showing a strong agreement between the results of both instrumental setups. These results establish this LC-MS/MS protocol as an accessible and reliable alternative to PCA monitoring within food safety and regulatory frameworks.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tin fractionation analysis in sediment samples via on-line ID ETV/ICP-MS.","authors":"Vera M Scharek, Jens Pfeifer, Jochen Vogl, Heike Traub, Björn Meermann","doi":"10.1007/s00216-025-06064-y","DOIUrl":"10.1007/s00216-025-06064-y","url":null,"abstract":"<p><p>We report a quantification approach for directly determining total tin and tin-based pollutants/species in sediments via electrothermal vaporization/inductively coupled plasma-mass spectrometry (ETV/ICP-MS) utilizing an on-line isotope dilution mass spectrometry (IDMS) approach. The method was developed and validated using an estuarine sediment reference material (BCR-277R), yielding a recovery of 106%. A relative standard deviation (RSD) of 14%, comparable to published data using a similar method, was obtained. A limit of quantification (LOQ) was estimated at 0.008 mg Sn kg^-1 and sufficient for quantifying the total tin mass fraction of surface sediments along the tidal River Elbe course. Hereby, a decrease towards the river mouth, presumably due to dilution effects by less polluted marine sediment, was observed. Besides total tin, monitoring of organotin compounds (OTCs)/species is of interest in sediments due to their toxic effects on aquatic life. The method's capability was extended by separating an OTC fraction in a sediment certified reference material (CRM) through the ETV temperature program. While spiking experiments with OTC standards confirmed the assignment, only a small fraction of the total certified OTC amount (3%), likely due to matrix effects, was recovered. However, applying the method to real-world samples, OTCs were detectable along the River Elbe course. By this, we demonstrated the potential of our method as a complementary fast-screening approach to species-specific analysis procedures.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Miniature mass spectrometer-based point-of-care assay for measuring three psychiatric drugs in human plasma and whole blood.","authors":"Shoufeng Jiao, Jinna Xiao, Zhengzheng Liao, Jinfang Hu, Zhentao Li","doi":"10.1007/s00216-025-06072-y","DOIUrl":"https://doi.org/10.1007/s00216-025-06072-y","url":null,"abstract":"<p><p>Developing a rapid, simple method to detect psychiatric drug concentrations is essential, as it facilitates long-term monitoring of treatment efficacy and is critical for managing drug poisoning in clinical settings due to abuse or accidental overdose. Conventional laboratory-based assays used for monitoring psychiatric medications often demonstrate prolonged processing times, leading to considerable delays in adjusting treatment regimens. To address this, this study introduced a point-of-care testing (POCT) approach using a miniature mass spectrometer, which allows for rapid and precise measurement of three psychiatric drugs including carbamazepine (CBZ), quetiapine (QTP), and olanzapine (OLZ) in human plasma and whole blood. Quantification is achieved through the use of paper capillary spray combined with miniature mass spectrometry, within the clinically relevant concentration range for three drugs. Only a minimal amount of bodily fluid (50 µl) is required, and the assay turnaround time is less than 2 min. Good linear relationships are established between mass spectrometry (MS)/MS responses and concentration, with correlation coefficients (R²) of no less than 0.99. The limits of detection (LODs) for CBZ, QTP, and OLZ were 0.05 µg/ml, 5 ng/ml, and 5 ng/ml, respectively. Satisfactory precision with relative standard deviations (RSDs) below 21.06% was obtained. Additionally, the developed method was successfully applied to determine the concentrations of psychiatric drugs in real clinical samples. The strengths of this work lie in its portability, speed, and timeliness of detection, which attributed to the characteristics of the miniature MS used, making it suitable for rapid on-site screening.