PATHOLOGICA最新文献_第7页

A diagnosis you wouldn't expect in a supraclavicular mass. 锁骨上肿块的诊断结果出乎你的意料。

IF 4.4

PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-962

Simone Mauramati, Fabio Pedretti, Irene Herman, Giuseppe Trisolini, Alberto Luchena, Rebecca Gelli, Emanuele Robiolio, Marta Minuti, Maria Vittoria Veneroni, Giulia Bertino, Monica Feltri, Gioacchino D'Ambrosio, Marco Benazzo, Patrizia Morbini

引用次数: 0

Concurrent presence of primary hemangioma and breast cancer metastasis within a lymph node: a case report inspired by the legacy of Professor Juan Rosai. 淋巴结内同时存在原发性血管瘤和乳腺癌转移：受胡安-罗赛教授遗产启发的病例报告。

IF 4.4

PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-911

Mariia Ivanova, Marianna D'Ercole, Francesca Maria Porta, Benedetta Di Venosa, Chiara Frascarelli, Camillo Di Bella, Fabio Pagni, Elena Guerini-Rocco, Nicola Fusco

{"title":"Concurrent presence of primary hemangioma and breast cancer metastasis within a lymph node: a case report inspired by the legacy of Professor Juan Rosai.","authors":"Mariia Ivanova, Marianna D'Ercole, Francesca Maria Porta, Benedetta Di Venosa, Chiara Frascarelli, Camillo Di Bella, Fabio Pagni, Elena Guerini-Rocco, Nicola Fusco","doi":"10.32074/1591-951X-911","DOIUrl":"10.32074/1591-951X-911","url":null,"abstract":"Secondary neoplastic lesions in lymph nodes are predominantly metastases from solid tumors, whereas primary lymph node hemangiomas are exceptionally uncommon, with only 24 well-documented cases in the literature. Histologically, they are characterized by endothelial cells that may appear flattened or enlarged, with variable vascular density, and the presence of stromal elements. Notably, the concurrent presence of a primary hemangioma and a metastasis from breast cancer - the latter being the most prevalent secondary lesion in axillary lymph nodes - represents an unprecedented observation. The unique case presented herein underscores the exceptional rarity of primary lymph node hemangiomas and demonstrates for the first time their possible coexistence with breast cancer metastasis within the same axillary lymph node. In sharing and discussing this case study, we pay homage to Professor Juan Rosai, whose work in redefining rare and complex diagnoses continues to enlighten our understanding of lymph node vascular lesions.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"153-157"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis. 子宫内膜浆液性癌：临床病理和分子分析。

IF 4.4

PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-974

Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Alessia Piermattei, Maria Elisabetta Onori, Angelo Minucci, Luigi Pedone Anchora, Francesco Fanfani, Gian Franco Zannoni

{"title":"Endometrial serous carcinoma with a corded and hyalinized pattern: a clinicopathological and molecular analysis.","authors":"Antonio Travaglino, Angela Santoro, Damiano Arciuolo, Giulia Scaglione, Antonio Raffone, Alessia Piermattei, Maria Elisabetta Onori, Angelo Minucci, Luigi Pedone Anchora, Francesco Fanfani, Gian Franco Zannoni","doi":"10.32074/1591-951X-974","DOIUrl":"10.32074/1591-951X-974","url":null,"abstract":"A corded and hyalinized pattern has been described in endometrial endometrioid carcinoma. Herein, we describe a clinicopathological and molecular analysis of the first reported case of endometrial serous carcinoma with a corded and hyalinized pattern.A 64-year-old woman underwent hysterectomy and bilateral salpingo-oophorectomy due to a 5.5 cm endometrial lesion. Histologically, the tumor was composed of a minor (20%) serous carcinoma component and a predominant corded component embedded in a hyaline-to-myxoid matrix. This component showed diffuse and strong p53 and p16 expression, heterogeneous positivity for epithelial markers and WT1, focal positivity for estrogen and progesterone receptors, retained MMR, SMARCA4/BRG1, and SMARCB1/INI1 expression, and negativity for smooth muscle, germ cell, sex cord, neuroendocrine, endothelial, and melanocytic markers and GATA3. Next-generation sequencing showed a mutation of uncertain significance in APC and no mutations in MLH1, MSH2, MSH6, PMS2, MUTYH, POLE, POLD1, EPCAM, or CTNNB1. The patient had a recurrence on the vaginal stump after 15 months.In conclusion, endometrial serous carcinoma can show a corded and hyalinized pattern, which may represent a diagnostic challenge.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 3","pages":"176-179"},"PeriodicalIF":4.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11447659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SMARCB1/INI1-deficient undifferentiated tumour of the thorax: a case report and review of the literature. SMARCB1/INI1缺陷型胸部未分化肿瘤：病例报告和文献综述。

IF 4.4

PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-955

Moreno Zagni, Alessandro Marando, Mariachiara Negrelli, Calogero Lauricella, Valentina Motta, Giulia Paglino, Silvio Veronese, Emanuele Valtorta, Emanuela Bonoldi, Giuseppe Pelosi

引用次数: 0

Pink-on-pink: hepatocellular carcinoma metastatic to oncocytic carcinoma of the thyroid. 粉红色对粉红色：肝细胞癌转移到甲状腺肿瘤细胞癌。

