Indian Journal of Nuclear Medicine最新文献

{"title":"Tiger-man Appearance in a Case of DLBCL.","authors":"A R Vishnu, Nishikant Avinash Damle, Sameer Bakhshi, Deepam Pushpam","doi":"10.4103/ijnm.ijnm_129_24","DOIUrl":"10.4103/ijnm.ijnm_129_24","url":null,"abstract":"<p><p>Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (PC-EBV-DLBCL) is a rare and aggressive neoplasm with a poorer prognosis than other cutaneous lymphoma. Here, we present the ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) scan findings of a 39-year-old male with erythematous ulcerative nodules, which showed a gamut of cutaneous lesions consistent with EBV-associated PC-DLBCL. We highlight the utility of ¹⁸F-FDG PET/CT in evaluating the extent of disease, involvement of extranodal sites, and response to treatment in PC-EBV-DLBCL.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"40-41"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Encephalitis Pattern on PET-MRI in a Patient with Amyotrophic Lateral Sclerosis.","authors":"Sandesh Voosala, M Sandhya, P S Mathuranath, Rohan R Mahale","doi":"10.4103/ijnm.ijnm_9_24","DOIUrl":"10.4103/ijnm.ijnm_9_24","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a progressive primary motor neuron disorder whose etiology is a subject of debate even today. Interplay between multiple genetic and environmental factors and co-existent/antecedent infection, inflammation, and malignancy have all been hypothesized as potentially causative for this disease. Owing to its hybrid diagnostic capability, fluorodeoxyglucose positron emission tomography-magnetic resonance imaging is highly valuable in detecting varied autoimmune encephalitis patterns, one of which we report in a patient with ALS providing insight into autoimmunity as a potential etiology in the pathogenesis of this disease.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"22-25"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of 6-Fluoro-18F-l-3,4-DOPA MR-PET in Clinical Workup in Movement Disorders Cases: An Exploratory Study in a Tertiary Care Neuropsychiatric Setup.","authors":"Keerti Sitani, Sandhya Mangalore, Manoj Kumar Verma, Pardeep Kumar, Pawan Bairwa Btech, Venkatesh Murthy Konappa Agrahara Shama","doi":"10.4103/ijnm.ijnm_151_23","DOIUrl":"10.4103/ijnm.ijnm_151_23","url":null,"abstract":"<p><strong>Introduction: </strong>6-Fluoro-18F-l-3,4-dihydroxyphenylalanine (18F-DOPA) is primarily used to differentiate nondopamine deficient symptomatic subjects from Parkinsonian disorders and various etiologies from one another, which otherwise can be challenging. The current study aimed to determine (18F)-DOPA positron emission tomography (PET) patterns in Idiopathic Parkinson's disease (IPD), nondopamine deficient symptomatic (NDDS) and other movement disorders.</p><p><strong>Materials and methods: </strong>Sixty patients referred from neuropsychiatric outpatient department were retrospectively analyzed who underwent (18F)-DOPA magnetic resonance (MR)-PET scans. Out of 60 subjects, 36 were diagnosed with IPD, 5 were cases of other movement disorders, and 19 were normal on PET imaging (NDDS). To evaluate and quantify the tracer uptake from the PET scans, a region of interest (ROI) was drawn on the least radiotracer uptake region, and subsequently, on bilateral occipital cortex, caudate (head, body, tail), putamen (anterior, posterior), periaqueductal gray matter and red nucleus using structural MR images (MRI) for better delineation of anatomical regions. Tracer uptake ratios from each selected region were generated as SUV_max of ROI/occipital. The statistical analysis was performed using SPSS 29.0 version.</p><p><strong>Results: </strong>The posterior putamen showed a significant difference between IPD and other patients with an SUV cutoff of 1.69 and 100% specificity and 99.2% accuracy for normal controls. Whereas, we observed an SUV cutoff of 1.75 and an accuracy and specificity of 100% in patients with other movement disorders. The absolute values from the caudate nucleus were demonstrating a statistical significance between other movement disorders compared to normal controls with a cutoff of 1.69 and an accuracy of 81.2%. The ratio of posterior putamen/occipital ratio was significant between IPD and normal controls, with a cutoff of 3.89 and an accuracy of 95.6%. Right caudate to occipital ratio (RCOR) was significant for differentiating between other movement disorders and normal controls with a cutoff of 3.01 and an accuracy of 95.6%. One novel finding was that occipital lobe uptake was significantly reduced in patients with IPD compared to other movement disorders.