病毒感染过程中泛素介导的自噬调节。

IF 3.1 Q2 MICROBIOLOGY
Joydeep Nag, Janvi Patel, Shashank Tripathi
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引用次数: 1

摘要

综述目的:病毒感染通过利用宿主控制自噬通量的关键调控机制来扭曲宿主的自噬反应,以满足其复制和传播的需要。这篇综述概述了以往的报道,强调了病毒适应劫持宿主泛素化机制以重新利用自噬来维持自身的机制。最新发现:新出现的证据表明宿主泛素机制在自噬的抗病毒或前病毒功能的表现中起关键作用。最近,更多的重点放在鉴定特异性宿主E3泛素连接酶及其靶点(病毒或宿主),并通过生化或全基因组遗传筛选方法表征相应的泛素连接。摘要:在这里,我们强调病毒如何巧妙地参与和破坏宿主泛素自噬系统,以促进病毒复制和对抗细胞内先天免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ubiquitin-Mediated Regulation of Autophagy During Viral Infection.

Ubiquitin-Mediated Regulation of Autophagy During Viral Infection.

Purpose of review: Virus infections skew the host autophagic response to meet their replication and transmission demands by tapping into the critical host regulatory mechanisms that control the autophagic flux. This review is a compendium of previous reports highlighting the mechanisms that viruses adapt to hijack the host ubiquitination machinery to repurpose autophagy for their sustenance.

Recent findings: Emerging evidence suggests a critical role of host ubiquitin machinery in the manifestation of the antiviral or proviral functions of autophagy. Lately, more emphasis has been laid to identify specific host E3 ubiquitin ligases, their targets (viral or host), and characterizing corresponding ubiquitin linkages by biochemical or genome-wide genetic screening approaches.

Summary: Here, we highlight how viruses ingeniously engage and subvert the host ubiquitin-autophagy system to promote virus replication and antagonize intracellular innate immune responses.

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来源期刊
CiteScore
7.50
自引率
1.90%
发文量
9
期刊介绍: Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.
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