Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第2页

Surgical excision and follow-up of nondysplastic oral leukoplakia. A systematic review

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-28 DOI: 10.1016/j.ajoms.2024.11.009

Haruki Sato , Hideki Nakayama , Takahiro Yagyuu , Masanobu Abe , Taiki Suzuki , Daisuke Takeda , Masatoshi Adachi , Hidemichi Yuasa , Narikazu Uzawa , Hiroshi Kurita

{"title":"Surgical excision and follow-up of nondysplastic oral leukoplakia. A systematic review","authors":"Haruki Sato , Hideki Nakayama , Takahiro Yagyuu , Masanobu Abe , Taiki Suzuki , Daisuke Takeda , Masatoshi Adachi , Hidemichi Yuasa , Narikazu Uzawa , Hiroshi Kurita","doi":"10.1016/j.ajoms.2024.11.009","DOIUrl":"10.1016/j.ajoms.2024.11.009","url":null,"abstract":"<div><h3>Objectives</h3><div>In this systematic review, we aimed to clarify the clinical question, “Should nondysplastic oral leukoplakia be surgically excised?”, in accordance with the Japanese Oral Cancer Clinical Practice Guidelines.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, Japana Centra Revuo Medicina Web, and the Cochrane Central Register of Controlled Trials to identify articles that met the pre-established criteria. We performed a statistical analysis using RevMan Web and assessed the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation approach.</div></div><div><h3>Results</h3><div>In total, 784 articles were identified, and one randomized controlled trial including 235 participants was selected. The only primary outcome that could be assessed was rate of malignant transformation, with a risk ratio of 1.14 and a 95 % confidence interval of 0.07–17.95. Meta-analysis was not performed because only one randomized controlled trial was available. The time to onset of malignant transformation, rate of recurrence, rate of clinical resolution, and rate of clinical deterioration were not analyzed due to the lack of data. The certainty of the evidence was very low.</div></div><div><h3>Conclusions</h3><div>We could not determine the superiority of surgical excision over follow-up in patients with non-dysplastic oral leukoplakia. Future multicenter data collection, utilizing standardized and objective measures, is essential to better define the indications for surgical excision in patients with non-dysplastic oral leukoplakia.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 414-419"},"PeriodicalIF":0.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the relationship between facial asymmetry and thoracic spine deviation

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-22 DOI: 10.1016/j.ajoms.2024.11.007

Sumire Ono, Riku Kohara, Ryohei Iwasaki, Karen Gomi, Akinori Moroi, Kunio Yoshizawa, Koichiro Ueki

{"title":"Investigation of the relationship between facial asymmetry and thoracic spine deviation","authors":"Sumire Ono, Riku Kohara, Ryohei Iwasaki, Karen Gomi, Akinori Moroi, Kunio Yoshizawa, Koichiro Ueki","doi":"10.1016/j.ajoms.2024.11.007","DOIUrl":"10.1016/j.ajoms.2024.11.007","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous studies have linked facial asymmetry to scoliosis, but the relationship with thoracic vertebral deviation is unclear. This study aimed to investigate the association between facial asymmetry and thoracic spinal deviation.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 92 Japanese women who underwent computed tomography (CT) and plain chest X-rays for oral surgery. Cephalometric radiographs were reconstructed from CT data using SIMPLANT. Patients were categorized into symmetric and asymmetric groups based on a 2.5° deviation from the maxillomandibular (Mx-Md) midline angle. Thoracic deviation (DTh) was measured on chest X-rays, and Cobb angles were determined using the Cobb method. Multiple regression analysis explored the relationship between thoracic spine deviation and cephalometric parameters. Unpaired t-tests compared thoracic vertebrae measurements between the groups.</div></div><div><h3>Results</h3><div>Significant associations were observed between DTh and several cephalometric parameters, including the Mx-Md midline angle (p = 0.011) and occlusal cant (p = 0.017) from frontal cephalometry, as well as the odontoid triangle angle and mandibular length (Co-Gn) from lateral cephalometry (R² = 0.18, p = 0.002). No significant association was found between cephalometric parameters and the Cobb angle. Of the 92 patients, 49 and 43 were included in the symmetric and asymmetric groups, respectively. The asymmetric group exhibited significantly larger thoracic deviation (p < 0.001), though no difference was observed in Cobb angle.</div></div><div><h3>Conclusion</h3><div>The findings suggest a relationship between facial asymmetry and thoracic vertebral deviation but no significant link with scoliosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 455-461"},"PeriodicalIF":0.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myxolipoma in the buccal region: A case report and review of literature

