Schizophrenia Research and Treatment最新文献_第10页

Elevated serum levels of homocysteine as an early prognostic factor of psychiatric disorders in children and adolescents. 血清同型半胱氨酸水平升高是儿童和青少年精神疾病的早期预后因素。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-10-02 DOI: 10.1155/2012/373261

Laura Kevere, Santa Purvina, Daiga Bauze, Marcis Zeibarts, Raisa Andrezina, Arnis Rizevs, Sergejs Jelisejevs, Linda Piekuse, Madara Kreile, Indulis Purvins

{"title":"Elevated serum levels of homocysteine as an early prognostic factor of psychiatric disorders in children and adolescents.","authors":"Laura Kevere, Santa Purvina, Daiga Bauze, Marcis Zeibarts, Raisa Andrezina, Arnis Rizevs, Sergejs Jelisejevs, Linda Piekuse, Madara Kreile, Indulis Purvins","doi":"10.1155/2012/373261","DOIUrl":"https://doi.org/10.1155/2012/373261","url":null,"abstract":"Background and Goal. The aim was to examine the serum levels of homocysteine (Hcy) and their associations with the methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism in patients with schizophrenia and mood disorders as well as controls. Materials and Methods. There were 198 patients: 82 with schizophrenia spectrum disorders, 22 with mood disorders, and 94 controls. The level of Hcy was determined by an isocratic high-performance liquid chromatography system. MTHFR C677T polymorphism was analysed using the restriction fragment length polymorphism-polymerase chain reaction method. Results. The average level of Hcy was 11.94 ± 5.6 μmol/L for patients with schizophrenia, 11.65 ± 3.3 μmol/L for patients with affective disorders, versus 6.80 ± 2.93 μmol/L in a control. The highest level of Hcy has been observed in patients with episodic-recurrent course of schizophrenia (11.30 ± 7.74 μmol/L), paranoid schizophrenia continuous (12.76 ± 5.25 μmol/L), and in patients with affective disorders (11.65 ± 3.26 μmol/L). An association between the MTHFR gene C677T polymorphism and Hcy level was found by linear regression analysis (r = 1.41, P = 0.029). Conclusions. The data indicate a link between Hcy levels and schizophrenia and mood disorders. No associations between the level of Hcy in patients with schizophrenia and mood disorders and the MTHFR C677T polymorphism were found.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/373261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30997891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Jumping to conclusions is associated with paranoia but not general suspiciousness: a comparison of two versions of the probabilistic reasoning paradigm. 妄下结论与偏执狂有关，但与一般多疑症无关：两种版本概率推理范式的比较。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-10-18 DOI: 10.1155/2012/384039

Steffen Moritz, Niels Van Quaquebeke, Tania M Lincoln

{"title":"Jumping to conclusions is associated with paranoia but not general suspiciousness: a comparison of two versions of the probabilistic reasoning paradigm.","authors":"Steffen Moritz, Niels Van Quaquebeke, Tania M Lincoln","doi":"10.1155/2012/384039","DOIUrl":"10.1155/2012/384039","url":null,"abstract":"Theoretical models ascribe jumping to conclusions (JTCs) a prominent role in the pathogenesis of paranoia. While many earlier studies corroborated this account, some newer investigations have found no or only small associations of the JTC bias with paranoid symptoms. The present study examined whether these inconsistencies in part reflect methodological differences across studies. The study was built upon the psychometric high-risk paradigm. A total of 1899 subjects from the general population took part in an online survey and were administered the Paranoia Checklist as well as one of two different variants of the probabilistic reasoning task: one variant with a traditional instruction (a) and one novel variant that combines probability estimates with decision judgments (b). Factor analysis of the Paranoia Checklist yielded an unspecific suspiciousness factor and a psychotic paranoia factor. The latter was significantly associated with scores indicating hasty decision making. Subjects scoring two standard deviations above the mean of the Paranoia Checklist showed an abnormal data-gathering style relative to subjects with normal scores. Findings suggest that the so-called decision threshold parameter is more sensitive than the conventional JTC index. For future research the specific contents of paranoid beliefs deserve more consideration in the investigation of decision making in schizophrenia as JTC seems to be associated with core psychosis-prone features of paranoia only.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31025434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence: A Case of the Emperor's New Clothes? 精神分裂症新试验的证据与现有证据在哪里相符:皇帝新衣的案例?

