PATHOLOGICA最新文献_第6页

Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies. 传统和数字工作流程之间的诊断一致性。1427例前列腺活检的研究。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-896

Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi

{"title":"Diagnostic concordance between traditional and digital workflows. A study on 1427 prostate biopsies.","authors":"Evelin Torresani, Maria Adalgisa Gentilini, Stefano Grassi, Luca Cima, Irene Pedrolli, Tommaso Cai, Marco Puglisi, Valentino Vattovani, Bianca Guadin, Matteo Brunelli, Claudio Doglioni, Mattia Barbareschi","doi":"10.32074/1591-951X-896","DOIUrl":"10.32074/1591-951X-896","url":null,"abstract":"Objective: To evaluate intra-observer diagnostic reproducibility using traditional slides (TS) versus whole slide images (WSI).Methods: TS and WSI of 1427 prostatic biopsies (107 consecutive patients) were evaluated by a single pathologist. Agreement between readings was evaluated with Gwet's Agreement coefficient (AC) and Landis and Koch benchmark scale.Results: The positive/negative agreement between the readings was almost perfect (AC1= 0.962; 95% CI[0.949,0.974]), with method independent distribution of discrepancies. Among positive biopsies, 212 had identical Gleason score (GS) on TS and WSI and discordant GS in 69 cases (AC2 = 0.932; 95% CI[0.907, 0.956]). Concordant negative and positive patient classification was observed in 39 and 64 cases, respectively; two cases were assigned to the positive group on TS and 2 on WSI configuring an almost perfect agreement (AC1=0.929; 95% C1[0.860, 0.998]). ISUP Grade group (ISUP GG) agreement was evaluated in the 60 concordantly positive cases: in 45 cases it was identical on TS and WSI; in 10 biopsies the discrepancy implied a modification of the assigned ISUP GG of ≤ 1 class and in 5 the discrepancy implied a modification of 2 classes. Gwet's agreement coefficient was (95% CI [0.834, 0.962]), i.e.: almost perfect agreement.Conclusions: Our data show almost perfect agreement between digital and traditional diagnostic activity in a routine setting, confirming that digital pathology can be safely introduced into routine workflows.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"221-226"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histology for nephrology, from pre-implantation to post-transplant kidney biopsy. Lesson learned from ReBIrth (Renal BIopsy for Kidney Transplantation Therapy). 肾学组织学，从植入前到移植后肾活检。重生(肾移植治疗的肾活检)的经验教训。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 Epub Date: 2023-06-13 DOI: 10.32074/1591-951X-858

Anna Caliò, Antonella Barreca, Stefano Marletta, Maria Italia Sara Achenza, Marianna Alessi, Roberta Angelico, Luca Apicella, Davide Argiolas, Nicola Bossini, Rosa Carrano, Concetta Carriero, Giuseppe Castellano, Giorgia Comai, Caterina Di Bella, Francesco D'Ignoto, Agnese Gallico, Fiorella Gastaldon, Guido Merlotti, Vera Paloschi, Alessandra Panarese, Angelica Parodi, Francesco Perna, Daniela Picciotto, Anna Regalia, Michele Rossini, Enrico Russo, Maria Paola Salerno, Luca Toti, Patrizia Tulissi, Gisella Vischini, Gianluigi Zaza, Albino Eccher

