Schizophrenia Research and Treatment最新文献_第4页

Symptoms and Etiological Attribution: A Cross-Sectional Study in Mexican Outpatients with Psychosis and Their Relatives. 症状和病因归因:墨西哥精神病门诊患者及其亲属的横断面研究。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-06-16 DOI: 10.1155/2016/9549683

Lizzette Gómez-de-Regil, Agnès Ros-Morente, Gisela Rodríguez-Hansen

{"title":"Symptoms and Etiological Attribution: A Cross-Sectional Study in Mexican Outpatients with Psychosis and Their Relatives.","authors":"Lizzette Gómez-de-Regil, Agnès Ros-Morente, Gisela Rodríguez-Hansen","doi":"10.1155/2016/9549683","DOIUrl":"https://doi.org/10.1155/2016/9549683","url":null,"abstract":"This cross-sectional study aimed at identifying the most common attributions of their mental disorder in a Mexican patients who have experienced psychosis and their relatives and exploring how having experienced or not characteristic psychotic symptoms and their present clinical status might affect their etiological attributions. Past and current symptom profiles of 66 patients were as assessed with the SCID-I (Structured Clinical Interview for DSM-IV Axis I Disorders) and the PANSS (Positive and Negative Syndrome Scale), respectively. The etiological attribution of psychosis of patients (n = 62) and the relatives (n = 65) was assessed with the Angermeyer and Klusmann scale comprising 30 items into five categories: biology, personality, family, society, and esoteric. Patients and relatives attribute psychosis mainly to social factors. Relatives' attributions were not influenced by clinical profile of patients, whereas in the case of patients it was only current clinical status that showed a difference, with those in nonremission scoring higher personality and family factors. Acknowledging patients' and relatives' beliefs about mental disorders at onset and later on is particularly important in psychosis, a mental condition with severe and/or persistent symptoms, in order to promote better involvement in treatment and in consequence efficacy and recovery. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2016 ","pages":"9549683"},"PeriodicalIF":2.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9549683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34668418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the Beck Cognitive Insight Scale Predict Response to Cognitive Remediation in Schizophrenia? 贝克认知洞察力量表能否预测精神分裂症患者对认知补救的反应?

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-07-19 DOI: 10.1155/2016/6371856

Audrey Benoit, Philippe-Olivier Harvey, Louis Bherer, Martin Lepage

{"title":"Does the Beck Cognitive Insight Scale Predict Response to Cognitive Remediation in Schizophrenia?","authors":"Audrey Benoit, Philippe-Olivier Harvey, Louis Bherer, Martin Lepage","doi":"10.1155/2016/6371856","DOIUrl":"https://doi.org/10.1155/2016/6371856","url":null,"abstract":"Cognitive remediation therapy (CRT) has emerged as a viable treatment option for people diagnosed with schizophrenia presenting disabling cognitive deficits. However, it is important to determine which variables can influence response to CRT in order to provide cost-effective treatment. This study's aim was to explore cognitive insight as a potential predictor of cognitive improvement after CRT. Twenty patients with schizophrenia completed a 24-session CRT program involving 18 hours of computer exercises and 6 hours of group discussion to encourage generalization of cognitive training to everyday activities. Pre- and posttest assessments included the CogState Research Battery and the Beck Cognitive Insight Scale (BCIS). Lower self-certainty on the BCIS at baseline was associated with greater improvement in speed of processing (r s = -0.48; p < 0.05) and visual memory (r s = -0.46; p < 0.05). The results of this study point out potential associations between self-certainty and cognitive improvement after CRT, a variable that can easily be measured in clinical settings to help evaluate which patients may benefit most from the intervention. They also underline the need to keep investigating the predictors of good CRT outcomes, which can vary widely between patients. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2016 ","pages":"6371856"},"PeriodicalIF":2.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6371856","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34749921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders. 药物再利用是开发神经精神疾病药物的新机遇。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-03-17 DOI: 10.1155/2016/6378137

