Two Synchronous Neonatal Tumors: An Extremely Rare Case.

IF 0.7 Q4 PATHOLOGY

Case Reports in Pathology Pub Date : 2021-04-19 eCollection Date: 2021-01-01 DOI:10.1155/2021/6674372

M Rodríguez-Zubieta, K Albarenque, C Lagues, A San Roman, M Varela, D Russo, G Podesta, D Steinberg, C Schauvinhold, A Etchegaray, M T G de Dávila

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引用次数: 3

Abstract

We report a case of a newborn with two synchronous tumors-sialoblastoma and hepatoblastoma-diagnosed at 20 weeks of gestation by magnetic resonance imaging (MRI) and ultrasonography (US). The aim of this study was to describe the management of this case together with a review of the literature. Our patient had a large facial tumor associated with extremely high alpha-fetoprotein levels. Diagnosis of the tumors was made by surgical biopsy, showing typical features in both. Sialoblastoma is a potentially aggressive tumor. In our case, the Ki67 index in the sialoblastoma was between 20 and 30%, indicating a possibly unfavorable behavior. The infant underwent surgery and chemotherapy in different steps. Complete surgical resection with clean margins is considered to be the best treatment option for sialoblastoma. Only four similar cases were previously reported. Timely management by a multidisciplinary team is essential in these difficult cases. In our patient, outcome was good at the time of this report.

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两个新生儿同步肿瘤:一例极为罕见的病例。

我们报告一例新生儿同时患有两种肿瘤-涎母细胞瘤和肝母细胞瘤-在妊娠20周时通过磁共振成像(MRI)和超声检查(US)诊断。本研究的目的是描述该病例的管理，并回顾文献。我们的病人有一个巨大的面部肿瘤，并伴有极高的甲胎蛋白水平。肿瘤的诊断是通过手术活检，表现出典型的特征。涎母细胞瘤是一种潜在的侵袭性肿瘤。在我们的病例中，涎母细胞瘤的Ki67指数在20 - 30%之间，表明可能存在不良行为。这名婴儿分阶段接受了手术和化疗。完整的手术切除和干净的边缘被认为是最好的治疗选择涎母细胞瘤。此前仅报告了4例类似病例。在这些困难的情况下，多学科团队的及时管理至关重要。在我们的患者中，在本报告发表时，结果很好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Case Reports in Pathology PATHOLOGY-

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12 weeks