{"title":"Histology for nephrology, from pre-implantation to post-transplant kidney biopsy. Lesson learned from ReBIrth (Renal BIopsy for Kidney Transplantation Therapy).","authors":"Anna Caliò, Antonella Barreca, Stefano Marletta, Maria Italia Sara Achenza, Marianna Alessi, Roberta Angelico, Luca Apicella, Davide Argiolas, Nicola Bossini, Rosa Carrano, Concetta Carriero, Giuseppe Castellano, Giorgia Comai, Caterina Di Bella, Francesco D'Ignoto, Agnese Gallico, Fiorella Gastaldon, Guido Merlotti, Vera Paloschi, Alessandra Panarese, Angelica Parodi, Francesco Perna, Daniela Picciotto, Anna Regalia, Michele Rossini, Enrico Russo, Maria Paola Salerno, Luca Toti, Patrizia Tulissi, Gisella Vischini, Gianluigi Zaza, Albino Eccher","doi":"10.32074/1591-951X-858","DOIUrl":"10.32074/1591-951X-858","url":null,"abstract":"A meeting entitled Renal BIopsy for Kidney Transplantation Therapy (ReBIrth) took place on May 31st, 2022 in Bologna, Italy. The meeting drew together nephrologists, surgeons, and pathologists and recognized as experts in the field of kidney transplantation in Italy. In this paper, we present our experience working with kidney transplants in the current era of immunosuppression therapy. The primary aim is to report the histopathological characteristics of failed kidney allografts after a consensus of experts reviewed the cases on a wholeslide imaging digital platform. Regardless of the cases discussed, digital pathology was reliable in identifying all the morphological and immunohistochemical features required to improve the correct use of immunosuppressive therapy to prevent graft failure and optimize patient management.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"199-204"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovarian schistosomiasis: challenges of a neglected ectopic involvement of blood flukes. Case report and review of literature. 卵巢血吸虫病:被忽视的异位参与血吸虫的挑战。病例报告及文献复习。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-891

Edrick Elias, Valeria Silvestri, Vivian Mushi, Martina Mandarano

{"title":"Ovarian schistosomiasis: challenges of a neglected ectopic involvement of blood flukes. Case report and review of literature.","authors":"Edrick Elias, Valeria Silvestri, Vivian Mushi, Martina Mandarano","doi":"10.32074/1591-951X-891","DOIUrl":"10.32074/1591-951X-891","url":null,"abstract":"Summary Introduction Female genital schistosomiasis (FGS), infection of Schistosoma spp. trematode in the gynaecological apparatus, is the most neglected sexual and reproductive health condition in sub-Saharan Africa with an estimated of 20-120 million cases. The ectopic entrapment of Schistosome eggs after oviposition can occur in 0.5% of cases in fallopian tubes and ovaries. The case We report a case of 38-years-old woman assessed for a 10 year history of infertility. On ultrasound, multiple cystic formations were observed in the ovary. Histology after oophorectomy to exclude malignancy showed granulomatous formations surrounding Schistosoma spp. eggs in proximity of corpus luteus and haemorragicum. Discussion Ectopic Schistosome oviposition, seen in the ovary and fallopian tubes as in our case, can be a potential cause of reproductive organ damage and complications such as infertility, ectopic pregnancy, miscarriage, premature birth, low birth weight, and even maternal death. Conclusions More studies are needed on ovarian FGS and its impact on women fertility to guide specific interventions targeting vulnerable population of childbearing age, contributing to the NTD WHO 2030 aim of eliminating schistosomiasis as a matter of public health.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 4","pages":"237-245"},"PeriodicalIF":3.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10688251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10277369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's reply to the Letter to the Editor from Mungunpuntipantip and Wiwanitkit. 作者对Mungunputiantip和Wiwanitkit给编辑的信的回复。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-917

Ilaria Girolami

引用次数: 0

Livedoid skin reaction and mRNA Covid-19 vaccine: correspondence. 活皮肤反应与mRNA新冠肺炎疫苗：对应关系。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-806

Rujittika Mungunpuntipantip, Viroj Wiwanitkit

引用次数: 0

Antepartum unscarred uterine rupture caused by placenta percreta: a case report and literature review. 先天性胎盘致产前无瘢痕子宫破裂1例并文献复习。

IF 3.5

PATHOLOGICA Pub Date : 2023-08-01 DOI: 10.32074/1591-951X-882

Eleonora Nardi, Viola Seravalli, Isabella Abati, Francesca Castiglione, Mariarosaria Di Tommaso

引用次数: 0

The ideal reporting of RAS testing in colorectal adenocarcinoma: a pathologists' perspective. 结直肠腺癌RAS检测的理想报告:病理学家的观点。

IF 3.5

PATHOLOGICA Pub Date : 2023-06-14 DOI: 10.32074/1591-951X-895

Umberto Malapelle, Valentina Angerilli, Francesco Pepe, Gabriella Fontanini, Sara Lonardi, Mario Scartozzi, Lorenzo Memeo, Gianfranco Pruneri, Antonio Marchetti, Giuseppe Perrone, Matteo Fassan

