Indian Journal of Nuclear Medicine最新文献

{"title":"Intriguing Encounter: Unveiling Squamous Cell Carcinoma Lung with Rare Bilateral Renal and Pituitary Metastasis on [18F]-FDG PET/CT.","authors":"Prakash Singh, Yogita Khandelwal, Vineet Mishra, Bela Jain","doi":"10.4103/ijnm.ijnm_57_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_57_24","url":null,"abstract":"<p><p>Metastases from squamous cell carcinoma of the lung typically occur in the brain, liver, adrenal glands, bone, and regional lymph nodes. It is exceedingly uncommon to encounter multiple rare sites of metastasis from a single primary neoplasm. Herein, we describe a case of a 44-year-old male diagnosed with squamous cell carcinoma lung with pituitary and renal metastasis detected on ¹⁸F-FDG (Fluorodeoxyglucose) PET/CT. ¹⁸F-FDG PET/CT is the standard of care and is an integral part of the clinical staging of patients with lung cancer. According to published literature, the incidence of symptomatic pituitary and renal metastasis from squamous cell carcinoma lung is rare to find with incidences <1% and 5%, respectively. The revelation of rare sites of metastasis originating from primary squamous cell carcinoma lung, as reported in this case on FDG PET/CT, illuminates the exceptional rarity and intricacies in oncology. The exquisite sensitivity of FDG PET/CT enables the identification of occult metastasis in atypical anatomical locations, presenting a distinct advantage over conventional imaging modalities.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"454-456"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Nuclear Medicine through Discovery, Invention, and Innovation - Contribution of a Physicist and Scientist (Vikram Sarabhai Memorial Oration-2023).","authors":"Ashish Kumar Jha","doi":"10.4103/ijnm.ijnm_118_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_118_24","url":null,"abstract":"<p><p>The history of radiation science began with Wilhelm Rontgen's discovery of X-rays in 1895, followed closely by Henri Becquerel's discovery of radioactivity in 1896. Subsequent research focused on developing radioisotope technology and exploring its applications in medical diagnosis and treatment. The first recorded use of radioisotopes for tumor treatment was by William Dune in Marie Curie's laboratory. George D Heawse employed radioisotopes to study plant and animal physiology. Irene and Joliot Curie pioneered the production of artificial radioisotopes using alpha particle bombardment. Ernest O. Lawrence's invention of the cyclotron furthered the development of artificial isotopes. His brother John Lawrence treated the first patient with cyclotron-produced phosphorus-32. Glenn Seaborg's discovery of Tc-99m and I-131 led to the development of radioiodine therapy by Saul Hertz and many diagnostic procedures using Tc-99m. Bendit Casin invented the rectilinear scanner, a pioneering imaging device, while Hal Anger developed the gamma camera. Over time, the contributions of researchers, scientists, engineers, and physicians have advanced the field of nuclear medicine, resulting in state-of-the-art equipment such as positron emission tomography (PET)/magnetic resonance imaging (MRI), positron emission tomography (PET)/computed tomography (CT), single-photon emission computed tomography (SPECT)/computed tomography (CT), and many other innovative technologies.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"421-427"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Teleradiology on Oncological Interpretation of PET-CT Scans.","authors":"Arjun Kalyanpur, Neetika Mathur","doi":"10.4103/ijnm.ijnm_31_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_31_24","url":null,"abstract":"<p><strong>Background: </strong>Cancer is a prime cause of death globally and accounted for about 10 million deaths in 2020. The accurate determination of the extent of disease is crucial for treatment conceptualization and planning. The aim of the present study was to assess the role of teleradiology in the oncological interpretation of positron emission tomography-computed tomography (PET-CT) scans.</p><p><strong>Materials and methods: </strong>In this retrospective study, a total of 1137 PET-CT scans of a cohort of 1057 patients from hospitals in India, the US and Nepal were uploaded to the teleradiology cloud server and interpreted by board certified radiologists empanelled by a teleradiology service provider.</p><p><strong>Results: </strong>The telehealth model proposed in the study was seen to provide timely and quality reporting of all PET- CT studies with a mean turnaround time of 20.06 h 95% confidence interval (19.35-20.78).</p><p><strong>Conclusion: </strong>The early-stage diagnosis of cancer before it has progressed or metastasized is crucial for the immediate treatment conceptualization and plan and improves the prognosis for long-term survival of the patient. Teleradiology is an important tool in the field of oncology, providing rapid and accurate interpretation of imaging findings, essential for appropriate treatment planning.