Schizophrenia Research and Treatment最新文献_第3页

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2018-01-01 DOI: 10.1155/2018/8501973

Lâle Battal Merlet, Alain Blanchet, Hazlin Lockman, Milena Kostova

{"title":"An Event Related Potentials Study of Semantic Coherence Effect during Episodic Encoding in Schizophrenia Patients.","authors":"Lâle Battal Merlet, Alain Blanchet, Hazlin Lockman, Milena Kostova","doi":"10.1155/2018/8501973","DOIUrl":"https://doi.org/10.1155/2018/8501973","url":null,"abstract":"The objective of this electrophysiological study was to investigate the processing of semantic coherence during encoding in relation to episodic memory processes promoted at test, in schizophrenia patients, by using the N400 paradigm. Eighteen schizophrenia patients and 15 healthy participants undertook a recognition memory task. The stimuli consisted of pairs of words either semantically related or unrelated to a given category name (context). During encoding, both groups exhibited an N400 external semantic coherence effect. Healthy controls also showed an N400 internal semantic coherence effect, but this effect was not present in patients. At test, related stimuli were accompanied by an FN400 old/new effect in both groups and by a parietal old/new effect in the control group alone. In the patient group, external semantic coherence effect was associated with FN400, while, in the control group, it was correlated to the parietal old/new effect. Our results indicate that schizophrenia patients can process the contextual information at encoding to enhance familiarity process for related stimuli at test. Therefore, cognitive rehabilitation therapies targeting the implementation of semantic encoding strategies can mobilize familiarity which in turn can overcome the recollection deficit, promoting successful episodic memory performance in schizophrenia patients.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2018 ","pages":"8501973"},"PeriodicalIF":2.4,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8501973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35911749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study. 异常的N400语义启动效应可能反映精神分裂症的精神病理过程:一项双胞胎研究。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-08-28 DOI: 10.1155/2017/7163198

Anuradha Sharma, Heinrich Sauer, Holger Hill, Claudia Kaufmann, Stephan Bender, Matthias Weisbrod

{"title":"Abnormal N400 Semantic Priming Effect May Reflect Psychopathological Processes in Schizophrenia: A Twin Study.","authors":"Anuradha Sharma, Heinrich Sauer, Holger Hill, Claudia Kaufmann, Stephan Bender, Matthias Weisbrod","doi":"10.1155/2017/7163198","DOIUrl":"https://doi.org/10.1155/2017/7163198","url":null,"abstract":"Objective: Activation of semantic networks is indexed by the N400 effect. We used a twin study design to investigate whether N400 effect abnormalities reflect genetic/trait liability or are related to psychopathological processes in schizophrenia.Methods: We employed robust linear regression to compare N400 and behavioral priming effects across 36 monozygotic twin pairs (6 pairs concordant for schizophrenia/schizoaffective disorder, 11 discordant pairs, and 19 healthy control pairs) performing a lexical decision task. Moreover, we examined the correlation between Brief Psychiatric Rating Scale (BPRS) score and the N400 effect and the influence of medication status on this effect.Results: Regression yielded a significant main effect of group on the N400 effect only in the direct priming condition (p = 0.003). Indirect condition and behavioral priming effect showed no significant effect of group. Planned contrasts with the control group as a reference group revealed that affected concordant twins had significantly reduced N400 effect compared to controls, and discordant affected twins had a statistical trend for reduced N400 effect compared to controls. The unaffected twins did not differ significantly from the controls. There was a trend for correlation between reduced N400 effect and higher BPRS scores, and the N400 effect did not differ significantly between medicated and unmedicated patients.Conclusions: Reduced N400 effect may reflect disease-specific processes in schizophrenia implicating frontotemporal brain network in schizophrenia pathology.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2017 ","pages":"7163198"},"PeriodicalIF":2.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7163198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35429324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. 出生季节和细胞因子基因对普通人群分裂型性状的互作效应。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-12-31 DOI: 10.1155/2017/5763094

