Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Comparative analysis of two flap designs for the extraction of horizontally impacted mandibular third molars: A multicenter randomized controlled trial","authors":"Tomofumi Naruse ,&nbsp;Satoshi Rokutanda ,&nbsp;Satoshi Inokuchi ,&nbsp;Keisuke Omori ,&nbsp;Kohei Furukawa ,&nbsp;Hiromasa Fukushima ,&nbsp;Masahiro Umeda ,&nbsp;Tomohiro Yamada","doi":"10.1016/j.ajoms.2025.06.005","DOIUrl":"10.1016/j.ajoms.2025.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>Most patients experience postoperative complications caused by the extraction of horizontally impacted mandibular third molars. The present study aimed to compare the effects of two flap designs on the reduction of postoperative complications.</div></div><div><h3>Methods</h3><div>A total of 188 patients with horizontally impacted mandibular third molars were included in this single-blind, multicenter, randomized control trial. The patients were assigned to either the modified envelope flap (mEF) or triangular flap (TF) group in a 1:1 ratio. The operation time and postoperative complications (pain, hemorrhage, neurosensory changes, dry socket [alveolar osteitis], and infection) were assessed for 7 ± 1 days postoperatively.</div></div><div><h3>Results</h3><div>In all cases, postoperative pain was significantly lower in the mEF group (P = 0.033). In the subgroup analysis, postoperative pain was significantly lower in cases of low difficulty (Pell and Gregory classification IA, IIA, IIA, IB; P = 0.018). Other factors were not significantly associated with the flap design.</div></div><div><h3>Conclusions</h3><div>Our study suggested that mEF resulted in less postoperative pain in cases of low difficulty of extracting horizontally impacted mandibular third molars. However, the current evidence is inadequate to recommend either flap design.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1203-1208"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of multiple minor salivary gland tumors with synchronous carcinoma ex pleomorphic adenoma and pleomorphic adenoma","authors":"Akio Shibata ,&nbsp;Kou Kawahara ,&nbsp;Yutaro Kondo ,&nbsp;Kumiko Hatsukawa ,&nbsp;Yuki Tange ,&nbsp;Satoru Miyabe","doi":"10.1016/j.ajoms.2025.05.009","DOIUrl":"10.1016/j.ajoms.2025.05.009","url":null,"abstract":"<div><div>Multiple salivary gland tumors<span><span> (MSGTs) are very rare, and can be categorized as unilateral or bilateral by topographic distribution and synchronous or metachronous by chronologic appearance. Intraoral MSGTs are extremely rare, and only very few cases have been reported. To our knowledge, the synchronous occurrence of a carcinoma ex pleomorphic adenoma (Ca-ex-PA) and a pleomorphic adenoma (PA) of minor </span>salivary glands<span> has not been reported in the literature. A 72-year-old woman presented with a 15 mm, firm, nontender, well-circumscribed nodule on the left side of the upper lip for &gt; 10 years and presented with an asymptomatic 18-mm, elastic mass of the right palate.</span></span></div><div><span>Magnetic resonance imaging detected an upper lip mass, T2-weighted imaging (T2WI) revealed a 15-mm mass in a well-demarcated area of heterogeneous intensity, and diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping revealed low-intensity medial components. Fat-saturated T2WI showed a 20-mm palate mass of homogeneous high intensity in a well-demarcated area, DW and ADC mapping indicated high intensity of the medial components. An excisional biopsy was performed with a safety margin. Histopathological examination revealed the palate tumor was PA, and the lip tumor was Ca-ex-PA, with salivary gland carcinoma not otherwise specified component accounting for approximately half of the central region of the tumor. Because the patient had noninvasive Ca-ex-PA, a wait-and-see approach without postoperative treatment was selected. No evidence of recurrence or </span>metastasis was noted 3 years after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1304-1308"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of mandibular gingival squamous cell carcinoma with mandibular lymph node metastasis","authors":"Yusuke Urata ,&nbsp;Norihisa Ichimura ,&nbsp;Masahito Fujio ,&nbsp;Satoshi Yamaguchi ,&nbsp;Takeru Kobayashi ,&nbsp;Ryo Ebata ,&nbsp;Akimune Suetsugi ,&nbsp;Hideharu Hibi","doi":"10.1016/j.ajoms.2025.06.011","DOIUrl":"10.1016/j.ajoms.2025.06.011","url":null,"abstract":"<div><div>Metastasis of