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-04-08 DOI: 10.1155/2012/625738

Mahesh Jayaram, Ranganath D Rattehalli, Clive E Adams

{"title":"Where Does Evidence from New Trials for Schizophrenia Fit with the Existing Evidence: A Case of the Emperor's New Clothes?","authors":"Mahesh Jayaram, Ranganath D Rattehalli, Clive E Adams","doi":"10.1155/2012/625738","DOIUrl":"https://doi.org/10.1155/2012/625738","url":null,"abstract":"Advent of \"atypical\" antipsychotics has spawned new trials in the recent years and the number of such trial reports has been increasing exponentially. As clinicians we have been led to believe that \"atypicals\" are better than \"typicals\" despite the odd dissenting voice in academic and clinical circles. This has been largely ignored until the publication of two landmark, independent, pragmatic trials, Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS), which proved that thoughtfully chosen \"typical\" antipsychotics were as good as the newer \"atypicals.\" We pooled \"leaving the study early data\" from Cochrane Reviews that existed before CATIE and CUtLASS and added data from CATIE and CUtLASS to the pool for a \"before and after\" comparison. Addition of CATIE and CUtLASS data only led to narrowing of the already existing confidence intervals, merely increasing precision, and decreasing the risk of Type II error. Perhaps surprisingly, CATIE and CUtLASS when pooled with the already existing data showed us that we had chosen to turn a blind eye to findings that already existed. This leads clinicians to question as to whether, in future, we need to feel less guilty about crying out early on that the emperor has no clothes on.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/625738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30895631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia. 精神分裂症患者情绪加工过程中黄体酮与脑功能的关系

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-02-15 DOI: 10.1155/2012/917901

Julie Champagne, Nadia Lakis, Josiane Bourque, Emmanuel Stip, Olivier Lipp, Adrianna Mendrek

{"title":"Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia.","authors":"Julie Champagne, Nadia Lakis, Josiane Bourque, Emmanuel Stip, Olivier Lipp, Adrianna Mendrek","doi":"10.1155/2012/917901","DOIUrl":"https://doi.org/10.1155/2012/917901","url":null,"abstract":"Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women) and 43 control participants (21 women) underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/917901","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30896096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Evaluation of factors affecting continuous performance test identical pairs version score of schizophrenic patients in a Japanese clinical sample. 日本临床样本中精神分裂症患者连续表现测试同对版本得分影响因素的评价。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-04-02 DOI: 10.1155/2012/970131

Takayoshi Koide, Branko Aleksic, Tsutomu Kikuchi, Masahiro Banno, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Tetsuya Iidaka, Norio Ozaki

