Case Reports in Pathology最新文献_第10页

Spindle Cell Melanoma Presenting as an Ulcer in a Black Diabetic. 梭形细胞黑色素瘤在黑人糖尿病患者中表现为溃疡。

IF 0.6

Case Reports in Pathology Pub Date : 2020-10-11 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3083195

D A Gaskin, D Brathwaite, N Depeiza, P S Gaskin, J Ward

{"title":"Spindle Cell Melanoma Presenting as an Ulcer in a Black Diabetic.","authors":"D A Gaskin, D Brathwaite, N Depeiza, P S Gaskin, J Ward","doi":"10.1155/2020/3083195","DOIUrl":"https://doi.org/10.1155/2020/3083195","url":null,"abstract":"Background. Melanoma in blacks is uncommon and exceedingly rare in association with a diabetic ulcer. We present a case of a spindle cell melanoma masquerading as a diabetic ulcer. Case Report. A 57-year-old overweight woman presented to The Maria Holder Diabetes Centre for the Caribbean with a nonhealing ulcer of the right heel after being treated by various primary care physicians over the preceding year. Her general and systematic examinations were unremarkable. There was a 1 × 1.5 cm ulcer with a necrotic base which bled easily on contact with no evidence of peripheral neuropathy nor arterial insufficiency. Microscopic examination of a biopsy of the lesion showed fascicles of spindle cells with plump nuclei and intracytoplasmic yellow-brown pigment. Immunohistochemistry confirmed a diagnosis of melanoma. Discussion. There should be a high index of suspicion of malignancy with nonhealing diabetic ulcer especially when coupled with short disease duration. This case highlights the importance of a biopsy and histological evaluation in ulcers presenting in recently diagnosed diabetics with no evidence of peripheral neuropathy or vascular disease. Melanoma should be considered in spindle cell lesions especially with pigment and residual nevus cells.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3083195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38528416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features. 具有横纹肌样特征的乳腺上皮-肌上皮癌。

IF 0.6

Case Reports in Pathology Pub Date : 2020-10-07 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8879035

Karl Grenier, Gulbeyaz Altinel, Zari Dastani, Atilla Omeroglu

{"title":"Epithelial-Myoepithelial Carcinoma of the Breast with Rhabdoid Features.","authors":"Karl Grenier, Gulbeyaz Altinel, Zari Dastani, Atilla Omeroglu","doi":"10.1155/2020/8879035","DOIUrl":"https://doi.org/10.1155/2020/8879035","url":null,"abstract":"Epithelial-myoepithelial carcinoma of the breast is a rare biphasic tumor composed of intermixed malignant epithelial and myoepithelial components. Myoepithelial cells are known to adopt varied morphologies, including spindle, chondroid, clear cell, and rhabdoid morphologies, and can represent a diagnostic challenge when isolated on biopsy. Rhabdomyosarcoma, phyllodes tumor, metaplastic carcinoma, and myoepithelial carcinoma are primary breast tumors that all have been shown to exhibit rhabdoid features, whether representing true differentiation or morphological mimic. We here report an epithelial-myoepithelial carcinoma of the breast with rhabdoid features in a 76-year-old woman. The rhabdoid-appearing myoepithelial cells are negative for myogenin, consistent with a rhabdoid-like morphology rather than a true rhabdoid differentiation, comparably to previously described myoepithelial carcinoma with rhabdoid features. To our knowledge, this is the first reported case of epithelial-myoepithelial carcinoma of the breast with rhabdoid features and thus adds another entity to the differential diagnosis of breast lesions with rhabdoid features.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8879035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38614356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Acute Coronary Syndrome in Acute Myeloid Leukemia with Maturation Accompanying Megakaryocytic Differentiation. 成熟伴巨核细胞分化的急性髓性白血病急性冠脉综合征。

IF 0.6

Case Reports in Pathology Pub Date : 2020-09-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8886298

Kentaro Odani, Junya Abe, Yoshiaki Tsuyuki, Soshi Yanagita, Kazuya Shiogama, Mitsuhiro Tachibana, Yutaka Tsutsumi