oral cancer to the mandibular lymph node (MLN) is rare, particularly in the early stages. Furthermore, no consensus about surgical treatment of metastasis to the MLNs exists. Herein, we describe a case of MLN identified early on computed tomography (CT) when the patient was initially diagnosed with squamous cell carcinoma of mandibular gingiva. Since no evident malignant findings on positron emission tomography-CT (PET-CT) or cervical ultrasonography were observed, the case was regarded as normal anatomy without metastasis. A diagnosis of mandibular gingival cancer (cT2N0M0) was made; marginal mandibulectomy was performed. However, three months later, contrast-enhanced CT images revealed an enlarged 12 mm × 7 mm MLN, and fluorodeoxyglucose (FDG) accumulation (SUV max: 3.9) was observed in both the MLN and submandibular lymph nodes on FDG-PET/CT. Therefore, we performed radical neck dissection including the MLN. Extra-nodal extensions were observed in the submandibular lymph nodes. Accordingly, weekly cisplatin at a dose of 40 mg/m² combined with radiotherapy (66 Gy) was performed as post-operative treatment. The MLN is an intercalated lymph node that may not be present in some patients or the lymph node may not be detected because it may have integrated into the tumor. However, when they are detected, even if there are no obvious malignant findings, considering them metastatic regions and proceeding with treatment accordingly are necessary.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1244-1248"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteopontin derived from tumor-associated macrophages modulates radiosensitivity of oral squamous cell carcinoma via reactive oxygen species production","authors":"Hikaru Nakashima ,&nbsp;Keisuke Yamana ,&nbsp;Ryoji Yoshida ,&nbsp;Yuichiro Matsuoka ,&nbsp;Hidetaka Arita ,&nbsp;Shunsuke Gohara ,&nbsp;Masatoshi Hirayama ,&nbsp;Kenta Kawahara ,&nbsp;Akiyuki Hirosue ,&nbsp;Yoshikazu Kuwahara ,&nbsp;Tomohiko Wakayama ,&nbsp;Hideki Nakayama","doi":"10.1016/j.ajoms.2025.05.008","DOIUrl":"10.1016/j.ajoms.2025.05.008","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the role of osteopontin (OPN), a secreted phosphoglycoprotein, in radioresistance in oral squamous cell carcinoma (OSCC).</div></div><div><h3>Methods</h3><div>Samples were collected from 66 patients with OSCC. Immunohistochemistry and double staining were performed on tissue sections to assess OPN levels in stromal and tumor cells and OPN and CD163 colocalization, respectively. Cell lines were treated to simulate cancer-associated environments. Macrophage and fibroblast differentiation were induced; enzyme-linked immunosorbent assays, in situ hybridization, and western blotting were performed; and reactive oxygen species (ROS) were detected to evaluate protein levels and cell responses. Cells were also irradiated for survival analysis.</div></div><div><h3>Results</h3><div>Immunohistochemical analysis of OSCC tissue samples revealed OPN localization predominantly in the tumor stroma, particularly in tumor-associated macrophages (TAMs). In vitro experiments demonstrated that TAM-like cells differentiated from THP-1 monocytes secreted higher OPN levels compared with cancer-associated fibroblast-like cells. Clinicopathological analysis revealed a significant correlation between high OPN expression and poor chemoradiotherapy response. The addition of recombinant OPN to OSCC cell lines decreased radiosensitivity, which was reversed by blocking OPN signaling using anti-CD44 and anti-integrin αVβ3 antibodies. Furthermore, OPN treatment reduced radiation-induced DNA double-strand breaks and ROS production and increased glutathione levels, which were inhibited by blocking OPN-CD44 and OPN-integrin αVβ3 pathways.</div></div><div><h3>Conclusions</h3><div>OPN secreted by the tumor stroma, particularly TAMs, contributes to OSCC radioresistance by regulating ROS and GSH levels via the OPN-CD44 and OPN-integrin αVβ3 axes. Therefore, targeting OPN signaling may represent a novel therapeutic strategy for overcoming radioresistance in OSCC.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1186-1195"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial growth patterns of female patients with cleft lip and/or palate: A longitudinal study from infancy to adolescence","authors":"Akira Suzuki ,&nbsp;Naoko Tamura ,&nbsp;Masaaki Sasaguri ,&nbsp;Takeshi Mitsuyasu ,&nbsp;Seiji Nakamura","doi":"10.1016/j.ajoms.2025.05.004","DOIUrl":"10.1016/j.ajoms.2025.05.