Hyeong-Min Lee, Yuna Kim

引用次数: 0

Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia. 抗精神病和抗胆碱能负荷对精神分裂症患者认知功能的影响。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-04-10 DOI: 10.1155/2016/8213165

Michael Rehse, Marina Bartolovic, Katlehn Baum, Dagmar Richter, Matthias Weisbrod, Daniela Roesch-Ely

{"title":"Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia.","authors":"Michael Rehse, Marina Bartolovic, Katlehn Baum, Dagmar Richter, Matthias Weisbrod, Daniela Roesch-Ely","doi":"10.1155/2016/8213165","DOIUrl":"https://doi.org/10.1155/2016/8213165","url":null,"abstract":"Many patients with schizophrenia show cognitive impairment. There is evidence that, beyond a certain dose of antipsychotic medication, the antipsychotic daily dose (ADD) may impair cognitive performance. Parallel to their D2 receptor antagonism, many antipsychotics show a significant binding affinity to cholinergic muscarinic receptors. Pharmacological treatment with a high anticholinergic daily dose (CDD) significantly impairs attention and memory performance. To examine the relationships between individual cognitive performance and ADD and/or CDD, we conducted a retrospective record-based analysis of a sample of n = 104 in patients with a diagnosis of schizophrenia, all of whom had completed a comprehensive neuropsychological test battery. To calculate the individual ADD and CDD, the medication at the time of testing was converted according to equivalence models. After extracting five principal cognitive components, we examined the impact of ADD and CDD on cognitive performance in the medicated sample and subgroups using multiple regression analysis. Finally, locally weighted scatterplot smoothing (Loess) was applied to further explore the course of cognitive performance under increasing dosage. Results showed significant negative effects of ADD on performance in tests of information processing speed and verbal memory. No effects were found for CDD. The potential neuropsychopharmacological and clinical implications are discussed. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2016 ","pages":"8213165"},"PeriodicalIF":2.4,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8213165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34370047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course 生殖期妄想障碍:更年期对临床病程的潜在影响

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2015-10-27 DOI: 10.1155/2015/979605

A. González-Rodríguez, O. Molina-Andreu, R. Penadés, M. Garriga, A. Pons, R. Catalán, M. Bernardo

{"title":"Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course","authors":"A. González-Rodríguez, O. Molina-Andreu, R. Penadés, M. Garriga, A. Pons, R. Catalán, M. Bernardo","doi":"10.1155/2015/979605","DOIUrl":"https://doi.org/10.1155/2015/979605","url":null,"abstract":"Background and Objectives. Recent evidence supports an association between estrogen levels and severity of psychopathology in schizophrenia women. Our main goal was to investigate whether delusional disorder (DD) women with premenopausal onset and those with postmenopausal onset differ in demographic and clinical features. Methods. Psychopathological symptoms were assessed in 80 DD women (DSM-IV-TR), at baseline and after six and 24 months. Scores in the PANSS, PSP for functionality, HRSD 17 items, C-SSRS for suicide, and the SUMD were considered outcome variables. For comparison purposes, t- and χ 2-tests were performed and nonparametric tests when necessary. Analysis of Covariance (ANCOVA) was conducted for multivariate comparisons. Results. 57 out of 80 DD women completed the study. When unadjusted, DD with premenopausal onset had a longer DUP, higher educational level, and a tendency toward higher rates of gynaecological disorders. Erotomanic type was most frequent in DD women premenopausal onset, and somatic and jealous types were most frequent in those with postmenopausal onset. After 24 months, DD women with premenopausal onset showed higher depressive symptoms and a tendency toward higher rates of psychotic relapses. Conclusions. Our results support that some aspects of psychopathology and insight may differ according to the onset of DD and the reproductive status.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"60 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2015-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75100948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review. 1966年芬兰北部出生队列二十年精神分裂症研究:系统回顾。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-05-18 DOI: 10.1155/2015/524875

