Case Reports in Pathology最新文献

Renal Metastasis of Adenocarcinoma of the Colon. 结肠腺癌的肾转移。

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Case Reports in Pathology Pub Date : 2025-09-16 eCollection Date: 2025-01-01 DOI: 10.1155/crip/5320139

Ramin Saadaat, Saifullah, Mohammad Asef Adelyar, Jamshid Abdul-Ghafar, Mohibullah Rahmani, Esmatullah Esmat, Ahmed Maseh Haidary, Haider Ali Malakzai

{"title":"Renal Metastasis of Adenocarcinoma of the Colon.","authors":"Ramin Saadaat, Saifullah, Mohammad Asef Adelyar, Jamshid Abdul-Ghafar, Mohibullah Rahmani, Esmatullah Esmat, Ahmed Maseh Haidary, Haider Ali Malakzai","doi":"10.1155/crip/5320139","DOIUrl":"10.1155/crip/5320139","url":null,"abstract":"Introduction: Metastasis is a critical factor in colorectal cancer (CRC) outcomes, with 22% of patients presenting with metastasis at diagnosis and an eventual 70% experiencing it. This report highlights a rare case of ascending colon adenocarcinoma with metastasis to the kidney, underscoring the diverse and complex nature of CRC progression. Case Presentation: A 60-year-old man presented with abdominal discomfort, constipation, and rectal bleeding after colonoscopy revealed a colon mass, leading to a diagnosis of adenocarcinoma after colonoscopic biopsy. Initially without distant metastasis, he underwent four cycles of chemotherapy, but follow-up imaging 6 months later showed liver and renal metastases, prompting a colectomy and nephrectomy. Pathological examination confirmed moderately differentiated adenocarcinoma in both the colon and kidney, with staging indicating advanced disease, and the patient succumbed to his illness shortly after surgery. Clinical Discussion: Metastatic carcinomas to the kidney are uncommon, with CRC metastasis being particularly rare, as evidenced by a limited number of cases in the literature. Typically originating from primary tumors in the lung, liver, and gastrointestinal tract, renal metastases often present as well-defined lesions, complicating the differentiation from primary renal cancers. Our case highlights a solitary, well-circumscribed renal metastasis from CRC, emphasizing the diagnostic challenges and the need for careful evaluation in patients with known malignancies. Conclusion: Metastatic carcinoma of the colorectal tract is very rarely reported to the kidney, it does so at a higher stage of the disease with systemic disease and has a poor outcome for the patient.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"5320139"},"PeriodicalIF":0.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Sneaky Spleen": Three Cases of Ectopic Splenic Tissue Mimicking Neoplasia. “鬼鬼祟祟的脾”：异位脾组织模拟瘤变3例。

IF 0.5

Case Reports in Pathology Pub Date : 2025-09-15 eCollection Date: 2025-01-01 DOI: 10.1155/crip/6644516

Emily W Gripp, Stacey M Gargano

引用次数: 0

Atypical (Symplastic) Leiomyoma Arising in Pararectal Endometriosis Associated With Metastatic Ovarian Clear Cell Carcinoma: A Case Report. 结直肠旁子宫内膜异位症并发转移性卵巢透明细胞癌的不典型（共生性）平滑肌瘤1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1155/crip/7026230

Nicholas Boivin, Ciaran Mannion

引用次数: 0

A Rare Presentation of Adult Primary Leptomeningeal Medulloblastoma: Case Report. 罕见的成人原发性轻脑膜髓母细胞瘤1例。

IF 0.5

Case Reports in Pathology Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.1155/crip/8937543

Grace E Hey, Megan E H Still, Rachel S F Moor, Amanda Stanton, Duane A Mitchell, Brent A Orr, Jesse L Kresak, Anthony A Yachnis, Tara Massini, Ashley P Ghiaseddin

引用次数: 0

Multifocal Medullary and Papillary Thyroid Carcinoma Occurring as a Collision Tumor: A Case Report. 多灶性甲状腺髓样和乳头状癌发生碰撞肿瘤1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI: 10.1155/crip/1510607

