Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Peripheral calcifying odontogenic cyst: A case report and literature review","authors":"Izumi Hara ,&nbsp;Kyoichi Obata ,&nbsp;Nana Yoshitani ,&nbsp;Kisho Ono ,&nbsp;Hotaka Kawai ,&nbsp;Yuki Kunisada ,&nbsp;Mayumi Yao ,&nbsp;Takayoshi Miyake ,&nbsp;Soichiro Ibaragi","doi":"10.1016/j.ajoms.2025.06.004","DOIUrl":"10.1016/j.ajoms.2025.06.004","url":null,"abstract":"<div><div>Calcifying odontogenic cyst<span> (COC), also known as Gorlin cyst, is a type of developmental odontogenic cyst characterized histologically according to the latest (2022) WHO classification by frequently calcifying ghost cells in epithelium. A COC is usually intraosseous but occasionally arises in soft tissue; these are called peripheral COCs (PCOCs). We describe a PCOC that manifested as a progressive growth of a gingival mass in the maxilla<span> of a 10-year-old Japanese boy. Radiological examinations<span> revealed no remarkable findings. An excisional biopsy was thus conducted for a definite diagnosis. The histological examination confirmed the diagnosis of PCOC with the presence of characteristic ghost cells and sporadic calcifications; no surrounding bone tissue<span> was present. No recurrence or complication were noted at the 1-year follow-up. We also extracted 39 cases from the literature that meet the current WHO criteria and statistically analyzed the 40 cases including our patient's. A multivariate analysis showed that the gender and location (maxilla or mandible) are two major factors related to the age factor, indicating that PCOC is more common in the maxilla of younger males. Additionally, the PCOCs were smaller than the COCs and had a significantly lower calcification rate on radiography (p &lt; 0.001), probably because PCOCs are usually resected when the lesion is small. Even if ghost cell calcification is present, it may not be large enough to be radiologically visible.</span></span></span></span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1314-1320"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking and molecules of interest for oral squamous cell carcinoma: A systematic review","authors":"Lorena dos Reis Pereira Queiroz,&nbsp;Fernando Veloso Caldeira Barcellos,&nbsp;Andréia Luiza Oliveira Costa,&nbsp;Vitória Regina Oliveira de Melo,&nbsp;Maria Rafaela Pereira Lacerda,&nbsp;André Luiz Sena Guimarães","doi":"10.1016/j.ajoms.2025.06.002","DOIUrl":"10.1016/j.ajoms.2025.06.002","url":null,"abstract":"<div><h3>Objective</h3><div>To compile published works on molecular docking to verify its effectiveness in identifying bioactive compounds and potential biomarkers targeted at the treatment of oral squamous cell carcinoma (OSCC).</div></div><div><h3>Methods</h3><div>This systematic review follows the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and also registered in PROSPERO. The PubMed, Web of Science, Science Direct, and Google Scholar databases were used to search for articles. A tool, with adaptations, was used to assess the quality of the studies found.</div></div><div><h3>Results</h3><div>Fifty-three articles were included after checking all eligibility criteria. About proteins, Akt1, EGFR, HIF1a, among others, were identified as the most frequently occurring. Similarly, Quercetin, Epigallocatechin-3-gallate, Curcumin, Kaempferol, and Luteolin were the most prevalent among the compounds. The most commonly utilized databases for the retrieval of structures were PubChem and the RCSB Protein Data Bank. AutoDock, Maestro, AutoDock Vina, and PyMOL were some of the most used software.</div></div><div><h3>Conclusions</h3><div>Molecular docking has proven to be an effective tool for identifying potential biomarkers and bioactive compounds for treating OSCC.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1159-1166"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Anxiety and depression following facial and dental trauma – A prospective study”","authors":"Faheela Tamseel ,&nbsp;Syed Saaib Hussain","doi":"10.1016/j.ajoms.2025.06.007","DOIUrl":"10.1016/j.ajoms.2025.06.007","url":null,"abstract":"","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1249-1250"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between positional changes and the sleep quality in patients with obstructive sleep apnea improved by an oral appliance","authors":"Takahiro Suzuki ,&nbsp;Takahiro Ikemori ,&nbsp;Shintaro Satou ,&nbsp;Hironori Miyamoto ,&nbsp;Kenichiro Ishibashi ,&nbsp;Shuhei Tsuchiya ,&nbsp;Shinichiro Kato ,&nbsp;Yasuyuki Shibuya","doi":"10.1016/j.ajoms.2025.05.013","DOIUrl":"10.1016/j.ajoms.2025.05.013","url":null,"abstract":"<div><h3>Introduction</h3><div><span>Obstructive sleep apnea<span> (OSA) is affected by the body position during sleep. However, the relationship between OSA and the number of times sleep position changes has not been examined. To clarify this relationship, we compared and analyzed </span></span>polysomnography (PSG) results before and after oral appliance (OA) fitting, focusing on changes in the number of position changes during sleep in patients whose OSA improved due to OA use.