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fingerprinting materials oxidation using laser-induced XUV spectroscopy (LIXS).","authors":"Davide Bleiner, Sharath Rameshbabu, Janosch Von Ballmoos","doi":"10.1007/s00216-025-06067-9","DOIUrl":"https://doi.org/10.1007/s00216-025-06067-9","url":null,"abstract":"<p><p>Laser-induced XUV spectroscopy (LIXS) is an emerging plasma-based microanalytical technique that offers access to the early, \"background-uncontaminated\" (pristine) stages of laser-induced plasma evolution. In this study, the capability of LIXS to resolve not only the elemental composition but also the oxidation state of complex materials is investigated, i.e., by exploiting radiative recombination dynamics. Using a spatial-filtered detection scheme, the evolution of plasma emission was tracked, revealing characteristic spectral features associated with electron recombination into unoccupied s or d atomic orbitals. The latter retain a distinct fingerprint of the parent material's oxidation state. Preliminary experiments on LiF, Al, and Ni served to calibrate the relationship between expansion kinetics, emission time delay, and atomic structure. Reference samples, including lithium manganese oxides with well-defined stoichiometries, were used to correlate LIXS spectral fingerprints to manganese oxidation levels. The results indicate that, contrary to the observations for the thermalized LIBS plasma, the LIXS laser plasma does not erase information on the material's stoichiometry. Instead, the recombination features in the XUV region directly reflect the electronic configuration of the parent material. This work introduces LIXS as a novel route for rapid, stoichiometry-sensitive mapping of oxidation states, with immediate applications in the quality control of energy materials and battery components. The approach lays the foundation for the development of oxidation-specific plasma spectroscopy, extending the analytical power of laser ablation far beyond elemental analysis.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of adulterated seized heroin samples and direct stereochemical analysis of methorphan by chiral HPLC–MS/MS","authors":"Tania Maria Grazia Salerno,&nbsp;Luca Zamengo,&nbsp;Carmelo Coppolino,&nbsp;Lorenzo Cucinotta,&nbsp;Paola Donato,&nbsp;Emanuela Trovato,&nbsp;Federica Vento,&nbsp;Flavio Zancanaro,&nbsp;Giampietro Frison,&nbsp;Luigi Mondello","doi":"10.1007/s00216-025-06063-z","DOIUrl":"10.1007/s00216-025-06063-z","url":null,"abstract":"<div><p>This research was focused on an in-depth investigation of 45 heroin samples seized in Northeast Italy, using complementary hyphenated analytical techniques. Gas chromatography coupled with mass spectrometry (GC–MS) and solid deposition Fourier transform infrared (FTIR) spectroscopy were employed to identify the seizure components. Common adulterants like caffeine and paracetamol were detected almost ubiquitously, along with other cutting agents from various chemical classes. Noticeably, some of them are known for their synergistic effects with heroin. Additionally, two unknown minor components were tentatively identified using combined GC–MS and GC–FTIR data. Notably, all samples contained methorphan, a chiral molecule with enantiomers having distinct effects and toxicological profiles. Thus, enantioselective liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) was implemented using a vancomycin-based column, obtaining an enantioselectivity (α) of approximately 1.2. Analyses were performed on a triple quadrupole mass spectrometer with atmospheric pressure chemical ionization in multiple reaction monitoring mode. The method was validated with calibration curves (0.0005–5 mg/L), limit of detection (0.0026 mg/L), limit of quantification (0.0088 mg/L), intra-day and inter-day precision (1.6–5.3%), and trueness (88.7–105.3%). Results showed that dextromethorphan was present in all samples (2.86–1,190 mg/L), while levomethorphan was detected at trace levels (0.21 and 0.038 mg/L) in two samples only, besides dextromethorphan.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":"417 23","pages":"5187 - 5198"},"PeriodicalIF":3.