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Current Clinical Microbiology Reports最新文献

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The Application Potential of Synthetic Biology in Microbial Communication 合成生物学在微生物传播中的应用潜力
Current Clinical Microbiology Reports Pub Date : 2023-09-21 DOI: 10.1007/s40588-023-00205-6
Yan Wang, Jin Zhou
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引用次数: 0
Molecular Mechanisms of Severe Diseases Caused by Epstein-Barr Virus Infection eb病毒感染导致严重疾病的分子机制
Current Clinical Microbiology Reports Pub Date : 2023-09-13 DOI: 10.1007/s40588-023-00203-8
Jun-ichi Kawada
{"title":"Molecular Mechanisms of Severe Diseases Caused by Epstein-Barr Virus Infection","authors":"Jun-ichi Kawada","doi":"10.1007/s40588-023-00203-8","DOIUrl":"https://doi.org/10.1007/s40588-023-00203-8","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135740827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling and Remodeling the Cell: How Digital Twins and HCMV Can Elucidate the Complex Interactions of Viral Latency, Epigenetic Regulation, and Immune Responses. 细胞建模和重塑：数字双胞胎和HCMV如何阐明病毒潜伏性、表观遗传学调节和免疫反应的复杂相互作用
IF 3.1
Current Clinical Microbiology Reports Pub Date : 2023-09-01 Epub Date: 2023-07-29 DOI: 10.1007/s40588-023-00201-w
Hana McMahon-Cole, Alicia Johnson, Sara Sadat Aghamiri, Tomáš Helikar, Lindsey B Crawford
{"title":"Modeling and Remodeling the Cell: How Digital Twins and HCMV Can Elucidate the Complex Interactions of Viral Latency, Epigenetic Regulation, and Immune Responses.","authors":"Hana McMahon-Cole, Alicia Johnson, Sara Sadat Aghamiri, Tomáš Helikar, Lindsey B Crawford","doi":"10.1007/s40588-023-00201-w","DOIUrl":"10.1007/s40588-023-00201-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Human cytomegalovirus (HCMV), while asymptomatic in most, causes significant complications during fetal development, following transplant or in immunosuppressed individuals. The host-virus interactions regulating viral latency and reactivation and viral control of the cellular environment (immune regulation, differentiation, epigenetics) are highly complex. Understanding these processes is essential to controlling infection and can be leveraged as a novel approach for understanding basic cell biology.</p><p><strong>Recent findings: </strong>Immune digital twins (IDTs) are digital simulations integrating knowledge of human immunology, physiology, and patient-specific clinical data to predict individualized immune responses and targeted treatments. Recent studies used IDTs to elucidate mechanisms of T cells, dendritic cells, and epigenetic control-all key to HCMV biology.</p><p><strong>Summary: </strong>Here, we discuss how leveraging the unique biology of HCMV and IDTs will clarify immune response dynamics, host-virus interactions, and viral latency and reactivation and serve as a powerful IDT-validation platform for individualized and holistic health management.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10601359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44737884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contagion Went Viral: Microbiology, Entertainment Media and the Public Understanding of Science 传染病变成病毒：微生物学、娱乐媒体和公众对科学的理解
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-08-02 DOI: 10.1007/s40588-023-00196-4
Amy C. Chambers
{"title":"Contagion Went Viral: Microbiology, Entertainment Media and the Public Understanding of Science","authors":"Amy C. Chambers","doi":"10.1007/s40588-023-00196-4","DOIUrl":"https://doi.org/10.1007/s40588-023-00196-4","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46490547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Disease in Children with Parechovirus-A Infection 儿童感染parechov - a的严重疾病
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-07-19 DOI: 10.1007/s40588-023-00197-3
Jun Tachikawa, Y. Aizawa, A. Saitoh
{"title":"Severe Disease in Children with Parechovirus-A Infection","authors":"Jun Tachikawa, Y. Aizawa, A. Saitoh","doi":"10.1007/s40588-023-00197-3","DOIUrl":"https://doi.org/10.1007/s40588-023-00197-3","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43991105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eliminating Candida auris: Between Ultraviolet-C Radiations and Medicinal Plants, Which One Is Better? 消除耳念珠菌:在紫外线c辐射和药用植物之间，哪个更好?
