Indian Journal of Nuclear Medicine最新文献

{"title":"Impact of Respiratory-gated 4D PET/CT Scan for Motion Correction in Characterizing Lesions Adjacent to the Diaphragm - A Cross-sectional Study at a Tertiary Care Institute.","authors":"Sai Sradha P Patro, Parag Aland, Vivek Mathew James, Vikram Lele","doi":"10.4103/ijnm.ijnm_142_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_142_23","url":null,"abstract":"<p><strong>Purpose: </strong>The blur introduced by breathing motion degrades the diagnostic accuracy of whole-body F-18 fluorodeoxyglucose positron emission tomography-computed tomography (¹⁸F-FDG PET-CT) in lesions adjacent to the diaphragm by increasing the apparent size and by decreasing their metabolic activity. This study aims to evaluate the efficacy of motion correction by four-dimensional phase-based respiratory-gated (RG) ¹⁸F-FDG PET-CT in improving metabolic parameters of lesions adjacent to the diaphragm (especially in the lungs or liver).</p><p><strong>Materials and methods: </strong>Eighteen patients with known lung or liver lesions underwent conventional ¹⁸F-FDG PET-CT and respiratory-gated PET-CT acquisition of the desired region using a pressure-sensing, phase-based respiratory-gating system. Maximum standardized uptake value (SUV_max), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained for these lesions from gated and nongated PET-CT images for analysis. Furthermore, a visual analysis of lesions was done.</p><p><strong>Statistics: </strong>Statistical significance of the RG image parameters was assessed by the two-tailed paired Student's <i>t</i> test and confirmed with the robust nonparametric Wilcoxon's signed-rank test (two-tailed asymptotic).</p><p><strong>Results: </strong>There was an overall significant increase in SUV_max (<i>P</i> 0.001) in all gating methods with a percentage increase maximum of about 18.13%. On gating methods, MTV decreased significantly (<i>P</i> = 0.001) than that of nongating method (maximum reduction of about 32.9%). There was a significant difference (<i>P</i> = 0.02) in TLG between gated and nongated methods.</p><p><strong>Conclusion: </strong>Motion correction with phase-based respiratory gating improves the diagnostic value of ¹⁸F-FDG PET-CT imaging for lung and liver lesions by more accurate delineation of the lesion volume and quantitation of SUV and can thus impact staging, diagnosis as well as management in selected patients.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"177-184"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large Vessel Vasculitis in a Patient Receiving G-CSF: A Possible Differential for Fever of Unknown Origin.","authors":"Raza Abbas Mahdi, Venkata Subramanian Krishnaraju, Bhagwant Rai Mittal, Harmandeep Singh, Rajender Kumar, Gaurav Prakash","doi":"10.4103/ijnm.ijnm_138_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_138_23","url":null,"abstract":"<p><p>Large vessel vasculitis is a known but rare side effect of granulocyte colony-stimulating factor (G-CSF) therapy. We report a case of adenocarcinoma lung with pleural infiltration and mediastinal lymphadenopathy, who was treated with neoadjuvant chemotherapy and pegylated G-CSF. After three cycles, he developed a fever. He underwent F-18 fludeoxyglucose (FDG) positron emission tomography computed tomography for fever of unkwnown origin evaluation, which revealed a response to chemotherapy along with the appearance of FDG avid mural thickening in a few large arteries, suggesting a diagnosis of G-CSF-induced large vessel vasculitis.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"224-226"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathological Variables and Laboratory Values in Infants with Neonatal Cholestasis Showing Nonexcretion on Tc-99m Mebrofenin Hepatobiliary Scans: A Descriptive Study.","authors":"Ahalya Nair, Madhusudhanan Ponnusamy","doi":"10.4103/ijnm.ijnm_127_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_127_23","url":null,"abstract":"<p><strong>Introduction: </strong>Cholescintigraphy using Tc-99m Mebrofenin is routinely performed as an initial diagnostic test in infants with neonatal cholestasis suspected of having biliary atresia. Demonstration of drainage of bile into the small intestine indicates patency of the biliary tract and thus rules out biliary atresia. Non-excretion of tracer into the small intestine, however, can be caused by obstructive as well as non-obstructive conditions, and it is known that false-positive findings are found with the use of Tc-99m Mebrofenin scintigraphy.</p><p><strong>Aim: </strong>In the present study, we retrospectively calculated the proportion of infants eventually diagnosed to have biliary atresia that were initially ruled to have a non-excreting cholescintigraphy pattern in our institution. We have also attempted a systematic description of the cardinal histological characteristics, haematological and hepatic biochemical variables in infants with non-excreting patterns.