Current Clinical Microbiology Reports最新文献_第4页

The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans. 宿主和真菌因子在白色念珠菌共生向病原体转化中的作用。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2023-01-01 DOI: 10.1007/s40588-023-00190-w

Ilse D Jacobsen

{"title":"The Role of Host and Fungal Factors in the Commensal-to-Pathogen Transition of Candida albicans.","authors":"Ilse D Jacobsen","doi":"10.1007/s40588-023-00190-w","DOIUrl":"https://doi.org/10.1007/s40588-023-00190-w","url":null,"abstract":"Abstract: Purpose of review: The fungus Candida albicans has evolved to live in close association with warm-blooded hosts and is found frequently on mucosal surfaces of healthy humans. As an opportunistic pathogen, C. albicans can also cause mucosal and disseminated infections (candidiasis). This review describes the features that differentiate the fungus in the commensal versus pathogenic state and the main factors underlying C. albicans commensal-to-pathogen transition.Recent findings: Adhesion, invasion, and tissue damage are critical steps in the infection process. Especially invasion and damage require transcriptional and morphological changes that differentiate C. albicans in the pathogenic from the commensal state. While the commensal-to-pathogen transition has some conserved causes and features in the oral cavity, the female urogenital tract, and the gut, site-specific differences have been identified in recent years.Summary: This review highlights how specific factors in the different mucosal niches affect development of candidiasis. Recent evidence suggests that colonization of the gut is not only a risk factor for systemic candidiasis but might also provide beneficial effects to the host.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 2","pages":"55-65"},"PeriodicalIF":5.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Conserved and Divergent Features of pH Sensing in Major Fungal Pathogens. 主要真菌病原菌pH敏感的保守性和发散性特征。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2023-01-01 Epub Date: 2023-07-28 DOI: 10.1007/s40588-023-00195-5

Shadab Farhadi Cheshmeh Morvari, Bethany L McCann, Elaine M Bignell

{"title":"Conserved and Divergent Features of pH Sensing in Major Fungal Pathogens.","authors":"Shadab Farhadi Cheshmeh Morvari, Bethany L McCann, Elaine M Bignell","doi":"10.1007/s40588-023-00195-5","DOIUrl":"10.1007/s40588-023-00195-5","url":null,"abstract":"Purpose of review: For human fungal pathogens, sensory perception of extracellular pH is essential for colonisation of mammalian tissues and immune evasion. The molecular complexes that perceive and transmit the fungal pH signal are membrane-proximal and essential for virulence and are therefore of interest as novel antifungal drug targets. Intriguingly, the sensory machinery has evolved divergently in different fungal pathogens, yet spatial co-ordination of cellular components is conserved.Recent findings: The recent discovery of a novel pH sensor in the basidiomycete pathogen Cryptococcus neformans highlights that, although the molecular conservation of fungal pH sensors is evolutionarily restricted, their subcellular localisation and coupling to essential components of the cellular ESCRT machinery are consistent features of the cellular pH sensing and adaptation mechanism. In both basidiomycetes and ascomycetes, the lipid composition of the plasma membrane to which pH sensing complexes are localised appears to have pivotal functional importance. Endocytosis of pH-sensing complexes occurs in multiple fungal species, but its relevance for signal transduction appears not to be universal.Summary: Our overview of current understanding highlights conserved and divergent mechanisms of the pH sensing machinery in model and pathogenic fungal species, as well as important unanswered questions that must be addressed to inform the future study of such sensing mechanisms and to devise therapeutic strategies for manipulating them.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 3","pages":"120-130"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10421798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10053874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata? 两种人类真菌病原体白色念珠菌和光滑念珠菌的交配和发病机制之间有关系吗？

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2023-01-01 Epub Date: 2023-04-22 DOI: 10.1007/s40588-023-00192-8

Tina Bedekovic, Jane Usher

{"title":"Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata?","authors":"Tina Bedekovic, Jane Usher","doi":"10.1007/s40588-023-00192-8","DOIUrl":"10.1007/s40588-023-00192-8","url":null,"abstract":"Purpose of review: Human fungal pathogens are rapidly increasing in incidence and readily able to evade the host immune responses. Our ability to study the genetic behind this has been limited due to the apparent lack of a sexual cycle and forward genetic tools. In this review, we discuss the evolution of mating, meiosis, and pathogenesis and if these processes are advantageous to pathogens.Recent findings: This review summarises what is currently known about the sexual cycles of two important human fungal pathogens, Candida albicans and Candida glabrata. This includes the identification of parasexual cycle in C. albicans and the observed low levels of recombination in C. glabrata populations.Summary: In this review, we present what is currently known about the mating types and mating/sexual cycles of two clinically important human fungal pathogens, Candida albicans and Candida glabrata. We discuss the evolution of meiosis using the knowledge that has been amassed from the decades of studying Saccharomyces cerevisiae and how this can be applied to fungal pathogens. We further discuss how the evolution of pathogenesis has played a role in influencing mating processes in human fungal pathogens and compare sexual cycles between C. albicans and C. glabrata, highlighting knowledge gaps and suggesting how these two fungi have evolved distinct mating niches to allow the development of disease in a human host.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"10 2","pages":"47-54"},"PeriodicalIF":3.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9431484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host and Environmental Sensing by Entomopathogenic Fungi to Infect Hosts 寄主与昆虫病原真菌对寄主的环境感知

