Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Clinical and diagnostic features of salivary glands disease related to COVID-19 infection: A systematic review of the literature","authors":"Pierre Guarino ,&nbsp;Francesco Chiari ,&nbsp;Claudio Donadio Caporale ,&nbsp;Livio Presutti ,&nbsp;Gabriele Molteni","doi":"10.1016/j.ajoms.2024.08.011","DOIUrl":"10.1016/j.ajoms.2024.08.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Coronavirus disease 2019 (COVID-19) results from primary infection by severe acute respiratory syndrome coronavirus 2 (Sars COV-2). The transmission thereof is based on mucosal inoculation of infected droplets or direct contact from carriers. However, coronavirus viral loads can be found in throat wash and saliva specimens. The aim of this work is to make an overview about clinical and diagnostic information of patients affected by sialadenitis related to Sars COV-2 infection.</div></div><div><h3>Methods</h3><div>A systematic literature review has been performed following PRISMA 2020 checklist statement. A computerized search has been carried on by an extensive set of queries on the Embase/Pubmed, Scopus and Cochrane databases, relating to articles published from January 2020 to February 2024.</div></div><div><h3>Results</h3><div>Information reported within ten papers has been processed in this review. The total amount of patients included was 27 (55 % females), with a mean age of 35.6 years. All patients showed a parotid gland infection, which was described bilaterally in 45 % of cases. However, submandibular and sublingual gland infections were reported only as of a single patient. Sialadenitis diagnosis was made through clinical examination, radiological tools and laboratory tests. The diagnosis of parotitis was contextual or delayed to COVID-19 detection in 78 % and 22 % of cases, respectively. The therapeutic management thereof consisted of symptomatic therapies as in Sars COV-2 infection. Antibiotics were reserved in a few cases (12 %).</div></div><div><h3>Conclusions</h3><div>Sialadenitis in patients affected by Sars COV-2 is an uncommon manifestation of COVID-19 infection. Its treatment and prognosis do not differ from those used to treat patients affected by Sars COV-2.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 167-174"},"PeriodicalIF":0.4,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tube feeding in patients with head and neck cancer undergoing chemoradio-/radio therapy: A systematic review and meta-analysis based on the GRADE approach","authors":"Taiki Suzuki ,&nbsp;Souichi Yanamoto ,&nbsp;Daisuke Takeda ,&nbsp;Hirokazu Saito ,&nbsp;Haruki Sato ,&nbsp;Seiji Asoda ,&nbsp;Masatoshi Adachi ,&nbsp;Hidemichi Yuasa ,&nbsp;Narikazu Uzawa ,&nbsp;Hiroshi Kurita","doi":"10.1016/j.ajoms.2024.08.015","DOIUrl":"10.1016/j.ajoms.2024.08.015","url":null,"abstract":"<div><h3>Scope</h3><div>The scope of this systematic review (SR) was to determine whether a nasogastric tube (NGT) or percutaneous endoscopic gastrostomy (PEG) is a more useful supportive therapy in patients with oral cancer undergoing chemoradio-/radio therapy.</div></div><div><h3>Methods</h3><div>For the review, two authors searched MEDLINE, Cochrane CENTRAL and Ichushi-Web to identify clinical practice guidelines, SRs and randomised controlled trials (RCTs) according to pre-determined criteria. RevMan Web was used to combine trials and analyse the data. We evaluated the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation system approach.</div></div><div><h3>Results</h3><div>It was not possible to perform a meta-analysis of only treatment completion based on the included RCTs; therefore, we performed a meta-analysis of treatment breaks as a surrogate outcome. A meta-analysis of potential treatment breaks, including treatment discontinuation, revealed no superiority between PEG and NGT (risk ratio=0.64 [0.23, 1.79]). A meta-analysis was conducted on two RCTs regarding the harms of infection. There does not appear to be a significant increase in the risk of infection with either PEG or NGT (risk ratio=1.18 [0.45, 3.08]). The certainty of the evidence for two outcomes was judged to be very low. Further, meta-analyses of quality of life and nutritional status were not possible because of differences in assessment methods.</div></div><div><h3>Conclusion</h3><div>We could not determine the superiority of NGT or PEG in the supportive care of oral cancer patients who received chemoradio-/radio therapy. The effect of PEG feeding is uncertain, and it is necessary to consider indications for each case.