Current Clinical Microbiology Reports最新文献_第3页

The Triple Food-borne Protozoan Parasites: Cryptosporidium spp., Giardia duodenalis, Cyclospora cayetanensis—Hope in Transmission Reduction 三种食源性原生动物寄生虫:隐孢子虫、十二指肠贾第鞭毛虫、卡耶坦环孢子虫——减少传播的希望

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-06-24 DOI: 10.1007/s40588-023-00199-1

Joyce Siwila

引用次数: 0

Genetic Diversity of Human Fungal Pathogens. 人类真菌病原体的遗传多样性。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-06-01 DOI: 10.1007/s40588-023-00188-4

Jillian Freese, Sinem Beyhan

{"title":"Genetic Diversity of Human Fungal Pathogens.","authors":"Jillian Freese, Sinem Beyhan","doi":"10.1007/s40588-023-00188-4","DOIUrl":"https://doi.org/10.1007/s40588-023-00188-4","url":null,"abstract":"Purpose of review: Fungi represent a central yet often overlooked domain of clinically relevant pathogens that have become increasingly important in human disease. With unique adaptive lifestyles that vary widely across species, human fungal pathogens show remarkable diversity in their virulence strategies. The majority of these fungal pathogens are opportunistic, primarily existing in the environment or as commensals that take advantage of immunocompromised hosts to cause disease. In addition, many fungal pathogens have evolved from non-pathogenic lifestyles. The extent of genetic diversity and heritability of virulence traits remains poorly explored in human fungal pathogens.Recent findings: Genetic variation caused by mutations, genomic rearrangements, gene gain or loss, changes in ploidy, and sexual reproduction have profound effects on genetic diversity. These mechanisms contribute to the remarkable diversity of fungal genomes and have large impacts on their prevalence in human disease, virulence, and resistance to antifungal therapies.Summary: Here, we focus on the genomic structure of the most common human fungal pathogens and the aspects of genetic variability that contribute to their dominance in human disease.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 2","pages":"17-28"},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310308/pdf/nihms-1910183.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10120220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Therapeutic Strategies to Ameliorate Antibiotic Resistance and Host-Inflammation Response in Sepsis: an Innovative Approach 改善败血症中抗生素耐药性和宿主炎症反应的治疗策略:一种创新方法

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-05-12 DOI: 10.1007/s40588-023-00194-6

Parkhi Shrivastava, R. Gothalwal, P. Gandhi

引用次数: 0

Zoonotic Parasites in Feral Animals Commonly Consumed in Australia — Is There a Risk? 澳大利亚常见的野生动物中的人畜共患寄生虫——有风险吗？

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-04-25 DOI: 10.1007/s40588-023-00193-7

D. Barton, Hannah Fahey, D. Jenkins, S. Shamsi

引用次数: 0

Cross-kingdom Microbial Interactions Within the Oral Cavity and Their Implications for Oral Disease 口腔内跨界微生物相互作用及其对口腔疾病的影响

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-04-05 DOI: 10.1007/s40588-023-00191-9

G. Wijesinghe, A. Nobbs, H. Bandara

引用次数: 0

The Metabolism of Susceptibility: Clearing the FoG Between Tolerance and Resistance in Candida albicans. 敏感性代谢：清除白色念珠菌耐受和耐药之间的FoG。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2023-03-28 DOI: 10.1007/s40588-023-00189-3

Marina Druseikis, Austin Mottola, Judith Berman

{"title":"The Metabolism of Susceptibility: Clearing the FoG Between Tolerance and Resistance in Candida albicans.","authors":"Marina Druseikis, Austin Mottola, Judith Berman","doi":"10.1007/s40588-023-00189-3","DOIUrl":"10.1007/s40588-023-00189-3","url":null,"abstract":"Purpose of review: Failure of antifungal treatment is alarmingly common in patients infected with Candida albicans isolates that test as susceptible in vitro. This means that clinical susceptibility tests have limited predictive value for treatment success. To guide the improvement of patient outcomes, we must understand the effects of environmental and metabolic states on drug responses.Recent findings: Lab conditions often deviate from host environments, and current susceptibility testing standards ignore slow-growing, tolerant phenotypes; both factors may contribute to antifungal treatment failure. Metabolomic studies reveal that strain background, nutrient availability, and drug exposure influence the metabolic state of C. albicans cells; similarly, the metabolic state influences drug susceptibility.Summary: Identifying tolerant strains in the clinic may improve patient outcomes. Studies that analyze the effects of essential but limited nutrients have the potential to improve the avoidance of persistent candidiasis and to reduce the frequency of antifungal treatment failures. Here, we highlight literature that explores the effect of drug exposure and antifungal drug resistance status on the C. albicans metabolome. Similar analyses need to be carried out relative to antifungal drug tolerance. Additionally, we focus on the biological relevance of four essential small molecules-iron, zinc, phosphate, and sphingolipids-to antifungal tolerance and resistance.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 2","pages":"36-46"},"PeriodicalIF":3.1,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614596/pdf/EMS176254.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9588421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