Erika Jääskeläinen, Marianne Haapea, Nina Rautio, Pauliina Juola, Matti Penttilä, Tanja Nordström, Ina Rissanen, Anja Husa, Emmi Keskinen, Riikka Marttila, Svetlana Filatova, Tiina-Mari Paaso, Jenni Koivukangas, Kristiina Moilanen, Matti Isohanni, Jouko Miettunen

{"title":"Twenty Years of Schizophrenia Research in the Northern Finland Birth Cohort 1966: A Systematic Review.","authors":"Erika Jääskeläinen, Marianne Haapea, Nina Rautio, Pauliina Juola, Matti Penttilä, Tanja Nordström, Ina Rissanen, Anja Husa, Emmi Keskinen, Riikka Marttila, Svetlana Filatova, Tiina-Mari Paaso, Jenni Koivukangas, Kristiina Moilanen, Matti Isohanni, Jouko Miettunen","doi":"10.1155/2015/524875","DOIUrl":"https://doi.org/10.1155/2015/524875","url":null,"abstract":"Birth cohort designs are useful in studying adult disease trajectories and outcomes, such as schizophrenia. We review the schizophrenia research performed in the Northern Finland Birth Cohort 1966 (NFBC 1966), which includes 10,934 individuals living in Finland at 16 years of age who have been monitored since each mother's mid-pregnancy. By the age of 44, 150 (1.4%) had developed schizophrenia. There are 77 original papers on schizophrenia published from the NFBC 1966. The early studies have found various risk factors for schizophrenia, especially related to pregnancy and perinatal phase. Psychiatric and somatic outcomes were heterogeneous, but relatively poor. Mortality in schizophrenia is high, especially due to suicides. Several early predictors of outcomes have also been found. Individuals with schizophrenia have alterations in brain morphometry and neurocognition, and our latest studies have found that the use of high lifetime doses of antipsychotics associated with these changes. The schizophrenia research in the NFBC 1966 has been especially active for 20 years, the prospective study design and long follow-up enabling several clinically and epidemiologically important findings. When compared to other birth cohorts, the research in the NFBC 1966 has offered also unique findings on course and outcome of schizophrenia. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2015 ","pages":"524875"},"PeriodicalIF":2.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/524875","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33401386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

The Impact of Childhood Adversity on the Clinical Features of Schizophrenia. 童年逆境对精神分裂症临床特征的影响。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-08-04 DOI: 10.1155/2015/532082

Ravi Philip Rajkumar

{"title":"The Impact of Childhood Adversity on the Clinical Features of Schizophrenia.","authors":"Ravi Philip Rajkumar","doi":"10.1155/2015/532082","DOIUrl":"https://doi.org/10.1155/2015/532082","url":null,"abstract":"Introduction. Recent research has drawn attention to the link between childhood maltreatment and schizophrenia. Child abuse and neglect may have an impact on symptoms and physical health in these patients. This association has not been studied to date in India. Materials and Methods. Clinically stable patients with schizophrenia (n = 62) were assessed for childhood adversity using the Childhood Trauma Questionnaire. The association of specific forms of adversity with symptomatology and associated variables was examined. Results. Emotional abuse was reported by 56.5% patients and physical abuse by 33.9%; scores for childhood neglect were also high. Persecutory delusions were linked to physical abuse, while anxiety was linked to emotional neglect and depression to emotional abuse and childhood neglect. Physical abuse was linked to elevated systolic blood pressure, while emotional abuse and neglect in women were linked to being overweight. Conclusions. Childhood adversity is common in schizophrenia and appears to be associated with a specific symptom profile. Certain components of the metabolic syndrome also appear to be related to childhood adversity. These results are subject to certain limitations as they are derived from remitted patients, and no control group was used for measures of childhood adversity. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2015 ","pages":"532082"},"PeriodicalIF":2.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/532082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33983425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Arousal Predisposition as a Vulnerability Indicator for Psychosis: A General Population Online Stress Induction Study. 唤醒易感性作为精神病的脆弱性指标:一项普通人群在线应激诱导研究。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2015-01-01 Epub Date: 2015-06-23 DOI: 10.1155/2015/725136

