Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Stability of the maxilla and mandible in patients with dentofacial deformities after multi-segmental Le Fort I osteotomy combined with sagittal split ramus osteotomy","authors":"Masaki Kasahara ,&nbsp;Daichi Hasebe ,&nbsp;Daisuke Suda ,&nbsp;Hidenobu Sakuma ,&nbsp;Naoaki Saito ,&nbsp;Daisuke Saito ,&nbsp;Jun Nihara ,&nbsp;Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2024.12.015","DOIUrl":"10.1016/j.ajoms.2024.12.015","url":null,"abstract":"<div><h3>Objective</h3><div>Skeletal stability after multi-segmental Le Fort I osteotomy combined with sagittal split ramus osteotomy in patients with dentofacial deformities was evaluated using frontal and lateral cephalograms in this study.</div></div><div><h3>Methods</h3><div>The subjects were 19 patients (3 males and 16 females) with dentofacial deformities who had undergone multi-segmental Le Fort I osteotomy at our hospital between January 2011 and December 2021. The mean age of the patients at the time of surgery was 27 years (age range: 15–46 years). The patients were classified into skeletal Class II and Class III groups according to the ANB angle determined by lateral cephalometric analysis: Class II (ANB angle&gt; 4), and Class III (ANB angle &lt; 1). Changes in the positions of the maxilla and mandible were analyzed with frontal and lateral cephalograms taken immediately before surgery (T0), a few days after surgery (T1), and one year after surgery (T2).</div></div><div><h3>Results</h3><div>The amount of movement of the maxilla and mandible at surgery varied from case to case. On the other hand, the amount of postoperative change in the maxilla and mandible was about 1 mm in most subjects, suggesting that skeletal stability after multi-segmental Le Fort I osteotomy is quite high.</div></div><div><h3>Conclusions</h3><div>Postoperative maxillary position after MSL1 was stable overall, but postoperative relapse should be carefully controlled in cases with open bite, asymmetry, and/or enlarged maxillary dental arch.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 475-479"},"PeriodicalIF":0.4,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrin α11: Key signaling pathways and tumor dynamics","authors":"Roshna Sankar ,&nbsp;Sharon John ,&nbsp;Kriti Sharma ,&nbsp;Priya Devi ,&nbsp;Prashasti Chundawat ,&nbsp;Shalini Gupta","doi":"10.1016/j.ajoms.2024.12.012","DOIUrl":"10.1016/j.ajoms.2024.12.012","url":null,"abstract":"<div><div>This review provides a comprehensive exploration of Integrin α11 (ITGA11), a crucial cell adhesion receptor involved in diverse biological processes. Composed of α and β chains, ITGA11 forms heterodimers, with specific subtypes acting as primary receptors for native collagens. Understanding its structure, physiology, and expression, particularly in activated fibroblasts prevalent in pathological conditions including cancer, is essential. ITGA11's physiological distribution extends to developing cartilage and embryonic tissues, implicating its role in various developmental processes. In pathological conditions like cancer, ITGA11 expression is associated with poor prognoses. It significantly influences the tumor microenvironment by regulating collagen assembly and matrix remodeling, particularly through pathways such as TGF-β and Hedgehog signaling. Moreover, ITGA11 contributes to cancer progression via interconnected pathways like PI3K/AKT and PDGFBR/JNK, influencing tumor growth, invasion, and metastasis. Understanding ITGA11's role offers promising avenues for cancer therapy interventions, making it a key target in oncology research and clinical practice. This review underscores the importance of unraveling ITGA11's molecular mechanisms to enhance diagnostics and develop effective therapeutic strategies against cancer.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 546-551"},"PeriodicalIF":0.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetry of the face – Review of a complex matter","authors":"Peter A.W.H Kessler ,&nbsp;Veronique C.M.L. Timmer ,&nbsp;Suen A.N. Lie","doi":"10.1016/j.ajoms.2024.11.010","DOIUrl":"10.1016/j.ajoms.2024.11.010","url":null,"abstract":"<div><div>Facial symmetry is one of the most important characteristics in the perception of a human face. Facial asymmetry means that both facial sides are not identical. Mild facial asymmetry is very common in the general population. Most people have slight facial asymmetry, and this is the normal biological situation in humans. Abnormalities of soft tissue, dental and skeletal elements result in facial asymmetry. Asymmetry has many causative factors and its etiology includes both congenital and acquired disorders. Extended knowledge of the embryology and anatomy of each branchial arch derivative is mandatory for the diagnosis, grading, treatment and followup of postoperative patients. In this review, we focus on the broad differential diagnosis of facial asymmetry. Treatment is multidisciplinary and must be related to the underlying cause. When formulating a treatment plan, complete knowledge of the etiological factors and character of the asymmetry plays a crucial role. The timing of treatment should be based on functional criteria, growth, the expected stability of the result and the patient's wishes. Patients in a functional crisis situation should be treated early.