An Event Related Potentials Study of Semantic Coherence Effect during Episodic Encoding in Schizophrenia Patients.

IF 3.6 Q1 PSYCHIATRY
Lâle Battal Merlet, Alain Blanchet, Hazlin Lockman, Milena Kostova
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引用次数: 3

Abstract

The objective of this electrophysiological study was to investigate the processing of semantic coherence during encoding in relation to episodic memory processes promoted at test, in schizophrenia patients, by using the N400 paradigm. Eighteen schizophrenia patients and 15 healthy participants undertook a recognition memory task. The stimuli consisted of pairs of words either semantically related or unrelated to a given category name (context). During encoding, both groups exhibited an N400 external semantic coherence effect. Healthy controls also showed an N400 internal semantic coherence effect, but this effect was not present in patients. At test, related stimuli were accompanied by an FN400 old/new effect in both groups and by a parietal old/new effect in the control group alone. In the patient group, external semantic coherence effect was associated with FN400, while, in the control group, it was correlated to the parietal old/new effect. Our results indicate that schizophrenia patients can process the contextual information at encoding to enhance familiarity process for related stimuli at test. Therefore, cognitive rehabilitation therapies targeting the implementation of semantic encoding strategies can mobilize familiarity which in turn can overcome the recollection deficit, promoting successful episodic memory performance in schizophrenia patients.

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精神分裂症患者情景编码中语义连贯效应的事件相关电位研究。
本电生理研究的目的是利用N400范式,探讨精神分裂症患者编码过程中语义连贯的加工与测试中促进的情景记忆过程的关系。18名精神分裂症患者和15名健康参与者接受了识别记忆任务。刺激物由与给定类别名称(上下文)语义相关或不相关的词对组成。在编码过程中,两组均表现出N400的外部语义连贯效应。健康对照组也表现出N400内部语义连贯效应,但这种效应在患者中不存在。在测试中,相关刺激在两组中都伴有FN400旧/新效应,而在对照组中仅伴有顶叶旧/新效应。患者组外语义连贯效应与FN400相关,对照组外语义连贯效应与顶叶新旧效应相关。研究结果表明,精神分裂症患者在编码过程中可以对情境信息进行加工,从而增强对相关刺激的熟悉过程。因此,以语义编码策略为目标的认知康复治疗可以调动熟悉度,从而克服回忆缺陷,促进精神分裂症患者成功的情景记忆表现。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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