Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第7页

Healing of tooth extraction wound socket, do we have current understanding? 拔牙创口的愈合，我们目前了解多少？

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-20 DOI: 10.1016/j.ajoms.2024.07.009

Aqsa Kamal , Maryam Kamal , Alina Hasnat , Abeera Mohsin , A.R. Samsudin

{"title":"Healing of tooth extraction wound socket, do we have current understanding?","authors":"Aqsa Kamal , Maryam Kamal , Alina Hasnat , Abeera Mohsin , A.R. Samsudin","doi":"10.1016/j.ajoms.2024.07.009","DOIUrl":"10.1016/j.ajoms.2024.07.009","url":null,"abstract":"<div><h3>Objective</h3><div>This review paper aims to provide an up to date understanding on tooth socket healing signifying the impact of osteoimmunology, cellular and molecular events, role of nerves, growth factors, signaling pathways, oxygen, endocrine and obesity in healing and regeneration.</div></div><div><h3><strong>Methods</strong></h3><div>A thorough literature search was conducted using up to date software and electronic databases including Python 3.9.7 and latent Dirichlet allocation (LDA).</div></div><div><h3><strong>Results</strong></h3><div>70 relevant articles were included. Tooth socket healing is different from other types of bone healing.</div></div><div><h3><strong>Conclusion</strong></h3><div>Role of osteoimmunology, macrophages, mesenchymal stem cells, growth factors, hormones and nerves in tooth socket healing have been ignored for long. These factors can result in impaired wound healing or disruption the healing process. Understanding the mechanisms involved in tooth socket healing can contribute to the development of targeted strategies for promoting optimal healing outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 8-22"},"PeriodicalIF":0.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The use of ubiquinone to improve the healing of soft and hard jaw tissues – A systematic review 使用泛醌改善颌骨软组织和硬组织的愈合--系统综述

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-19 DOI: 10.1016/j.ajoms.2024.07.008

Alini Cardoso Soares , Camila Barcellos Calderipe , Rafael dos Santos Giorgis , Luisa Quevedo Grave , Antonio Cesar Manentti Fogaça , Marcos Antonio Torriani , Ana Carolina Uchoa Vasconcelos , Lauren Frenzel Schuch

{"title":"The use of ubiquinone to improve the healing of soft and hard jaw tissues – A systematic review","authors":"Alini Cardoso Soares , Camila Barcellos Calderipe , Rafael dos Santos Giorgis , Luisa Quevedo Grave , Antonio Cesar Manentti Fogaça , Marcos Antonio Torriani , Ana Carolina Uchoa Vasconcelos , Lauren Frenzel Schuch","doi":"10.1016/j.ajoms.2024.07.008","DOIUrl":"10.1016/j.ajoms.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the present study was to survey the scientific literature for conclusive evidence about the capacity of ubiquinone to improve the healing process of soft and hard jaw tissue.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was undertaken in six databases and in the gray literature<strong>.</strong></div></div><div><h3>Results</h3><div>Eight studies were identified, four of them <em>in vitro,</em> three <em>in vivo,</em> and one clinical. All articles demonstrated that ubiquinone accelerates the repair of soft tissue, whereas one study found little effect on the remodeling of bone tissue. Despite the possibility that ubiquinone application may be beneficial, the limited knowledge about the action of this coenzyme on oral tissue repair requires further preclinical studies before the development of human clinical trials.</div></div><div><h3>Conclusion</h3><div>This systematic review provides valuable information about potential new medications that could help the healing of oral tissues, especially for oral and maxillofacial surgeons.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 157-166"},"PeriodicalIF":0.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) following stomatitis 一例口腔炎后的药物过敏综合征（DIHS）/嗜酸性粒细胞增多和全身症状的药物反应（DRESS）病例

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-17 DOI: 10.1016/j.ajoms.2024.07.007

Masafumi Nakamoto , Akiyuki Hirosue , Kazuhito Tanaka , Hikaru Nakashima , Junki Inoue , Nozomu Takahashi , Daiki Fukuma , Yuichiro Matsuoka , Takuya Tanaka , Yoshihiro Yoshitake , Hideki Nakayama