{"title":"Acute Coronary Syndrome in Acute Myeloid Leukemia with Maturation Accompanying Megakaryocytic Differentiation.","authors":"Kentaro Odani, Junya Abe, Yoshiaki Tsuyuki, Soshi Yanagita, Kazuya Shiogama, Mitsuhiro Tachibana, Yutaka Tsutsumi","doi":"10.1155/2020/8886298","DOIUrl":"https://doi.org/10.1155/2020/8886298","url":null,"abstract":"An autopsy case (85-year-old Japanese male) of myeloperoxidase- (MPO-) positive acute myeloid leukemia with maturation (M1) accompanying megakaryocytic differentiation is presented. The patient manifested acute coronary syndrome. Even after emergent percutaneous coronary intervention, his performance status remained poor, so no chemotherapy against leukemia was given. The final white blood cell count reached 291,700/μL, and the platelet count was elevated to 510,000/μL. No cytogenetic studies were performed. He died at the 25th day of hospitalization. Autopsy revealed marked leukemic infiltration to the endocardium and subendocardial myocardium. Subendocardial myonecrosis was surrounded or replaced by the leukemic blasts, and neither granulation tissue reaction nor fibrosis was observed. In the cardiovascular lumen, lard-like blood clots were formed and microscopically consisted of leukemic blasts and platelets (leukemic thrombi). Infiltration of leukemic blasts was seen in the body cavities and systemic organs including the lung. The MPO-positive blasts lacked azurophilic granules and expressed the stem cell markers, CD34 and CD117 (c-kit). No features of myelofibrosis were seen in the 100% cellular marrow. In the endocardium, liver, lymph nodes, and bone marrow, megakaryocytic cells (CD42b/CD61+, MPO-) were distributed, while the small-sized blastic cells in the blood and tissues predominantly expressed MPO. The blasts lacked expression of CD42b/CD61. Megakaryocytic differentiation might be stimulated by certain tissue factors. AML accompanying megakaryocytic differentiation in certain tissues and organs should be distinguished from acute megakaryoblastic leukemia. The mechanisms provoking acute coronary syndrome in acute myeloid leukemia are discussed.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8886298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38453037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature. 一例成人多灶性髓母细胞瘤:罕见病例描述及文献回顾。

IF 0.6

Case Reports in Pathology Pub Date : 2020-09-11 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4502878

Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi, Angelo Paolo Dei Tos, Giuseppe Canova

{"title":"Multifocal Medulloblastoma in an Adult Patient: Description of a Rare Presentation and Review of the Literature.","authors":"Irene Troncon, Angela Guerriero, Sabrina Rossi, Monica Ronzon, Marta Padovan, Caccese Mario, Lucia Zanatta, Luisa Toffolatti, Elisabetta Marton, Giuseppe Lombardi, Angelo Paolo Dei Tos, Giuseppe Canova","doi":"10.1155/2020/4502878","DOIUrl":"10.1155/2020/4502878","url":null,"abstract":"Medulloblastoma is an embryonal neuroepithelial tumor that affects mainly childhood and more rarely adults. Medulloblastoma occurring as multiple nodules at diagnosis is a rare and tricky presentation. Here, we describe the case of a previously healthy 47-year-old woman with multiple posterior fossa cerebellar tumors. Histological, immunohistochemical, and molecular analyses were performed to best characterize the two excised lesions. The histopathological analysis revealed different variants of medulloblastoma in the excised nodules, one being extensive nodularity, rare in adults, and the other desmoplastic/nodular with areas of anaplasia. Immunostains and molecular analysis classified both nodules as SHH medulloblastoma. Adult medulloblastoma is extremely rare. Important differences exist between adult medulloblastoma and medulloblastoma arising in children and infants. Such differences are in location, distribution of histological variants and of molecular subgroups, survival rates, and therapeutic options. An extensive morphological and molecular characterization of such rare tumors is necessary to choice the best-tailored therapy.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4502878","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38541160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Extracranial Meningioma in the Scalp with Concurrent Steatocystoma. 头皮颅外脑膜瘤并发脂肪囊瘤。