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Abnormal craniofacial morphology<span><span> in patients with cleft lip and/or palate has been attributed to defects in craniofacial growth potential and to the effects of surgical and </span>orthodontic treatment. The influence of these factors was examined by analyzing craniofacial growth patterns throughout the growth process from infancy to adulthood.</span></div></div><div><h3>Design</h3><div>Retrospective longitudinal study</div></div><div><h3>Participants</h3><div>The subjects were 46 Japanese female CL/P patients who underwent surgical lip and/or palatal repairs and orthodontic treatment at the Kyushu University Dental Hospital, Fukuoka, Japan.</div></div><div><h3>Methods</h3><div>Using serial cephalometric<span> radiographs from 4 months to 15 + years of age, growth patterns of craniofacial morphology were compared for three cleft types (12 patients with UCLA, 13 CP, and 21 UCLP) using repeated measures ANOVA.</span></div></div><div><h3>Results</h3><div><span>The growth patterns of the patients with UCLP differed from those of the patients with UCLA in the maxillofacial angle (S-N-A), maxillary basal length (A’-Ptm’), posterior maxillary height (S-Ptm’), maxillofacial widths (NC-NC’ and Mx-Mx’), and three maxillofacial ratios (Cd-Go/S-N, Pog-Go/S-N, N-PP/Cd-Go). The growth patterns of the patients with UCLP differed from those of the patients with CP in cranial </span>base lengths (N-Ba and S-Ba), the maxillary basal length, maxillofacial angle, maxillofacial width, and the ratio S-Ptm'/N-PP.</div></div><div><h3>Conclusion</h3><div>Craniofacial growth patterns varied by the cleft types, the presence of both cleft lip and cleft palate inhibited forward and downward growth of the posterior maxillofacial complex, and surgical intervention on the lips, alveolar bone, and palate had a cumulative inhibitory effect on maxillofacial growth.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1167-1180"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of cold devices for tumor resection improves the engraftment rate of full-thickness skin grafts in buccal mucosal cancer","authors":"Yoshio Ohyama ,&nbsp;Yasuyuki Michi ,&nbsp;Yoshinori Inaba ,&nbsp;Kazuki Hasegawa","doi":"10.1016/j.ajoms.2025.05.007","DOIUrl":"10.1016/j.ajoms.2025.05.007","url":null,"abstract":"<div><h3>Objective</h3><div><span><span>Skin grafting<span> is a less invasive option for reconstruction following the excision of buccal mucosal cancer and can help prevent </span></span>trismus. Although it is a valuable method, skin survival rates have traditionally been suboptimal. We report a high skin </span>engraftment rate achieved by performing full-thickness skin grafts for buccal mucosal cancer up to T-stage III, coupled with tumor excision using cold devices instead of an electric knife.</div></div><div><h3>Methods</h3><div>This study analyzed 15 cases of full-thickness skin grafting performed on the patients with buccal mucosal cancer who visited our department between April 2016 and December 2023. Radical surgery was performed, with skin fixation achieved through tying and applying an anchor suture. The primary outcome was the engraftment rate of the grafted skin, and explanatory factors included age, sex, tumor site, the extent of resection, depth, device used for tumor resection, and use of a buccal fat pad.</div></div><div><h3>Results</h3><div>The mean age of the enrolled patients (n = 15) was 74.5 (range, 35–96) years. Of the 15 cases analyzed, 7 and 8 were in the electric knife and cold device groups, respectively. Univariate analysis<span> revealed that resection below the buccal muscle and the use of cold devices were significantly associated with a higher engraftment rate. Multivariate analysis confirmed that a smaller resection area and the use of cold devices were significantly associated with better skin engraftment outcomes.</span></div></div><div><h3>Conclusion</h3><div>The use of cold devices during the resection of buccal mucosa cancer significantly improves the engraftment rate of full-thickness skin grafts.