Case Reports in Pathology最新文献

Intraventricular WHO Grade 3 Pleomorphic Xanthoastrocytoma: A Rare Case Report and Review of the Literature. 脑室内WHO三级多形性黄色星形细胞瘤：一例罕见病例报告及文献复习。

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Case Reports in Pathology Pub Date : 2025-04-28 eCollection Date: 2025-01-01 DOI: 10.1155/crip/9992805

Mohamed Alhantoobi, Nadeen Alkhoori, Euan Zhang, John Provias, Kesava Reddy

{"title":"Intraventricular WHO Grade 3 Pleomorphic Xanthoastrocytoma: A Rare Case Report and Review of the Literature.","authors":"Mohamed Alhantoobi, Nadeen Alkhoori, Euan Zhang, John Provias, Kesava Reddy","doi":"10.1155/crip/9992805","DOIUrl":"https://doi.org/10.1155/crip/9992805","url":null,"abstract":"Background: Cerebral pleomorphic xanthoastrocytoma (PXA) in patients with Neurofibromatosis Type 1 (NF1) is truly a rare entity. Intraventricular anaplastic PXA (APXA) is an even more uncommon presentation, with only three cases reported in the literature. Case Description: We present the case of a 30-year-old female with known NF1 who developed an intraventricular WHO Grade 3 PXA. The tumor was initially resected but recurred aggressively, requiring further surgery and adjuvant therapy with radiation, lomustine, and bevacizumab. Despite treatment, the tumor continued to progress, and the patient's clinical course deteriorated. Discussion: Distinguishing Grade 3 PXA from epithelioid glioblastoma can be diagnostically challenging and often requires further molecular testing. Aggressive multimodal therapy including maximal safe resection, radiation, and chemotherapy may be warranted, but outcomes remain poor. The challenging location of this patient's tumor in the ventricular system added to the complexity of overall treatment. Furthermore, the association of WHO Grade 3 PXA with NF1 is exceedingly rare, and the optimal management and prognosis of this rare tumor in the setting of NF1 are not well established. Conclusions: This case report highlights the unique challenges in diagnosing and managing intraventricular WHO Grade 3 PXA, particularly in the context of NF1. Additional research is necessary to enhance the understanding and effective management of these rare and aggressive tumors.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"9992805"},"PeriodicalIF":0.7,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Findings With Imaging-Guided Fine Needle Aspiration. 影像引导下细针抽吸异常表现。

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Case Reports in Pathology Pub Date : 2025-04-24 eCollection Date: 2025-01-01 DOI: 10.1155/crip/7005824

Robert Pei, Shane M Woods, Brant G Wang

引用次数: 0

A Rare Case of Atypical Choroid Plexus Papilloma in an Adult Male Patient: A Case Report. 成年男性非典型脉络丛乳头状瘤1例报告。

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Case Reports in Pathology Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI: 10.1155/crip/8927598

Abebe Melis Nisiro, Teketel Tadesse Geremew

引用次数: 0

Female Genital Schistosomiasis as a Cause of Tubal Ectopic Pregnancy and Recurrent Pregnancy Loss: A Case Report. 女性生殖器血吸虫病作为输卵管异位妊娠和复发性妊娠丢失的原因：1例报告。

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Case Reports in Pathology Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI: 10.1155/crip/7652671

Dirar Medhanie Gebremedhin, Hale Teka, Kidan Fssaha Tsehaye

{"title":"Female Genital Schistosomiasis as a Cause of Tubal Ectopic Pregnancy and Recurrent Pregnancy Loss: A Case Report.","authors":"Dirar Medhanie Gebremedhin, Hale Teka, Kidan Fssaha Tsehaye","doi":"10.1155/crip/7652671","DOIUrl":"https://doi.org/10.1155/crip/7652671","url":null,"abstract":"Background: Schistosomiasis is a widespread parasitic disease that affects various organs, including the female genital tract. Female genital schistosomiasis can lead to significant reproductive morbidity, such as ectopic pregnancies and infertility. Case Presentation: A 27-year-old woman with a history of recurrent spontaneous abortions presented with acute abdominal pain. She was diagnosed with a ruptured left ectopic pregnancy. Histopathologic examination of the resected tissue revealed numerous Schistosoma haematobium eggs within the ovarian parenchyma and fallopian tube, surrounded by granulomatous inflammation. The patient was treated with praziquantel and informed about the possible effects of schistosomiasis on her reproductive health. Conclusion: This case emphasizes the importance of considering female genital schistosomiasis in women from endemic areas with ectopic pregnancies and recurrent pregnancy loss. Early diagnosis and treatment are essential to prevent long-term reproductive sequelae.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"7652671"},"PeriodicalIF":0.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myoepithelioma-Like Tumor of the Vulva. 外阴肌上皮瘤样肿瘤。

