Current Clinical Microbiology Reports最新文献

SARS-CoV-2 Resistance to Small Molecule Inhibitors. SARS-CoV-2 对小分子抑制剂的抗药性。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1007/s40588-024-00229-6

Uxua Modrego Lopez, Md Mehedi Hasan, Brandon Havranek, Shahidul M Islam

{"title":"SARS-CoV-2 Resistance to Small Molecule Inhibitors.","authors":"Uxua Modrego Lopez, Md Mehedi Hasan, Brandon Havranek, Shahidul M Islam","doi":"10.1007/s40588-024-00229-6","DOIUrl":"10.1007/s40588-024-00229-6","url":null,"abstract":"Purpose of the review: SARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Concern (VOCs), affecting transmissibility, illness severity, and the effectiveness of antiviral drugs. Continuous monitoring and research are crucial to comprehend variant behavior and develop effective response strategies, including identifying mutations that may affect current drug therapies.Recent findings: Antiviral therapies such as Nirmatrelvir and Ensitrelvir focus on inhibiting 3CLpro, whereas Remdesivir, Favipiravir, and Molnupiravir target nsp12, thereby reducing the viral load. However, the emergence of resistant mutations in 3CLpro and nsp12 could impact the efficiency of these small molecule drug therapeutics.Summary: This manuscript summarizes mutations in 3CLpro and nsp12, which could potentially reduce the efficacy of drugs. Additionally, it encapsulates recent advancements in small molecule antivirals targeting SARS-CoV-2 viral proteins, including their potential for developing resistance against emerging variants.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"11 3","pages":"127-139"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections. 将基因组数据与开发基于 CRISPR 的细菌感染护理点检测相结合。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2024-01-01 Epub Date: 2024-10-15 DOI: 10.1007/s40588-024-00236-7

Thanyapat Wanitchanon, Claire Chewapreecha, Chayasith Uttamapinant

{"title":"Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections.","authors":"Thanyapat Wanitchanon, Claire Chewapreecha, Chayasith Uttamapinant","doi":"10.1007/s40588-024-00236-7","DOIUrl":"https://doi.org/10.1007/s40588-024-00236-7","url":null,"abstract":"Purpose of review: Bacterial infections and antibiotic resistance contribute to global mortality. Despite many infections being preventable and treatable, the lack of reliable and accessible diagnostic tools exacerbates these issues. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based diagnostics has emerged as a promising solution. However, the development of CRISPR diagnostics has often occurred in isolation, with limited integration of genomic data to guide target selection. In this review, we explore the synergy between bacterial genomics and CRISPR-based point-of-care tests (POCT), highlighting how genomic insights can inform target selection and enhance diagnostic accuracy.Recent findings: We review recent advances in CRISPR-based technologies, focusing on the critical role of target sequence selection in improving the sensitivity of CRISPR-based diagnostics. Additionally, we examine the implementation of these technologies in resource-limited settings across Asia and Africa, presenting successful case studies that demonstrate their potential.Summary: The integration of bacterial genomics with CRISPR technology offers significant promise for the development of effective point-of-care diagnostics.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"11 4","pages":"241-258"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intimate Relationship Between Stress and Human Alpha‑Herpes Virus 1 (HSV‑1) Reactivation from Latency. 应激与人类甲型疱疹病毒1型(HSV-1)潜伏期再激活的密切关系

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-12-01 Epub Date: 2023-07-27 DOI: 10.1007/s40588-023-00202-9

Clinton Jones

{"title":"Intimate Relationship Between Stress and Human Alpha‑Herpes Virus 1 (HSV‑1) Reactivation from Latency.","authors":"Clinton Jones","doi":"10.1007/s40588-023-00202-9","DOIUrl":"10.1007/s40588-023-00202-9","url":null,"abstract":"Purpose of review: Numerous studies concluded stress (acute, episodic acute, or chronic) increases the incidence of human alpha-herpes virus 1 (HSV-1) reactivation from latency in neurons. This review will summarize how stress stimulates viral gene expression, replication, and reactivation from latency.Recent findings: Stress (capital S) stress-mediated activation of the glucocorticoid receptor (GR) accelerates reactivation from latency, whereas a corticosteroid-specific antagonist impairs viral replication and reactivation from latency. GR and specific stress-induced cellular transcription factors also stimulate viral promoters that drive expression of key viral transcriptional regulators: infected cell protein 0 (ICP0), ICP4, ICP27 and viral tegument protein (VP16). Hence, GR is predicted to initially stimulate viral gene expression. GR-mediated immune-inhibitory functions are also predicted to enhance viral replication and viral spread.Summary: Identifying cellular factors and viral regulatory proteins that trigger reactivation from latency in neurons may provide new therapeutic strategies designed to reduce the incidence of reactivation from latency.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"1 1","pages":"236-245"},"PeriodicalIF":5.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48421532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial and Fungal Keratitis: Current Trends in Its Diagnosis and Management 细菌性和真菌性角膜炎：诊断和管理的当前趋势

