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Current Clinical Microbiology Reports最新文献

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Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations 肠道微生物群与自身免疫性疾病：机制、治疗、挑战和未来建议
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2024-01-16 DOI: 10.1007/s40588-023-00213-6
Fatemah Sadeghpour Heravi
{"title":"Gut Microbiota and Autoimmune Diseases: Mechanisms, Treatment, Challenges, and Future Recommendations","authors":"Fatemah Sadeghpour Heravi","doi":"10.1007/s40588-023-00213-6","DOIUrl":"https://doi.org/10.1007/s40588-023-00213-6","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139619121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intimate Relationship Between Stress and Human Alpha‑Herpes Virus 1 (HSV‑1) Reactivation from Latency. 应激与人类甲型疱疹病毒1型(HSV-1)潜伏期再激活的密切关系
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-12-01 Epub Date: 2023-07-27 DOI: 10.1007/s40588-023-00202-9
Clinton Jones
{"title":"Intimate Relationship Between Stress and Human Alpha‑Herpes Virus 1 (HSV‑1) Reactivation from Latency.","authors":"Clinton Jones","doi":"10.1007/s40588-023-00202-9","DOIUrl":"10.1007/s40588-023-00202-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Numerous studies concluded stress (acute, episodic acute, or chronic) increases the incidence of human alpha-herpes virus 1 (HSV-1) reactivation from latency in neurons. This review will summarize how stress stimulates viral gene expression, replication, and reactivation from latency.</p><p><strong>Recent findings: </strong>Stress (capital S) stress-mediated activation of the glucocorticoid receptor (GR) accelerates reactivation from latency, whereas a corticosteroid-specific antagonist impairs viral replication and reactivation from latency. GR and specific stress-induced cellular transcription factors also stimulate viral promoters that drive expression of key viral transcriptional regulators: infected cell protein 0 (ICP0), ICP4, ICP27 and viral tegument protein (VP16). Hence, GR is predicted to initially stimulate viral gene expression. GR-mediated immune-inhibitory functions are also predicted to enhance viral replication and viral spread.</p><p><strong>Summary: </strong>Identifying cellular factors and viral regulatory proteins that trigger reactivation from latency in neurons may provide new therapeutic strategies designed to reduce the incidence of reactivation from latency.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48421532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial and Fungal Keratitis: Current Trends in Its Diagnosis and Management 细菌性和真菌性角膜炎：诊断和管理的当前趋势
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-11-15 DOI: 10.1007/s40588-023-00210-9
Surya Prakash Sharma, Sujata Dwivedi, Sunil Kumar, K. Dhama, A. K. Sharma
{"title":"Bacterial and Fungal Keratitis: Current Trends in Its Diagnosis and Management","authors":"Surya Prakash Sharma, Sujata Dwivedi, Sunil Kumar, K. Dhama, A. K. Sharma","doi":"10.1007/s40588-023-00210-9","DOIUrl":"https://doi.org/10.1007/s40588-023-00210-9","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139271310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineered Therapeutic Antibody Against SARS-CoV-2 针对SARS-CoV-2的工程化治疗性抗体
Current Clinical Microbiology Reports Pub Date : 2023-11-14 DOI: 10.1007/s40588-023-00212-7
Monrat Chulanetra
{"title":"Engineered Therapeutic Antibody Against SARS-CoV-2","authors":"Monrat Chulanetra","doi":"10.1007/s40588-023-00212-7","DOIUrl":"https://doi.org/10.1007/s40588-023-00212-7","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms 从微生物产生的新型抗菌素的生物勘探角度看湿地药物发现的现状
Current Clinical Microbiology Reports Pub Date : 2023-11-08 DOI: 10.1007/s40588-023-00209-2
Bojana Stekovic, Karl Anderson, Delainey Lancaster, Evelyn Stuck, Tsebaot Getachew, Venugopal Mukku, Brian J. Dingmann
{"title":"Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms","authors":"Bojana Stekovic, Karl Anderson, Delainey Lancaster, Evelyn Stuck, Tsebaot Getachew, Venugopal Mukku, Brian J. Dingmann","doi":"10.1007/s40588-023-00209-2","DOIUrl":"https://doi.org/10.1007/s40588-023-00209-2","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135392122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Porin-Mediated Carbapenem Resistance in Klebsiella pneumoniae: an Alarming Threat to Global Health 肺炎克雷伯菌中孔蛋白介导的碳青霉烯耐药:对全球健康的惊人威胁
Current Clinical Microbiology Reports Pub Date : 2023-11-04 DOI: 10.1007/s40588-023-00211-8
Indrani Gogoi, Minakshi Puzari, Pankaj Chetia
{"title":"Porin-Mediated Carbapenem Resistance in Klebsiella pneumoniae: an Alarming Threat to Global Health","authors":"Indrani Gogoi, Minakshi Puzari, Pankaj Chetia","doi":"10.1007/s40588-023-00211-8","DOIUrl":"https://doi.org/10.1007/s40588-023-00211-8","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135773460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective 从染色质和表观遗传学的角度看HIV-1潜伏期的分子机制
Current Clinical Microbiology Reports Pub Date : 2023-10-20 DOI: 10.1007/s40588-023-00208-3