{"title":"A case of drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) following stomatitis","authors":"Masafumi Nakamoto , Akiyuki Hirosue , Kazuhito Tanaka , Hikaru Nakashima , Junki Inoue , Nozomu Takahashi , Daiki Fukuma , Yuichiro Matsuoka , Takuya Tanaka , Yoshihiro Yoshitake , Hideki Nakayama","doi":"10.1016/j.ajoms.2024.07.007","DOIUrl":"10.1016/j.ajoms.2024.07.007","url":null,"abstract":"<div><div>Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe form of drug-related rash with distinct features. This condition is characterized by late onset from specific causative drugs, and symptoms worsen despite discontinuation of the causative agent, followed by organ dysfunction. Notably, DIHS/DRESS results from the reactivation of human herpesvirus 6 (HHV-6). Herein, we report a case of DIHS/DRESS in which rash, fever and liver dysfunction were observed during hospitalization for stomatitis, and HHV-6 reactivation was confirmed. A 67-year-old man who had been taking carbamazepine for the sequelae of cerebral hemorrhage was referred to our hospital because of pain in the oral mucosa. Initially, he was diagnosed with a herpes virus infection and treated with acyclovir. Afterward, despite improvement in stomatitis, papules appeared on the trunk of the body and worsened. The symptoms were accompanied by fever and liver dysfunction. Eventually, the patient developed decreased systolic blood pressure, tachypnea, and atrial fibrillation. After pulse steroid therapy was initiated, the patient’s clinical condition improved. Real-time polymerase chain reaction was performed suspecting with DIHS/DRESS, and HHV-6 DNA was detected. Based on this process, we diagnosed the patient with DIHS/DRESS induced by carbamazepine.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 333-339"},"PeriodicalIF":0.4,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraosseous xanthoma of the fronto-malar suture: Case report and literature review 骨内前臼齿缝黄瘤：病例报告和文献综述。

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-14 DOI: 10.1016/j.ajoms.2024.07.001

Gilli Massimiliano , Sacchi Federica , Prosperini Annapaola , Giovacchini Francesco , Mitro Valeria , Committeri Umberto , Tullio Antonio

{"title":"Intraosseous xanthoma of the fronto-malar suture: Case report and literature review","authors":"Gilli Massimiliano , Sacchi Federica , Prosperini Annapaola , Giovacchini Francesco , Mitro Valeria , Committeri Umberto , Tullio Antonio","doi":"10.1016/j.ajoms.2024.07.001","DOIUrl":"10.1016/j.ajoms.2024.07.001","url":null,"abstract":"<div><div>Intraosseous xanthomas<span><span><sup>1</sup></span></span> (IOX) are rare benign lesions characterized by the deposition of lipid-laden histiocytes within bone tissue. We present a case of IOX involving the fronto-malar suture in a 71-year-old male patient, which is an unusual location for this lesion. The patient presented with a painless swelling over his left fronto-malar region, which had been progressively enlarging over several months. Clinical examination and imaging studies revealed a well-defined radiolucent lesion involving the fronto-malar suture. Surgical excision was performed, and histopathological examination confirmed the diagnosis of IOX. The patient had an uncomplicated postoperative course with no evidence of recurrence at the follow-up. The literature review highlighted 47 cases of IOX. The distribution of these lesions in the facial bones is prevalent in the mandible (77 %). Other localizations are rare. This case highlights the importance of considering intraosseous xanthoma in the differential diagnosis of radiolucent lesions involving craniofacial bones.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 371-375"},"PeriodicalIF":0.4,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subgemmal neurogenous plaque and oral squamous cell carcinoma: Association or coincidence? 巨网膜下神经源性斑块与口腔鳞状细胞癌：关联还是巧合？

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-06 DOI: 10.1016/j.ajoms.2024.07.005

Giovanna Lopes Carvalho , Juliana Mota Siqueira , Daniele Heguedusch , David Eduardo Zuluaga Liberato , Andressa Teruya Ramos , Emília Maria Gomes Aguiar , Fabio Daumas Nunes

引用次数: 0

Two cases of lichen planus in the oral cavity and laryngopharynx 两例口腔和喉咽部扁平苔藓病例

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-06 DOI: 10.1016/j.ajoms.2024.06.009

Atsushi Tsurumi , Masaki Minabe , Sari Ueno , Yuria Akira , Nana Morita , Kazuhiko Hashimoto , Nobuyuki Matsuura , Takeshi Nomura , Michiyoshi Kouno