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2022-10-29 DOI: 10.1007/s40588-022-00185-z

Jun-mei Shang, Guirong Tang, Mengting Lu, Chengshu Wang

引用次数: 4

Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens 新型治疗试验相关菌株的选择:肺囊性纤维化优先病原菌的指导文件

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2022-10-14 DOI: 10.1007/s40588-022-00182-2

E. Mahenthiralingam, R. Weiser, R. Floto, J. Davies, J. Fothergill

引用次数: 1

Microbial Interplay in Skin and Chronic Wounds 皮肤和慢性伤口中的微生物夹层

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2022-08-06 DOI: 10.1007/s40588-022-00180-4

Chandni Sachdeva, K. Satyamoorthy, T. S. Murali

引用次数: 4

Correction to: Germination of a Field: Women in Candida albicans Research 修正:一个领域的萌芽:女性在白色念珠菌研究

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2022-03-10 DOI: 10.1007/s40588-022-00176-0

Faith M. Anderson, Elizabeth J. Polvi, Amanda O. Veri, Teresa R. O’Meara

引用次数: 0

Correction to: A Review of Coccidioides Research, Outstanding Questions in the Field, and Contributions by Women Scientists 更正:球虫研究综述、领域内的突出问题和女科学家的贡献

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2022-03-01 DOI: 10.1007/s40588-022-00177-z

M. Gorris, M. V. Van Dyke, A. Carey, Paris S. Hamm, Heather L. Mead, J. Uehling

引用次数: 0

Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public Health Problem. 新出现的真菌感染：从田间到临床》，《耐药曲霉菌和皮癣菌种：从单一健康视角看待亟待解决的公共健康问题》，《新出现的真菌感染：从田间到临床》，《耐药曲霉菌和皮癣菌种：从单一健康视角看待亟待解决的公共健康问题》。

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2022-01-01 Epub Date: 2022-09-27 DOI: 10.1007/s40588-022-00181-3

Antonia Langfeldt, Jeremy A W Gold, Tom Chiller

{"title":"Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public Health Problem.","authors":"Antonia Langfeldt, Jeremy A W Gold, Tom Chiller","doi":"10.1007/s40588-022-00181-3","DOIUrl":"10.1007/s40588-022-00181-3","url":null,"abstract":"Purpose of review: For this review, we use a One Health approach to examine two globally emerging public health threats related to antifungal drug resistance: triazole-resistant Aspergillus fumigatus infections, which can cause a life-threatening illness in immunocompromised hosts, and antifungal-resistant dermatophytosis, which is an aggressive skin infection caused by dermatophyte molds. We describe the state of current scientific knowledge and outline necessary public health actions to address each issue.Recent findings: Recent evidence has identified the agricultural use of triazole fungicides as an important driver of triazole-resistant A. fumigatus infections. Antifungal-resistant dermatophyte infections are likely driven by the inappropriate use of antifungal drugs and antibacterial and corticosteroid creams.Summary: This review highlights the need for a One Health approach to address emerging antifungal resistant infections, emphasizing judicious antifungal use to preserve available treatments; strengthened laboratory capacity to identify antifungal resistance; and improved human, animal, and environmental surveillance to detect emerging resistance, monitor trends, and evaluate the effectiveness of efforts to decrease spread.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"9 4","pages":"46-51"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MinION Whole-Genome Sequencing in Resource-Limited Settings: Challenges and Opportunities. 资源有限环境下的全基因组测序:挑战与机遇。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2022-01-01 DOI: 10.1007/s40588-022-00183-1

Fredrickson B Wasswa, Kennedy Kassaza, Kirsten Nielsen, Joel Bazira

{"title":"MinION Whole-Genome Sequencing in Resource-Limited Settings: Challenges and Opportunities.","authors":"Fredrickson B Wasswa, Kennedy Kassaza, Kirsten Nielsen, Joel Bazira","doi":"10.1007/s40588-022-00183-1","DOIUrl":"https://doi.org/10.1007/s40588-022-00183-1","url":null,"abstract":"Purpose of review: The introduction of MinION whole-genome sequencing technology greatly increased and simplified complete genome sequencing in various fields of science across the globe. Sequences have been generated from complex organisms to microorganisms and are stored in genome databases that are readily accessible by researchers. Various new software for genome analysis, along with upgrades to older software packages, are being generated. New protocols are also being validated that enable WGS technology to be rapidly and increasingly used for sequencing in field settings.Recent findings: MinION WGS technology has been implemented in developed countries due to its advantages: portability, real-time analysis, and lower cost compared to other sequencing technologies. While these same advantages are critical in developing countries, MinION WGS technology is still under-utilized in resource-limited settings.Summary: In this review, we look at the applications, advantages, challenges, and opportunities of using MinION WGS in resource-limited settings.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"9 4","pages":"52-59"},"PeriodicalIF":5.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9601454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0