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 92-98"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor budding and complete epithelial mesenchymal transition correlate with late nodal metastasis in early-stage tongue squamous cell carcinoma","authors":"Takayoshi Kikuchi ,&nbsp;Kinue Kurihara ,&nbsp;Homare Kawachi ,&nbsp;Satoru Ogane ,&nbsp;Kazuhiko Hashimoto ,&nbsp;Takahiko Shibahara ,&nbsp;Takeshi Nomura","doi":"10.1016/j.ajoms.2024.08.012","DOIUrl":"10.1016/j.ajoms.2024.08.012","url":null,"abstract":"<div><h3>Background</h3><div>Late nodal metastasis is a poor prognostic factor for early-stage tongue squamous cell carcinoma. However, for most early-stage patients, there is a low risk for late nodal metastasis, which currently lacks a diagnostic marker. Tumor budding is a nodal metastasis risk factor in other human cancers. Here, we evaluated tumor budding by partial or complete epithelial-mesenchymal transition and Ovol2 expression, a transcription factor that directly suppresses epithelial-mesenchymal transition.</div></div><div><h3>Methods</h3><div>Sixty-six T1–2N0 patients were enrolled in this retrospective study. Tumor expressions of E-cadherin and vimentin (epithelial-mesenchymal transition markers) and Ovol2 were assessed by immunohistochemistry. Tumor histopathological and immunohistochemical features, mode of invasion, and tumor budding were assessed. Correlations between these potential predictive factors and late nodal metastasis were determined statistically.</div></div><div><h3>Results</h3><div>Univariate analysis demonstrated lymphoid infiltrate, perineural invasion, infiltrative growth pattern, tumor budding, vimentin positive, and complete epithelial-mesenchymal transition were significant factors of late nodal metastasis (all P &lt; 0.05), observed in 25.8 % of patients. Multivariate analysis identified tumor budding and vimentin positive were independent prognostic factors (both P &lt; 0.025). Ovol2 expression was significantly decreased in partial and complete epithelial-mesenchymal transition cells (both P &lt; 0.01) compared with normal epithelia. Univariate analysis, but not multivariate analysis, showed Ovol2 correlated with depth of invasion and tumor budding (both P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Tumor budding and vimentin expression are risk factors for late nodal metastasis in T1–2N0 tongue squamous cell carcinoma. Ovol2 might be involved in the early stages of epithelial-mesenchymal transition. Evaluation of these factors might identify patients susceptible to late nodal metastasis who require elective neck dissection.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 201-209"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical assessment of stem cell-related Sox2 and Klf4 in ameloblastomas","authors":"Kanako Kuroda ,&nbsp;Atsumu Kouketsu ,&nbsp;Haruka Saito ,&nbsp;Tetsu Takahashi ,&nbsp;Kensuke Yamauchi ,&nbsp;Tsuyoshi Sugiura ,&nbsp;Hiroyuki Kumamoto","doi":"10.1016/j.ajoms.2024.08.014","DOIUrl":"10.1016/j.ajoms.2024.08.014","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to investigate the potential roles of sex-determining region Y-related high mobility group-box 2 (Sox2) and Krüppel-like factor 4 (Klf4), two stem cell-related molecules, in odontogenic tissues.</div></div><div><h3>Methods</h3><div>Immunohistochemical reactivity to Sox2 and Klf4 was examined in 10 dental follicle and 54 ameloblastoma specimens. The association between these molecules and clinical variables was analyzed in ameloblastoma cases.</div></div><div><h3>Results</h3><div>Dental follicles showed immunoreactivity to Sox2 and Klf4 predominantly in the dental lamina. In ameloblastomas, Sox2 and Klf4 expression was detected in 48 of the 54 cases, and was predominantly localized in neoplastic cells adjacent to the basement membrane. Sox2 showed substantially higher expression in dental follicles than in ameloblastomas. Granular cell ameloblastomas presented lower levels of Sox2 and Klf4 than acanthomatous ameloblastomas. Moreover, immunoreactivity of ameloblastomas to Sox2 and Klf4 was slightly higher in recurrent cases than in non-recurrent cases.