Margarita V Alfimova, Galina I Korovaitseva, Tatyana V Lezheiko, Vera E Golimbet

{"title":"Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population.","authors":"Margarita V Alfimova, Galina I Korovaitseva, Tatyana V Lezheiko, Vera E Golimbet","doi":"10.1155/2017/5763094","DOIUrl":"https://doi.org/10.1155/2017/5763094","url":null,"abstract":"Literature suggests that the effect of winter birth on vulnerability to schizophrenia might be mediated by increased expression of proinflammatory cytokines due to prenatal infection and its inadequate regulation by anti-inflammatory factors. As the response of the immune system depends on genotype, this study assessed the interaction effects of cytokine genes and season of birth (SOB) on schizotypy measured with the Schizotypal Personality Questionnaire (SPQ-74). We searched for associations of IL1B rs16944, IL4 rs2243250, and IL-1RN VNTR polymorphisms, SOB, and their interactions with the SPQ-74 total score in a sample of 278 healthy individuals. A significant effect of the IL4 X SOB interaction was found, p = 0.007 and η2 = 0.028. We confirmed this effect using an extended sample of 373 individuals. Homozygotes CC born in winter showed the highest SPQ total score and differed significantly from winter-born T allele carriers, p = 0.049. This difference was demonstrated for cognitive-perceptual and disorganized but not interpersonal dimensions. The findings are consistent with the hypothesis that the cytokine genes by SOB interaction can influence variability of schizotypal traits in the general population. The IL4 T allele appeared to have a protective effect against the development of positive and disorganized schizotypal traits in winter-born individuals.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2017 ","pages":"5763094"},"PeriodicalIF":2.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5763094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35849383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Impact of Pharmacist Counselling on Clozapine Knowledge. 药师咨询对氯氮平知识的影响。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-06-13 DOI: 10.1155/2017/6120970

Ciara Ní Dhubhlaing, Ailish Young, Laura J Sahm

{"title":"Impact of Pharmacist Counselling on Clozapine Knowledge.","authors":"Ciara Ní Dhubhlaing, Ailish Young, Laura J Sahm","doi":"10.1155/2017/6120970","DOIUrl":"https://doi.org/10.1155/2017/6120970","url":null,"abstract":"Clozapine is the only antipsychotic with evidence for efficacy in treatment of resistant schizophrenia but it carries a high side effect burden. Patient information is provided but may be poorly retained. This study aims to examine the impact of pharmacist counselling upon patient knowledge of clozapine. Outpatients, aged 18 years and over, attending St. Patrick's University Hospital, Dublin, participated in this study between June and August 2015. The intervention consisted of pharmacist counselling on two occasions one month apart. Knowledge was assessed using a 28-point checklist devised from the currently available clozapine patient information sources, at baseline and after each counselling session. Ethics approval was obtained. Twenty-five participants (40% female; mean age 45.1 years, SD 9.82; 64% unemployed, 28% smokers) showed an improvement in knowledge scores of clozapine from baseline to postcounselling on each occasion with an overall improvement in knowledge score, from baseline to postcounselling at one month, of 39.43%; p < 0.001. This study adds to the evidence that interventions involving pharmacist counselling can improve patient knowledge, whilst the specific knowledge gained relating to recognition of side effects may help patients towards more empowerment regarding their treatment.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2017 ","pages":"6120970"},"PeriodicalIF":2.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6120970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35158941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Improving Theory of Mind in Schizophrenia by Targeting Cognition and Metacognition with Computerized Cognitive Remediation: A Multiple Case Study. 以认知和元认知为目标的计算机认知修复改善精神分裂症患者的心理理论:一个多案例研究。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-01-26 DOI: 10.1155/2017/7203871

Élisabeth Thibaudeau, Caroline Cellard, Clare Reeder, Til Wykes, Hans Ivers, Michel Maziade, Marie-Audrey Lavoie, William Pothier, Amélie M Achim