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"436-440"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Muscular NK/T Cell Lymphoma: A Rare Presentation of Post-Transplant Lymphoproliferative Disorders.","authors":"Srishti Srivastava, Parag Jilhare, Aftab Hasan Nazar, Manish Ora, Sanjay Gambhir","doi":"10.4103/ijnm.ijnm_108_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_108_24","url":null,"abstract":"<p><p>Posttransplant lymphoproliferative disorders (PTLDs) represent a spectrum of malignancies occurring in transplant recipients under immunosuppression, often linked with Epstein-Barr Virus infection. PTLD has a varied presentation, and isolated muscular involvement is infrequent. Here, we present the case of a 47-year-old female renal transplant recipient presenting with acute left knee joint swelling, initially suggestive of an infective or inflammatory etiology. Biopsy revealed high-grade non-Hodgkin lymphoma of natural killer/T-cell lymphoma. F-18 Fluorodeoxyglucose positron emission tomography-computed tomography scan revealed metabolically active soft tissue mass lesions isolated to thigh muscles. The patient was on a modified chemotherapy regimen tailored to accommodate renal function. This case underscores the necessity for heightened vigilance in diagnosing PTLD, particularly considering its atypical presentations.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"457-459"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Pattern of Brain Metabolism in Drug-naive versus Refractory OCD using [18F]-FDG PET/MRI Brain.","authors":"Shailesh Jha, Amarnath Jena, Prerana Rana, Achal Bhagat","doi":"10.4103/ijnm.ijnm_112_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_112_24","url":null,"abstract":"<p><p>Obsessive-compulsive disorder is among the most extensively researched mental health disorder. Various metabolic neuroimaging research findings are consistent but still nonconclusive. The major limitation is a homogeneous sample. There are research findings which have established the impact of treatment in changing brain metabolism. Therefore, it is important to highlight differential metabolic changes with respect to treatment staging and its outcome. It will also help to individualized neuromodulation protocol based on differential metabolic findings. This study highlights the distinct differential fluorodeoxyglucose metabolic changes among two distinct cases: drug-naïve and treatment-refractory.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"449-453"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Time of Diagnostic and Posttherapeutic Iodine-131 Whole-body Scan in Post-Operative Pediatric and Young Adult Differentiated Thyroid Cancer Patients.","authors":"Praveen Kumar, Chandrasekhar Bal, Nishikant Avinash Damle","doi":"10.4103/ijnm.ijnm_133_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_133_24","url":null,"abstract":"<p><strong>Purpose of the study: </strong>The 2015 American Thyroid Association pediatric differentiated thyroid cancer (DTC) guidelines recommend posttherapy whole body scan (PTS) 4-7 days after (Iodine-131) I-131 activity administration. There is no recommendation of timing of performing a diagnostic whole-body scan (Dx-WBS). However, this 4-7 day time frame for PTS lacks a solid basis and is essentially arbitrary. This is especially crucial as it has the potential to significantly impact patient management. Our primary goal in this study was to establish the optimal timing for both Dx-WBS and PTS in pediatric and young adult patients with DTC.</p><p><strong>Methods: </strong>The DTC patients aged ≤21 years underwent serial whole-body scan (WBS) at 24 h, 48 h, and/or 72 h or more after the administration of diagnostic and therapeutic activities of I-131. The utility of Dx-WBS and PTS was assessed based on the identification of new lesions that could potentially influence the prescribed therapeutic activity of I-131. The optimal timing for acquiring Dx-WBS and PTS was determined based on when the first lesion appeared in the I-131 WBS.</p><p><strong>Results: </strong>Ninety-five patients (27 males and 68 females) with an average age of 17.9 ± 3 years received a 74 MBq I-131 for Dx-WBS. Ten patients (10.5%) showed no uptake in Dx-WBS, thus, no I-131 therapy was given. The remaining 85 patients received a therapeutic activity of 1.11-5.55 GBq I-131 based on the extent of their disease. The serial Dx-WBS or PTS showed no additional lesions in patients with thyroid remnants. However, additional nodes were detected in 2/32 patients in the ≥48 h Dx-WBS, and 1/32 patients in the known nodal disease patients, which were not clinically relevant. Importantly, 72 h PTS picked up pulmonary metastases in 17.6% (3 out of 17) of patients, which were missed in serial Dx-WBS. However, >72 h PTS did not have additional value.