Case Reports in Pathology最新文献_第2页

Primary Ewing's Sarcoma of the Sinonasal Region: A Rare Clinical Encounter. 鼻窦区原发性尤文氏肉瘤：罕见的临床病例。

IF 0.5

Case Reports in Pathology Pub Date : 2026-03-06 eCollection Date: 2026-01-01 DOI: 10.1155/crip/4920419

Ujjwal Sangroula, Prajeeta Bhandari, Ratan Shah, Prajjwol Luitel, Sadmarg Thakur, Monica Shah, Manoj Tamang

引用次数: 0

Pericardial Metaplastic Ossification With Widespread Bone Formation: A Case Report. 心包化生骨化伴广泛骨形成1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.1155/crip/4462684

B Gharia, A Graham, McEwen C C, R P Whitlock

{"title":"Pericardial Metaplastic Ossification With Widespread Bone Formation: A Case Report.","authors":"B Gharia, A Graham, McEwen C C, R P Whitlock","doi":"10.1155/crip/4462684","DOIUrl":"https://doi.org/10.1155/crip/4462684","url":null,"abstract":"Pericardial disease can present clinically as acute pericarditis, pericardial effusion, cardiac tamponade, and constrictive pericarditis (CP). Pericardial calcification is present in less than 25% of all cases of CP, and patients with this finding are at risk for developing additional cardiac complications. A case of extensive pericardial ossification in a 65-year-old male presenting with pericardial effusion is reported. The patient had several episodes of pericardial effusion and was diagnosed with CP and subsequently managed on medical therapy. Due to worsening symptoms, additional investigations were completed, including echocardiogram, which revealed diastolic dysfunction with constrictive physiology. He underwent bilateral anterior pericardiectomy, and during the surgery, thickened, calcified, and adherent pericardium was identified, along with pockets of effusion. Cytology of pericardial fluid was negative for malignant cells. Histologic sections of the pericardium demonstrated extensive pericardial ossification with widespread bone formation in pericardial/epicardial adipose tissue. Idiopathic pericardial ossification, as identified in our case, is a rare phenomenon only described several times in the literature and may cause CP. Early intervention with pericardiectomy is a predictor of good outcome in CP, and thus, it is important to include rare entities such as metaplastic ossification in the differential for pericardial disease, to facilitate prompt diagnosis and surgical intervention.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"4462684"},"PeriodicalIF":0.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basaloid-Solid Adenoid Cystic Carcinoma of the Breast: A Case Report and Literature Review. 乳腺基底样实体腺样囊性癌1例报告及文献复习。

IF 0.5

Case Reports in Pathology Pub Date : 2026-03-03 eCollection Date: 2026-01-01 DOI: 10.1155/crip/3701240

Yijia Zhou, Yun Hu, Yansheng Zhang

{"title":"Basaloid-Solid Adenoid Cystic Carcinoma of the Breast: A Case Report and Literature Review.","authors":"Yijia Zhou, Yun Hu, Yansheng Zhang","doi":"10.1155/crip/3701240","DOIUrl":"https://doi.org/10.1155/crip/3701240","url":null,"abstract":"Solid-basaloid adenoid cystic carcinoma (SB-AdCC) of the breast is a rare neoplasm. We report the case of a 78-year-old woman who presented with a progressively enlarging right breast mass over 3 years. Clinical examination revealed a 6-cm mass with visible skin ulceration and right axillary lymphadenopathy. Imaging suggested malignancy, and biopsy showed a poorly differentiated tumor composed of basaloid cells arranged in solid nests with focal cribriform areas and necrosis. Immunohistochemically, the epithelial cells were positive for CD117 and CK7, whereas the myoepithelial component showed focal positivity for p63, CK5/6, and S100, and the tumor was negative for ER, PR, and HER2, with a Ki-67 index of approximately 40%. These findings supported a diagnosis of SB-AdCC of the breast with nodal metastasis. After multidisciplinary discussion, the patient underwent palliative mastectomy. At 12-month follow-up, local recurrence and bilateral axillary metastases were identified. This case emphasizes the diagnostic challenge of SB-AdCC, its overlap with basaloid carcinoma, and the importance of recognizing its distinct morphological and molecular features.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"3701240"},"PeriodicalIF":0.5,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive Nodular Fibrous Pseudotumor Presenting as Gastric Outlet Obstruction in a Young Adult Male Patient: A Case Report and Review of the Medical Literature. 反应性结节性纤维性假瘤表现为胃出口梗阻：一例报告及医学文献复习。

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-27 eCollection Date: 2026-01-01 DOI: 10.1155/crip/6943449

David Saulino, David Gonzalo, Michael Still, Meredith Thompson, Christopher Forsmark, Alexander Ayzengart, Michael Feely