</div></div><div><h3>Conclusions</h3><div>The differential expression patterns of Sox2 and Klf4 in dental follicles and ameloblastomas indicate that these transcription factors may be involved in the regulation of odontogenic tissues. As these transcription factors are associated with cell proliferation and differentiation in the odontogenic epithelium, they may contribute to tumorigenesis or disease prognosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 228-233"},"PeriodicalIF":0.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of pathologic fracture risk and residual bone height in unicortical and bicortical mandibular corpus defects: A 3D finite analysis","authors":"Arzum Yilmaz ,&nbsp;Sedat Çeti̇ner ,&nbsp;Ilgin Ari","doi":"10.1016/j.ajoms.2024.08.013","DOIUrl":"10.1016/j.ajoms.2024.08.013","url":null,"abstract":"<div><h3>Objective</h3><div>Mandibular bone defects are a common problem and difficult to manage. A defected area mostly left to heal spontaneously. It doesn’t have a definite protocol in the literature, when the area will be left to heal spontaneously or when supported with materials such as plates, screws, grafts, especially in intermediate-sized defects. In this study, it was aimed to determine by examining the areas where the stresses due to chewing forces are concentrated on the mandible bone and the risk of fracture in intermediate size unicortical and bicortical defects.</div></div><div><h3>Material and Methods</h3><div>The all defect models which was the residual bone heights were 6, 8, 10 mm in mandibular corpus region were created. Two different loading scenarios were applied anterior and defected premolar side. Von Mises, Pmax and Pmin stresses in models were evaluated by three-dimensional finite element analysis method.</div></div><div><h3>Results</h3><div>The study found higher stress accumulation on the buccal anterior side of defects in both unicortical and bicortical models, with the most stress concentrated at the buccal corners. Under Loading 1, bicortical defects with 10 mm residual bone height showed slightly higher stress accumulations than unicortical defects, while bicortical defects with 8 and 6 mm residual bone height exhibited significantly higher stress values. Under Loading 2, stress accumulations in bicortical defects were higher than in unicortical defects, with bicortical defects at 6 mm residual bone height showing almost double the stress values. Pmax stress values were higher in bicortical defects under both loadings, especially when the residual bone height decreased. Pmin stress values were comparable in unicortical defects but were higher in bicortical defects, particularly at 6 mm residual bone height, under both loading conditions.</div></div><div><h3>Conclusion</h3><div>This study was presented that mandibular resistance decreases significantly when residual bone height is less than 10 mm for bicortical defects and less than 8 mm at unicortical defects. In these conditions it may need supported with materials to prevent fractures. However, in vivo and in vitro studies are necessary for definitive conclusions.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 84-91"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of periodontal tissue regeneration using octacalcium phosphate and collagen composite","authors":"Keiko Matsui ,&nbsp;Shinji Kamakura ,&nbsp;Atsumu Kouketsu ,&nbsp;Yushi Ezoe ,&nbsp;Kei-ichiro Miura ,&nbsp;Kensuke Yamauchi","doi":"10.1016/j.ajoms.2024.08.009","DOIUrl":"10.1016/j.ajoms.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate periodontal tissue regenerative potential of octacalcium phosphate (OCP) and collagen composite (OCPcol), recognized as excellent bone-regenerative materials, in artificial bone defect models using beagle dogs. This study specifically assessed the efficacy of OCPcol in periodontal soft-tissue regeneration.</div></div><div><h3>Methods</h3><div>OCPcol was implanted in bone defects adjacent to the roots of the left mandibular third and fourth premolars in six beagle dogs (OCP group), while five dogs did not receive OCPcol (control group). The dogs were observed for 3 months. The specimens were evaluated radiologically and histologically.