IF 0.6

Case Reports in Pathology Pub Date : 2020-09-08 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6539064

Jiankun Tong, Sergei A Aksenov, Mitchell I Chorost, William H Rodgers

{"title":"Extracranial Meningioma in the Scalp with Concurrent Steatocystoma.","authors":"Jiankun Tong, Sergei A Aksenov, Mitchell I Chorost, William H Rodgers","doi":"10.1155/2020/6539064","DOIUrl":"https://doi.org/10.1155/2020/6539064","url":null,"abstract":"This report documents a rare case of an extracranial meningioma on the posterior scalp without apparent dural connection. Additionally, a sebaceous steatocystoma of the anterior scalp presented alongside the meningioma. A steatocystoma localized to the scalp is also remarkably rare. To our knowledge, this is the first report documenting both an extracranial meningioma and a steatocystoma presenting concurrently on the scalp. A male patient in his thirties presented with a mass lesion on the scalp. A CT scan revealed one posterior scalp mass with no intracranial abnormalities. Post excision histologic examination confirmed an extracranial meningioma (meningothelial variant, WHO Grade I). A second anterior scalp mass, not revealed by CT scan, was discovered during surgery. It was excised and diagnosed as a steatocystoma. Meningiomas predominantly occur intracranially but, in some instances, may present as a standalone extracranial tumor without intracranial abnormalities. Because extracranial meningioma is uncommon, it may be overlooked during clinical diagnosis of scalp masses. We recommend that this neoplasm be routinely considered in the differential diagnosis of extracranial tumors. The discovery of another rare tumor-a steatocystoma located in immediate proximity on the scalp-is further remarkable. We briefly review relevant case reports and etiologies and consider a potential relationship between the two neoplasms. However, it remains more likely that the concurrence of these tumors in our patient was simply coincidental.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2020-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/6539064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38411672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bone Marrow Burkitt Lymphoma in a Child. 儿童骨髓伯基特淋巴瘤。

IF 0.6

Case Reports in Pathology Pub Date : 2020-09-08 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5606391

Matija Knežić, Irena Seili Bekafigo, Jelena Roganović, Ita Hadžisejdić, Nives Jonjić

引用次数: 0

Metaplastic Carcinoma of the Breast with Squamous Differentiation: A Case Report from the University Teaching Hospital of Kigali (CHUK), Rwanda. 乳腺化生癌伴鳞状分化:卢旺达基加利大学教学医院一例报告。

IF 0.6

Case Reports in Pathology Pub Date : 2020-08-28 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4806342

Delphine Uwamariya, Carine Nyampinga, Anne Yvette Nsenguwera, Belson Rugwizangoga

引用次数: 3

Angiodysplasia of the Gallbladder: An Unknown Risk Factor for Cholecystolithiasis. 胆囊血管发育不良:胆囊结石的未知危险因素。

IF 0.6

Case Reports in Pathology Pub Date : 2020-08-27 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7192634

Ivan Švagelj, Mirta Vučko, Mato Hrskanović, Dražen Švagelj

引用次数: 3

A Rare Case of Intraductal Papilloma Arising from Minor Salivary Gland in the Floor of the Mouth. 口腔底部小唾液腺引起的导管内乳头状瘤1例。

IF 0.6

Case Reports in Pathology Pub Date : 2020-08-25 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8882871

Agnes Assao, Silas Antonio Juvencio de Freitas Filho, Luiz Antônio Simonetti Júnior, Denise Tostes Oliveira

引用次数: 0

An Unusual Case of Acute Appendicitis due to Metastatic Prostatic Adenocarcinoma. 转移性前列腺腺癌致急性阑尾炎1例。

IF 0.6

Case Reports in Pathology Pub Date : 2020-08-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/9430452

Numbereye Numbere, Andrew Dunn, Aaron R Huber

引用次数: 2