Rodolfo Pérez-Garza, Gamaliel Victoria-Figueroa, R. E. Ulloa-Flores
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引用次数: 18
摘要
背景。先前的研究报道了成年精神分裂症患者的临床表现和预后的性别差异;本研究的目的是比较临床特征,社会功能,治疗依从性,并在六个月的随访诊断青少年的认知。方法。采用阳性和阴性症状量表(PANSS)、矩阵共识认知电池(MCCB)、个人和社会表现量表(PSP)和药物影响评分(ROMI)对87例DSM-IV诊断为精神分裂症或精神分裂样障碍的青少年进行评估。结果。在随访期间,两组在所有PANSS因素和PSP评分方面均有相似的改善。雄性对治疗的依从性更好。女性在社会认知(F = 6.3, df = 2,52, p = 0.003)和注意/警觉性(F = 8.3, df = 2,51, p = 0.001)方面表现更好。结论。男性和女性青少年表现出相似的临床表现和功能,但认知改善和坚持治疗的模式不同。该试验已在Clinicaltrials.gov II3/02/0811注册
Sex Differences in Severity, Social Functioning, Adherence to Treatment, and Cognition of Adolescents with Schizophrenia
Background. Previous studies have reported sex differences in the clinical presentation and outcome of adult patients with schizophrenia; the aim of present study was to compare the clinical characteristics, social functioning, adherence to treatment, and cognition of adolescents with this diagnosis in a six-month followup. Methods. A total of 87 adolescents with a DSM-IV diagnosis of schizophrenia or schizophreniform disorder were evaluated with the Positive and Negative Symptoms Scale (PANSS), the Matrics Consensus Cognitive Battery (MCCB), Personal and Social Performance Scale (PSP), and the Rating of Medication Influences (ROMI). Results. Both groups showed a similar improvement in all PANSS factors and in the PSP scores during the followup. Males better adhered to treatment. Females displayed better results in the area of social cognition (F = 6.3, df = 2,52, and p = 0.003) and attention/vigilance (F = 8.3, df = 2,51, and p = 0.001). Conclusions. Male and female adolescents showed similar clinical presentation and functioning but a different pattern of cognitive improvement and adherence to treatment. This trial is registered with Clinicaltrials.gov II3/02/0811.
期刊介绍:
Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.