IF 4.4

PATHOLOGICA Pub Date : 2024-06-01 DOI: 10.32074/1591-951X-922

Marcello Maestri, Ottavia Cicerone, Alessia Messina, Anna Gallotti, Salvatore Corallo, Simone Mauramati, Pietro Canzi, Giacomo Fiandrino, Marco Paulli, Alessandro Vanoli

引用次数: 0

Cardiovascular pathology in vasculitis. 脉管炎的心血管病变。

IF 3.5

PATHOLOGICA Pub Date : 2024-04-01 DOI: 10.32074/1591-951X-993

Monica De Gaspari, Andrea Ascione, Chiara Baldovini, Andrea Marzullo, Angela Pucci, Stefania Rizzo, Cecilia Salzillo, Annalisa Angelini, Cristina Basso, Giulia d'Amati, Cira Rosaria Tiziana di Gioia, Allard C van der Wal, Carla Giordano

引用次数: 0

Giulio Rossi MD, PhD. In Memoriam. 朱利奥-罗西（Giulio Rossi）医学博士。悼念

IF 3.5

PATHOLOGICA Pub Date : 2024-04-01

Thomas Colby, Kevin Leslie, Mattia Barbareschi, Alberto Cavazza, Paolo Graziano

引用次数: 0

Systemic vasculitis involving the kidney: the nephropathologist's point of view. 涉及肾脏的全身性血管炎：肾病病理学家的观点。

IF 3.5

PATHOLOGICA Pub Date : 2024-04-01 DOI: 10.32074/1591-951X-990

Vincenzo L'Imperio, Stefano Ceola, Bruna Cerbelli, Antonella Barreca, Fabio Pagni

{"title":"Systemic vasculitis involving the kidney: the nephropathologist's point of view.","authors":"Vincenzo L'Imperio, Stefano Ceola, Bruna Cerbelli, Antonella Barreca, Fabio Pagni","doi":"10.32074/1591-951X-990","DOIUrl":"10.32074/1591-951X-990","url":null,"abstract":"Kidneys are often targets of systemic vasculitis (SVs), being affected in many different forms and representing a possible sentinel of an underlying multi-organ condition. Renal biopsy still remains the gold standard for the identification, characterization and classification of these diseases, solving complex differential diagnosis thanks to the combined application of light microscopy (LM), immunofluorescence (IF) and electron microscopy (EM). Due to the progressively increasing complexity of renal vasculitis classification systems (e.g. pauci-immune vs immune complex related forms), a clinico-pathological approach is mandatory and adequate technical and interpretative expertise in nephropathology is required to ensure the best standard of care for our patients. In this complex background, the present review aims at summarising the current knowledge and challenges in the world of renal vasculitis, unveiling the potential role of the introduction of digital pathology in this setting, from the creation of hub-spoke networks to the future application of artificial intelligence (AI) tools to aid in the diagnostic and scoring/classification process.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 2","pages":"104-118"},"PeriodicalIF":3.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous vasculitis: insights into pathogenesis and histopathological features. 皮肤血管炎：对发病机制和组织病理学特征的认识。

IF 3.5

PATHOLOGICA Pub Date : 2024-04-01 DOI: 10.32074/1591-951X-985

Angelo Cassisa, Luca Cima

{"title":"Cutaneous vasculitis: insights into pathogenesis and histopathological features.","authors":"Angelo Cassisa, Luca Cima","doi":"10.32074/1591-951X-985","DOIUrl":"10.32074/1591-951X-985","url":null,"abstract":"The mechanisms underlying the onset and progression of vasculitis remain poorly understood. This condition is characterized by damage to the vascular wall, recruitment of inflammatory cells, and subsequent structural remodeling, which are hallmarks of vasculitis. The histopathological classification of vasculitis relies on the size of the affected vessel and the predominant type of inflammatory cell involved - neutrophils in acute cases, lymphocytes in chronic conditions, and histiocytes in granulomatous forms. Pathological changes progress in every context, and a single vasculitic pattern can be associated with various systemic conditions. Conversely, a single causative agent may lead to multiple distinct clinical and pathological manifestations of vasculitis. Moreover, many cases of vasculitis have no identifiable cause. A foundational understanding of the normal structure of the cutaneous vascular network is crucial. Similarly, identifying the cellular and molecular participants and their roles in forming the \"dermal microvascular unit\" is propedeutical.This review aims to elucidate the complex mechanisms involved in the initiation and progression of vasculitis, offering a comprehensive overview of its histopathological classification, underlying causes, and the significant role of the cutaneous vascular network and cellular dynamics. By integrating the latest insights from studies on NETosis and the implications of lymphocytic infiltration in autoimmune diseases, we seek to bridge gaps in current knowledge and highlight areas for future research. Our discussion extends to the clinical implications of vasculitis, emphasizing the importance of identifying etiological agents and understanding the diverse histopathological manifestations to improve diagnostic accuracy and treatment outcomes.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 2","pages":"119-133"},"PeriodicalIF":3.5,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary pathology in vasculitis. 脉管炎的肺部病理。

IF 3.5

PATHOLOGICA Pub Date : 2024-04-01 DOI: 10.32074/1591-951X-988

Elisa Ambrogi, Alberto Cavazza, Maxwell L Smith, Paolo Graziano

引用次数: 0