</p><p><strong>Conclusion: </strong>I-131 Dx-WBS is best to be performed at 48 h, and PTS at 72 h in pediatric and young adult patients with DTC.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"428-435"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Primary Aldosteronism with Negative ⁶⁸Ga-Pentixafor PET/CT and Positive FDG-PET/CT in a Left Adrenal Adenoma.","authors":"Aamir Nazar, Gaurav Malhotra, Sandip Basu","doi":"10.4103/ijnm.ijnm_150_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_150_24","url":null,"abstract":"<p><p>A 65-year-old male with systemic hypertension, progressively rising aldosterone levels, low plasma renin activity, contrast Magnetic resonance imaging (MRI) described left adrenal lesion isointense to liver parenchyma on T2-weighted images and other features suggestive of left adrenal incidentaloma underwent ⁶⁸Ga-Pentixafor Positron emission tomography-computed tomography (PET/CT), which unexpectedly did not show tracer uptake in the known left adrenal adenoma. However, the said nodule showed significant focal tracer uptake on F-18 Fluorodeoxyglucose (FDG)-PET/CT that was done within 2 weeks of ⁶⁸Ga-Pentixafor PET/CT study. This unusual finding, which has hitherto been unreported in known patients of primary aldosteronism needs further exploration to determine its clinical significance.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"472-474"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SSTR Expressing Mediastinal Ectopic Thyroid: A Rarity Unveiled.","authors":"Yogita Khandelwal, Nishikant Avinash Damle, Mohit Kumar Joshi, Aruna Nambiranjan, Surabhi Jain, Rajinder Parshad","doi":"10.4103/ijnm.ijnm_88_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_88_24","url":null,"abstract":"<p><p>Rarely, ectopic thyroid tissue can coexist with an eutopic thyroid. Technetium pertechnetate scan is peculiar for thyroid tissue uptake. However, DOTANOC uptake in mediastinal ectopic thyroid has been rarely reported. We present a unique case of an ectopic mediastinal thyroid mass that did not show any uptake on a pertechnetate scan and showed significantly increased uptake on ⁶⁸Ga-DOTANOC positron emission tomography-computed tomography with an eutopic cervical thyroid with normal pertechnetate and physiological mild DOTANOC uptake.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"469-471"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]FDG- PET/CT in Diagnosis, Staging, and Management of Patients with Langerhans Cell Histiocytosis.","authors":"V M Vimala Priyadharshini, Indirani Muthukrishnan, Dinesh Kumar Gauthaman, Shelley Simon","doi":"10.4103/ijnm.ijnm_46_24","DOIUrl":"10.4103/ijnm.ijnm_46_24","url":null,"abstract":"<p><strong>Background: </strong>Langerhans cell histiocytosis (LCH), a rare hematological disorder, presents significant diagnostic challenges due to its varied clinical manifestations. This study aims to analyse the use of F-18 fluoro-deoxy-glucose positron emission tomography computed tomography (F-18 FDG PET/CT) in diagnosis, staging, and management of LCH.</p><p><strong>Materials and methods: </strong>Fifty-nine patients with LCH were included, who underwent a total of ninety-three F-18 FDG PET/CT scans (including follow-up scans in 19 patients). The sites of abnormal FDG uptake were assessed and the maximum standardized uptake value was measured in all the scans.</p><p><strong>Results: </strong>Twenty-five patients (42.4%) had single system LCH (SS-LCH) and 34 patients (57.6%) had multisystem involvement LCH, 49/59. The most common sites of LCH involvement were bones (49/59, 83.1%) and lymph nodes (39/59, 44.9%). 12/59 patients (20.3%) had unifocal SS-LCH bone lesions, mostly in skull. The other common sites involved were lungs, liver, spleen, marrow, skin, and soft tissues. Less commonly involved sites included pancreas (2 cases), occipital lobe (1 case), and bowel (1 case). PET/CT was used in response assessment in 19 patients and helped in initiation of second line chemotherapy in cases of disease progression (2 cases) and relapse (2 cases). Seven cases with clinical suspicion were diagnosed as LCH based on lesion characteristics and FDG uptake, which were later biopsy proven.</p><p><strong>Conclusion: </strong>F-18 FDG PET/CT revealed morphological and metabolic characteristics of LCH lesions, aiding in accurate diagnosis, assessment of disease burden, and prognostication, thereby can be used as a comprehensive imaging tool in management of LCH.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"341-346"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Manuscript Preparation: Are We Becoming Dependent on Machines?","authors":"Himel Mondal","doi":"10.4103/ijnm.ijnm_130_24","DOIUrl":"10.4103/ijnm.ijnm_130_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"415-416"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}