Neurophysiology for Detection of High Risk for Psychosis.

IF 3.6 Q1 PSYCHIATRY
Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-08-07 DOI:10.1155/2016/2697971
Lara N Pantlin, Deana Davalos
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引用次数: 12

Abstract

Schizophrenia is a complex and often disabling disorder that is characterized by a wide range of social, emotional, and cognitive deficits. Increasing research suggests that the greatest social and cognitive therapeutic impact comes from early identification. The present study applied a well-established neurophysiological paradigm in the schizophrenia literature, mismatch negativity (MMN), to college students identified as high risk (HR) for psychosis to investigate MMN as a potential biomarker for the onset of psychosis. The hypothesis was that HR would exhibit attenuated MMN amplitudes compared to controls, as has been established in individuals with chronic schizophrenia. Participants (N = 121) were separated into Group 1 (controls) (n 1 = 72) and Group 2 (HR) (n 2 = 49) based on the established cutoff score of the 16-item Prodromal Questionnaire. Participants then completed a time based MMN paradigm during which brain activity was recorded with EEG. For all electrode locations, controls demonstrated significantly more negative amplitudes than HR (Cz: F(1,119) = 8.09, p = .005; Fz: F(1, 119) = 5.74, p = .018; Pz: F(1,119) = 5.88, p = .017). Results suggested that MMN may assist in identifying those who appear high-functioning but may be at risk for later development of psychosis or cognitive and psychological difficulties associated with psychosis.

Abstract Image

精神疾病高危人群的神经生理学检测。
精神分裂症是一种复杂且经常致残的疾病,其特征是广泛的社会、情感和认知缺陷。越来越多的研究表明,最大的社会和认知治疗影响来自早期识别。本研究应用精神分裂症文献中一个成熟的神经生理学范式,失配负性(MMN),对被确定为精神病高风险(HR)的大学生进行研究,以探讨MMN作为精神病发病的潜在生物标志物。假设是,与对照组相比,HR会表现出减弱的MMN振幅,这在慢性精神分裂症患者中已经得到证实。根据16项前驱症状问卷的截止分值,将121名参与者分为1组(对照组)(72名)和2组(HR)(49名)。然后,参与者完成了一个基于时间的MMN模式,在此过程中,大脑活动被EEG记录下来。对于所有电极位置,对照组的负振幅明显大于HR (Cz: F(1,119) = 8.09, p = 0.005;Fz: F(1,119) = 5.74, p = 0.018;Pz: F(1,119) = 5.88, p = 0.017)。结果表明,MMN可能有助于识别那些表现出高功能,但可能有后期发展为精神病或与精神病相关的认知和心理困难风险的人。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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