神经活性类固醇治疗首发精神病:黄体酮的作用?

IF 3.6 Q1 PSYCHIATRY

Schizophrenia Research and Treatment Pub Date : 2016-08-17 DOI:10.1155/2016/1942828

M. Belvederi Murri, F. Fanelli, U. Pagotto, E. Bonora, F. Triolo, L. Chiri, F. Allegri, M. Mezzullo, M. Menchetti, V. Mondelli, C. Pariante, D. Berardi, I. Tarricone

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引用次数: 14

摘要

神经活性类固醇可能在精神障碍的病理生理中起作用，但很少有研究调查这一问题。我们比较了首发精神病(FEP)患者的代表性样本和年龄和性别匹配的健康受试者的血清皮质醇、睾酮、脱氢表雄酮和孕酮水平。此外，我们分析了神经活性类固醇水平与精神病症状严重程度之间的关系。男性患者的孕酮水平低于对照组(p = 0.03)。孕酮水平与阳性症状的严重程度呈负相关(p = 0.007)。与临床前研究结果一致，结果表明黄体酮可能在精神障碍的病理生理中起作用。

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Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.

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来源期刊

Schizophrenia Research and Treatment PSYCHIATRY-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.