</div></div><div><h3>Results</h3><div>Microcomputed tomography revealed bone regeneration originating from the lateral cortical bone surface adjacent to the created defect. The superficial layer of the regenerated bone was cortical bone-like and continuous with the upper and lower alveolar bone. The bone was regenerated by maintaining a continuous void in the periodontal ligament space above and below the dentinal defect. Dental defects of roots were not regenerated. The control group did not exhibit sufficient bone regeneration. Histologically, in the OCP group, formation of new cementum was observed on the outer surface of the root dentin, with connective tissue attachment and an oblique-running periodontal ligament in the space between the new bone and dentin. However, the dentinal defects were not regenerated．</div></div><div><h3>Conclusions</h3><div>Alveolar bone and periodontal ligament regenerated when OCPcol was implanted into a bone and dentinal defect created around a natural tooth root. These results suggest that OCPcol effectively regenerates periodontal tissue, without ankylosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 76-83"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using texture analysis of ultrasonography images of neck lymph nodes to differentiate metastasis to non-metastasis in oral maxillary gingival squamous cell carcinoma","authors":"Yusuke Kawashima ,&nbsp;Aya Hagimoto ,&nbsp;Hiroshi Abe ,&nbsp;Masaaki Miyakoshi ,&nbsp;Yoshihiro Kawabata ,&nbsp;Hiroko Indo ,&nbsp;Tatsurou Tanaka","doi":"10.1016/j.ajoms.2024.07.013","DOIUrl":"10.1016/j.ajoms.2024.07.013","url":null,"abstract":"<div><h3>Object</h3><div>To differentiate between metastatic neck nodes and non-metastatic neck nodes in oral maxillary gingival squamous cell carcinoma, textural analysis of these lymph nodes in ultrasound images was performed in this study.</div></div><div><h3>Methods</h3><div>Twenty five metastatic neck nodes and 28 non-metastatic neck nodes were enrolled in this study. Seventy eight texture characteristics were retrieved from the US images using the LIFEx software.</div><div>The Mann Whitney U test was measurably utilized to survey on the off chance that there was a measurably noteworthy distinction within the textural characteristics between metastatic neck nodes and non-metastatic neck nodes. The capacity of the surface highlights to recognize between metastatic neck nodes and non-metastatic neck nodes was illustrated utilizing the Receiver Operating Characteristic analysis curves (ROC). Youden's J statistic was used to determine the cut-off positions in each ROC curve that maximized sensitivity and specificity.</div></div><div><h3>Results</h3><div>Zone size non uniformity (ZSNU) highlight appeared the foremost noteworthy contrast between these nodes (p &lt; 0.001).</div><div>Strength had Area Under the Curve (AUC) of 0.811, specificity of 0.821 and sensitivity of 0.8, when measured at the cutoff value of 896.344.</div></div><div><h3>Conclusions</h3><div>Our results come about uncovered that quality highlight may be the finest surface highlight to distinguish from non-metastatic neck nodes and to anticipate metastatic neck nodes in oral maxillary gingival squamous cell carcinoma.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 70-75"},"PeriodicalIF":0.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Lefort-1 advancement by internal and external distraction osteogenesis in non-syndromic cleft lip and palate: A systematic review and meta-analysis","authors":"Sameer Pandey ,&nbsp;Ashi Chug ,&nbsp;Srinivas Gosla Reddy ,&nbsp;Saurabh S. Simre","doi":"10.1016/j.ajoms.2024.08.002","DOIUrl":"10.1016/j.ajoms.2024.08.002","url":null,"abstract":"<div><h3>Purpose</h3><div>In 25 % of Cleft lip and palate (CLP) patients, midface hypoplasia (MH) is non-responsive to orthodontics. Post-surgical scarring in cleft patients causes large relapse with conventional osteotomies. Distraction osteogenesis (DO) has become the choice of treatment for midface hypoplasia in CLP patient. The systematic review aims to generate evidence to guide the selection of distraction devices for non-syndromic CLP associated maxillary hypoplasia.</div></div><div><h3>Materials and methods</h3><div>A PRISMA-guided systematic review was planned. Studies with LeFort 1 distraction osteogenesis in non-syndromic CLP patients were included. Four literature databases (PubMed, Embase, Cochrane and Ovid) were searched. Identified studies were shortlisted based on PICOS criteria for data extraction. SNA, SNB and ANB angle measurements were extracted pre-distraction and within 1 year and after 1-year post-distraction. Forest plots were generated to understand the maxillary advancement and relapse associated with external and internal distractor. Risk of bias was evaluated for non-randomized studies and a traffic light plot as well as summary plot was generated for inference.