There Is More to Wounds than Bacteria: Fungal Biofilms in Chronic Wounds 伤口不仅仅是细菌：慢性伤口中的真菌生物膜

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-01-11 DOI: 10.1007/s40588-022-00187-x

B. Short, A. Bakri, Abdullah Baz, Craig Williams, Jason L. Brown, G. Ramage

引用次数: 3

Ubiquitin-Mediated Regulation of Autophagy During Viral Infection. 病毒感染过程中泛素介导的自噬调节。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-01-01 DOI: 10.1007/s40588-022-00186-y

Joydeep Nag, Janvi Patel, Shashank Tripathi

引用次数: 1

The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans. 宿主和真菌因子在白色念珠菌共生向病原体转化中的作用。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-01-01 DOI: 10.1007/s40588-023-00190-w

Ilse D Jacobsen

{"title":"The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans.","authors":"Ilse D Jacobsen","doi":"10.1007/s40588-023-00190-w","DOIUrl":"https://doi.org/10.1007/s40588-023-00190-w","url":null,"abstract":"Abstract: Purpose of review: The fungus Candida albicans has evolved to live in close association with warm-blooded hosts and is found frequently on mucosal surfaces of healthy humans. As an opportunistic pathogen, C. albicans can also cause mucosal and disseminated infections (candidiasis). This review describes the features that differentiate the fungus in the commensal versus pathogenic state and the main factors underlying C. albicans commensal-to-pathogen transition.Recent findings: Adhesion, invasion, and tissue damage are critical steps in the infection process. Especially invasion and damage require transcriptional and morphological changes that differentiate C. albicans in the pathogenic from the commensal state. While the commensal-to-pathogen transition has some conserved causes and features in the oral cavity, the female urogenital tract, and the gut, site-specific differences have been identified in recent years.Summary: This review highlights how specific factors in the different mucosal niches affect development of candidiasis. Recent evidence suggests that colonization of the gut is not only a risk factor for systemic candidiasis but might also provide beneficial effects to the host.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 2","pages":"55-65"},"PeriodicalIF":5.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Conserved and Divergent Features of pH Sensing in Major Fungal Pathogens. 主要真菌病原菌pH敏感的保守性和发散性特征。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2023-01-01 Epub Date: 2023-07-28 DOI: 10.1007/s40588-023-00195-5

Shadab Farhadi Cheshmeh Morvari, Bethany L McCann, Elaine M Bignell

{"title":"Conserved and Divergent Features of pH Sensing in Major Fungal Pathogens.","authors":"Shadab Farhadi Cheshmeh Morvari, Bethany L McCann, Elaine M Bignell","doi":"10.1007/s40588-023-00195-5","DOIUrl":"10.1007/s40588-023-00195-5","url":null,"abstract":"Purpose of review: For human fungal pathogens, sensory perception of extracellular pH is essential for colonisation of mammalian tissues and immune evasion. The molecular complexes that perceive and transmit the fungal pH signal are membrane-proximal and essential for virulence and are therefore of interest as novel antifungal drug targets. Intriguingly, the sensory machinery has evolved divergently in different fungal pathogens, yet spatial co-ordination of cellular components is conserved.Recent findings: The recent discovery of a novel pH sensor in the basidiomycete pathogen Cryptococcus neformans highlights that, although the molecular conservation of fungal pH sensors is evolutionarily restricted, their subcellular localisation and coupling to essential components of the cellular ESCRT machinery are consistent features of the cellular pH sensing and adaptation mechanism. In both basidiomycetes and ascomycetes, the lipid composition of the plasma membrane to which pH sensing complexes are localised appears to have pivotal functional importance. Endocytosis of pH-sensing complexes occurs in multiple fungal species, but its relevance for signal transduction appears not to be universal.Summary: Our overview of current understanding highlights conserved and divergent mechanisms of the pH sensing machinery in model and pathogenic fungal species, as well as important unanswered questions that must be addressed to inform the future study of such sensing mechanisms and to devise therapeutic strategies for manipulating them.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 3","pages":"120-130"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0