Sayali Gadre, Raji T Naidu, Prachi R Gaddam, Neha Mittal, Susan Cherian

{"title":"Multifocal Medullary and Papillary Thyroid Carcinoma Occurring as a Collision Tumor: A Case Report.","authors":"Sayali Gadre, Raji T Naidu, Prachi R Gaddam, Neha Mittal, Susan Cherian","doi":"10.1155/crip/1510607","DOIUrl":"10.1155/crip/1510607","url":null,"abstract":"Collision tumors are rare tumors comprising two morphologically distinct tumors within the same organ without histological admixture. Thyroid collision tumors are extremely rare. We present a case of a 64-year-old male patient with a radiologically suspicious, TI-RADS-TR4 lesion in the right lobe of the thyroid. Fine needle aspiration cytology (FNAC) from the lesion was diagnosed as medullary thyroid carcinoma. Total thyroidectomy with central and right lateral neck dissection was performed. On histopathological evaluation, a collision tumor was identified. Components of the collision tumor were multifocal medullary thyroid carcinoma (MTC) and multifocal infiltrative follicular variant of papillary thyroid carcinoma (PTC). Several hypotheses have been suggested regarding the pathogenesis of the collision tumor. Further management and prognosis of the tumor depend on the component with the higher stage and more aggressive behavior. The case report emphasizes the need for thorough sampling of uninvolved areas in the specimen for microscopic evaluation and staging of each component.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"1510607"},"PeriodicalIF":0.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12431820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fallopian Tube's Placental Site Nodule: A Case Report. 输卵管胎盘结节1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI: 10.1155/crip/4514707

Nicolas Chauveau, Jean-Christophe Tille, Jessica Kartotaroeno

{"title":"Fallopian Tube's Placental Site Nodule: A Case Report.","authors":"Nicolas Chauveau, Jean-Christophe Tille, Jessica Kartotaroeno","doi":"10.1155/crip/4514707","DOIUrl":"10.1155/crip/4514707","url":null,"abstract":"Introduction: Placental site nodules (PSNs) are uncommon lesions typically found in uterine specimens and extremely rarely in extrauterine locations such as the fallopian tubes. PSNs are usually discovered incidentally and result from prior implantation sites. This case report describes an unexpected PSN found in a fallopian tube during a cesarean section with concurrent tubal sterilization. Case Presentation: A 38-year-old multiparous woman (gravida 4, para 2) with a previous vaginal delivery underwent tubal sterilization during a cesarean section. The surgical procedure was uneventful, with no macroscopic abnormalities noted. The patient's medical history included treatment for an ectopic pregnancy with methotrexate. Pathological examination revealed the right fallopian tube to be unremarkable. However, the left fallopian tube contained a 0.3 cm nodule within its wall, characterized by central hyalinization, dystrophic calcifications, and peripheral intermediate trophoblast cells. Immunohistochemical analysis demonstrated GATA3 positivity and a low proliferative index (MIB-1). The absence of mitotic activity, necrosis, and typical morphology confirmed the diagnosis of a PSN. Discussion: PSNs are benign lesions derived from intermediate extravillous trophoblasts. Their identification relies on both morphological characteristics and immunohistochemical staining. The differential diagnosis includes various trophoblastic diseases, which can be distinguished from PSNs by their specific features. This case contributes to the limited literature on extrauterine PSNs, highlighting the importance of recognizing these lesions in atypical locations and differentiating them from pathologies that are more aggressive. Conclusion: This case highlights the rarity of PSNs in the fallopian tubes and underscores the importance of comprehensive pathological analysis for an accurate diagnosis.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"4514707"},"PeriodicalIF":0.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial Sarcoma: Malignant Soft Tissue Sarcoma With Benign Clinical Characteristics-A Case Report. 滑膜肉瘤：具有良性临床特征的恶性软组织肉瘤1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2025-09-01 eCollection Date: 2025-01-01 DOI: 10.1155/crip/9585628

Jay Lodhia, David Msuya, Joshua Tadayo, Alex Mremi

引用次数: 0

An Advanced-Stage Encapsulated Papillary Breast Carcinoma in a Male: A Case Report. 男性晚期包膜乳头状乳腺癌1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2025-08-28 eCollection Date: 2025-01-01 DOI: 10.1155/crip/6518104

Elyssa Glassheim, Jain Zhou, Stephanie Fine, Nadja K Falk, Mary Torrez

引用次数: 0

A Rare Osteoid Forming Carcinosarcoma Ex-Pleomorphic Adenoma of the Parotid Gland. 一例罕见的腮腺前多形性腺瘤。

IF 0.5

Case Reports in Pathology Pub Date : 2025-08-26 eCollection Date: 2025-01-01 DOI: 10.1155/crip/7588391

Nyein Nyein Htun, Daniel Nguyen, Beverly Y Wang, Anoosh Montaser, Behdokht Nowroozizadeh