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A ratiometric AIE probe with sequential activation for selective dual detection and imaging of fluoride and hypochlorous acid.","authors":"Mingjie Wei, Ruiqing Long, Rong Liu, Linxin Zheng, Simiao Wang, Yu Jiang, Biao Gu, Li Niu","doi":"10.1007/s00216-025-06065-x","DOIUrl":"10.1007/s00216-025-06065-x","url":null,"abstract":"<p><p>The development of efficient dual-detection systems for fluoride ions (F^-) and hypochlorous acid (HClO) in biological environments represents a significant challenge in analytical chemistry, given their distinct chemical properties and crucial yet contrasting roles in physiological processes. Addressing this challenge, we have engineered a sequentially activated fluorescent probe (SA-S-TBM) that leverages aggregation-induced emission (AIE) characteristics to achieve unprecedented simultaneous detection of both analytes under physiological conditions. The design overcomes traditional limitations through a unique cascade activation mechanism: initial F^--induced desilylation generates a red-emitting SA-S intermediate, which subsequently undergoes HClO-specific oxidation to produce green-fluorescent SA-SO, creating two well-resolved emission peaks (Δλ = 98 nm) that effectively eliminate spectral interference-a critical advancement in dual-analyte detection technology. Remarkably, SA-S-TBM demonstrates exceptional analytical performance with ultrahigh sensitivity (detection limits of 20.3 nM for F^- and 1.72 μM for HClO) and outstanding selectivity against competing biological species. Moreover, with low toxicity and excellent cell permeability, SA-S-TBM successfully visualized intracellular F⁻ and HClO through distinct fluorescence signals, highlighting its strong potential for biological detection and as a tool to explore their roles in pathophysiological processes.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating rapid evaporative ionization mass spectrometry profiles of human breast cancer cells using a 3D in vitro assay","authors":"Rachel E. Rubino,&nbsp;Martin Kaufmann,&nbsp;Amoon Jamzad,&nbsp;Natasha Iaboni,&nbsp;Kevin Yi Mi Ren,&nbsp;Jian Yu,&nbsp;Haidy Metwally,&nbsp;Manuela Kunz,&nbsp;John F. Rudan,&nbsp;Parvin Mousavi,&nbsp;Gabor Fichtinger,&nbsp;Richard Oleschuk,&nbsp;Christopher J. B. Nicol","doi":"10.1007/s00216-025-06035-3","DOIUrl":"10.1007/s00216-025-06035-3","url":null,"abstract":"<div><p>Rapid evaporative ionization mass spectrometry (REIMS) enables near real-time sampling and classification of tissues on the basis of lipid and small molecule profiles. Because samples are ablated during REIMS, validation of mass spectra by assignment of class labels using gold-standard methods remains challenging. Further, determining the number of abnormal cells within a mixture of normal cells by REIMS remains an elusive but critical parameter when evaluating the utility of REIMS for use in clinical settings. To address this, we developed a three-dimensional assay based on fluorescently labelled human breast cell lines, MCF-10A (pseudo-normal) and MDA-MB-231 (malignant), embedded in matrigel cubes that enables calculation of cell numbers ablated by REIMS by measuring fluorescence before and after REIMS sampling. We observed a reasonably uniform distribution of cells throughout the matrigel matrix, which yielded REIMS spectra rich in complex glycerophospholipids resembling solid tissues and cell pellets. A non-linear relationship between signal intensity and the number of cells ablated was observed. We trained multivariate models using 10% increments of MDA-MB-231 cells mixed with MCF-10A, and blindly tested the models on separate cubes containing 1–100% MDA-MB-231s. Percent difference from target MDA-MB-231 cell composition was within 34% for cubes containing as little as 5% MDA-MB-231 cells. Overall, our study highlights how a simple 3D in vitro approach may help reveal the quantitative potential of mass spectral profiling methods such as REIMS to assist with validating REIMS spectra containing mixtures of different cell lines. This assay platform may help calibrate REIMS-based methods to recognize specific cell type mixtures encountered at surgical resection margins.