Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public Health Problem.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2022-01-01 Epub Date: 2022-09-27 DOI:10.1007/s40588-022-00181-3

Antonia Langfeldt, Jeremy A W Gold, Tom Chiller

{"title":"Emerging Fungal Infections: from the Fields to the Clinic, Resistant Aspergillus fumigatus and Dermatophyte Species: a One Health Perspective on an Urgent Public Health Problem.","authors":"Antonia Langfeldt, Jeremy A W Gold, Tom Chiller","doi":"10.1007/s40588-022-00181-3","DOIUrl":null,"url":null,"abstract":"Purpose of review: For this review, we use a One Health approach to examine two globally emerging public health threats related to antifungal drug resistance: triazole-resistant Aspergillus fumigatus infections, which can cause a life-threatening illness in immunocompromised hosts, and antifungal-resistant dermatophytosis, which is an aggressive skin infection caused by dermatophyte molds. We describe the state of current scientific knowledge and outline necessary public health actions to address each issue.Recent findings: Recent evidence has identified the agricultural use of triazole fungicides as an important driver of triazole-resistant A. fumigatus infections. Antifungal-resistant dermatophyte infections are likely driven by the inappropriate use of antifungal drugs and antibacterial and corticosteroid creams.Summary: This review highlights the need for a One Health approach to address emerging antifungal resistant infections, emphasizing judicious antifungal use to preserve available treatments; strengthened laboratory capacity to identify antifungal resistance; and improved human, animal, and environmental surveillance to detect emerging resistance, monitor trends, and evaluate the effectiveness of efforts to decrease spread.","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"9 4","pages":"46-51"},"PeriodicalIF":3.1000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9512973/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Clinical Microbiology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40588-022-00181-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/9/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: For this review, we use a One Health approach to examine two globally emerging public health threats related to antifungal drug resistance: triazole-resistant Aspergillus fumigatus infections, which can cause a life-threatening illness in immunocompromised hosts, and antifungal-resistant dermatophytosis, which is an aggressive skin infection caused by dermatophyte molds. We describe the state of current scientific knowledge and outline necessary public health actions to address each issue.

Recent findings: Recent evidence has identified the agricultural use of triazole fungicides as an important driver of triazole-resistant A. fumigatus infections. Antifungal-resistant dermatophyte infections are likely driven by the inappropriate use of antifungal drugs and antibacterial and corticosteroid creams.

Summary: This review highlights the need for a One Health approach to address emerging antifungal resistant infections, emphasizing judicious antifungal use to preserve available treatments; strengthened laboratory capacity to identify antifungal resistance; and improved human, animal, and environmental surveillance to detect emerging resistance, monitor trends, and evaluate the effectiveness of efforts to decrease spread.

查看原文本刊更多论文

新出现的真菌感染：从田间到临床》，《耐药曲霉菌和皮癣菌种：从单一健康视角看待亟待解决的公共健康问题》，《新出现的真菌感染：从田间到临床》，《耐药曲霉菌和皮癣菌种：从单一健康视角看待亟待解决的公共健康问题》。

综述的目的：在这篇综述中，我们采用 "一体健康 "方法研究了与抗真菌药物耐药性有关的两种全球新出现的公共卫生威胁：耐三唑曲霉菌感染和耐抗真菌皮癣菌病，前者可导致免疫力低下的宿主患上危及生命的疾病，后者则是由皮癣菌引起的一种侵袭性皮肤感染。我们描述了当前的科学知识状况，并概述了解决每个问题所需的公共卫生行动：最近的证据表明，农业中使用三唑类杀菌剂是导致抗三唑类药物的烟曲霉菌感染的重要原因。抗真菌耐药性皮癣菌感染很可能是由于抗真菌药物以及抗菌和皮质类固醇药膏的不当使用造成的。总结：本综述强调了采用 "一体健康 "方法应对新出现的抗真菌耐药性感染的必要性，强调要明智使用抗真菌药物，以保护可用的治疗方法；加强实验室能力，以确定抗真菌耐药性；改进人类、动物和环境监测，以检测新出现的耐药性、监测趋势并评估减少传播的工作成效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.