</p><p><strong>Materials and methods: </strong>This retrospective, descriptive study was conducted in Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry. We reviewed data from infants who underwent cholescintigraphy with Tc-99m Mebrofenin between January 2016 through June 2022. We included infants in whom the scan was ruled \"non-excreting\" i.e. those infants in whom biliary atresia could not be ruled out based on the results of the scan. The difference in mean for haematological parameters and ALP were compared between the two groups i.e., biliary atresia versus other than biliary atresia by using Independent student's t-test; the remaining liver biochemical parameters were compared by using Mann-Whitney U Test and a p value < 0.05 was considered to be statistically significant.</p><p><strong>Results: </strong>A non-excretory pattern on cholescintigraphy was found to be due to biliary atresia in 49% of cases (as confirmed by exploratory surgery) and an additional 19.6 % of cases by trucut biopsy (total 68.6%). The difference in the mean serum GGT levels was found to be statistically significant (<0.001).</p><p><strong>Conclusion: </strong>A non-draining pattern on cholescintigraphy is caused by biliary atresia in the greater percentage of cases presenting with cholestasis. The difference in mean GGT levels was found to be statistically significant between biliary atresia and other causes of non-draining patterns on cholescintigraphy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"163-169"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Extrarenal Accumulation of Tc-99m Ethylene Dicysteine in a Case of Liposarcoma.","authors":"Zahra Jamshidi, Sepideh Hekmat, Leila Hassanzadeh","doi":"10.4103/ijnm.ijnm_38_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_38_24","url":null,"abstract":"<p><p>The technetium-99m ethylene dicysteine (Tc-99m EC) is a radiopharmaceutical used for renal scintigraphy, a noninvasive imaging technique that assesses kidney function as well as urinary tract obstruction. We describe the extrarenal Tc-99m EC uptake in a 70-year-old man with recurrent well-differentiated abdominal liposarcoma. In the present case, both liposarcoma lesions which were diagnosed by abdominal CT scan showed heterogeneous accumulation of the Tc-99m EC.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"234-235"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Thyroid Gland Metastasis from Laryngeal Cancer, Findings on [18F]FDG PET/CT.","authors":"Parneet Singh, Tejasvini Singhal, Girish Kumar Parida, Pramit Kumar, Madhusmita Sethy, Deepak Kumar Das, Kanhaiyalal Agrawal, P Sai Sradha Patro","doi":"10.4103/ijnm.ijnm_133_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_133_23","url":null,"abstract":"<p><p>Thyroid gland metastases from nonthyroidal malignancies are extremely rare. The most common primary malignancies associated with metastasis to thyroid gland include renal cell carcinoma, colorectal carcinoma, lung cancer, and breast cancer. Metastasis to thyroid rarely arises from primary laryngeal cancer. The presence of metastasis to thyroid gland is invariable and associated with poor prognosis and thus, should be differentiated from primary thyroid malignancy. Hereby, we have one such case of metastasis to thyroid gland from laryngeal cancer diagnosed on 18F-fluorodeoxyglucose positron emission tomography/computed tomography scan.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"229-231"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Docetaxel-induced Interstitial Pneumonitis on Ga-68 PSMA PET/CT Imaging.","authors":"Anjali Meena, Bhagwant Rai Mittal, Harmandeep Singh, Girdhar S Bora, Rajender Kumar","doi":"10.4103/ijnm.ijnm_147_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_147_23","url":null,"abstract":"<p><p>Ga-68 labeled prostate-specific membrane antigen (PSMA) positron emission tomography-computed tomography (PET/CT) is increasingly recognized as the best imaging modality for disease staging and detection of recurrent prostate cancer. Despite its name, PSMA expression has been reported in the neovasculature of several nonprostatic benign and malignant pathologies. Docetaxel, a taxane antineoplastic agent, is the mainstay of treatment in castration-resistant prostate cancer and high-volume hormone-sensitive prostate cancer. Although the occurrence of docetaxel-related interstitial lung disease is rare, it may lead to respiratory failure if treatment is delayed. We present a case of metastatic castration-resistant prostate cancer, wherein docetaxel-induced interstitial pneumonitis was detected on Ga-68 PSMA PET/CT after docetaxel administration.