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 397-405"},"PeriodicalIF":0.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication-related osteonecrosis of the jaw secondary to peri-implantitis: Report of a case with a unique clinical course","authors":"Takuma Watanabe ,&nbsp;Dai Kawahara ,&nbsp;Makoto Hirota","doi":"10.1016/j.ajoms.2024.12.009","DOIUrl":"10.1016/j.ajoms.2024.12.009","url":null,"abstract":"<div><div>The number of older adults with systemic conditions who have undergone dental implant treatment is increasing. Peri-implantitis is a local factor associated with medication-related osteonecrosis of the jaw (MRONJ). Treatment methods for severe MRONJ with pathological fracture remain controversial. An 86-year-old woman with dementia and osteoporosis was referred to our department with a chief complaint of left mandibular peri-implantitis. We diagnosed her with MRONJ secondary to peri-implantitis and performed conservative surgery in which the sequestrum was completely excised. Although a pathological fracture occurred approximately 2 months after surgery, we observed the patient conservatively because of the minimal deviation and absence of active inflammation. Spontaneous bone regeneration had occurred by approximately 1 year postoperatively. Our findings suggested that dental implants placed in older adults with dementia who are receiving antiresorptive therapy should be carefully monitored to prevent peri-implantitis and peri-implant MRONJ. In patients with severe MRONJ and pathological fracture, favorable bone healing can be achieved with conservative surgery if the remaining bone has remodeling capability.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 540-545"},"PeriodicalIF":0.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Control of microbial contamination in dental unit waterlines: Effectiveness of neutral electrolytic water","authors":"Sayaka Mishima,&nbsp;Takuma Watanabe,&nbsp;Shizuko Fukuhara,&nbsp;Shigeki Ymanaka,&nbsp;Kazumasa Nakao","doi":"10.1016/j.ajoms.2024.11.012","DOIUrl":"10.1016/j.ajoms.2024.11.012","url":null,"abstract":"<div><h3>Objective</h3><div>With an emphasis on nosocomial infection control, dental healthcare settings face challenges in managing and preventing microbial contamination, particularly in dental unit waterlines (DUWL). Currently, there are a lack of studies on clear measures to prevent contamination of DUWLs. Therefore, in this study, we investigated the effectiveness of neutral electrolytic water in controlling microbial contamination of DUWLs.</div></div><div><h3>Methods</h3><div>Water samples collected from DUWL were tested for <em>Legionella</em> species. Adenosine triphosphate levels were measured as indicators of contamination in the DUWL and water supply models. Heterotrophic bacterial counts were assessed before and after implementation of neutral electrolytic water purification systems. During dental treatment, plate sampling of heterotrophic bacteria was conducted before and after implementation of the neutral electrolytic water purification systems.</div></div><div><h3>Results</h3><div><em>Legionella</em> spp<em>.</em> were not detected in the water samples collected from DUWL. However, samples collected using three-way syringes, gargle water, and high-speed handpieces indicated inadequate hygiene levels. Heterotrophic bacterial counts were significantly reduced after neutral electrolytic water purification systems were implemented. In the environmental survey conducted during dental treatment, no significant differences were found between tap water and neutral electrolytic water in terms of heterotrophic bacterial counts.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate the effectiveness of neutral electrolytic water in reducing microbial contamination in DUWLs. Additionally, use of an extraoral vacuum aspirator during dental procedures can significantly reduce the risk of infection. These findings highlight the importance of implementing effective disinfection strategies to ensure patient safety in dental settings.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 512-517"},"PeriodicalIF":0.