Current Clinical Microbiology Reports最新文献

Bridging Ecology and Microbiomes: Applying Ecological Theories in Host-associated Microbial Ecosystems. 桥梁生态学和微生物组：应用生态学理论在宿主相关微生物生态系统。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI: 10.1007/s40588-025-00246-z

Clara Flores, Sophie Millard, Anna M Seekatz

{"title":"Bridging Ecology and Microbiomes: Applying Ecological Theories in Host-associated Microbial Ecosystems.","authors":"Clara Flores, Sophie Millard, Anna M Seekatz","doi":"10.1007/s40588-025-00246-z","DOIUrl":"https://doi.org/10.1007/s40588-025-00246-z","url":null,"abstract":"Purpose of review: This review explores the application of classical ecological theory to host-associated microbiomes during initial colonization, maintenance, and recovery. We discuss unique challenges of applying these theories to host-associated microbiomes and host factors to consider going forward.Recent findings: Recent studies applying community ecology principles to host microbiomes continue to demonstrate a role for both selective and stochastic processes in shaping host-associated microbiomes. However, ecological frameworks developed to describe dynamics during homeostasis do not necessarily apply during diseased or highly perturbed states, where large variations can potentially lead to alternate stable states.Summary: Despite providing valuable insights, the application of ecological theories to host-associated microbiomes has some unique challenges. The integration of host-specific factors, such as genotype or immune dynamics in ecological models or frameworks is crucial for understanding host microbiome assembly and stability, which could improve our ability to predict microbiome outcomes and improve host health.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"12 1","pages":"9"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Read Sequencing for the Rapid Response to Infectious Diseases Outbreaks. 用于传染病暴发快速反应的长读测序。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1007/s40588-025-00247-y

Josephine B Oehler, Kaitlin Burns, Jeffrey Warner, Ulf Schmitz

{"title":"Long-Read Sequencing for the Rapid Response to Infectious Diseases Outbreaks.","authors":"Josephine B Oehler, Kaitlin Burns, Jeffrey Warner, Ulf Schmitz","doi":"10.1007/s40588-025-00247-y","DOIUrl":"10.1007/s40588-025-00247-y","url":null,"abstract":"Purpose of review: Long-read sequencing (LRS) has revolutionized pathogen surveillance by enabling real-time, high-fidelity genomic analysis critical for outbreak response. This review synthesizes recent breakthroughs in LRS, evaluating its impact on genomic epidemiology, metagenomics, and public health decision-making while addressing limitations and prospects for integrating LRS into global outbreak surveillance.Recent findings: Unlike short-read sequencing, LRS-pioneered by Oxford Nanopore Technologies (ONT) and Pacific Biosciences (PacBio)-resolves complex genomic structures, antimicrobial resistance determinants, and transmission dynamics with unprecedented accuracy. The portability of some LRS devices has facilitated rapid pathogen identification in field settings, notably during the Ebola and COVID-19 pandemics. Despite advancements in basecalling algorithms and target enrichment, challenges including sequencing errors, computational bottlenecks, and cost barriers remain.Summary: By critically evaluating recent findings and discussing future directions, this review highlights the importance of leveraging LRS for outbreak preparedness and response, equipping researchers and public health professionals with the knowledge necessary to navigate the complexities of modern infectious disease challenges.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"12 1","pages":"10"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 Resistance to Small Molecule Inhibitors. SARS-CoV-2 对小分子抑制剂的抗药性。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI: 10.1007/s40588-024-00229-6

Uxua Modrego Lopez, Md Mehedi Hasan, Brandon Havranek, Shahidul M Islam

{"title":"SARS-CoV-2 Resistance to Small Molecule Inhibitors.","authors":"Uxua Modrego Lopez, Md Mehedi Hasan, Brandon Havranek, Shahidul M Islam","doi":"10.1007/s40588-024-00229-6","DOIUrl":"10.1007/s40588-024-00229-6","url":null,"abstract":"Purpose of the review: SARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Concern (VOCs), affecting transmissibility, illness severity, and the effectiveness of antiviral drugs. Continuous monitoring and research are crucial to comprehend variant behavior and develop effective response strategies, including identifying mutations that may affect current drug therapies.Recent findings: Antiviral therapies such as Nirmatrelvir and Ensitrelvir focus on inhibiting 3CLpro, whereas Remdesivir, Favipiravir, and Molnupiravir target nsp12, thereby reducing the viral load. However, the emergence of resistant mutations in 3CLpro and nsp12 could impact the efficiency of these small molecule drug therapeutics.Summary: This manuscript summarizes mutations in 3CLpro and nsp12, which could potentially reduce the efficacy of drugs. Additionally, it encapsulates recent advancements in small molecule antivirals targeting SARS-CoV-2 viral proteins, including their potential for developing resistance against emerging variants.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"11 3","pages":"127-139"},"PeriodicalIF":3.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections. 将基因组数据与开发基于 CRISPR 的细菌感染护理点检测相结合。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2024-01-01 Epub Date: 2024-10-15 DOI: 10.1007/s40588-024-00236-7