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"220-221"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of [18F]FDG PET/CT Findings in Primary Central Nervous System Lymphoma - A Pictorial Essay.","authors":"V Nithya, N C Valaiyapathy, Dhamarcherla S Hemalatha, Rallapeta Ramya Priya, D Bhargavi, Tekchand Kalawat","doi":"10.4103/ijnm.ijnm_21_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_21_24","url":null,"abstract":"<p><p>Primary central nervous system lymphoma (PCNSL) is a rare, aggressive variant of extranodal non-Hodgkin's lymphoma. Although gadolinium-enhanced magnetic resonance imaging remains the initial imaging modality of choice, a whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography is imperative to exclude systemic lymphomatous involvement. Furthermore, the metabolic parameter, maximum standardized uptake value (SUV_max) of the lesion, tumor-to-normal cerebral tissue SUV_max ratio, and FDG uptake patterns help in differentiating intracranial lymphomas from High-grade Glioblastoma Multiforme (HGM) and infectious lesions, and hence, consolidating the diagnosis. In this pictorial essay, we present a series of PCNSL cases, representing the different imaging characteristics and metabolic uptake patterns.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"191-197"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Side Effect of COVID-19 Infection; Osteonecrosis of the Femoral Head in SPECT/CT Bone Scintigraphy.","authors":"Mahdi Haghighatafshar","doi":"10.4103/ijnm.ijnm_19_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_19_24","url":null,"abstract":"<p><p>Avascular necrosis (AVN) of the femoral head is a condition characterized by limited mobility, discomfort, and changes in walking patterns due to insufficient blood supply in this region. Our objective is to investigate the possible connection between COVID-19 and AVN. In this study, we detail the case of a 41-year-old male patient who developed AVN in both femoral heads after contracting COVID-19. The mere occurrence of a COVID-19 infection and the use of corticosteroids for its treatment may increase the probability of AVN in the femoral head. Hence, post the COVID-19 pandemic, it is crucial to consider AVN vigilantly for timely detection and treatment.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"207-209"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of the Diagnostic Performance of Tc-99m PSMA SSPECT/CT in Biochemically Recurrent Prostate Cancer Compared with Ga-68 PSMA PET/CT: A Single-center, Prospective Study.","authors":"Manish Ora, Vivek Kumar Saini, Manish Dixit, Uday Pratap Singh, Sanjay Gambhir","doi":"10.4103/ijnm.ijnm_8_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_8_24","url":null,"abstract":"<p><strong>Objective: </strong>Biochemical recurrence (BCR) after initial management of Prostate Carcinoma (PC) is frequent. Subsequent interventions rely on disease burden and metastasis distribution. ⁶⁸Ga prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) is an excellent imaging modality in BCR. However, ⁶⁸Ga is radionuclide generator produced and has restricted availability. ⁹⁹mTc-labeled PSMA could be a potential cost-effective alternative. We compared the performance of ^99mTc-PSMA single-photon emission CT (SPECT)/CT and ⁶⁸Ga-PSMA PET/CT in BCR with a serum prostate surface antigen (PSA) level of <20 ng/mL.</p><p><strong>Materials and methods: </strong>The prospective study included 25 patients with BCR and at least one lesion on a ⁶⁸Ga-PSMA PET/CT. All patients underwent 99 mTc-PSMA SPECT/CT, and disease distribution and metastatic burden were compared with ⁶⁸Ga-PSMA PET/CT. The maximum standard uptake value (SUVmax) and the tumor-to-background ratio (TBR) were computed and analyzed.</p><p><strong>Results: </strong>The mean age and serum PSA (SPSA) were 69.72 ± 6.69 years and 5.65 ± 6.07 ng/mL. Eleven patients (44%) had SPSA ≤2 ng/mL. Recurrent sites were noted in the prostate (19, 76%), prostatic bed (3, 12%), and pelvis lymph nodes (LNs) (13, 52%). Distant metastasis to bones (13, 52%), lungs (5, 20%), and retroperitoneal LNs (2, 8%) were noted. Both modalities were concordant for the recurrent disease at the prostate, prostatic bed, bone, and lung lesions. ^99mTc-PSMA could localize pelvis LNs in most patients (10/13, 76.9%). The site-specific sensitivity and specificity between the two modalities were not significantly different (<i>P</i> > 0.05). TBR shows excellent correlation with SUVmax (0.783, <i>P</i> < 0.001). Four (16%) patients were understaged with ^99mTc-PSMA due to the nonvisualization of the subcentimeter size LNs. No patient with systemic metastases was understaged.</p><p><strong>Conclusions: </strong>^99mTc-PSMA SPECT/CT has good concordance with ⁶⁸Ga-PSMA PET/CT in BCR, even at low PSA levels. However, it may miss a few subcentimeter LNs due to lower resolution. ^99mTc-PSMA SPECT/CT could be a simple, cost-effective, and readily available imaging alternative to PET/CT.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"170-176"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tc-99m UBI Scintigraphy as a Cost-effective Alternative to Ga-68 NOTA-UBI PET/CT for Imaging Infections.","authors":"Satya Dev Maurya, Sanjana Ballal, Nishikant Avinash Damle, Varsha Tiwari, Chandra Sekhar Bal","doi":"10.4103/ijnm.ijnm_16_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_16_23","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 3","pages":"237-238"},"PeriodicalIF":0.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}