</div></div><div><h3>Methods</h3><div>we retrospectively analyzed 26 OSA patients (18 males, 8 females; mean age 60.6 ± 12.0 years old) who underwent PSG at our hospital and demonstrated improvement in the apnea-hypopnea index (AHI) after OA use. Items such as the postural change index (PCI), sleep stages, wake time after sleep onset (WASO), arousal index (ArI), and 3 % oxygen desaturation index (ODI) were evaluated.</div></div><div><h3>Results</h3><div>After OA fitting, the PCI significantly decreased (p &lt;0.05), indicating a reduced number of body position changes during sleep. The sleep quality improved, as evidenced by a significant decrease in N1 stage sleep (p &lt;0.01), WASO (p &lt;0.05), ArI (p &lt;0.01), and 3 % ODI (p &lt;0.01) and a significant increase in N2 stage sleep (p &lt;0.01). The reduction in the PCI was significant in the patients with severe OSA (p &lt;0.05). Improvements in the sleep quality were more pronounced in the PCI decrease group than in the PCI increase group.</div></div><div><h3>Conclusions</h3><div>OA reduces position changes and enhances sleep quality, particularly in severe cases, improving sleep stability. Further studies are needed.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1257-1262"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid growth of a melanotic neuroectodermal tumor after biopsy in a 3-month-old infant","authors":"Hideki Ichikawa ,&nbsp;Junko Yagisawa ,&nbsp;Junichi Tanaka ,&nbsp;Hiroyuki Kato ,&nbsp;Aki Ito","doi":"10.1016/j.ajoms.2025.05.006","DOIUrl":"10.1016/j.ajoms.2025.05.006","url":null,"abstract":"<div><div>Melanotic neuroectodermal tumor of infancy<span><span><span> (MNTI) is a rare pigmented tumor of neural crest origin, commonly occurring in the head and neck region. Despite being a </span>benign tumor<span><span>, MNTI is characterized by high cell proliferation activity and can sometimes enlarge while destroying surrounding tissues. Herein, we report a case of MNTI in a 3-month-old girl who exhibited rapid tumor growth following a biopsy; we have included a discussion of the case and review of the relevant literature. Upon initial examination, a 20-mm (long axis) elastic hard mass was observed in the left upper alveolar region extending to the oral </span>vestibule<span>. The mucosal surface was smooth, and submucosal blue-gray tissue was visible. A biopsy was performed under </span></span></span>general anesthesia<span>, but the lesion rapidly enlarged into a grayish-white, irregular mass within a few days. Subsequently, a diagnosis of MNTI was made, and 14 days after the biopsy, the patient underwent a left maxillary tumor<span><span><span> resection and surrounding bone removal under general anesthesia. Following the surgery, a pediatric<span> prosthesis was timely fabricated by the Department of Pediatric Dentistry, resulting in both morphological and functional recovery. Treatment options should carefully consider factors related to </span></span>quality of life to address potential </span>facial deformities that may become more prominent with the subsequent growth of the child.</span></span></span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1232-1238"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter prospective study on the development of bisphosphonate-related osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates (complete translation)","authors":"Masaki Fujimori ,&nbsp;Yoshiyuki Toriyabe ,&nbsp;Nobuhiro Kaku ,&nbsp;Kosuke Shimazaki ,&nbsp;Masayoshi Miyasawa ,&nbsp;Hiroki Mityate ,&nbsp;Hideaki Kitada ,&nbsp;Yuji Satoh ,&nbsp;Hajime Misawa ,&nbsp;Tetsuro Yamashita ,&nbsp;Yoritoshi Nakajima ,&nbsp;Yasushi Hariya ,&nbsp;Ichizo Kobayashi ,&nbsp;Satoshi Nishikata ,&nbsp;Taishi Yoshihito ,&nbsp;Sugiura Chihiro ,&nbsp;Kazue Kasahiara ,&nbsp;Yuichiro Asaka ,&nbsp;Noriyuki Sakakibara ,&nbsp;Masuhiko Okada ,&nbsp;Shujiroh Makino","doi":"10.1016/j.ajoms.2025.06.006","DOIUrl":"10.1016/j.ajoms.2025.06.006","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to determine the frequency of bisphosphonate-related osteonecrosis of the jaw (BRONJ) after tooth extraction in patients treated with bisphosphonates (BPs) and to assess the efficacy of preventive BPs discontinuation in reducing BRONJ risk.