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-11-15 DOI: 10.1007/s40588-023-00210-9

Surya Prakash Sharma, Sujata Dwivedi, Sunil Kumar, K. Dhama, A. K. Sharma

引用次数: 0

Engineered Therapeutic Antibody Against SARS-CoV-2 针对SARS-CoV-2的工程化治疗性抗体

Current Clinical Microbiology Reports Pub Date : 2023-11-14 DOI: 10.1007/s40588-023-00212-7

Monrat Chulanetra

引用次数: 0

Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms 从微生物产生的新型抗菌素的生物勘探角度看湿地药物发现的现状

Current Clinical Microbiology Reports Pub Date : 2023-11-08 DOI: 10.1007/s40588-023-00209-2

Bojana Stekovic, Karl Anderson, Delainey Lancaster, Evelyn Stuck, Tsebaot Getachew, Venugopal Mukku, Brian J. Dingmann

引用次数: 0

Porin-Mediated Carbapenem Resistance in Klebsiella pneumoniae: an Alarming Threat to Global Health 肺炎克雷伯菌中孔蛋白介导的碳青霉烯耐药:对全球健康的惊人威胁

Current Clinical Microbiology Reports Pub Date : 2023-11-04 DOI: 10.1007/s40588-023-00211-8

Indrani Gogoi, Minakshi Puzari, Pankaj Chetia

引用次数: 0

Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective 从染色质和表观遗传学的角度看HIV-1潜伏期的分子机制

Current Clinical Microbiology Reports Pub Date : 2023-10-20 DOI: 10.1007/s40588-023-00208-3

Bianca B. Jütte, Luca Love, J. Peter Svensson

引用次数: 0

Gut Microbiota Resilience Mechanisms Against Pathogen Infection and its Role in Inflammatory Bowel Disease 肠道微生物群抗病原体感染的恢复机制及其在炎症性肠病中的作用

Current Clinical Microbiology Reports Pub Date : 2023-10-07 DOI: 10.1007/s40588-023-00207-4

Marcella Cipelli, Eloísa Martins da Silva, Niels Olsen Saraiva Câmara

引用次数: 0

Symbiotic Interactions of Archaea in Animal and Human Microbiomes 古生菌在动物和人类微生物群中的共生相互作用

Current Clinical Microbiology Reports Pub Date : 2023-09-29 DOI: 10.1007/s40588-023-00204-7

Nancy Weiland-Bräuer

{"title":"Symbiotic Interactions of Archaea in Animal and Human Microbiomes","authors":"Nancy Weiland-Bräuer","doi":"10.1007/s40588-023-00204-7","DOIUrl":"https://doi.org/10.1007/s40588-023-00204-7","url":null,"abstract":"Abstract Purpose of Review Since the introduction of Archaea as a new domain of life more than 45 years ago, progress in their phylogenetic classification and knowledge of their exclusive biological characteristics has identified archaea as unique microorganisms which are widespread in extreme but also in various moderate ecosystems, including eukaryotic hosts. However, archaea are still neglected players within microbiomes, and research on archaea-bacteria interactions is still in its infancy due to methodological challenges. Recent Findings This review summarizes the current knowledge of archaea as components within microbiomes and focuses on their interactions with their bacterial neighbors and the principles of archaeal interactions. Summary Archaea are common constituents of animal and human microbiomes, which are dominated by Euryarchaeota. The gastrointestinal tract is the most studied body site, where archaea account for up to 4% of all microorganisms, primarily represented by methanogens. No archaeal pathogen has yet been identified, although methanogens are hypothesized to be indirectly involved in pathogenicity. Archaeal interactions comprise symbiotic relationships, and the cell membrane and wall might be as crucial as quorum sensing/quenching for these interactions. Particularly, syntrophic interactions under energy-deficiency stress seem to be an essential strategy for archaea. However, more research is urgently needed to discover how archaea sense their environment, compete with bacteria, and interact within complex microbiomes associated with multicellular organisms.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135133102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0