Case Reports in Pathology最新文献

A Rare Presentation of Intracerebellar Schwannoma: A Case Report. 小脑内许旺瘤的罕见表现：病例报告。

IF 0.7

Case Reports in Pathology Pub Date : 2024-10-16 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8678186

Mohamed Alhantoobi, Nadeen Alkhoori, Hassan Khayat, Euan Zhang, Almunder Algird, John Provias

引用次数: 0

An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient. 健康患者全身感染产气荚膜梭菌并伴有多种毒素的尸检病例

IF 0.7

Case Reports in Pathology Pub Date : 2024-09-14 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9213132

Ayano Osamura, Hiromi Onizuka, Kenta Masui, Kumiko Murakami, Tomoko Yamamoto, Yoji Nagashima, Munekazu Takeda, Atsushi Kurata

{"title":"An Autopsy Case of Fulminant Systemic Infection of Clostridium perfringens With a Diverse Role of Toxins in a Healthy Patient.","authors":"Ayano Osamura, Hiromi Onizuka, Kenta Masui, Kumiko Murakami, Tomoko Yamamoto, Yoji Nagashima, Munekazu Takeda, Atsushi Kurata","doi":"10.1155/2024/9213132","DOIUrl":"10.1155/2024/9213132","url":null,"abstract":"We herein report an autopsy case of a fulminant Clostridium perfringens (C. perfringens or Welch bacilli) infection in a healthy adult. A 72-year-old, immunocompetent man visited the emergency department with lower back pain, and blood test revealed hemolytic attack. His condition rapidly worsened with severe acidosis and anemia, and he died despite symptomatic treatment. An autopsy examination demonstrated an abscess with necrosis and air spaces in the right lobe of his liver. Numerous Gram-positive bacilli were seen in the liver and bone marrow, and C. perfringens was identified in culture of the antemortem blood sample. Of note, a mucosal epithelium of the ileum showed loss of tight junctions (claudin 4), suggesting the involvement of C. perfringens toxins with its systemic spreading. Welch toxins were suggested to be involved in serious pathological conditions such as hemolytic anemia and systemic infections, and it is necessary to raise Welch infection as one of the differential diagnoses for fulminant systemic infections even in healthy individuals.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rare Pathology Case Report: Low-Grade Endometrial Stromal Sarcoma Forming Sex Cord- and Endometrioid Gland-Like Differentiation in Metastatic Foci. 罕见病理病例报告：转移灶中形成性索和子宫内膜样腺体样分化的低级别子宫内膜间质肉瘤

IF 0.7

Case Reports in Pathology Pub Date : 2024-09-04 eCollection Date: 2024-01-01 DOI: 10.1155/2024/4073869

Haneen Al-Maghrabi, Ghadeer Mokhtar, Jaudah Al-Maghrabi

{"title":"Rare Pathology Case Report: Low-Grade Endometrial Stromal Sarcoma Forming Sex Cord- and Endometrioid Gland-Like Differentiation in Metastatic Foci.","authors":"Haneen Al-Maghrabi, Ghadeer Mokhtar, Jaudah Al-Maghrabi","doi":"10.1155/2024/4073869","DOIUrl":"https://doi.org/10.1155/2024/4073869","url":null,"abstract":"Low-grade endometrial stromal sarcomas (LGESSs) are indolent tumors with a slow progression rate that tend to recur locally. They represent up to 10% of all primary sarcomas of the uterus and endometrium and only 0.2% of all genital tract tumors. They are commonly present in a younger demographic compared to other uterine tumors, with patients' ages typically between 42 and 58 years old. Although the overall 5-year survival rate is excellent, it has a natural history of delayed metastases which may manifest even decades after the disease was first diagnosed. They typically present as poorly defined lesions infiltrating the myometrium, along with extensive engagement of surrounding vascular structures. LGESS may display variants of different morphologies such as smooth muscle, fibromyxoid, sex cord-like, and endometrioid-type gland differentiation. These variations can pose a diagnostic challenge. The occurrence of this differentiation in a metastatic focus rather than in the primary tumor is seldom recorded in the literature. We present a case of a 51-year-old lady with a history of LGESS who was treated with surgery and radiotherapy and then presented after 12 years with an inferior vena cava (IVC) mass, which was confirmed histologically to be metastatic LGESS. Immunohistochemistry studies reveal strong positivity for CD10, WT1, and PR. These markers were negative in the sex cord and endometrioid gland-like differentiation counterparts. The patient had her initial follow-up appointment after the IVC mass resection, and she was in good health with no complications. To the best of our knowledge, this case represents a unique instance of metastatic LGESS exhibiting both sex cord and endometrioid gland-like differentiation that has not been observed in the primary tumor.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11390231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nasopharyngeal Carcinoma: Connecting Antemortem and Postmortem Findings to Highlight a Rare Case of EBV and HPV Negativity. 鼻咽癌：将死前和死后研究结果联系起来，突显 EBV 和 HPV 阴性的罕见病例。