{"title":"Evaluation of factors affecting continuous performance test identical pairs version score of schizophrenic patients in a Japanese clinical sample.","authors":"Takayoshi Koide, Branko Aleksic, Tsutomu Kikuchi, Masahiro Banno, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Tetsuya Iidaka, Norio Ozaki","doi":"10.1155/2012/970131","DOIUrl":"https://doi.org/10.1155/2012/970131","url":null,"abstract":"Aim. Cognitive impairment in schizophrenia strongly relates to social outcome and is a good candidate for endophenotypes. When we accurately measure drug efficacy or effects of genes or variants relevant to schizophrenia on cognitive impairment, clinical factors that can affect scores on cognitive tests, such as age and severity of symptoms, should be considered. To elucidate the effect of clinical factors, we conducted multiple regression analysis using scores of the Continuous Performance Test Identical Pairs Version (CPT-IP), which is often used to measure attention/vigilance in schizophrenia. Methods. We conducted the CPT-IP (4-4 digit) and examined clinical information (sex, age, education years, onset age, duration of illness, chlorpromazine-equivalent dose, and Positive and Negative Symptom Scale (PANSS) scores) in 126 schizophrenia patients in Japanese population. Multiple regression analysis was used to evaluate the effect of clinical factors. Results. Age, chlorpromazine-equivalent dose, and PANSS-negative symptom score were associated with mean d' score in patients. These three clinical factors explained about 28% of the variance in mean d' score. Conclusions. As conclusion, CPT-IP score in schizophrenia patients is influenced by age, chlorpromazine-equivalent dose and PANSS negative symptom score.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/970131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30896097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Psychosis and gender. 精神病和性别。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-04-18 DOI: 10.1155/2012/694870

Susana Ochoa, Judith Usall, Jesús Cobo, Javier Labad, Jayashri Kulkarni

引用次数: 3

High order linguistic features such as ambiguity processing as relevant diagnostic markers for schizophrenia. 高阶语言特征如歧义处理作为精神分裂症的相关诊断标记。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-12-11 DOI: 10.1155/2012/825050

Daniel Ketteler, Anastasia Theodoridou, Simon Ketteler, Matthias Jäger

引用次数: 13

Intervention to prevent child custody loss in mothers with schizophrenia. 预防精神分裂症母亲丧失子女监护权的干预措施。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2011-11-01 DOI: 10.1155/2012/796763

Mary V Seeman

引用次数: 60

Integrated treatment to achieve functional recovery for first-episode psychosis. 综合治疗以实现首发精神病的功能恢复。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-05-10 DOI: 10.1155/2012/962371

Marcelo Valencia, Francisco Juarez, Hector Ortega

引用次数: 33

Cognitive control and discourse comprehension in schizophrenia. 精神分裂症患者的认知控制与话语理解。

IF 2.4

Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-04-08 DOI: 10.1155/2012/484502

Megan A Boudewyn, Cameron S Carter, Tamara Y Swaab

{"title":"Cognitive control and discourse comprehension in schizophrenia.","authors":"Megan A Boudewyn, Cameron S Carter, Tamara Y Swaab","doi":"10.1155/2012/484502","DOIUrl":"https://doi.org/10.1155/2012/484502","url":null,"abstract":"Cognitive deficits across a wide range of domains have been consistently observed in schizophrenia and are linked to poor functional outcome (Green, 1996; Carter, 2006). Language abnormalities are among the most salient and include disorganized speech as well as deficits in comprehension. In this review, we aim to evaluate impairments of language processing in schizophrenia in relation to a domain-general control deficit. We first provide an overview of language comprehension in the healthy human brain, stressing the role of cognitive control processes, especially during discourse comprehension. We then discuss cognitive control deficits in schizophrenia, before turning to evidence suggesting that schizophrenia patients are particularly impaired at processing meaningful discourse as a result of deficits in control functions. We conclude that domain-general control mechanisms are impaired in schizophrenia and that during language comprehension this is most likely to result in difficulties during the processing of discourse-level context, which involves integrating and maintaining multiple levels of meaning. Finally, we predict that language comprehension in schizophrenia patients will be most impaired during discourse processing. We further suggest that discourse comprehension problems in schizophrenia might be mitigated when conflicting information is absent and strong relations amongst individual words are present in the discourse context.\"There is no \"centre of Speech\" in the brain any more than there is a faculty of Speech in the mind.The entire brain, more or less, is at work in a man who uses language\"William JamesFrom The Principles of Psychology, 1890\"The mind in dementia praecox is like an orchestra without a conductor\"Kraepelin, 1919.","PeriodicalId":45388,"journal":{"name":"Schizophrenia Research and Treatment","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/484502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30900409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25