Bridging Ecology and Microbiomes: Applying Ecological Theories in Host-associated Microbial Ecosystems.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2025-01-01 Epub Date: 2025-04-15 DOI:10.1007/s40588-025-00246-z

Clara Flores, Sophie Millard, Anna M Seekatz

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引用次数: 0

Abstract

Purpose of review: This review explores the application of classical ecological theory to host-associated microbiomes during initial colonization, maintenance, and recovery. We discuss unique challenges of applying these theories to host-associated microbiomes and host factors to consider going forward.

Recent findings: Recent studies applying community ecology principles to host microbiomes continue to demonstrate a role for both selective and stochastic processes in shaping host-associated microbiomes. However, ecological frameworks developed to describe dynamics during homeostasis do not necessarily apply during diseased or highly perturbed states, where large variations can potentially lead to alternate stable states.

Summary: Despite providing valuable insights, the application of ecological theories to host-associated microbiomes has some unique challenges. The integration of host-specific factors, such as genotype or immune dynamics in ecological models or frameworks is crucial for understanding host microbiome assembly and stability, which could improve our ability to predict microbiome outcomes and improve host health.

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桥梁生态学和微生物组：应用生态学理论在宿主相关微生物生态系统。

综述目的：本文综述了经典生态学理论在宿主相关微生物群落的初始定植、维持和恢复过程中的应用。我们讨论了将这些理论应用于宿主相关微生物组和宿主因子的独特挑战，以考虑向前发展。最近的发现：最近的研究将群落生态学原理应用于宿主微生物组，继续证明了选择性和随机过程在形成宿主相关微生物组中的作用。然而，用于描述体内平衡期间动态的生态框架不一定适用于患病或高度扰动状态，在这些状态下，大的变化可能导致交替的稳定状态。摘要：尽管提供了有价值的见解，但生态学理论在宿主相关微生物组中的应用仍面临一些独特的挑战。在生态模型或框架中整合宿主特异性因素，如基因型或免疫动力学，对于理解宿主微生物组的组装和稳定性至关重要，这可以提高我们预测微生物组结果和改善宿主健康的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.