IF 0.7

Case Reports in Pathology Pub Date : 2024-06-10 eCollection Date: 2024-01-01 DOI: 10.1155/2024/8881912

Thomas Auen, Geoffrey Talmon

引用次数: 0

Central Neurocytoma in a Teenager, a Rare Cause of Hemiplegia, and a Diagnostic Dilemma in a Resource-Poor Setting 一名青少年的中枢神经细胞瘤，半身不遂的罕见病因，资源贫乏地区的诊断难题

IF 0.6

Case Reports in Pathology Pub Date : 2024-03-05 DOI: 10.1155/2024/4514981

Kofi Ulzen-Appiah, K. Akakpo

{"title":"Central Neurocytoma in a Teenager, a Rare Cause of Hemiplegia, and a Diagnostic Dilemma in a Resource-Poor Setting","authors":"Kofi Ulzen-Appiah, K. Akakpo","doi":"10.1155/2024/4514981","DOIUrl":"https://doi.org/10.1155/2024/4514981","url":null,"abstract":"Background. Central neurocytoma is a benign intraventricular neuroectodermal tumor most often arising in the lateral ventricles. Due to the location of this tumor, common signs and symptoms include obstructive hydrocephalus, recurrent headache, visual impairment, nausea, and vomiting. Central neurocytoma and intraventricular oligodendroglioma share similar gross features and cellular and architectural morphology, which may pose a diagnostic challenge in a poor resource setting. Immunohistochemical neuronal stains are useful for the two tumors in our setting. Report. An 18-year-old male patient presented with a 1-year history of right-sided weakness, recurrent seizures, and sudden loss of consciousness. The patient showed signs of increased intracranial pressure, but an antemortem CT or MRI scan could not be done to determine the underlying cause, due to lack of availability and poor prognosis of the patient at the time of presentation. An autopsy revealed a well-demarcated solid cystic, gritty intraventricular tumor causing obstructive hydrocephalus, with associated dilated ventricles and severe cerebral edema. Postmortem histopathological examination of the tumor confirmed central neurocytoma. Conclusion. Central neurocytoma (CN) is an uncommon cause of intracranial space occupying lesion (ICSOL) in the teenage age group in our setting. Central neurocytoma and intraventricular oligodendroglioma share similar radiologic and histomorphological features. Immunohistochemical evaluation with neuronal markers is essential in these two tumors, as they have different prognoses and surgical and treatment outcomes.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary Fibrous Tumor of the Central Nervous System: A Report of Two Cases with Emphasis on Diagnostic Pitfalls 中枢神经系统孤立性纤维瘤：两个病例的报告，强调诊断误区

IF 0.6

Case Reports in Pathology Pub Date : 2024-01-09 DOI: 10.1155/2024/3467025

A. Mwazha, Nondabula Moyeni, Zuzile Zikalala, G. Nhlonzi

引用次数: 0

Primary Synovial Sarcoma of the Scrotum 阴囊原发性滑膜肉瘤

IF 0.6

Case Reports in Pathology Pub Date : 2023-12-29 DOI: 10.1155/2023/7839846

Nourah Al-Oudah, Sara Alanazi, Sarah Saad Alotaibi, Nayef Alzahrani

引用次数: 0

A Case Report of Primary Malignant Melanoma of the Gallbladder with Multiple Metastases. 胆囊原发性恶性黑色素瘤合并多处转移的病例报告。