{"title":"The ideal reporting of RAS testing in colorectal adenocarcinoma: a pathologists' perspective.","authors":"Umberto Malapelle, Valentina Angerilli, Francesco Pepe, Gabriella Fontanini, Sara Lonardi, Mario Scartozzi, Lorenzo Memeo, Gianfranco Pruneri, Antonio Marchetti, Giuseppe Perrone, Matteo Fassan","doi":"10.32074/1591-951X-895","DOIUrl":"https://doi.org/10.32074/1591-951X-895","url":null,"abstract":"RAS gene mutational status represents an imperative predictive biomarker to be tested in the clinical management of metastatic colorectal adenocarcinoma. Even if it is one of the most studied biomarkers in the era of precision medicine, several pre-analytical and analytical factors may still impasse an adequate reporting of RAS status in clinical practice, with significant therapeutic consequences. Thus, pathologists should be aware on the main topics related to this molecular evaluation: (i) adopt diagnostic limit of detections adequate to avoid the interference of sub-clonal cancer cell populations; (ii) choose the most adequate diagnostic strategy according to the available sample and its qualification for molecular testing; (iii) provide all the information regarding the mutation detected, since many RAS mutation-specific targeted therapeutic approaches are in development and will enter into routine clinical practice. In this review, we give a comprehensive description of the current scenario about RAS gene mutational testing in the clinic focusing on the pathologist's role in patient selection for targeted therapies.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2023-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/60/pathol-2023-03-137.PMC10462993.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10107819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The slow-paced digital evolution of pathology: lights and shadows from a multifaceted board. 慢节奏的数字化病理学进化:多面板上的光和影。

IF 3.5

PATHOLOGICA Pub Date : 2023-06-01 DOI: 10.32074/1591-951X-868

Alessandro Caputo, Vincenzo L'Imperio, Francesco Merolla, Ilaria Girolami, Eleonora Leoni, Vincenzo Della Mea, Fabio Pagni, Filippo Fraggetta

{"title":"The slow-paced digital evolution of pathology: lights and shadows from a multifaceted board.","authors":"Alessandro Caputo, Vincenzo L'Imperio, Francesco Merolla, Ilaria Girolami, Eleonora Leoni, Vincenzo Della Mea, Fabio Pagni, Filippo Fraggetta","doi":"10.32074/1591-951X-868","DOIUrl":"https://doi.org/10.32074/1591-951X-868","url":null,"abstract":"Objective: The digital revolution in pathology represents an invaluable resource fto optimise costs, reduce the risk of error and improve patient care, even though it is still adopted in a minority of laboratories. Barriers include concerns about initial costs, lack of confidence in using whole slide images for primary diagnosis, and lack of guidance on transition. To address these challenges and develop a programme to facilitate the introduction of digital pathology (DP) in Italian pathology departments, a panel discussion was set up to identify the key points to be considered.Methods: On 21 July 2022, an initial conference call was held on Zoom to identify the main issues to be discussed during the face-to-face meeting. The final summit was divided into four different sessions: (I) the definition of DP, (II) practical applications of DP, (III) the use of AI in DP, (IV) DP and education.Results: Essential requirements for the implementation of DP are a fully tracked and automated workflow, selection of the appropriate scanner based on the specific needs of each department, and a strong commitment combined with coordinated teamwork (pathologists, technicians, biologists, IT service and industries). This could reduce human error, leading to the application of AI tools for diagnosis, prognosis and prediction. Open challenges are the lack of specific regulations for virtual slide storage and the optimal storage solution for large volumes of slides.Conclusion: Teamwork is key to DP transition, including close collaboration with industry. This will ease the transition and help bridge the gap that currently exists between many labs and full digitisation. The ultimate goal is to improve patient care.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 3","pages":"127-136"},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/f1/pathol-2023-03-127.PMC10462988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10489971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical implications of Cytokeratin 19 expression in patients with oral squamous cell carcinoma. 口腔鳞状细胞癌细胞角蛋白19表达的临床意义。