{"title":"Two cases of lichen planus in the oral cavity and laryngopharynx","authors":"Atsushi Tsurumi , Masaki Minabe , Sari Ueno , Yuria Akira , Nana Morita , Kazuhiko Hashimoto , Nobuyuki Matsuura , Takeshi Nomura , Michiyoshi Kouno","doi":"10.1016/j.ajoms.2024.06.009","DOIUrl":"10.1016/j.ajoms.2024.06.009","url":null,"abstract":"<div><div>Lichen planus (LP) is a chronic inflammatory disease that frequently occurs in the oral mucosa and skin; however, it rarely occurs in the laryngopharynx. Here, we describe the cases of an 83-year-old woman (Case 1) and a 77-year-old man (Case 2) who presented with LP in the oral cavity and laryngopharynx. Both patients had erythema and erosion of the palate, pharynx, and epiglottis as well as pain during swallowing. Case 1 had airway stenosis caused by laryngopharyngeal mucosa scarring. Mucosal pemphigoid was clinically suspected in both cases; however, direct immunofluorescence findings of specimens obtained from the oral cavity and pharynx were negative. Together with the histopathological findings, we diagnosed the patients with LP. We administered topical therapy with tacrolimus (Case 1) and steroids (Case 2) for intraoral lesions. Inhaled corticosteroids were administered to the laryngopharynx by an otorhinolaryngologist at our hospital. Consequently, the patient’s symptoms alleviated. In both cases, odynophagia, erythema, erosion of the palate, and the histopathological findings of bullous LP were observed. If such findings are observed, it is necessary to consider the possibility that oral LP that is accompanied by laryngopharyngeal LP.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 221-227"},"PeriodicalIF":0.4,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sialolithiasis of minor salivary glands in multiple areas of the lips: Scanning electron microscopy and energy dispersive X-ray spectroscopy analysis 嘴唇多个部位的小唾液腺矽结石：扫描电子显微镜和能量色散 X 射线光谱分析

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-04 DOI: 10.1016/j.ajoms.2024.07.002

Takuma Watanabe , Dai Kawahara , Tatsuya Kawamura , Ryo Inoue , Akihiko Yamaguchi , Kazumasa Nakao

{"title":"Sialolithiasis of minor salivary glands in multiple areas of the lips: Scanning electron microscopy and energy dispersive X-ray spectroscopy analysis","authors":"Takuma Watanabe , Dai Kawahara , Tatsuya Kawamura , Ryo Inoue , Akihiko Yamaguchi , Kazumasa Nakao","doi":"10.1016/j.ajoms.2024.07.002","DOIUrl":"10.1016/j.ajoms.2024.07.002","url":null,"abstract":"<div><div><span><span>Sialolithiasis<span> of minor salivary gland<span> (SMSG) clinically manifests as an asymptomatic, small, and firm submucosal nodule, and its occurrence in multiple areas is rare. Diagnosing SMSG may be challenging owing to similarities in clinical characteristics with other lesions; misdiagnoses may also occur. In addition to pathological examination, scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDS) analysis can be used to determine the nature of the material. Herein, we report a rare case of a patient with SMSGs in multiple areas of lips, along with SEM-EDS analysis. A 45-year-old female consulted our department with complaints of mild pain and swelling in her lips. Oral examination revealed firm multiple nodules beneath the upper and lower labial mucosa, whereas </span></span></span>computed tomography (CT) revealed well-circumscribed multiple hyperdense lesions suggestive of calculi in the upper and lower lips. Following a tentative clinical diagnosis of SMSGs in multiple areas of the lips, three calculi were removed. Histological and SEM-EDS findings supported a final diagnosis of SMSGs. SMSG could be a clinical differential diagnosis of a firm, mobile, and small lip nodule, and SEM-EDS analysis could provide valuable information on the structure and composition of </span>sialoliths<span>. We clinically diagnosed the nodules as SMSGs by careful interpretation of clinical and imaging manifestations. Clinicians should consider SMSG as a clinical differential diagnosis of unknown hard, mobile, and small nodules in lips and buccal mucosa. CT and ultrastructural analysis with SEM and EDS may effectively characterize the sialoliths.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 297-302"},"PeriodicalIF":0.4,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of bilateral odontoma in the retromolar region of the mandible 下颌骨后磨牙区双侧牙瘤的罕见病例

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-03 DOI: 10.1016/j.ajoms.2024.07.003