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-22 DOI: 10.1016/j.ajoms.2024.11.008

Takashi Baba , Hiroshi Baba , Takehito Fukui , Takeshi Kaneuji , Koji Kashima , Yoshihiro Yamashita

{"title":"Myxolipoma in the buccal region: A case report and review of literature","authors":"Takashi Baba , Hiroshi Baba , Takehito Fukui , Takeshi Kaneuji , Koji Kashima , Yoshihiro Yamashita","doi":"10.1016/j.ajoms.2024.11.008","DOIUrl":"10.1016/j.ajoms.2024.11.008","url":null,"abstract":"<div><div>Lipomas are benign mesenchymal tumors with a relatively high incidence rate. However, myxolipomas, a histological variant characterized by mature adipose tissue and abundant myxoid substances, are rare, especially in the oral cavity. This case report focuses on a 90-year-old-female patient, the oldest reported with oral myxolipoma, who presented with the chief complaint of a painless mass in her right buccal region that had persisted for several years. The mass (approximately 25 mm in diameter) was palpable, soft, elastic, and covered with normal mucosa. In general, the Hounsfield unit (HU) of lipomas is approximately –100 units on computed tomography, and lipomas show high signal intensity on both T1- and T2-weighted magnetic resonance imaging. In contrast, in this case, the HU was approximately 50 units, which is slightly lower than that of the common muscle, similar to a previous report on myxomas. Unlike common lipomas, the present case exhibited low and high signal intensities on T1- and T2-weighted images, respectively. The tumor was surgically excised under local anesthesia and histopathological examination revealed a well-defined lobulated mass surrounded by a thin fibrous capsule. The tumor cells exhibited a solid proliferation of mature adipocytes, which were replaced by abundant myxoid substances. Based on these findings, the patient was diagnosed with a myxolipoma. Myxolipoma should be considered as a differential diagnosis when myxomas are suspected on preoperative imaging studies. The postoperative follow-up was uneventful, and no evidence of recurrence was observed 2 years postoperatively.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 594-598"},"PeriodicalIF":0.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Otodental syndrome in a 6-year-old child: A report of a rare condition

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-20 DOI: 10.1016/j.ajoms.2024.11.005

Diego Girotto Bussaneli , Nilton José da Silva-Filho , Kasandra Veronica Yupanqui , Manuel Restrepo , Aline Leite Farias , Elisa Maria Aparecida Giro , Lourdes Santos-Pinto

