Evaluation of factors affecting continuous performance test identical pairs version score of schizophrenic patients in a Japanese clinical sample.

IF 3.6 Q1 PSYCHIATRY
Schizophrenia Research and Treatment Pub Date : 2012-01-01 Epub Date: 2012-04-02 DOI:10.1155/2012/970131
Takayoshi Koide, Branko Aleksic, Tsutomu Kikuchi, Masahiro Banno, Kunihiro Kohmura, Yasunori Adachi, Naoko Kawano, Tetsuya Iidaka, Norio Ozaki
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引用次数: 7

Abstract

Aim. Cognitive impairment in schizophrenia strongly relates to social outcome and is a good candidate for endophenotypes. When we accurately measure drug efficacy or effects of genes or variants relevant to schizophrenia on cognitive impairment, clinical factors that can affect scores on cognitive tests, such as age and severity of symptoms, should be considered. To elucidate the effect of clinical factors, we conducted multiple regression analysis using scores of the Continuous Performance Test Identical Pairs Version (CPT-IP), which is often used to measure attention/vigilance in schizophrenia. Methods. We conducted the CPT-IP (4-4 digit) and examined clinical information (sex, age, education years, onset age, duration of illness, chlorpromazine-equivalent dose, and Positive and Negative Symptom Scale (PANSS) scores) in 126 schizophrenia patients in Japanese population. Multiple regression analysis was used to evaluate the effect of clinical factors. Results. Age, chlorpromazine-equivalent dose, and PANSS-negative symptom score were associated with mean d' score in patients. These three clinical factors explained about 28% of the variance in mean d' score. Conclusions. As conclusion, CPT-IP score in schizophrenia patients is influenced by age, chlorpromazine-equivalent dose and PANSS negative symptom score.

日本临床样本中精神分裂症患者连续表现测试同对版本得分影响因素的评价。
的目标。精神分裂症的认知障碍与社会结果密切相关,是一个很好的内表型候选者。当我们准确测量药物疗效或与精神分裂症相关的基因或变异对认知障碍的影响时,应考虑可能影响认知测试得分的临床因素,如年龄和症状的严重程度。为了阐明临床因素的影响,我们使用连续表现测试同对版本(CPT-IP)的分数进行多元回归分析,该分数通常用于衡量精神分裂症的注意/警觉性。方法。我们对126名日本精神分裂症患者进行了CPT-IP(4-4位数),并检查了临床信息(性别、年龄、受教育年限、发病年龄、病程、氯丙嗪当量剂量和阳性和阴性症状量表(PANSS)评分)。采用多元回归分析评价临床因素的影响。结果。年龄、氯丙嗪当量剂量和panss阴性症状评分与患者的平均d'评分相关。这三个临床因素解释了大约28%的平均d' score差异。结论。综上所述,精神分裂症患者CPT-IP评分受年龄、氯丙嗪当量剂量和PANSS阴性症状评分的影响。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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