{"title":"Improving Theory of Mind in Schizophrenia by Targeting Cognition and Metacognition with Computerized Cognitive Remediation: A Multiple Case Study.","authors":"Élisabeth Thibaudeau, Caroline Cellard, Clare Reeder, Til Wykes, Hans Ivers, Michel Maziade, Marie-Audrey Lavoie, William Pothier, Amélie M Achim","doi":"10.1155/2017/7203871","DOIUrl":"https://doi.org/10.1155/2017/7203871","url":null,"abstract":"Schizophrenia is associated with deficits in theory of mind (ToM) (i.e., the ability to infer the mental states of others) and cognition. Associations have often been reported between cognition and ToM, and ToM mediates the relationship between impaired cognition and impaired functioning in schizophrenia. Given that cognitive deficits could act as a limiting factor for ToM, this study investigated whether a cognitive remediation therapy (CRT) that targets nonsocial cognition and metacognition could improve ToM in schizophrenia. Four men with schizophrenia received CRT. Assessments of ToM, cognition, and metacognition were conducted at baseline and posttreatment as well as three months and 1 year later. Two patients reached a significant improvement in ToM immediately after treatment whereas at three months after treatment all four cases reached a significant improvement, which was maintained through 1 year after treatment for all three cases that remained in the study. Improvements in ToM were accompanied by significant improvements in the most severely impaired cognitive functions at baseline or by improvements in metacognition. This study establishes that a CRT program that does not explicitly target social abilities can improve ToM.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2017 ","pages":"7203871"},"PeriodicalIF":2.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7203871","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34771962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia. 认知正常和低于正常范围的精神分裂症中网络相关区域皮质变薄。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2017-01-01 Epub Date: 2017-02-28 DOI: 10.1155/2017/9760905

R Walter Heinrichs, Farena Pinnock, Melissa Parlar, Colin Hawco, Lindsay Hanford, Geoffrey B Hall

{"title":"Cortical Thinning in Network-Associated Regions in Cognitively Normal and Below-Normal Range Schizophrenia.","authors":"R Walter Heinrichs, Farena Pinnock, Melissa Parlar, Colin Hawco, Lindsay Hanford, Geoffrey B Hall","doi":"10.1155/2017/9760905","DOIUrl":"https://doi.org/10.1155/2017/9760905","url":null,"abstract":"This study assessed whether cortical thickness across the brain and regionally in terms of the default mode, salience, and central executive networks differentiates schizophrenia patients and healthy controls with normal range or below-normal range cognitive performance. Cognitive normality was defined using the MATRICS Consensus Cognitive Battery (MCCB) composite score (T = 50 ± 10) and structural magnetic resonance imaging was used to generate cortical thickness data. Whole brain analysis revealed that cognitively normal range controls (n = 39) had greater cortical thickness than both cognitively normal (n = 17) and below-normal range (n = 49) patients. Cognitively normal controls also demonstrated greater thickness than patients in regions associated with the default mode and salience, but not central executive networks. No differences on any thickness measure were found between cognitively normal range and below-normal range controls (n = 24) or between cognitively normal and below-normal range patients. In addition, structural covariance between network regions was high and similar across subgroups. Positive and negative symptom severity did not correlate with thickness values. Cortical thinning across the brain and regionally in relation to the default and salience networks may index shared aspects of the psychotic psychopathology that defines schizophrenia with no relation to cognitive impairment.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2017 ","pages":"9760905"},"PeriodicalIF":2.4,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9760905","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34861755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Sex Differences in Severity, Social Functioning, Adherence to Treatment, and Cognition of Adolescents with Schizophrenia 青少年精神分裂症严重程度、社会功能、治疗依从性和认知的性别差异

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-09-14 DOI: 10.1155/2016/1928747

Rodolfo Pérez-Garza, Gamaliel Victoria-Figueroa, R. E. Ulloa-Flores

{"title":"Sex Differences in Severity, Social Functioning, Adherence to Treatment, and Cognition of Adolescents with Schizophrenia","authors":"Rodolfo Pérez-Garza, Gamaliel Victoria-Figueroa, R. E. Ulloa-Flores","doi":"10.1155/2016/1928747","DOIUrl":"https://doi.org/10.1155/2016/1928747","url":null,"abstract":"Background. Previous studies have reported sex differences in the clinical presentation and outcome of adult patients with schizophrenia; the aim of present study was to compare the clinical characteristics, social functioning, adherence to treatment, and cognition of adolescents with this diagnosis in a six-month followup. Methods. A total of 87 adolescents with a DSM-IV diagnosis of schizophrenia or schizophreniform disorder were evaluated with the Positive and Negative Symptoms Scale (PANSS), the Matrics Consensus Cognitive Battery (MCCB), Personal and Social Performance Scale (PSP), and the Rating of Medication Influences (ROMI). Results. Both groups showed a similar improvement in all PANSS factors and in the PSP scores during the followup. Males better adhered to treatment. Females displayed better results in the area of social cognition (F = 6.3, df = 2,52, and p = 0.003) and attention/vigilance (F = 8.3, df = 2,51, and p = 0.001). Conclusions. Male and female adolescents showed similar clinical presentation and functioning but a different pattern of cognitive improvement and adherence to treatment. This trial is registered with Clinicaltrials.gov II3/02/0811.‏","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"55 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2016-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84535936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone? 神经活性类固醇治疗首发精神病:黄体酮的作用?