{"title":"Reactive Nodular Fibrous Pseudotumor Presenting as Gastric Outlet Obstruction in a Young Adult Male Patient: A Case Report and Review of the Medical Literature.","authors":"David Saulino, David Gonzalo, Michael Still, Meredith Thompson, Christopher Forsmark, Alexander Ayzengart, Michael Feely","doi":"10.1155/crip/6943449","DOIUrl":"https://doi.org/10.1155/crip/6943449","url":null,"abstract":"Mesenchymal proliferations involving the gastrointestinal tract are uncommon and often unexpected upon initial clinical presentation. Here, we are reporting a case of a 20-year-old male patient presenting to the hospital with abdominal pain and vomiting. Upon evaluation, the patient was initially discharged home on antacid therapy. The symptoms progressed in intensity, and a subsequent CT scan was remarkable for marked gastric expansion and a prepyloric mass. The macroscopic examination of the resected lesion revealed a 5.6 cm multilobular fibrotic mass involving the gastric wall. Microscopic analysis was notable for a spindle-cell lesion with admixed lymphoplasmacytic inflammation, patchy necrosis, and calcifications. The immunohistochemical workup was suggestive of a reactive nodular fibrous pseudotumor. This case is notable for several aspects, including the acute clinical presentation, intralesional calcifications, abundant IgG4-positive plasma cells, and lack of CD117 immunohistochemical expression. The peculiarities of the case and a review of the medical literature will be presented.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"6943449"},"PeriodicalIF":0.5,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Invasive Lobular Carcinoma of the Male Breast With BRCA2 Mutation. 男性乳腺浸润性小叶癌伴BRCA2突变

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-26 eCollection Date: 2026-01-01 DOI: 10.1155/crip/3580444

Misaki Abe, Fumi Saito, Naoko Honma, Yuko Tamaki, Mayu Goto, Katsunori Fukutake, Satoshi Sonobe, Yukiko Katagiri, Tomoko Shibayama, Hideaki Ogata

引用次数: 0

Distant Metastases of an Atypical Meningioma 14 Years Later After Primary Tumor Resection: A Case Report and Review of the Literature. 原发肿瘤切除14年后非典型脑膜瘤远处转移一例报告及文献复习。

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-25 eCollection Date: 2026-01-01 DOI: 10.1155/crip/5717203

Kassaye Firde, Douglas Flieder, Maria Gonzalez, Laura Barry, Alessandro Bombonati, Israh Akhtar, Ibrahim Khalifeh, Curtis Miyamoto, Yuan Rong

引用次数: 0

Uterine PEComa With Lymphangioleiomyomatosis (LAM)-Like Features: A Case Report. 子宫PEComa合并淋巴管平滑肌瘤样特征1例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-25 eCollection Date: 2026-01-01 DOI: 10.1155/crip/1620175

Ramani Raman, Daisy Maharjan, Carina Dehner, Sheila Segura

{"title":"Uterine PEComa With Lymphangioleiomyomatosis (LAM)-Like Features: A Case Report.","authors":"Ramani Raman, Daisy Maharjan, Carina Dehner, Sheila Segura","doi":"10.1155/crip/1620175","DOIUrl":"10.1155/crip/1620175","url":null,"abstract":"Perivascular epithelioid cell tumors (PEComas) of the uterus are rare mesenchymal neoplasms characterized by myogenic and melanocytic differentiation. These tumors can mimic other uterine mesenchymal tumors in their clinical presentation and morphology. We report a case of a 58-year-old woman who presented with abnormal uterine bleeding. Initial imaging revealed an endometrial polyp, which was later diagnosed as a leiomyoma on excision biopsy. A subsequent hysterectomy with bilateral salpingectomy revealed a uterine neoplasm composed of spindled to epithelioid cells with low-grade cytologic atypia, infiltrative edges, and extensive lymphovascular invasions, initially suggestive of low-grade endometrial stromal sarcoma. However, immunohistochemical stains demonstrated tumor positivity for HMB45, desmin, and Cathepsin K, and genetic testing revealed a TSC1 variant, leading to a definite diagnosis of uterine PEComa with lymphangioleiomyomatosis (LAM)-like features. The patient's postoperative course was uneventful, and follow-up imaging showed no evidence of metastatic disease. This case highlights the importance of integrated morphological, immunohistochemical, and molecular assessment in differentiating uterine mesenchymal neoplasms to guide appropriate clinical management.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"1620175"},"PeriodicalIF":0.5,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147311082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Melanoma Mimicking Primary Breast Cancer-A Diagnostic Challenge: A Case Report. 模拟原发性乳腺癌的转移性黑色素瘤——诊断挑战：一个病例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-24 eCollection Date: 2026-01-01 DOI: 10.1155/crip/8820195