</div></div><div><h3>Methods</h3><div>A 26-center prospective study was conducted on 1323 patients with current or past BPs treatment (2013–2016). Patients underwent tooth extraction under a standardized protocol, and the incidence of BRONJ and adverse events were evaluated.</div></div><div><h3>Results</h3><div>Among 1323 cases (2371 teeth extracted), 808 were in the preventive BPs discontinuation group, and 515 were in the BPs continuation group. The overall BRONJ incidence was 1.74 %, with rates of 1.73 % and 1.75 % in the discontinuation and continuation groups, respectively (P = 1.000). The incidence rates of BRONJ in the osteoporosis and malignancy groups were 1.23 % and 28.00 %, respectively (P &lt; 0.001). Factors associated with BRONJ development included sex, BPs indications, oral hygiene, tooth extraction site, and denosumab use. Propensity score analysis using the inverse probability weighting method showed no significant association between BRONJ development and preventive BPs discontinuation (P = 0.834; odds ratio: 1.131, 95 % confidence interval: 0.36–3.57). No fragility fractures occurred in the discontinuation group.</div></div><div><h3>Conclusions</h3><div>The incidence of BRONJ after tooth extraction in patients receiving BPs was 1.74 %, with no preventive effect of BPs discontinuation in the osteoporosis group. Significant risk factors included sex, denosumab use, BPs indication, oral hygiene, and extraction site.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1209-1219"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of craniofacial defect using patient-specific polyetheretherketone (PEEK) in recurrent ameloblastoma","authors":"Victor C.K. Fung ,&nbsp;Velda L.Y. Chow ,&nbsp;Kevin K.F. Cheng","doi":"10.1016/j.ajoms.2025.06.009","DOIUrl":"10.1016/j.ajoms.2025.06.009","url":null,"abstract":"<div><div><span><span>Ameloblastoma<span> (AM) is a histologically benign but locally aggressive odontogenic tumour that commonly affects the mandible or </span></span>maxilla. A 66-year-old man with a history of recurrent AM presented with right </span>eye floater<span><span> during follow-up was found to have local recurrence over the right temporal bone and lateral orbital wall. In view of the complex craniofacial resection, a 3D-printed patient-specific implant (PSI) using </span>polyetheretherketone<span> (PEEK) was manufactured and deployed intraoperatively. This utilization of PSI allows for precise surgical planning and reconstruction and should be considered a viable alternative to autologous bone graft<span> in craniofacial reconstruction for patients suffering from AM.</span></span></span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1239-1243"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA repair mechanisms and their therapeutic implications in oral cancer","authors":"Makoto Adachi ,&nbsp;Naoki Umemura","doi":"10.1016/j.ajoms.2025.05.011","DOIUrl":"10.1016/j.ajoms.2025.05.011","url":null,"abstract":"<div><div>Oral cancer, especially oral squamous cell carcinoma (OSCC), remains a significant global health problem due to poor prognosis and high mortality despite advances in conventional treatment. DNA repair mechanisms are essential for maintaining genomic stability and influencing both oral cancer development and treatment response. In this review, we discuss the current understanding of DNA repair pathways in oral cancer, their clinical significance, and potential therapeutic applications. We systematically reviewed the literature and analyzed studies on DNA repair mechanisms, their dysregulation in oral cancer, and emerging targeted therapies. Key findings indicate that DNA repair defects are prevalent in OSCC, contributing to genomic instability and resistance to DNA-damaging therapies. Tobacco, alcohol, and chronic inflammation are major carcinogenic factors that cause widespread DNA damage and often overwhelm cellular repair systems. Epigenetic modifications further exacerbate repair failure, affecting tumor progression and treatment