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety and depression following facial and dental trauma – A prospective study","authors":"Waleed Ahmad ,&nbsp;Abdur Rehman","doi":"10.1016/j.ajoms.2024.12.005","DOIUrl":"10.1016/j.ajoms.2024.12.005","url":null,"abstract":"","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 491-492"},"PeriodicalIF":0.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical study of anterior maxillary impacted supernumerary teeth based on the classification of horizontal and vertical positions","authors":"Keiichiro Nakazato ,&nbsp;Yasufumi Niinaka ,&nbsp;Eiji Fujii ,&nbsp;Reiko Hoshi ,&nbsp;Nobuyoshi Tomomatsu ,&nbsp;Tetsuya Yoda","doi":"10.1016/j.ajoms.2024.12.006","DOIUrl":"10.1016/j.ajoms.2024.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to reveal the relationship between the surgical approach of extraction and the dimensional position of the anterior maxillary impacted supernumerary teeth (AMIST), impacted mesiodens according to the definition of the systematized classification of horizontal and vertical position.</div></div><div><h3>Methods</h3><div>This retrospective study included patients with AMIST who required computed tomography for extraction. The number of teeth, direction of impaction, age at the surgery, operative time, and surgical approach for AMIST were analyzed. AMIST was classified into two groups (H: horizontal position and V: vertical position); each group was divided into several subgroups (H1, 2, 3; V1, 2, 3, 4).</div></div><div><h3>Results</h3><div>In total, 223 AMIST were included. Based on the direction of impaction, 142 teeth were categorized as inverted, 69 normal, and 12 horizontal. With vertically higher positions, age at the operation and operative time were considerably increased in the H2 region (the area between the palatal side of the permanent central incisor and the incisive canal). The operative time was markedly increased in &lt; 7 years old versus ≥ 10 years old and ≥ 7 years old and &lt; 8 years old versus ≥ 10 years old in the H2 region. The palatal approach was the most common (214 teeth, 96.0 %), followed by the labial (8 teeth, 3.6 %) and nasal floor (1 tooth, 0.4 %) approaches.</div></div><div><h3>Conclusions</h3><div>Classifying of horizontal and vertical positions by computed tomography images is crucial in preoperative treatment planning since it helps surgeons decide on the surgical approach methods and evaluate surgical difficulty and invasion.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 470-474"},"PeriodicalIF":0.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of high phosphate concentration on osteoblastic differentiation using 3D cell culture system","authors":"Miki Sharyo ,&nbsp;Yu Usami ,&nbsp;Katsutoshi Hirose ,&nbsp;Kaori Oya ,&nbsp;Miho Hyodo ,&nbsp;Akari Teramoto ,&nbsp;Takumi Shibahara ,&nbsp;Li-Jie Li ,&nbsp;Satoru Toyosawa ,&nbsp;Sunao Sato","doi":"10.1016/j.ajoms.2024.12.003","DOIUrl":"10.1016/j.ajoms.2024.12.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of phosphate concentration on osteoblastic differentiation in the murine preosteoblastic cell line MC3T3-E1 within 3D collagen gel culture system.</div></div><div><h3>Methods</h3><div>To examine the impact of phosphate concentrations on cellular behavior, we constructed the 3D collagen gel culture system. The 3D culture system was used to observe morphological changes and to detect the expression of osteogenic markers (Runx2 and Dmp1).</div></div><div><h3>Results</h3><div>High (50 mM) concentrations of inorganic phosphate (Pi), a phosphate donor, reduce the cellular matrix production and proliferation compared with the control concentration (10 mM) during the experimental period. Immunohistochemical analysis revealed that Runx2 expression at high phosphate concentration was increased compared with the control concentration, while after 2 weeks, Runx2 expression at high phosphate concentration was decreased compared with the control concentration. Dmp1 expression was increased in high phosphate concentration from 1 week throughout the experimental period compared with the control concentration.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that phosphate concentration plays a crucial role in modulating osteoblastic differentiation in 3D cell culture. A High phosphate concentration appears to accelerate Runx2 expression at initial stage, and subsequently suppress it, while maintaining sustained Dmp1 expression. Our results suggests that the influence of phosphate on osteoblastic differentiation within 3D cell culture may contribute to elucidation of the mechanisms underlying bone formation and mineralization related to skeletal development and bone disease pathogenesis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 552-557"},"PeriodicalIF":0.