Thanyapat Wanitchanon, Claire Chewapreecha, Chayasith Uttamapinant

{"title":"Integrating Genomic Data with the Development of CRISPR-Based Point-of-Care-Testing for Bacterial Infections.","authors":"Thanyapat Wanitchanon, Claire Chewapreecha, Chayasith Uttamapinant","doi":"10.1007/s40588-024-00236-7","DOIUrl":"https://doi.org/10.1007/s40588-024-00236-7","url":null,"abstract":"Purpose of review: Bacterial infections and antibiotic resistance contribute to global mortality. Despite many infections being preventable and treatable, the lack of reliable and accessible diagnostic tools exacerbates these issues. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-based diagnostics has emerged as a promising solution. However, the development of CRISPR diagnostics has often occurred in isolation, with limited integration of genomic data to guide target selection. In this review, we explore the synergy between bacterial genomics and CRISPR-based point-of-care tests (POCT), highlighting how genomic insights can inform target selection and enhance diagnostic accuracy.Recent findings: We review recent advances in CRISPR-based technologies, focusing on the critical role of target sequence selection in improving the sensitivity of CRISPR-based diagnostics. Additionally, we examine the implementation of these technologies in resource-limited settings across Asia and Africa, presenting successful case studies that demonstrate their potential.Summary: The integration of bacterial genomics with CRISPR technology offers significant promise for the development of effective point-of-care diagnostics.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"11 4","pages":"241-258"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intimate Relationship Between Stress and Human Alpha‑Herpes Virus 1 (HSV‑1) Reactivation from Latency. 应激与人类甲型疱疹病毒1型(HSV-1)潜伏期再激活的密切关系

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-12-01 Epub Date: 2023-07-27 DOI: 10.1007/s40588-023-00202-9

Clinton Jones

{"title":"Intimate Relationship Between Stress and Human Alpha‑Herpes Virus 1 (HSV‑1) Reactivation from Latency.","authors":"Clinton Jones","doi":"10.1007/s40588-023-00202-9","DOIUrl":"10.1007/s40588-023-00202-9","url":null,"abstract":"Purpose of review: Numerous studies concluded stress (acute, episodic acute, or chronic) increases the incidence of human alpha-herpes virus 1 (HSV-1) reactivation from latency in neurons. This review will summarize how stress stimulates viral gene expression, replication, and reactivation from latency.Recent findings: Stress (capital S) stress-mediated activation of the glucocorticoid receptor (GR) accelerates reactivation from latency, whereas a corticosteroid-specific antagonist impairs viral replication and reactivation from latency. GR and specific stress-induced cellular transcription factors also stimulate viral promoters that drive expression of key viral transcriptional regulators: infected cell protein 0 (ICP0), ICP4, ICP27 and viral tegument protein (VP16). Hence, GR is predicted to initially stimulate viral gene expression. GR-mediated immune-inhibitory functions are also predicted to enhance viral replication and viral spread.Summary: Identifying cellular factors and viral regulatory proteins that trigger reactivation from latency in neurons may provide new therapeutic strategies designed to reduce the incidence of reactivation from latency.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"1 1","pages":"236-245"},"PeriodicalIF":5.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48421532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial and Fungal Keratitis: Current Trends in Its Diagnosis and Management 细菌性和真菌性角膜炎：诊断和管理的当前趋势

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-11-15 DOI: 10.1007/s40588-023-00210-9

Surya Prakash Sharma, Sujata Dwivedi, Sunil Kumar, K. Dhama, A. K. Sharma

引用次数: 0

Engineered Therapeutic Antibody Against SARS-CoV-2 针对SARS-CoV-2的工程化治疗性抗体

Current Clinical Microbiology Reports Pub Date : 2023-11-14 DOI: 10.1007/s40588-023-00212-7

Monrat Chulanetra

引用次数: 0

Status of Drug Discovery in Wetlands Through a Lens of Bioprospecting for New Antimicrobials Being Produced by Microorganisms 从微生物产生的新型抗菌素的生物勘探角度看湿地药物发现的现状

Current Clinical Microbiology Reports Pub Date : 2023-11-08 DOI: 10.1007/s40588-023-00209-2

Bojana Stekovic, Karl Anderson, Delainey Lancaster, Evelyn Stuck, Tsebaot Getachew, Venugopal Mukku, Brian J. Dingmann

引用次数: 0

Porin-Mediated Carbapenem Resistance in Klebsiella pneumoniae: an Alarming Threat to Global Health 肺炎克雷伯菌中孔蛋白介导的碳青霉烯耐药:对全球健康的惊人威胁

Current Clinical Microbiology Reports Pub Date : 2023-11-04 DOI: 10.1007/s40588-023-00211-8

Indrani Gogoi, Minakshi Puzari, Pankaj Chetia

引用次数: 0

Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective 从染色质和表观遗传学的角度看HIV-1潜伏期的分子机制

Current Clinical Microbiology Reports Pub Date : 2023-10-20 DOI: 10.1007/s40588-023-00208-3

Bianca B. Jütte, Luca Love, J. Peter Svensson

引用次数: 0