Current Clinical Microbiology Reports最新文献_第5页

The Role of Chronic Infection in Alzheimer's Disease: Instigators, Co-conspirators, or Bystanders? 慢性感染在阿尔茨海默病中的作用：煽动者、共谋者还是旁观者？

IF 3.1

Current Clinical Microbiology Reports Pub Date : 2021-12-01 Epub Date: 2021-04-24 DOI: 10.1007/s40588-021-00168-6

Lauren Butler, Keenan A Walker

{"title":"The Role of Chronic Infection in Alzheimer's Disease: Instigators, Co-conspirators, or Bystanders?","authors":"Lauren Butler, Keenan A Walker","doi":"10.1007/s40588-021-00168-6","DOIUrl":"10.1007/s40588-021-00168-6","url":null,"abstract":"Purpose of review: Herein, we provide a critical review of the clinical and translational research examining the relationship between viral and bacterial pathogens and Alzheimer's disease. In addition, we provide an overview of the biological pathways through which chronic infection may contribute to Alzheimer's disease.Recent findings: Dementia due to Alzheimer's disease is a leading cause of disability among older adults in developed countries, yet knowledge of the causative factors that promote Alzheimer's disease pathogenesis remains incomplete. Over the past several decades, numerous studies have demonstrated an association of chronic viral and bacterial infection with Alzheimer's disease. Implicated infectious agents include numerous herpesviruses (HSV-1, HHV-6, HHV-7) and various gastric, enteric, and oral bacterial species, as well as Chlamydia pneumonia and multiple spirochetes.Summary: Evidence supports the association between multiple pathogens and Alzheimer's disease risk. Whether these pathogens play a causal role in Alzheimer's pathophysiology remains an open question. We propose that the host immune response to active or latent infection in the periphery or in the brain triggers or accelerates the Alzheimer's disease processes, including the accumulation of amyloid-ß and pathogenic tau, and neuroinflammation. While recent research suggests that such theories are plausible, additional longitudinal studies linking microorganisms to Aß and phospho-tau development, neuroinflammation, and clinically defined Alzheimer's dementia are needed.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"8 4","pages":"199-212"},"PeriodicalIF":3.1,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8849576/pdf/nihms-1716713.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39940433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Introduction to Current Trends in Meat Microbiology and Hygiene 介绍肉类微生物学和卫生的最新趋势

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-09-12 DOI: 10.1007/s40588-021-00175-7

S. Johler, C. Guldimann

引用次数: 2

Livestock-Associated Meticillin-Resistant Staphylococcus aureus—Current Situation and Impact From a One Health Perspective 家畜相关耐甲氧西林金黄色葡萄球菌——现状及健康影响

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-08-06 DOI: 10.1007/s40588-021-00170-y

A. Fetsch, Danai Etter, S. Johler

引用次数: 11

The Interplay Between Neutral and Adaptive Processes Shapes Genetic Variation During Candida Species Evolution 中性和适应性过程之间的相互作用形成了念珠菌物种进化过程中的遗传变异

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-06-23 DOI: 10.1007/s40588-021-00171-x

Iuliana V. Ene, Meleah A. Hickman, A. Gerstein

引用次数: 2

Hemozoin: a Complex Molecule with Complex Activities. 血色素:具有复杂活性的复杂分子。

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-06-01 Epub Date: 2021-04-11 DOI: 10.1007/s40588-021-00166-8

Trisha Dalapati, Julie M Moore

{"title":"Hemozoin: a Complex Molecule with Complex Activities.","authors":"Trisha Dalapati, Julie M Moore","doi":"10.1007/s40588-021-00166-8","DOIUrl":"https://doi.org/10.1007/s40588-021-00166-8","url":null,"abstract":"Purpose of review: Malaria is a disease caused by parasites that reside in host red blood cells and use hemoglobin as a nutrient source. Heme released by hemoglobin catabolism is modified by the parasite to produce hemozoin (HZ), which has toxic effects on the host. Experimentation aiming to elucidate how HZ contributes to malaria pathogenesis has utilized different preparations of this molecule, complicating interpretation and comparison of findings. We examine natural synthesis and isolation of HZ and highlight studies that have used multiple preparations, including synthetic forms, in a comparative fashion.Recent findings: Recent work utilizing sophisticated imaging and detection techniques reveals important molecular characteristics of HZ synthesis and biochemistry. Other recent studies further refine understanding of contributions of HZ to malaria pathogenesis yet highlight the continuing need to characterize HZ preparations and contextualize experimental conditions in the in vivo infection milieu.Summary: This review highlights the necessity of collectively determining what is physiologically relevant HZ. Characterization of isolated natural HZ and use of multiple preparations in each study are recommended with application of in vivo studies whenever possible. Adoption of such practices is expected to improve reproducibility of results and elucidate the myriad of ways that HZ participates in malaria pathogenesis.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"8 2","pages":"87-102"},"PeriodicalIF":5.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-021-00166-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39962016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A One Health Perspective on a Multi-hurdle Approach to Combat Campylobacter spp. in Broiler Meat 肉鸡肉中弯曲杆菌多障碍防治的一个健康视角

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-04-08 DOI: 10.1007/s40588-021-00167-7

S. Kittler, G. Shakeri, E. Peh, M. Plötz

引用次数: 5

Alternative Curing Methods 替代养护方法

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-03-13 DOI: 10.1007/s40588-021-00164-w

Lisa Siekmann, M. Plötz, C. Krischek

引用次数: 10

Physical Methods for the Decontamination of Meat Surfaces 肉类表面去污的物理方法

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-02-23 DOI: 10.1007/s40588-021-00156-w

T. Albert, P. Braun, Jasem Saffaf, C. Wiacek

引用次数: 12

Assessment of the Effectiveness of Pre-harvest Meat Safety Interventions to Control Foodborne Pathogens in Broilers: a Systematic Review 采前肉类安全干预措施控制肉鸡食源性病原体的有效性评估：系统综述

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-02-14 DOI: 10.1007/s40588-021-00161-z

Joana Pessoa, Maria Rodrigues da Costa, T. Nesbakken, D. Meemken

引用次数: 7

Wild Game Meat—a Microbiological Safety and Hygiene Challenge? 野生野味——微生物安全和卫生挑战?

IF 5.2

Current Clinical Microbiology Reports Pub Date : 2021-02-07 DOI: 10.1007/s40588-021-00158-8

E. Gomes-Neves, A. Abrantes, M. Vieira-Pinto, Alexandra Müller

引用次数: 21