Annika Clamor, A Malika Warmuth, Tania M Lincoln

{"title":"Arousal Predisposition as a Vulnerability Indicator for Psychosis: A General Population Online Stress Induction Study.","authors":"Annika Clamor, A Malika Warmuth, Tania M Lincoln","doi":"10.1155/2015/725136","DOIUrl":"https://doi.org/10.1155/2015/725136","url":null,"abstract":"Explanatory models ascribe to arousability a central role for the development of psychotic symptoms. Thus, a disposition to hyperarousal (i.e., increased arousal predisposition (AP)) may serve as an underlying vulnerability indicator for psychosis by interacting with stressors to cause symptoms. In this case, AP, stress-response, and psychotic symptoms should be linked before the development of a diagnosable psychotic disorder. We conducted a cross-sectional online study in a population sample (N = 104; M age = 27.7 years, SD = 11.2, range 18-70). Participants rated their AP and subclinical psychotic symptoms. Participants reported their stress-levels before and after two stress inductions including an arithmetic and a social stressor. The participants with an increased AP generally felt more stressed. However, AP was not associated with the specific stress-response. As expected, positive psychotic symptoms were significantly associated with AP, but this was not mediated by general stress-levels. Its association to subtle, nonclinical psychotic symptoms supports our assumption that AP could be a vulnerability indicator for psychosis. The trait is easily accessible via a short self-report and could facilitate the identification of people at risk and be a promising target for early stress-management. Further research is needed to clarify its predictive value for stress-responses. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2015 ","pages":"725136"},"PeriodicalIF":2.4,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2015/725136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33859192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Prolactin and psychopathology in schizophrenia: a literature review and reappraisal. 催乳素与精神分裂症的精神病理:文献回顾与再评价。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-03-27 DOI: 10.1155/2014/175360

Ravi Philip Rajkumar

引用次数: 36

Effect of a system-oriented intervention on compliance problems in schizophrenia: a pragmatic controlled trial. 系统导向干预对精神分裂症患者依从性问题的影响:一项实用对照试验。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2014-01-01 Epub Date: 2014-06-02 DOI: 10.1155/2014/789403

Hanne Skarsholm, Henrik Stoevring, Bent Nielsen

{"title":"Effect of a system-oriented intervention on compliance problems in schizophrenia: a pragmatic controlled trial.","authors":"Hanne Skarsholm, Henrik Stoevring, Bent Nielsen","doi":"10.1155/2014/789403","DOIUrl":"https://doi.org/10.1155/2014/789403","url":null,"abstract":"Background. Numerous studies have been conducted with a view to developing strategies for improvement of medical compliance in patients with schizophrenia. All of the studies conducted so far have had an individual approach to compliance based on the assumption that noncompliance is determined individually due to inappropriate behavior in the patient. We conducted a pragmatic controlled trial with a system-oriented approach, to provide a new perspective on compliance and test the efficacy of a multifactorial intervention at the system level in a routine clinical setting, an approach that has not previously been used for the improvement of compliance. Methods. 30 patients were allocated to the system-oriented therapy and 40 patients were allocated to the reference intervention, which consisted of individually based compliance therapy. The follow-up period was six months. Primary endpoint was improvement in compliance, measured by improvement in a compliance scale specifically developed for the project. Results. When accounting for missing values with a multiple imputation approach, we found a tendency toward a difference in both the compliance scale and PANSS favoring the system-oriented therapy, although it did not reach statistical significance. A significant difference in incidence of adverse events and time to first readmission was found. Attrition rates were significantly higher in the reference group and nonsignificant among individuals with lower compliance, which may have diluted effect estimates. This was reflected by significant differences found in an analysis based on a last observation carried forward approach. Conclusion. This study suggests that compliance problems are better solved by a multifactorial intervention at the system level than at the individual level. ","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":"2014 ","pages":"789403"},"PeriodicalIF":2.4,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/789403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32479010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4