</div></div><div><h3>Results</h3><div>A total of 2395 articles were identified after a database search. 131 articles were included for full-text review and 31 articles were selected for data synthesis. A total of 361 patients underwent distraction osteogenesis, out of which 265 patients underwent external DO, and 96 underwent internal DO. Pooled data analysis revealed a larger increase in SNA angle for external distractors than internal distractors.</div></div><div><h3>Conclusion</h3><div>External DO provide a greater degree of midface advancement than internal DO. The degree of relapse is more with external distraction.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 23-30"},"PeriodicalIF":0.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the duration of vitamin B12 administration for hypoesthesia caused by inferior alveolar nerve injury after horizontally impacted mandibular third molar: A retrospective study","authors":"Takumi Shimura,&nbsp;Ken-ichiro Sakata,&nbsp;Hiroyuki Hato,&nbsp;Haruhisa Watanabe,&nbsp;Takuya Asaka,&nbsp;Jun Sato,&nbsp;Yoshimasa Kitagawa","doi":"10.1016/j.ajoms.2024.07.010","DOIUrl":"10.1016/j.ajoms.2024.07.010","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the time to cure of hypoesthesia caused by inferior alveolar nerve (IAN) injury after horizontally impacted mandibular third molar (M3) extraction under continuous administration of mecobalamin, a vitamin B12 preparation, and factors that influence the time to cure.</div></div><div><h3>Methods</h3><div>This was a single-center retrospective study including 33 patients who experienced hypoesthesia after horizontally impacted M3 extraction and were treated with continuous oral administration of mecobalamin alone. The patients were divided into cured (n = 28) and uncured groups (n = 5). Demographic and clinical data were collected and analyzed.</div></div><div><h3>Results</h3><div>Of the 33 patients, 5 (15 %) reported uncured hypoesthesia. The median time to cure of hypoesthesia with mecobalamin administration was 33 (range, 6–202) days, and no cure beyond 7 months was reported. Age (≥30 years), Pell and Gregory classification (Position), and presence of Rood and Shehab signs (\"interruption of white line of canal\" and \"diversion of canal\") were significantly associated with prolonged time to cure.</div></div><div><h3>Conclusions</h3><div>It may be necessary to evaluate the efficacy of mecobalamin for IAN injury after horizontally impacted M3 extraction approximately 30 days after the initiation of administration and consider treatment modification or additional treatment within approximately 7 months.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 195-200"},"PeriodicalIF":0.4,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healing of tooth extraction wound socket, do we have current understanding?","authors":"Aqsa Kamal ,&nbsp;Maryam Kamal ,&nbsp;Alina Hasnat ,&nbsp;Abeera Mohsin ,&nbsp;A.R. Samsudin","doi":"10.1016/j.ajoms.2024.07.009","DOIUrl":"10.1016/j.ajoms.2024.07.009","url":null,"abstract":"<div><h3>Objective</h3><div>This review paper aims to provide an up to date understanding on tooth socket healing signifying the impact of osteoimmunology, cellular and molecular events, role of nerves, growth factors, signaling pathways, oxygen, endocrine and obesity in healing and regeneration.</div></div><div><h3><strong>Methods</strong></h3><div>A thorough literature search was conducted using up to date software and electronic databases including Python 3.9.7 and latent Dirichlet allocation (LDA).</div></div><div><h3><strong>Results</strong></h3><div>70 relevant articles were included. Tooth socket healing is different from other types of bone healing.</div></div><div><h3><strong>Conclusion</strong></h3><div>Role of osteoimmunology, macrophages, mesenchymal stem cells, growth factors, hormones and nerves in tooth socket healing have been ignored for long. These factors can result in impaired wound healing or disruption the healing process. Understanding the mechanisms involved in tooth socket healing can contribute to the development of targeted strategies for promoting optimal healing outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 8-22"},"PeriodicalIF":0.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}