Kengo Hashimoto , Mizuki Hyodo , Yutaro Kondo , Yuya Urano , Masahiro Umemura

{"title":"A rare case of bilateral odontoma in the retromolar region of the mandible","authors":"Kengo Hashimoto , Mizuki Hyodo , Yutaro Kondo , Yuya Urano , Masahiro Umemura","doi":"10.1016/j.ajoms.2024.07.003","DOIUrl":"10.1016/j.ajoms.2024.07.003","url":null,"abstract":"<div><div>Among oral pathologic lesions, odontomas are one of the most common odontogenic tumor of the jaw. Odontomas are generally asymptomatic and most cases involve only one region of the maxilla<span><span> or mandible<span>. An 18-year-old man visited our department for examination and treatment of cystic lesions in the bilateral mandibular retromolar area. Surgery was performed with the patient under general anesthesia for a diagnosis of the lesions. The histopathological diagnosis was immature stages of odontomas, partially including a findings of benign mixed epithelial and mesenchymal odontogenic tumor. These findings suggested the possibility of ameloblastic fibro-odontoma, which was excluded from current WHO classification. It consists of proliferation of odontogenic epithelial and mesenchymal components combined with hard tissues such as dentin and enamel. Recently, the majority of such cases have been identified as immature odontoma. However, because of previous reports of cases of recurrence and </span></span>malignant transformation, the possibility of a true tumor has not been completely ruled out. Herein, along with a literature review, we report the case of bilateral odontoma containing a findings of benign mixed epithelial and mesenchymal odontogenic tumor in the retromolar region of the mandible.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 303-307"},"PeriodicalIF":0.4,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141705086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclooxygenase upregulation in cytomegalovirus-infected gingival fibroblasts: Implications for periodontal disease 受巨细胞病毒感染的牙龈成纤维细胞中环氧化酶的上调：对牙周病的影响

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-02 DOI: 10.1016/j.ajoms.2024.07.004

Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos

{"title":"Cyclooxygenase upregulation in cytomegalovirus-infected gingival fibroblasts: Implications for periodontal disease","authors":"Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos","doi":"10.1016/j.ajoms.2024.07.004","DOIUrl":"10.1016/j.ajoms.2024.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the changes in the expression of COX-1 and COX-2 in primary gingival fibroblasts upon infection with two strains of human cytomegalovirus (CMV).</div></div><div><h3>Methods</h3><div>Primary human gingival fibroblasts (HGFs) were cultured and infected with two strains of human CMV the laboratory strain (Towne) and a clinical isolate (B52) at a multiplicity of infection of 0.5. The relative mRNA levels of COX-1 and COX-2 were evaluated using multiplex reverse transcriptase quantitative polymerase chain reaction with specific hydrolysis probes. Additionally, immunofluorescence was performed for COX-2, IE1, and IE2 viral proteins.</div></div><div><h3>Results</h3><div>At 24 h post infection, CMV infection of HGFs resulted in a decrease in COX-1 transcripts in cells infected with both the Towne strain and B52 clinical isolate, and in non-infected cells. Conversely, COX-2 transcripts increased in infected cells (Towne and B52); they were significantly higher in B52 infected cells, similar to the immunofluorescence detection results for COX-2.</div></div><div><h3>Conclusions</h3><div>Infection of HGFs with CMV increased in both mRNA and protein expression of COX-2. Furthermore, the B52 isolate induced higher COX-2 expression than the Towne laboratory strain. This study provides a basis for understanding the putative relationships between CMV infection and inflammatory responses in gingival diseases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 188-194"},"PeriodicalIF":0.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review COVID-19患者口腔病变的形态学和组织分子特征：在世系统综述的更新

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-28 DOI: 10.1016/j.ajoms.2024.06.010

Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos

{"title":"Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review","authors":"Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos","doi":"10.1016/j.ajoms.2024.06.010","DOIUrl":"10.1016/j.ajoms.2024.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>This is the update of the previously published living systematic review that integrated the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected with COVID-19 (OLICs).</div></div><div><h3>Methods</h3><div>This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.</div></div><div><h3>Results</h3><div>Six studies, reporting nineteen cases of OLICs, were included. Of the patients, 73.7 % were males with a mean age of 54.8 (± 18.8) years. The most commonly observed clinical presentation was ulcers (42.9 %), primarily in the palate (52 %). Histopathologically, the most frequently reported features in the mesenchymal layer were thrombi/microvascular thrombosis (36.6 %), inflammation (24.4 %), and hemorrhage (14.7 %). Immunohistochemistry for SARS-CoV-2 or Spike Protein was conducted in 15 cases, revealing 86.7 % positivity. In one study, RT-PCR yielded a negative result, which was further confirmed by negative immunohistochemistry.</div></div><div><h3>Conclusion</h3><div>The occurrence of thrombotic events associated with the presence of the spike protein could explain the etiopathogenesis of some cases of OLICs, probably also associated with other etiological factors.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 151-156"},"PeriodicalIF":0.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0