\u0000</p></div>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":"417 22","pages":"5115 - 5130"},"PeriodicalIF":3.8,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RGB color correction and gamut limitations in smartphone-based kinetic analysis of chemical reactions.","authors":"Calum Fyfe, Shengkai Yu, Jing Zhang, Marc Reid","doi":"10.1007/s00216-025-06021-9","DOIUrl":"https://doi.org/10.1007/s00216-025-06021-9","url":null,"abstract":"<p><p>The variability in hardware specifications and environmental factors poses significant challenges to the use of smartphone cameras in analytical measurement. Towards time-resolved color analysis and reaction monitoring, we systematically quantified multiple sources of measurement uncertainty in smartphone-based color measurements, finding that while sensor repeatability is high ( <math><mrow><mi>Δ</mi> <mi>E</mi> <mo><</mo> <mn>0.5</mn></mrow> </math> ), lighting conditions and viewing angles can introduce substantial bias ( <math><mrow><mi>Δ</mi> <mi>E</mi></mrow> </math> versus reference colors increasing by up to 64% at oblique angles). We implemented and evaluated a matrix-based image color correction methodology using a color reference chart, reducing inter-device and lighting-dependent variations by 65-70% (quantified by the color change metric, <math><mrow><mi>Δ</mi> <mi>E</mi></mrow> </math> ). Moving beyond static image correction to video analysis, our approach was validated through the monitoring of Blue1 dye degradation kinetics using videos recorded on two different smartphones. Time-resolved and color-corrected measurements from both devices produced consistent kinetic profiles. Importantly, we identified a fundamental limitation in RGB-based colorimetry: highly saturated colors that exceed the sRGB color gamut create artificial discontinuities in kinetic profiles, manifesting as \"shouldering\" effects not present in spectrophotometric data. Unlike previous methods that focused on controlling environmental factors through custom enclosures, our time-resolved color correction methodology systematically quantifies and corrects for multiple sources of color bias across various smartphone models, enabling standardized measurements even in variable conditions. This advancement enhances the reliability of field-ready, smartphone-based colorimetric applications and establishes a framework for calibrating video-based reaction monitoring against established spectroscopic measurements.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled aggregation-induced emission supramolecular probe for sensitive temozolomide detection and intracellular imaging","authors":"Chenrui Jiang,&nbsp;Feifei Chen,&nbsp;Yue Chen,&nbsp;Yu Sun,&nbsp;Hua He,&nbsp;Pierre Dramou,&nbsp;Tao Xu,&nbsp;Hongbin Xu","doi":"10.1007/s00216-025-06045-1","DOIUrl":"10.1007/s00216-025-06045-1","url":null,"abstract":"<div><p>Temozolomide (TMZ) is a first-line chemotherapy drug for treating malignant glioblastoma but faces challenges due to its short plasma half-life and limited brain distribution. There is a need for a more efficient, cost-effective, and sensitive method for monitoring TMZ in clinical settings. This work presents a novel fluorescent probe based on the host–guest interaction of cucurbit[7]uril (CB[7]) and aggregation-induced emission molecule 1,1,2,2-tetra(biphenyl-4-yl)ethene (TTPE) for trace-level detection of TMZ in serum. The CB[7]@TTPE nanoprobe demonstrated high sensitivity, with a detection range of 1–20 μg/mL and a limit of detection of 0.25 μg/mL. Comprehensive characterization by ITC, FT-IR, NMR, UV–vis, and fluorescence spectroscopy confirmed the sensing behavior of the probe. The system exhibited excellent selectivity for TMZ and was successfully applied to serum samples with good recovery rates. In addition, the probe enabled fluorescence imaging of TMZ in human glioma cells (U87 and T98G), making it suitable for monitoring of drug distribution in cellular environments. The self-assembled CB[7]@TTPE probe provides a highly sensitive and selective method for TMZ detection in biological fluids. Its strong fluorescence and water solubility offer promising potential for both clinical diagnostics and drug resistance monitoring in cancer therapy.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":"417 23","pages":"5253 - 5262"},"PeriodicalIF":3.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}