outcomes. Recent advances demonstrate the efficacy of DNA repair-targeted strategies, especially poly ADP-ribose polymerase (PARP) inhibitors, which hold promise for homologous recombination-deficient tumors. Furthermore, DNA repair status has emerged as a valuable biomarker for prognostic applications and can guide patient selection for precision medicine approaches. However, resistance mechanisms to DNA repair inhibitors, such as pathway rewiring and compensatory repair activation, remain a major challenge. Future studies should focus on integrating DNA repair assessment into clinical decision-making, refining biomarker strategies, and developing rational combination therapies to overcome resistance. A deeper understanding of DNA repair dynamics in oral cancer may lead to more effective and personalized treatment strategies, ultimately improving patient outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1273-1282"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of facial asymmetry and cervical spine deviation: A retrospective study","authors":"Karen Gomi,&nbsp;Akinori Moroi,&nbsp;Riku Kohara,&nbsp;Sumire Ono,&nbsp;Kunio Yoshizawa,&nbsp;Koichiro Ueki","doi":"10.1016/j.ajoms.2025.06.010","DOIUrl":"10.1016/j.ajoms.2025.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>Facial asymmetry may be associated with cervical spine deviation; however, a relationship has not yet been established. This study aimed to clarify an association between facial asymmetry and cervical spine deviation.</div></div><div><h3>Methods</h3><div>We evaluated facial asymmetry and measured cervical spine angles to determine their effects on cervical deviation in 92 female patients with jaw deformities that were assessed using computed tomography (CT). Frontal, lateral, and axial radiographs were analyzed using cephalometry. We measured distances and angles from the external occipital protuberance to reference points on an atlas and up to the fifth cervical spine. Maxillofacial morphology was constructed in three dimensions from CT images. The primary outcome measure was the cervical spine angle in association with the maxillomandibular (Mx-Md) midline angle.</div></div><div><h3>Results</h3><div>The cervical spine angle significantly and positively correlated with the Mx-Md midline angle (p &lt; 0.001). Patients with Mx-Md midline angles &gt; 2.5° or ≤ 2.5° were respectively classified as asymmetric (n = 43) and symmetric (n = 49). The average cervical spine angles were 11.21° ± 7.23° in the asymmetric group and 7.53° ± 6.05° in the symmetric group. The cervical spine angle significantly differed between the symmetric and asymmetric groups, with larger cervical spine angles corresponding to increased facial asymmetry (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>This study identified an association between cervical spine deviation and facial symmetry, which may play a role in postural distortion.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1220-1225"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A primary osteosarcoma of the mandibular articular process with long-term follow-up: A case report","authors":"Tomomi Sakuma ,&nbsp;Hiroyuki Yoshitake ,&nbsp;Namiaki Takahara ,&nbsp;Tohru Ikeda ,&nbsp;Tetsuya Yoda","doi":"10.1016/j.ajoms.2025.05.005","DOIUrl":"10.1016/j.ajoms.2025.05.005","url":null,"abstract":"<div><div><span>Primary neoplastic lesions of the temporomandibular joint<span><span> (TMJ) are rare, with malignant tumors in this region being even more uncommon. The prognosis of maxillofacial malignancies is often poor due to challenges in achieving an adequate surgical margin. Heein, we report a case of TMJ </span>osteosarcoma<span> with an exceptional 34-year disease-free survival following surgery. A 26-year-old patient underwent preoperative chemotherapy and radiation therapy, followed by surgical resection and adjuvant postoperative radiation therapy. Despite significant postoperative cheek deformity, the patient remained free of recurrence or </span></span></span>metastasis<span>. We propose that the favorable outcome may be attributed to complete tumor resection facilitated by the TMJ joint capsule, which may have acted as a barrier to tumor spread. This case highlights the potential protective role of the joint capsule in achieving successful outcomes in TMJ osteosarcoma.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1226-1231"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}