</p><p><strong>Conclusion: </strong>The findings from the current study demonstrated that hybrid imaging using 18F-DOPA PET/MRI could efficiently differentiate between various causes of Parkinson's disease with diagnostic accuracy and necessary cut-offs.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"10-15"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pitfall We Should Be Aware of on Bone Scintigraphy.","authors":"Majdouline Bel Lakhdar, Ouafae Boumaaza, Ayat Mouaden, Imad Ghfir, Hasnae Guerrouj","doi":"10.4103/ijnm.ijnm_73_24","DOIUrl":"10.4103/ijnm.ijnm_73_24","url":null,"abstract":"<p><p>Nuclear medicine imaging frequently encounters injection artifacts. Although inadvertent intra-arterial injection is infrequent, it may pose diagnostic difficulties in pathological contexts. We present a case study of a woman with breast cancer and increased bone uptake in her right forearm and hand on bone scintigraphy. The pitfall was corrected by her clinical background and three-phase bone scintigraphy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"26-27"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case.","authors":"Ghasemali Divband, Raheleh Hedayati, Hamidreza Amini, Leila Hassanzadeh","doi":"10.4103/ijnm.ijnm_79_24","DOIUrl":"10.4103/ijnm.ijnm_79_24","url":null,"abstract":"<p><p>A 55-year-old male with advanced malignant melanoma received surgery, radiotherapy, and chemotherapy. Despite these treatments, [18F]FDG PET/CT showed significant disease progression. Targeted imaging with gallium-68 radiotracers for CXCR4, SSTR₂, and FAP identified biomarkers for personalized therapy. This led to the choice of [177Lu]Lu-FAPI-2286. After the first cycle, the patient reported pain relief, but subsequent imaging revealed rapid brain metastasis. This case highlights the importance of personalized medicine and molecular imaging in treating advanced melanoma.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"28-31"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Invasive Lobular Carcinoma of the Breast Presenting with Gastric and Uterine Metastases Demonstrated on F-18 FDG PET CT.","authors":"Pramukh Kulkarni, Gayana Shankaramurthy, Vivek Belathur, B S Ravindra","doi":"10.4103/ijnm.ijnm_105_24","DOIUrl":"10.4103/ijnm.ijnm_105_24","url":null,"abstract":"<p><p>Invasive lobular carcinoma (ILC) of the breast is distinct among breast cancer subtypes due to its unique metastatic patterns, including the involvement of the liver, genital tract, and gastrointestinal tract. As ILC often exhibits low-grade fluorodeoxyglucose (FDG) avidity, the role of fluorine-18 FDG (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in evaluating this subtype remains under re-explored. This case report highlights a rare presentation of ILC of the right breast with concurrent gastric and uterine metastases detected on F-18 FDG PET/CT, emphasizing its diagnostic utility.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"36-39"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary Renal Metastasis in Esophageal Squamous Cell Cancer Detected on F-18 FDG PET/CT - A Rare Presentation.","authors":"Tanvi Sarwal, Althaf K Majeed, B Selvakumar, Vaibhav Kumar Varshney, Meenakshi Rao, Rajesh Kumar","doi":"10.4103/ijnm.ijnm_96_24","DOIUrl":"10.4103/ijnm.ijnm_96_24","url":null,"abstract":"<p><p>Positron emission tomography with computed tomography using fluorine-18 fluoro-D-glucose positron emission tomography-computed tomography (F-18 FDG PET/CT) is routinely used for baseline staging and response assessment for esophageal squamous cell cancer (E-SCC). Metastases in E-SCC are usually seen in regional lymph nodes and lungs with solitary metastases to the kidney being extremely rare. We present a case of solitary unilateral renal metastasis detected on baseline F-18 FDG PET/CT in an otherwise operable E-SCC.