{"title":"A Rare Osteoid Forming Carcinosarcoma Ex-Pleomorphic Adenoma of the Parotid Gland.","authors":"Nyein Nyein Htun, Daniel Nguyen, Beverly Y Wang, Anoosh Montaser, Behdokht Nowroozizadeh","doi":"10.1155/crip/7588391","DOIUrl":"10.1155/crip/7588391","url":null,"abstract":"Salivary gland carcinosarcoma is a combination of malignant epithelial and sarcomatous tumors and can develop from a preexisting pleomorphic adenoma or de novo. These tumors are rapidly growing infiltrative tumors and have an extremely poor prognosis, with a high frequency of lymphatic and hematogenous spread at the time of diagnosis. Approximately half of the cases of carcinosarcoma arise from preexisting pleomorphic adenoma with a long-standing clinical history of parotid mass. The carcinomatous component is most commonly squamous cell carcinoma or adenocarcinoma, while chondrosarcoma is the most frequent sarcomatous component. Our case is particularly unusual due to the presence of osteosarcomatous differentiation as the sarcomatous component. In addition to its histological rarity, our patient has never been reported a prior parotid mass or history of pleomorphic adenoma in this location. However, thorough examination of the radical parotidectomy specimen revealed sclerosed foci of pleomorphic adenoma in addition to carcinosarcoma with osteoid formation. In conclusion, we report an unusual case of carcinosarcoma ex-pleomorphic adenoma with osteoid formation and osteoclast giant cells in a patient without a history of pleomorphic adenoma or parotid mass.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"7588391"},"PeriodicalIF":0.5,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144993859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous Lymphoepithelioma-Like and Plasmacytoid Subtypes of Urothelial Carcinoma, Along With Prostatic Adenocarcinoma With Clinical Follow-Up. 尿路上皮癌伴前列腺腺癌同时发生淋巴上皮瘤样和浆细胞样亚型及临床随访。

IF 0.5

Case Reports in Pathology Pub Date : 2025-08-21 eCollection Date: 2025-01-01 DOI: 10.1155/crip/9068792

Siddharth Venkatesh, John S Costanza, Bettye Cox, Chris Finch, Ya Xu

{"title":"Simultaneous Lymphoepithelioma-Like and Plasmacytoid Subtypes of Urothelial Carcinoma, Along With Prostatic Adenocarcinoma With Clinical Follow-Up.","authors":"Siddharth Venkatesh, John S Costanza, Bettye Cox, Chris Finch, Ya Xu","doi":"10.1155/crip/9068792","DOIUrl":"10.1155/crip/9068792","url":null,"abstract":"Lymphoepithelioma-like urothelial carcinoma (LELUC) and plasmacytoid urothelial carcinoma (PUC) are rare subtypes. We report a case of simultaneous urothelial carcinoma composed of LELUC and PUC subtypes, along with prostatic adenocarcinoma, with successful clinical management by immunotherapy. The patient, a 54-year-old man with a 40 pack-year smoking history, presented with gross hematuria and dysuria. Imaging revealed focal bladder wall thickening. The patient underwent transurethral resection of bladder tumor (TURBT), followed by cystoprostatectomy. The TURBT revealed LELUC, with muscle invasion. The subsequent cystoprostatectomy specimen displayed a 6.0 cm ulcerative mass, which had focal penetration through the urinary bladder wall. Microscopically, the tumor consisted of sheets of enlarged and pleomorphic tumor cells, mixed with a lymphoplasmacytic infiltrate. Focal plasmacytoid and occasional signet ring cell-like morphologies were observed. Rare tumor cells showed positivity for GATA-3 and p63 immunostains, while the plasmacytoid tumor cells exhibited loss of E-cadherin expression. Additionally, adenocarcinoma of the prostate was present, with a Gleason score of 3 + 3, involving 2% of the prostate tissue. The diagnoses of LELUC, comprising 95% of the tumor, PUC, comprising 5%, and prostatic adenocarcinoma were made. Molecular studies revealed a high tumor mutational burden, and the tumor exhibited PD-L1 expression. The patient received adjuvant immunotherapy with Pembrolizumab and showed no evidence of disease for 3 years up to the time of this report. Morphologic recognition of the various subtypes of urothelial carcinoma, supported by immunohistochemistry, is essential for the proper clinical management of patients. A search of the literature on PubMed revealed no similar cases.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2025 ","pages":"9068792"},"PeriodicalIF":0.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144973474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0