IF 3.5

PATHOLOGICA Pub Date : 2023-06-01 DOI: 10.32074/1591-951X-842

Nur Rahadiani, Sarwanti Sarwanti, Diah Rini Handjari, Marini Stephanie, Ening Krisnuhoni

{"title":"Clinical implications of Cytokeratin 19 expression in patients with oral squamous cell carcinoma.","authors":"Nur Rahadiani, Sarwanti Sarwanti, Diah Rini Handjari, Marini Stephanie, Ening Krisnuhoni","doi":"10.32074/1591-951X-842","DOIUrl":"https://doi.org/10.32074/1591-951X-842","url":null,"abstract":"Objective: This study was done to quantify the prevalence of high cytokeratin (CK) 19 expression in Indonesian oral squamous cell carcinoma (OSCC) patients and explore the prognostic role of CK19 in OSCC.Methods: Clinical data and samples from 61 patients diagnosed with OSCC at a tertiary national referral hospital in Jakarta, Indonesia were analyzed in this retrospective cohort study. Immunohistochemical staining of CK19 was performed on all patients and its expression was scored using the H system. All patients were followed up for a minimum of 36 months after diagnosis. Comparative and survival analyses were performed.Results: Twenty six point two percent of Indonesian OSCC patients had high CK19 expression. There were no differences in clinicopathological characteristics between patients with low and high CK19 expression. The 3-year overall survival (OS) of our cohort was 11.5%. Patients with high CK19 expression had lower 3-year OS compared to patients with low CK19 expression, even if the difference in OS was not statistically significant. Keratinization was an independent prognostic factor for survival in multivariate regression analysis.Conclusions: Data obtained here indicate a possible prognostic role of CK19 in OSCC. This prognostic role should be confirmed in larger series.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 3","pages":"155-163"},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/7a/pathol-2023-03-155.PMC10462989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10489974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoural metastasis of primary lung adenocarcinoma to non-invasive follicular thyroid neoplasm with papillary-like nuclear features. 原发性肺腺癌向具有乳头状核特征的非侵袭性滤泡甲状腺肿瘤的瘤内转移。

IF 3.5

PATHOLOGICA Pub Date : 2023-06-01 DOI: 10.32074/1591-951X-780

Subhash Yadav, Suman Kumar Ankathi, Asawari Patil, Rajiv Kaushal

{"title":"Intratumoural metastasis of primary lung adenocarcinoma to non-invasive follicular thyroid neoplasm with papillary-like nuclear features.","authors":"Subhash Yadav, Suman Kumar Ankathi, Asawari Patil, Rajiv Kaushal","doi":"10.32074/1591-951X-780","DOIUrl":"https://doi.org/10.32074/1591-951X-780","url":null,"abstract":"Metastasis to the thyroid gland is very uncommon with an incidence of 2-3% of all thyroid malignancies. A higher incidence is noted in autopsy studies indicating incidental detection. However, tumour-to-tumour metastasis is extremely uncommon with a handful of cases published in the literature to date. Also, non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P) is a rare neoplasm; diagnosis requires meticulous sampling of the entire capsule and fulfilment of other diagnostic criteria. We report a case of primary adenocarcinoma of lung in a 57-year-old female who additionally had a left thyroid nodule which appeared suspicious on ultrasonography. Histology of lung tumour was conventional papillary adenocarcinoma while aspiration cytology from the thyroid raised suspicion of metastatic adenocarcinoma. On hemithyroidectomy, the thyroid nodule showed metastatic adenocarcinoma in the centre of the nodule, while the peripheral portion showed non-invasive follicular thyroid neoplasm with papillary-like nuclear features; the diagnosis of which was confirmed with complete sampling of the thyroid capsule. The immunoprofile also supported the above dual histology. This is an extremely uncommon occurrence and metastasis within a NIFT-P has not been reported to the best of our knowledge.","PeriodicalId":45893,"journal":{"name":"PATHOLOGICA","volume":"115 3","pages":"186-191"},"PeriodicalIF":3.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/4a/pathol-2023-03-186.PMC10462986.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10116091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0