The 2023 WHO updates on skin tumors: advances since the 2018 edition.

IF 4.4 Q1 PATHOLOGY
Francesco Fortarezza, Gerardo Cazzato, Giuseppe Ingravallo, Angelo Paolo Dei Tos
{"title":"The 2023 WHO updates on skin tumors: advances since the 2018 edition.","authors":"Francesco Fortarezza, Gerardo Cazzato, Giuseppe Ingravallo, Angelo Paolo Dei Tos","doi":"10.32074/1591-951X-1006","DOIUrl":null,"url":null,"abstract":"<p><p>Pathology is pivotal in diagnosing skin tumors, and the precision of diagnosis is crucial to devise customized treatment plans and enhance patient care in dermatology. The latest edition of the World Health Organization's classification of skin tumors serves as a comprehensive compendium, summarizing and categorizing all recent advancements in both anatomical-pathological and molecular aspects of cutaneous neoplasms. Several relevant advances have been introduced and new entities have been described. While the fundamental structure of the classification remains unchanged, notable additions include three new sections aimed at providing a more exhaustive description of skin lesions: nail unit tumors, skin metastases, and genetic tumor syndromes associated with skin malignancies. Recent strides in molecular pathology have led to significant breakthroughs in decoding the underlying mechanisms of various skin tumors, ranging from adnexal neoplasms to hematolymphoid neoplasms, soft tissue tumors, and melanocytic lesions. Of particular importance is the evolution in our understanding of melanocytic neoplasms, with the introduction of the term \"melanocytoma\" reserved for lesions exhibiting \"intermediate\" biological behavior and characterized by specific molecular mutations. The pathologic diagnosis process integrates morphological, immunohistochemical, and molecular features, playing a crucial role in clinical decision-making. The WHO classification serves as a valuable tool in promoting multidisciplinarity in the management of cutaneous neoplasms with the aim of translating novel pathological discoveries into more effective treatments. This review aims to distill the major updates introduced by the new classification, providing a synthesis of the latest scientific insights.</p>","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"116 4","pages":"193-206"},"PeriodicalIF":4.4000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460152/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"PATHOLOGICA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32074/1591-951X-1006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PATHOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Pathology is pivotal in diagnosing skin tumors, and the precision of diagnosis is crucial to devise customized treatment plans and enhance patient care in dermatology. The latest edition of the World Health Organization's classification of skin tumors serves as a comprehensive compendium, summarizing and categorizing all recent advancements in both anatomical-pathological and molecular aspects of cutaneous neoplasms. Several relevant advances have been introduced and new entities have been described. While the fundamental structure of the classification remains unchanged, notable additions include three new sections aimed at providing a more exhaustive description of skin lesions: nail unit tumors, skin metastases, and genetic tumor syndromes associated with skin malignancies. Recent strides in molecular pathology have led to significant breakthroughs in decoding the underlying mechanisms of various skin tumors, ranging from adnexal neoplasms to hematolymphoid neoplasms, soft tissue tumors, and melanocytic lesions. Of particular importance is the evolution in our understanding of melanocytic neoplasms, with the introduction of the term "melanocytoma" reserved for lesions exhibiting "intermediate" biological behavior and characterized by specific molecular mutations. The pathologic diagnosis process integrates morphological, immunohistochemical, and molecular features, playing a crucial role in clinical decision-making. The WHO classification serves as a valuable tool in promoting multidisciplinarity in the management of cutaneous neoplasms with the aim of translating novel pathological discoveries into more effective treatments. This review aims to distill the major updates introduced by the new classification, providing a synthesis of the latest scientific insights.

2023年世卫组织皮肤肿瘤更新:2018年版以来的进展。
病理学是诊断皮肤肿瘤的关键,而诊断的精确性对于制定个性化治疗方案和加强皮肤科患者护理至关重要。最新版的世界卫生组织皮肤肿瘤分类法是一部全面的汇编,总结了皮肤肿瘤在解剖病理和分子方面的所有最新进展并进行了分类。其中引入了一些相关进展,并描述了新的实体。虽然分类的基本结构保持不变,但新增了三个显著部分,旨在更详尽地描述皮肤病变:甲单位肿瘤、皮肤转移和与皮肤恶性肿瘤相关的遗传肿瘤综合征。分子病理学的最新进展使我们在解码各种皮肤肿瘤(从附件肿瘤到血淋巴肿瘤、软组织肿瘤和黑素细胞病变)的内在机制方面取得了重大突破。尤其重要的是,我们对黑色素细胞肿瘤的认识也在不断发展,"黑色素细胞瘤 "这一术语是专门针对表现出 "中间 "生物学行为并以特定分子突变为特征的病变而使用的。病理诊断过程综合了形态学、免疫组化和分子特征,在临床决策中起着至关重要的作用。世卫组织分类是促进皮肤肿瘤多学科管理的重要工具,其目的是将新的病理发现转化为更有效的治疗方法。本综述旨在提炼新分类所引入的主要更新内容,提供最新科学见解的综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信