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, characterisation, biocompatibility, and corrosion analysis of gadolinium and selenium doped bioactive glass surface coating for dental implants","authors":"Vamshi Ram V ,&nbsp;Parkavi Arumugam ,&nbsp;Saheb Ali ,&nbsp;Pradeep Kumar Yadalam ,&nbsp;Seyed Ali Mosaddad ,&nbsp;Artak Heboyan","doi":"10.1016/j.ajoms.2024.12.002","DOIUrl":"10.1016/j.ajoms.2024.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop novel gadolinium and selenium-doped bioactive glass (gsBG)-coated titanium dental implants and analyse their surface, chemical, corrosion, and biocompatibility properties.</div></div><div><h3>Methods</h3><div>A sol-gel method was used to prepare gsBG by hydrolysing 45 % tetraethyl orthosilicate (TEOS) in water with nitric acid, followed by adding calcium nitrate, sodium nitrate, orthophosphoric acid, gadolinium, and selenous acid. The mixture was stirred, dip-coated on titanium, and sintered at 400 °C. The coating was characterised using Field Emission Scanning Electron Microscope (FE-SEM), Energy Dispersive X-ray (EDX), and Fourier Transform Infrared Spectroscopy (FTIR). Biocompatibility was tested with MG63 cells, comparing gsBG-coated (Group A) and bare titanium implants (Group B). Cell viability was assessed at 24, 48, 72, 96, and 120 h. An unpaired student t-test was performed to statistically analyse the effect of both groups on cell viability at various time points. Corrosion resistance was analysed via impedance and polarisation in artificial saliva.</div></div><div><h3>Results</h3><div>The SEM, EDX, and FTIR analysis proved the successful coating of the gsBG surface on the titanium implant. Confocal analysis following cell culture showed excellent biocompatibility. No statistically significant difference was observed between Groups A and B, with a <em>P</em> &gt; 0.05 noted at all time points, suggesting that the developed implant coating was biocompatible as a bare titanium surface. Corrosion analysis revealed that the developed surface coating was thermodynamically stable with high corrosion resistance.</div></div><div><h3>Conclusion</h3><div>The developed novel gsBG surface coating has shown great potential as an implant surface coating for better osseointegration outcomes and long-term implant success.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 462-469"},"PeriodicalIF":0.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of salivary-gland and oral-mucosa massage in alleviating xerostomia in patients with schizophrenia","authors":"Yuki Iwashima ,&nbsp;Yutaka Watanabe ,&nbsp;Kimiya Ozaki ,&nbsp;Eri Arai ,&nbsp;Kazuhito Miura ,&nbsp;Ayako Yokoyama ,&nbsp;Miyako Kondo ,&nbsp;Seitaro Nakazawa ,&nbsp;Matsuhiko Oka ,&nbsp;Kazutaka Okada ,&nbsp;Takae Matsushita ,&nbsp;Yutaka Yamazaki","doi":"10.1016/j.ajoms.2024.11.011","DOIUrl":"10.1016/j.ajoms.2024.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effectiveness of salivary-gland and oral-mucosa massage in alleviating xerostomia, which is an adverse effect of antipsychotics, in patients with schizophrenia and to investigate factors associated with its efficacy and clarify its indications.</div></div><div><h3>Methods</h3><div>In this randomized controlled trial, 47 patients with chronic schizophrenia were randomly divided into the intervention and control groups. The intervention group underwent salivary-gland and oral-mucosa massage and was followed up from baseline to week 8. The control group was assessed at baseline and after 8 weeks.</div></div><div><h3>Results</h3><div>Overall, 30 patients completed the study (15 in the intervention group and 15 in the control group). In the intervention group, the salivary flow rate stimulated by the chewing gum test significantly increased after 8 weeks. Furthermore, the use of first-generation antipsychotic (FGA) equivalents was significantly higher in patients whose salivary flow rate was unchanged after salivary gland oral-mucosal massage than in patients who showed improvement. Compared with the patients who used SGA alone, those who used second-generation antipsychotics (SGAs) and FGAs had less recognition of the tendency for salivary secretion to increase, and most of them used levomepromazine, an FGA with high muscarinic receptor affinity.</div></div><div><h3>Conclusions</h3><div>Salivary-gland and oral-mucosa massage may promote salivation in patients with chronic schizophrenia. FGA intake inhibited the effects of the massage, and levomepromazine may have influenced this inhibition. Understanding the interactions　between levomepromazine and salivary-gland and oral-mucosa massage can improve treatment strategies and patient care in chronic schizophrenia.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 500-511"},"PeriodicalIF":0.4,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}