Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?

IF 3.6 Q1 PSYCHIATRY
M. Belvederi Murri, F. Fanelli, U. Pagotto, E. Bonora, F. Triolo, L. Chiri, F. Allegri, M. Mezzullo, M. Menchetti, V. Mondelli, C. Pariante, D. Berardi, I. Tarricone
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引用次数: 14

Abstract

Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
神经活性类固醇治疗首发精神病:黄体酮的作用?
神经活性类固醇可能在精神障碍的病理生理中起作用,但很少有研究调查这一问题。我们比较了首发精神病(FEP)患者的代表性样本和年龄和性别匹配的健康受试者的血清皮质醇、睾酮、脱氢表雄酮和孕酮水平。此外,我们分析了神经活性类固醇水平与精神病症状严重程度之间的关系。男性患者的孕酮水平低于对照组(p = 0.03)。孕酮水平与阳性症状的严重程度呈负相关(p = 0.007)。与临床前研究结果一致,结果表明黄体酮可能在精神障碍的病理生理中起作用。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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