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"47-48"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Perspective on Production and Quality Control of Iodine-123 Radiopharmaceutical for Applications in Nuclear Medicine.","authors":"Rimmo Loyi Lego","doi":"10.4103/ijnm.ijnm_104_24","DOIUrl":"10.4103/ijnm.ijnm_104_24","url":null,"abstract":"<p><p>The present work aims to provide a comprehensive analysis of the production methods for Iodine-123 (¹²³I), with a particular focus on recent advances in nuclear medicine in India and relevant future perspectives. ¹²³I, a radioisotope widely used in nuclear medicine for diagnostic imaging, plays a crucial role in the diagnosis and management of various medical conditions. It examines the historical background of ¹²³I production and their importance in the medical field, emphasizing the recent breakthroughs in the field of nuclear chemistry and radiopharmaceuticals. This work also explores the challenges associated with the production of these isotopes, including their short half-lives and complex production routes. In addition, the report highlights emerging technologies and methodologies that have shown promise for more efficient and cost-effective production of ¹²³I. Finally, the report provides an outlook on the future of radiopharmaceuticals (¹²³I and beyond) production, including the potential impact of new advancements on clinical applications and research endeavors.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"1-9"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentinel Lymph Node Detection in Early-stage Ovarian Cancer Using Radionuclide Technetium-99m Sulfur Colloid - A Feasibility Study.","authors":"Ayush Heda, Shalini Rajaram, Anupama Bahadur, Amrita Gaurav, Vandana Kumar Dhingra, Nilotpal Chowdhury, Manishi L Narayan, Jaya Chaturvedi, Parmita Tiwari, Pallavi Verma","doi":"10.4103/ijnm.ijnm_149_24","DOIUrl":"10.4103/ijnm.ijnm_149_24","url":null,"abstract":"<p><strong>Purpose of the study: </strong>This study evaluates the feasibility and diagnostic accuracy of Tc-99 m sulfur colloid as a tracer for sentinel lymph node (SLN) mapping in early-stage epithelial ovarian cancer (EOC) with the aim to explore SLN mapping as a less invasive alternative to traditional lymphadenectomy.</p><p><strong>Materials and methods: </strong>This prospective observational study involved 10 patients with early-stage EOC or suspicious ovarian masses. Tc-99 m S colloid (37 mBq) was injected subperitoneally at infundibulopelvic and ovarian ligaments near the ovary, followed by SLN detection with a gamma probe. SLNs were analyzed using ultrastaging. Diagnostic accuracy metrics, including sensitivity, specificity, positive predictive value, and negative predictive value, were calculated.</p><p><strong>Results: </strong>SLN detection was achieved in 100% of cases, with detection rates of 10% in the pelvic region and 30% in the para-aortic region alone and in both in 60%. The time for SLN detection was 14.2 ± 4.89 min. Histopathology revealed isolated tumor cells in two cases, with no false negatives observed. Postoperative complications included surgical site infections, transfusions, and paralytic ileus, but no SLN-specific complications were reported.</p><p><strong>Conclusions: </strong>This study demonstrates the feasibility and diagnostic accuracy of SLN detection using technetium-99m sulfur colloid in early-stage ovarian cancer. The findings indicate a high detection rate, no false negatives, and the potential to reduce the need for systematic lymphadenectomy. Further research is required to validate these findings and evaluate their impact on long-term clinical outcomes.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"16-21"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Early Visualization of Foregut Duplication Cyst in Meckel Scan.","authors":"Anushna S Babu, Dikhra Khan, Madhavi Tripathi, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_153_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_153_23","url":null,"abstract":"<p><p>Enteric duplications are rare congenital anomalies, which can have varying presentations depending on the size, location, and type of mucosa present. Meckel scan, using technetium-^99m pertechnetate (Tc-^99m pertechnetate), is a useful modality for the detection of ectopic functioning gastric mucosa. Thoracic duplication cysts present as the initial photopenic area which is getting filled by Tc-^99m pertechnetate in the delayed static images of Meckel scan. We report a rare case of foregut duplication cyst, where foregut duplication cyst is visualized earlier in Meckel scan.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"445-448"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}