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Case Reports in Pathology Pub Date : 2025-01-19 eCollection Date: 2025-01-01 DOI: 10.1155/crip/2100330

Jiansheng Ma, Qingda Meng, Fangshu Chen, Jiang Wei

{"title":"Myoepithelioma-Like Tumor of the Vulva.","authors":"Jiansheng Ma, Qingda Meng, Fangshu Chen, Jiang Wei","doi":"10.1155/crip/2100330","DOIUrl":"10.1155/crip/2100330","url":null,"abstract":"Background: Myoepithelioma-like tumor of the vulvar region (MELTVR) is a rare mesenchymal tumor that typically arises in the female vulva. Case Presentation: Here, we report a case of a 48-year-old woman who presented with a 2-year history of subcutaneous mass in the vulvar region. As the mass rapidly increased in the last 2 months, personal slight swelling pain appeared. Histologically, the tumor exhibited a distinctive feature of abundant tumor cells and sparse mucus regions. While each region appeared alternately, the sparse mucus region was about 30% of the whole tumor. The tumor had two types of cells, namely, epithelioid and spindle cells. The tumor-rich region demonstrated a cell type of epithelioid, showing hermaphroditic cytoplasm, the center-located nucleus, and abundant chromatin of fasciculate or cord-braid arrangement, whereas the cell of the mucus region was fusiform or epithelioid with partial vacuole-shaped and small visible nucleolus, exhibiting red-stained cytoplasm and loose chromatin. Immunohistochemically, vimentin, smooth muscle actin (SMA), and P16 were diffuse positive in tumor cells, whereas desmin, cytokeratin (CK), P40, P63, CK5, HMB45, MyoD1, myogenin, S100, and SOX10 were all negative. While the proliferation index of Ki-67 was about 7%, the expression of SMARCBl/lNI-1 protein was absent. The pathological diagnosis is myoepithelioma-like tumor of the vulva (right labia majora). Finally, the tumor was surgically and completely removed, and no recurrence or metastasis was found after 6 months of follow-up. Conclusions: Histologically, the morphology of MELTVR is changeable and variation existed for each individual tumor. Moreover, it needs to be differentiated from various other types of tumors, whereas more reports and studies are required to further clarify MELTVR.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"2100330"},"PeriodicalIF":0.7,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acellular Appendix Vermiform Mucinous Neoplasm. 无细胞阑尾蚓状粘液瘤。

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Case Reports in Pathology Pub Date : 2024-12-05 eCollection Date: 2024-01-01 DOI: 10.1155/crip/7732249

Panagiotis Tsikouras, Christos Tsalikidis, Efthymios Oikonomou, Maria Kouroupi, Konstantinos Nikolettos, Anastasia Bothou, Theopi Nalmpanti, Nektaria Kritsotaki, Sonia Kotanidou, Georgios Iatrakis, Nikolaos Nikolettos

{"title":"Acellular Appendix Vermiform Mucinous Neoplasm.","authors":"Panagiotis Tsikouras, Christos Tsalikidis, Efthymios Oikonomou, Maria Kouroupi, Konstantinos Nikolettos, Anastasia Bothou, Theopi Nalmpanti, Nektaria Kritsotaki, Sonia Kotanidou, Georgios Iatrakis, Nikolaos Nikolettos","doi":"10.1155/crip/7732249","DOIUrl":"10.1155/crip/7732249","url":null,"abstract":"Appendiceal neoplasms are usually asymptomatic or associated with mild, nonspecific symptoms. Due to the rarity of the disease and the lack of specific symptoms, this clinical entity escapes the diagnostic consideration of the gynecologist, when women come in with right iliac fossa pain. A case is presented of a 56-year-old woman with a mass in the right small pelvis, which was preoperatively diagnosed as originating from the ovary. An exploratory laparotomy followed in which the uterus and appendages were found to be macroscopically normal, while the mass described above came from the appendix, extended into the anatomical area of the right accessory, and was in contact with the atrophic right ovary. The appendix vermiformis was removed intact. The final pathologic examination confirmed an acellular mucinous tumor of the appendix. Accurate preoperative diagnosis of mucoceles is extremely difficult to make. The formation is discovered in a random imaging test, and the diagnosis is confirmed only intraoperatively.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2024 ","pages":"7732249"},"PeriodicalIF":0.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Presentation of Intracerebellar Schwannoma: A Case Report. 小脑内许旺瘤的罕见表现：病例报告。

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Case Reports in Pathology Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8678186