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1181-1185"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternation of salivary microbiome and Lautropia dominancy after allogenic hematopoietic stem cell transplantation","authors":"Osamu Imataki ,&nbsp;Akihiro Takeuchi ,&nbsp;Tomoya Ishida ,&nbsp;Makiko Uemura ,&nbsp;Minoru Miyake ,&nbsp;Yumiko Ohbayashi","doi":"10.1016/j.ajoms.2025.05.001","DOIUrl":"10.1016/j.ajoms.2025.05.001","url":null,"abstract":"<div><h3>Objective</h3><div><span>In a patient with hematological malignancy<span>, oral microbiome is disturbed during chemotherapy including </span></span>hematopoietic stem cell transplantation<span> (HSCT). A critical role of salivary microbiota has not been fully investigated.</span></div></div><div><h3>Methods</h3><div><span>We collected saliva of 6 HSCT recipients before and after (around 30 day) transplantation, and characterized patterns of oral microbiota<span>. We set up a healthy control cohort (N = 6) as a normal reference. A two-step PCR protocol was used to amplify a 16S rDNA<span> in the V3-V4 region. Sequencing of the amplicons was performed on an </span></span></span>Illumina MiSeq<span> (Illumina). A significance of alpha and beta diversity of microbiota, and taxonomic composition were investigated.</span></div></div><div><h3>Results</h3><div><span>The patients’ characteristics were median age 43 years old (range 39–58) and 4 female patients. The diversity of microorganisms in saliva were significantly decreased after HSCT. Shannon index (t-test, P = 0.03) and Simpson index (P = 0.06) were significantly lower in recipients after HSCT comparing to before HSCT. In recipients experienced severe (&gt;grade 2) oral mucositis<span>, alpha index was less diverse compared to recipients with mild or moderate oral mucositis, and in whose saliva genus </span></span><em>Lautropia</em> were predominant after HSCT. A common observation of salivary microbiota after HSCT were significant increase of phylum <em>Actinomycetacea</em> and genus <span><span>Actinomyces</span><em>.</em></span> Genus <span><span>Neisseria</span></span> was significantly decreased after HSCT.</div></div><div><h3>Conclusions</h3><div><span>We observed substantial decreases in the number and diversity of salivary microbiota through HSCT in recipient with hematological malignancy. </span><em>Lautropia</em> is newly found microorganism, which is possible to linked to mitigation of severe oral mucositis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1251-1256"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of haemolytic anemia triggered by an odontogenic infection in a patient with cold agglutinin disease","authors":"Takehiro Watanabe ,&nbsp;Mako Yokoyama ,&nbsp;Takuma Watanabe ,&nbsp;Shigeki Yamanaka ,&nbsp;Shizuko Fukuhara ,&nbsp;Yuria Onishi ,&nbsp;Yasuko Miyahara ,&nbsp;Kazumasa Nakao ,&nbsp;Makoto Hirota","doi":"10.1016/j.ajoms.2025.06.008","DOIUrl":"10.1016/j.ajoms.2025.06.008","url":null,"abstract":"<div><div>Cold agglutinin disease (CAD) is a rare autoimmune haemolytic anaemia characterised by the presence of cold agglutinins, which are autoantibodies that agglutinate erythrocytes upon exposure to low temperatures. Although CAD patients typically develop haemolytic anaemia in response to febrile infections, no reports have been documented thus far regarding haemolytic anaemia in CAD patients resulting from odontogenic infections. A 47-year-old male patient with haemolysis because of an odontogenic infection is presented in this report. The patient had been diagnosed with CAD dating back approximately a decade, although the patient had not undergone haematological treatment. In November 2021, the patient was referred to our department from the haematology department because of haemolysis, which would have been triggered by acute right maxillary sinusitis. The sinusitis was caused by apical periodontitis of the second molar in the right maxilla. To address the condition, the patient received a red blood cell (RBC) transfusion along with antibiotics to control the sinusitis. After sinusitis had been improved, according to the suggestion from haematologists, the maxillary right second molar was extracted under local anaesthesia under body temperature control in January 2022. The patient’s body was kept warm, and infusion fluid for intravenous administration was controlled at approximately 37℃ during the peri- and postoperative period to avoid CAD. Because an odontogenic infection could be a trigger of haemolysis, maintenance of oral hygiene and early treatment of bacterial infections are important in patients with CAD.