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-08-17 DOI: 10.1155/2016/1942828

M. Belvederi Murri, F. Fanelli, U. Pagotto, E. Bonora, F. Triolo, L. Chiri, F. Allegri, M. Mezzullo, M. Menchetti, V. Mondelli, C. Pariante, D. Berardi, I. Tarricone

引用次数: 14

Parents' Experiences of Caring Responsibility for Their Adult Child with Schizophrenia 父母照顾精神分裂症成年子女的经验

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-02-04 DOI: 10.1155/2016/1958198

Ann Blomgren Mannerheim, Ulla Hellström Muhli, Eleni Siouta

{"title":"Parents' Experiences of Caring Responsibility for Their Adult Child with Schizophrenia","authors":"Ann Blomgren Mannerheim, Ulla Hellström Muhli, Eleni Siouta","doi":"10.1155/2016/1958198","DOIUrl":"https://doi.org/10.1155/2016/1958198","url":null,"abstract":"As a consequence of the latest psychiatry-related reform in Sweden and its implementation, relatives and family members have taken over from the formal healthcare system significant responsibility for the care of persons with a mental disability and illness. The aim of this study was to systematically describe and analyze the experiences of parents' informal care responsibility. The questions were, what are the experiences around parents' informal care activities and responsibilities and how do parents construct and manage their caring responsibility and with what consequences? Semistructured in-depth interviews were conducted (16 hours of recorded material) with eight parents who were all members of the Interest Association for Schizophrenia (Intresseföreningen för Schizofreni (IFS)) in Sweden. A mixed hermeneutic deductive and inductive method was used for the interpretation of the material. The parents endow their informal caring responsibility with meaning of being a good, responsible, and accountable parent with respect to their social context and social relationships as well as with respect to the psychiatric care representatives. In this tense situation, parents compromise between elements of struggle, cooperation, avoidance, and adaption in their interaction with the world outside, meaning the world beyond the care provision for their child, as well as with the world inside themselves.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"135 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2016-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86381886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Neurophysiology for Detection of High Risk for Psychosis. 精神疾病高危人群的神经生理学检测。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-08-07 DOI: 10.1155/2016/2697971

Lara N Pantlin, Deana Davalos

{"title":"Neurophysiology for Detection of High Risk for Psychosis.","authors":"Lara N Pantlin, Deana Davalos","doi":"10.1155/2016/2697971","DOIUrl":"https://doi.org/10.1155/2016/2697971","url":null,"abstract":"Schizophrenia is a complex and often disabling disorder that is characterized by a wide range of social, emotional, and cognitive deficits. Increasing research suggests that the greatest social and cognitive therapeutic impact comes from early identification. The present study applied a well-established neurophysiological paradigm in the schizophrenia literature, mismatch negativity (MMN), to college students identified as high risk (HR) for psychosis to investigate MMN as a potential biomarker for the onset of psychosis. The hypothesis was that HR would exhibit attenuated MMN amplitudes compared to controls, as has been established in individuals with chronic schizophrenia. Participants (N = 121) were separated into Group 1 (controls) (n 1 = 72) and Group 2 (HR) (n 2 = 49) based on the established cutoff score of the 16-item Prodromal Questionnaire. Participants then completed a time based MMN paradigm during which brain activity was recorded with EEG. For all electrode locations, controls demonstrated significantly more negative amplitudes than HR (Cz: F(1,119) = 8.09, p = .005; Fz: F(1, 119) = 5.74, p = .018; Pz: F(1,119) = 5.88, p = .017). Results suggested that MMN may assist in identifying those who appear high-functioning but may be at risk for later development of psychosis or cognitive and psychological difficulties associated with psychosis. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2016 ","pages":"2697971"},"PeriodicalIF":2.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2697971","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34405107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12