Angela de Salles Rezende, Teresa Cristina Ferreira Gutman, Marcus Vinicius Teixeira Calejon Stumpf, Karin Soares Gonçalves Cunha, Fabiana Resende Rodrigues, Vânia Gloria Silami Lopes

引用次数: 0

Ask-Upmark Kidney Disease: Case Report of a Rare Congenital Malformation. Ask-Upmark肾病：1例罕见先天性畸形。

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-20 eCollection Date: 2026-01-01 DOI: 10.1155/crip/5533202

Raiane Machado Maia, Guilherme Alves Andrade, Heitor Lino Guimarães, Flávio Ricardo Manzi, Luís Cândido Pinto da Silva, Izabella Lucas de Abreu Lima

{"title":"Ask-Upmark Kidney Disease: Case Report of a Rare Congenital Malformation.","authors":"Raiane Machado Maia, Guilherme Alves Andrade, Heitor Lino Guimarães, Flávio Ricardo Manzi, Luís Cândido Pinto da Silva, Izabella Lucas de Abreu Lima","doi":"10.1155/crip/5533202","DOIUrl":"https://doi.org/10.1155/crip/5533202","url":null,"abstract":"Ask-Upmark kidney disease is a congenital renal malformation characterized by segmental hypoplasia, leading to progressive impairment of renal function and severe hypertension. It is a rare anomaly that presents with various complications. A 14-year-old boy diagnosed with Ask-Upmark kidney was referred for dental care. The patient presented with mouth breathing, unsatisfactory occlusion, and severe drug-induced gingival hyperplasia, which hindered speech, diet, and oral hygiene. Imaging revealed the presence of all permanent teeth, but with delayed eruption, oblique eruption pathways, and risk of impaction. Management included oral hygiene instructions, prophylaxis, and ulectomy to facilitate tooth eruption. This case highlights the oral manifestations associated with the management of Ask-Upmark kidney, specifically drug-induced gingival enlargement and eruption disturbances. It underscores the necessity of multidisciplinary treatment, including dentistry, to improve the quality of life for these patients.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"5533202"},"PeriodicalIF":0.5,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Illuminating Blurry Vision: Visualization of Corneal Protein Deposition With Immunofluorescence in Two Illustrative Case Reports. 视力模糊：用免疫荧光观察角膜蛋白沉积的两例报告。

IF 0.5

Case Reports in Pathology Pub Date : 2026-02-20 eCollection Date: 2026-01-01 DOI: 10.1155/crip/2915592

Sena Zengin, Chaow Charoenkijkajorn, David Warner, T David Bourne, Daisy Alapat, Neriman Gokden, Murat Gokden, Stephen Nix

{"title":"Illuminating Blurry Vision: Visualization of Corneal Protein Deposition With Immunofluorescence in Two Illustrative Case Reports.","authors":"Sena Zengin, Chaow Charoenkijkajorn, David Warner, T David Bourne, Daisy Alapat, Neriman Gokden, Murat Gokden, Stephen Nix","doi":"10.1155/crip/2915592","DOIUrl":"https://doi.org/10.1155/crip/2915592","url":null,"abstract":"Background: Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, premalignant disease with a progression rate of 0.5%-1% per year to multiple myeloma. It can rarely present with significant ocular symptoms in the context of crystalline keratopathy, necessitating medical and surgical interventions. Lattice corneal dystrophy Type I (LCD-1), a rare inherited disorder caused by mutations of TGFBI, manifests with amyloid deposition within the corneal stroma and causes visual impairment. Here, we pictorially highlight protein deposition using immunofluorescence in two representative cases, both having undergone penetrating keratoplasty for blurry vision.Methods: Medical records were reviewed. Hematoxylin and eosin, special staining, immunohistochemistry, and immunofluorescent techniques were performed. A literature review was performed.Results: Case 1: Eosinophilic accumulations of the cornea were highlighted with PAS-D and IgG-kappa by immunohistochemistry, whereas immunofluorescence (IF) technique demonstrated IgG-kappa (2+) staining in the stroma with rare globules in the epithelium. Case 2: Amorphous, eosinophilic deposits within the corneal stroma were congophilic with apple-green birefringence on polarized light. Thioflavin T highlighted the amyloid through immunofluorescence. Mass spectrometry detected a peptide profile consistent with ATGFBI-type amyloid deposition.Conclusion: Immunofluorescence can be helpful in the workup of corneal protein deposition, such as MGUS-related crystalline keratopathy and LCD-1.","PeriodicalId":45638,"journal":{"name":"Case Reports in Pathology","volume":"2026 ","pages":"2915592"},"PeriodicalIF":0.5,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147272405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0