Mohamed Alhantoobi, Nadeen Alkhoori, Hassan Khayat, Euan Zhang, Almunder Algird, John Provias

引用次数: 0

An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient. 健康患者全身感染产气荚膜梭菌并伴有多种毒素的尸检病例

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Case Reports in Pathology Pub Date : 2024-09-14 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9213132

Ayano Osamura, Hiromi Onizuka, Kenta Masui, Kumiko Murakami, Tomoko Yamamoto, Yoji Nagashima, Munekazu Takeda, Atsushi Kurata

{"title":"An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient.","authors":"Ayano Osamura, Hiromi Onizuka, Kenta Masui, Kumiko Murakami, Tomoko Yamamoto, Yoji Nagashima, Munekazu Takeda, Atsushi Kurata","doi":"10.1155/2024/9213132","DOIUrl":"10.1155/2024/9213132","url":null,"abstract":"We herein report an autopsy case of a fulminant Clostridium perfringens (C. perfringens or Welch bacilli) infection in a healthy adult. A 72-year-old, immunocompetent man visited the emergency department with lower back pain, and blood test revealed hemolytic attack. His condition rapidly worsened with severe acidosis and anemia, and he died despite symptomatic treatment. An autopsy examination demonstrated an abscess with necrosis and air spaces in the right lobe of his liver. Numerous Gram-positive bacilli were seen in the liver and bone marrow, and C. perfringens was identified in culture of the antemortem blood sample. Of note, a mucosal epithelium of the ileum showed loss of tight junctions (claudin 4), suggesting the involvement of C. perfringens toxins with its systemic spreading. Welch toxins were suggested to be involved in serious pathological conditions such as hemolytic anemia and systemic infections, and it is necessary to raise Welch infection as one of the differential diagnoses for fulminant systemic infections even in healthy individuals.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2024 ","pages":"9213132"},"PeriodicalIF":0.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Pathology Case Report: Low-Grade Endometrial Stromal Sarcoma Forming Sex Cord- and Endometrioid Gland-Like Differentiation in Metastatic Foci. 罕见病理病例报告：转移灶中形成性索和子宫内膜样腺体样分化的低级别子宫内膜间质肉瘤

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Case Reports in Pathology Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4073869

Haneen Al-Maghrabi, Ghadeer Mokhtar, Jaudah Al-Maghrabi

{"title":"Rare Pathology Case Report: Low-Grade Endometrial Stromal Sarcoma Forming Sex Cord- and Endometrioid Gland-Like Differentiation in Metastatic Foci.","authors":"Haneen Al-Maghrabi, Ghadeer Mokhtar, Jaudah Al-Maghrabi","doi":"10.1155/2024/4073869","DOIUrl":"https://doi.org/10.1155/2024/4073869","url":null,"abstract":"Low-grade endometrial stromal sarcomas (LGESSs) are indolent tumors with a slow progression rate that tend to recur locally. They represent up to 10% of all primary sarcomas of the uterus and endometrium and only 0.2% of all genital tract tumors. They are commonly present in a younger demographic compared to other uterine tumors, with patients' ages typically between 42 and 58 years old. Although the overall 5-year survival rate is excellent, it has a natural history of delayed metastases which may manifest even decades after the disease was first diagnosed. They typically present as poorly defined lesions infiltrating the myometrium, along with extensive engagement of surrounding vascular structures. LGESS may display variants of different morphologies such as smooth muscle, fibromyxoid, sex cord-like, and endometrioid-type gland differentiation. These variations can pose a diagnostic challenge. The occurrence of this differentiation in a metastatic focus rather than in the primary tumor is seldom recorded in the literature. We present a case of a 51-year-old lady with a history of LGESS who was treated with surgery and radiotherapy and then presented after 12 years with an inferior vena cava (IVC) mass, which was confirmed histologically to be metastatic LGESS. Immunohistochemistry studies reveal strong positivity for CD10, WT1, and PR. These markers were negative in the sex cord and endometrioid gland-like differentiation counterparts. The patient had her initial follow-up appointment after the IVC mass resection, and she was in good health with no complications. To the best of our knowledge, this case represents a unique instance of metastatic LGESS exhibiting both sex cord and endometrioid gland-like differentiation that has not been observed in the primary tumor.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2024 ","pages":"4073869"},"PeriodicalIF":0.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasopharyngeal Carcinoma: Connecting Antemortem and Postmortem Findings to Highlight a Rare Case of EBV and HPV Negativity. 鼻咽癌：将死前和死后研究结果联系起来，突显 EBV 和 HPV 阴性的罕见病例。

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Case Reports in Pathology Pub Date : 2024-06-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8881912

Thomas Auen, Geoffrey Talmon

引用次数: 0