Bianca B. Jütte, Luca Love, J. Peter Svensson
{"title":"Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective","authors":"Bianca B. Jütte, Luca Love, J. Peter Svensson","doi":"10.1007/s40588-023-00208-3","DOIUrl":"https://doi.org/10.1007/s40588-023-00208-3","url":null,"abstract":"Abstract Purpose of Review The main obstacle to an HIV-1 cure is the reservoir of HIV-1 infected cells. While antiretroviral therapy (ART) eliminates the HIV-1 virus effectively, it does not target the reservoir. To eliminate infected cells, we need an improved understanding of the reservoir maintenance and reactivation mechanisms, including the influence of chromatin. Recent Findings The last years’ technological advances enable an in-depth study of the reservoir, uncovering subsets of infected cells, proviral integration sites, and single-cell nucleosome histone modifications. These revelations illustrate how the immune system and cell proliferation shape reservoirs under long-term ART. These forces create highly individual reservoirs that will require personalized treatment for their eradication. Summary A greater understanding of HIV-1 latency mechanisms, focusing on chromatin features, proviral reservoir dynamics, and inter-individual differences, can drive the development of more precise HIV-1 treatment strategies, ultimately achieving a globally available HIV-1 cure.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135566816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Microbiota Resilience Mechanisms Against Pathogen Infection and its Role in Inflammatory Bowel Disease 肠道微生物群抗病原体感染的恢复机制及其在炎症性肠病中的作用
Current Clinical Microbiology Reports Pub Date : 2023-10-07 DOI: 10.1007/s40588-023-00207-4
Marcella Cipelli, Eloísa Martins da Silva, Niels Olsen Saraiva Câmara
{"title":"Gut Microbiota Resilience Mechanisms Against Pathogen Infection and its Role in Inflammatory Bowel Disease","authors":"Marcella Cipelli, Eloísa Martins da Silva, Niels Olsen Saraiva Câmara","doi":"10.1007/s40588-023-00207-4","DOIUrl":"https://doi.org/10.1007/s40588-023-00207-4","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135253345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symbiotic Interactions of Archaea in Animal and Human Microbiomes 古生菌在动物和人类微生物群中的共生相互作用
Current Clinical Microbiology Reports Pub Date : 2023-09-29 DOI: 10.1007/s40588-023-00204-7
Nancy Weiland-Bräuer
{"title":"Symbiotic Interactions of Archaea in Animal and Human Microbiomes","authors":"Nancy Weiland-Bräuer","doi":"10.1007/s40588-023-00204-7","DOIUrl":"https://doi.org/10.1007/s40588-023-00204-7","url":null,"abstract":"Abstract Purpose of Review Since the introduction of Archaea as a new domain of life more than 45 years ago, progress in their phylogenetic classification and knowledge of their exclusive biological characteristics has identified archaea as unique microorganisms which are widespread in extreme but also in various moderate ecosystems, including eukaryotic hosts. However, archaea are still neglected players within microbiomes, and research on archaea-bacteria interactions is still in its infancy due to methodological challenges. Recent Findings This review summarizes the current knowledge of archaea as components within microbiomes and focuses on their interactions with their bacterial neighbors and the principles of archaeal interactions. Summary Archaea are common constituents of animal and human microbiomes, which are dominated by Euryarchaeota. The gastrointestinal tract is the most studied body site, where archaea account for up to 4% of all microorganisms, primarily represented by methanogens. No archaeal pathogen has yet been identified, although methanogens are hypothesized to be indirectly involved in pathogenicity. Archaeal interactions comprise symbiotic relationships, and the cell membrane and wall might be as crucial as quorum sensing/quenching for these interactions. Particularly, syntrophic interactions under energy-deficiency stress seem to be an essential strategy for archaea. However, more research is urgently needed to discover how archaea sense their environment, compete with bacteria, and interact within complex microbiomes associated with multicellular organisms.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight into the Physiological and Molecular Crosstalk During Bacterial-Fungal Interactions 细菌-真菌相互作用中生理和分子串扰的深入研究
Current Clinical Microbiology Reports Pub Date : 2023-09-29 DOI: 10.1007/s40588-023-00206-5
Dibya Jyoti Hazarika, Merilin Kakoti, Tanushree Borgohain, Alokesh Ghosh, Robin Chandra Boro
{"title":"Insight into the Physiological and Molecular Crosstalk During Bacterial-Fungal Interactions","authors":"Dibya Jyoti Hazarika, Merilin Kakoti, Tanushree Borgohain, Alokesh Ghosh, Robin Chandra Boro","doi":"10.1007/s40588-023-00206-5","DOIUrl":"https://doi.org/10.1007/s40588-023-00206-5","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135193863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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