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-06-28 DOI: 10.1007/s40588-023-00200-x
K. Nwachukwu, O. Ugbogu, E. Nwarunma, C. Nwankpa
{"title":"Eliminating Candida auris: Between Ultraviolet-C Radiations and Medicinal Plants, Which One Is Better?","authors":"K. Nwachukwu, O. Ugbogu, E. Nwarunma, C. Nwankpa","doi":"10.1007/s40588-023-00200-x","DOIUrl":"https://doi.org/10.1007/s40588-023-00200-x","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42580784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of the Oxidative Stress-Inflammation Axis in the COVID-19-Infected Patients with Chagas Disease: A Key Parameter To Be Considered During the Pandemic 氧化应激-炎症轴在covid -19感染恰加斯病患者中的作用:大流行期间需要考虑的关键参数
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-06-24 DOI: 10.1007/s40588-023-00198-2
D. Aydemir, N. N. Ulusu
{"title":"The Role of the Oxidative Stress-Inflammation Axis in the COVID-19-Infected Patients with Chagas Disease: A Key Parameter To Be Considered During the Pandemic","authors":"D. Aydemir, N. N. Ulusu","doi":"10.1007/s40588-023-00198-2","DOIUrl":"https://doi.org/10.1007/s40588-023-00198-2","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41411825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Triple Food-borne Protozoan Parasites: Cryptosporidium spp., Giardia duodenalis, Cyclospora cayetanensis—Hope in Transmission Reduction 三种食源性原生动物寄生虫:隐孢子虫、十二指肠贾第鞭毛虫、卡耶坦环孢子虫——减少传播的希望
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-06-24 DOI: 10.1007/s40588-023-00199-1
Joyce Siwila
{"title":"The Triple Food-borne Protozoan Parasites: Cryptosporidium spp., Giardia duodenalis, Cyclospora cayetanensis—Hope in Transmission Reduction","authors":"Joyce Siwila","doi":"10.1007/s40588-023-00199-1","DOIUrl":"https://doi.org/10.1007/s40588-023-00199-1","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41493562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Diversity of Human Fungal Pathogens. 人类真菌病原体的遗传多样性。
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-06-01 DOI: 10.1007/s40588-023-00188-4
Jillian Freese, Sinem Beyhan
{"title":"Genetic Diversity of Human Fungal Pathogens.","authors":"Jillian Freese,&nbsp;Sinem Beyhan","doi":"10.1007/s40588-023-00188-4","DOIUrl":"https://doi.org/10.1007/s40588-023-00188-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Fungi represent a central yet often overlooked domain of clinically relevant pathogens that have become increasingly important in human disease. With unique adaptive lifestyles that vary widely across species, human fungal pathogens show remarkable diversity in their virulence strategies. The majority of these fungal pathogens are opportunistic, primarily existing in the environment or as commensals that take advantage of immunocompromised hosts to cause disease. In addition, many fungal pathogens have evolved from non-pathogenic lifestyles. The extent of genetic diversity and heritability of virulence traits remains poorly explored in human fungal pathogens.</p><p><strong>Recent findings: </strong>Genetic variation caused by mutations, genomic rearrangements, gene gain or loss, changes in ploidy, and sexual reproduction have profound effects on genetic diversity. These mechanisms contribute to the remarkable diversity of fungal genomes and have large impacts on their prevalence in human disease, virulence, and resistance to antifungal therapies.</p><p><strong>Summary: </strong>Here, we focus on the genomic structure of the most common human fungal pathogens and the aspects of genetic variability that contribute to their dominance in human disease.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310308/pdf/nihms-1910183.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10120220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Therapeutic Strategies to Ameliorate Antibiotic Resistance and Host-Inflammation Response in Sepsis: an Innovative Approach 改善败血症中抗生素耐药性和宿主炎症反应的治疗策略:一种创新方法
IF 5.2
Current Clinical Microbiology Reports Pub Date : 2023-05-12 DOI: 10.1007/s40588-023-00194-6
Parkhi Shrivastava, R. Gothalwal, P. Gandhi
{"title":"Therapeutic Strategies to Ameliorate Antibiotic Resistance and Host-Inflammation Response in Sepsis: an Innovative Approach","authors":"Parkhi Shrivastava, R. Gothalwal, P. Gandhi","doi":"10.1007/s40588-023-00194-6","DOIUrl":"https://doi.org/10.1007/s40588-023-00194-6","url":null,"abstract":"","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":null,"pages":null},"PeriodicalIF":5.2,"publicationDate":"2023-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44436177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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