神经活性类固醇治疗首发精神病:黄体酮的作用?

IF 3.6 Q1 PSYCHIATRY
Schizophrenia Research and Treatment Pub Date : 2016-01-01 Epub Date: 2016-09-22 DOI:10.1155/2016/1942828
Martino Belvederi Murri, Flaminia Fanelli, Uberto Pagotto, Elena Bonora, Federico Triolo, Luigi Chiri, Fabio Allegri, Marco Mezzullo, Marco Menchetti, Valeria Mondelli, Carmine Pariante, Domenico Berardi, Ilaria Tarricone
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引用次数: 0

摘要

神经活性类固醇可能在精神障碍的病理生理中起作用,但很少有研究调查这一问题。我们比较了首发精神病(FEP)患者的代表性样本和年龄和性别匹配的健康受试者的血清皮质醇、睾酮、脱氢表雄酮和孕酮水平。此外,我们分析了神经活性类固醇水平与精神病症状严重程度之间的关系。男性患者的孕酮水平低于对照组(p = 0.03)。孕酮水平与阳性症状的严重程度呈负相关(p = 0.007)。与临床前研究结果一致,结果表明黄体酮可能在精神障碍的病理生理中起作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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