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1269-1272"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular pathogenetic options for differentiating fibrous dysplasia and ossifying fibroma: A systematically conducted literature review","authors":"Raniah Abdullah Al Eid","doi":"10.1016/j.ajoms.2025.06.001","DOIUrl":"10.1016/j.ajoms.2025.06.001","url":null,"abstract":"<div><h3>Objectives</h3><div><span>A diverse set of lesions known as fibro-osseous lesions (FOLs) have overlapping clinical, radiological, and histopathological features, resulting in diagnostic and therapeutic challenges. Distinguishing between fibrous dysplasia<span> (FD) and ossifying fibroma (OF) lesions is particularly difficult owing to their overlapping characteristics. Therefore, we conducted a </span></span>systematic literature review of the molecular pathogenetic approaches for differentially diagnosing FD and OF.</div></div><div><h3>Methods</h3><div><span>Databases, including Web of Science, PubMed, </span>Scopus<span>, and the Cochrane Library, were used as data sources for this study. Data were obtained from a database using manual snowball searches and predefined search phrases. To prevent selection bias, independent reviewers conducted screening, and only 13 articles that directly addressed the research issue were included.</span></div></div><div><h3>Results</h3><div><span><span>Nine molecular differential diagnostic approaches for differentiating the two lesions were identified in the assessment of the included papers. The most popular molecular pathogenetic method for FD and OF differentiation was mutation analysis of the guanine nucleotide-binding protein alpha-subunit (GNAS) gene using various techniques, including </span>pyrosequencing, direct </span>DNA sequencing<span>, polymerase chain reaction<span> (PCR), real-time polymerase chain reaction (qPCR), high-resolution melting, and allele-specific PCR.</span></span></div></div><div><h3>Conclusions</h3><div><span>These molecular diagnostic<span> options enable differentiation of FD and OF, but combining two or more techniques, particularly with other molecular markers alongside the GNAS mutation on exon 8, may further improve the differential diagnosis. We recommend </span></span>clinical trials to combine these molecular options with other appropriate approaches to improve the differential diagnosis of FD and OF with increased detection sensitivity.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1283-1293"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of osteocartilaginous choristoma at the floor of the oral cavity","authors":"Takasuke Usuki ,&nbsp;Soju Seki ,&nbsp;Toshihiro Uchihashi ,&nbsp;Tomonori Sasahira ,&nbsp;Shingo Kodama ,&nbsp;Kohei Kawamura ,&nbsp;Susumu Tanaka ,&nbsp;Syoichiro Ishii ,&nbsp;Munehiro Hamaguchi","doi":"10.1016/j.ajoms.2025.05.003","DOIUrl":"10.1016/j.ajoms.2025.05.003","url":null,"abstract":"<div><div><span>Osteocartilaginous choristomas<span><span> are benign bone lesion<span> composed of hyaline cartilage that undergo ossification and arise when osteochondral cells proliferate into surrounding tissues. In the oral and maxillofacial regions, these lesions usually occur on the dorsum of the </span></span>tongue<span>, with no reported cases of osteocartilaginous choristomas occurring on the oral floor. We report the case of a 57-year-old Japanese male referred to our hospital in late November 2021 with the chief complaint of tongue hypoaesthesia and a mass on the right side of the oral floor. Clinical examination revealed that the lesion was a 22 × 13 mm elastic hard mass with an ulcer at the centre of the lesion on the right side of the oral floor behind Walton's canal orifice. Computed tomography images showed an opaque mass with a major diameter of 20 mm, internal heterogeneity, and a well-defined border located slightly to the right of the floor of the </span></span></span>oral cavity<span>. Surgical resection was performed through an intraoral incision<span> under local anaesthesia. The imaging and surgical findings at our hospital showed a 22 × 15 mm lesion with clear boundaries, which could be removed as a single mass from the surrounding connective tissue. Histological investigation revealed that lesion has the characteristics of hyaline cartilage with some areas showing ossification, leading to a diagnosis of osteocartilaginous choristoma of the oral floor. The patient has progressed well and remains recurrence-free 2 years postoperatively.</span></span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1299-1303"},"PeriodicalIF":0.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}