{"title":"Otodental syndrome in a 6-year-old child: A report of a rare condition","authors":"Diego Girotto Bussaneli , Nilton José da Silva-Filho , Kasandra Veronica Yupanqui , Manuel Restrepo , Aline Leite Farias , Elisa Maria Aparecida Giro , Lourdes Santos-Pinto","doi":"10.1016/j.ajoms.2024.11.005","DOIUrl":"10.1016/j.ajoms.2024.11.005","url":null,"abstract":"<div><div>Otodental syndrome (ODS) is a rare autosomal dominant disorder characterized by globodontia, sensorineural hearing loss, and sometimes eye coloboma. First described in 1969 by Denis and Csiba, ODS features dental anomalies in number, eruption, size, shape, and structure. It predominantly affects primary and permanent dentition, sparing incisors and often resulting in premolar absence and delayed eruption. A 6-year-old girl presented with delayed tooth eruption and morphological alterations, experiencing pain during brushing and recent hearing loss. Her father had similar dental anomalies and hearing loss. Examination revealed severely altered teeth with bulbous crowns, normal incisors, and no oral mucosal changes. Radiographs showed agenesis of premolars and complex odontoma-like lesions. The patient had no systemic diseases. ODS is linked to microdeletions on chromosomes 11q13.3 and 20q13.1, and mutations in FGF3 and other dental development genes. Diagnosis is challenging due to variable expressivity and incomplete penetrance. Differential diagnosis includes syndromes with sensorineural hearing loss and dental abnormalities. Effective ODS management requires a multidisciplinary approach, often involving surgical removal of odontomas, planned extractions, and orthodontic treatment. Preventive measures and continuous monitoring are essential to improve outcomes. Genetic counseling and specialized care for hearing loss are recommended.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 535-539"},"PeriodicalIF":0.4,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the impact of periodontal disease management before the onset of type 2 diabetes mellitus on medical costs using administrative claims database 利用行政索赔数据库分析 2 型糖尿病发病前牙周病管理对医疗费用的影响

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-18 DOI: 10.1016/j.ajoms.2024.11.006

Yukiko Sakamoto , Kahori Kawamura , Hideki Yoshimatsu , Takashi Doi , Tatsuro Miyake

{"title":"Analysis of the impact of periodontal disease management before the onset of type 2 diabetes mellitus on medical costs using administrative claims database","authors":"Yukiko Sakamoto , Kahori Kawamura , Hideki Yoshimatsu , Takashi Doi , Tatsuro Miyake","doi":"10.1016/j.ajoms.2024.11.006","DOIUrl":"10.1016/j.ajoms.2024.11.006","url":null,"abstract":"<div><h3>Objective</h3><div>Although periodontal disease management has been shown to reduce the medical costs of diabetes mellitus, no studies have investigated management before the onset of type 2 diabetes mellitus. Therefore, this study examined the association between periodontal disease management before the onset of type 2 diabetes mellitus and medical costs.</div></div><div><h3>Methods</h3><div>We extracted information for periodontal disease management status from Japanese medical claims and specific health check-up databases among 4010 patients with periodontal disease and type 2 diabetes mellitus aged ≥ 30 years who had continued periodontal disease management for 2 years after diabetes onset. We divided patients into two groups: those who had received periodontal disease management for 2 years before and 2 years after onset and those who had received periodontal disease management for only 2 years after the onset of type 2 diabetes mellitus.</div></div><div><h3>Results</h3><div>The HbA1c level in patients without periodontal disease management during the year of diabetes onset improved by 0.13 % in male and 0.24% in female 2 years later, while that in the group with periodontal disease management improved by 0.49 % and 0.74%, respectively. The medical costs were significantly lower in the group with periodontal disease management 2 years later than in the group with no periodontal disease management.</div></div><div><h3>Conclusions</h3><div>Regular periodontal disease prevention and management under professional care before type 2 diabetes mellitus onset contribute to improved health and reduced medical costs.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 493-499"},"PeriodicalIF":0.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cemento-osseous dysplasia-like lesions associated with impacted tooth: A case series with review of the literature

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-15 DOI: 10.1016/j.ajoms.2024.11.004

Robert A. Heck , Shokoufeh Shahrabi-Farahani

引用次数: 0

Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-13 DOI: 10.1016/j.ajoms.2024.11.003

Mikako Kuroda , Noriko Komatsu , Azuma Kosai , Takao Hamakubo , Takahiro Abe

{"title":"Anti-EGFR antibody immunotoxins improve cytotoxic effects in the salivary gland cancer A253 cell line","authors":"Mikako Kuroda , Noriko Komatsu , Azuma Kosai , Takao Hamakubo , Takahiro Abe","doi":"10.1016/j.ajoms.2024.11.003","DOIUrl":"10.1016/j.ajoms.2024.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>Salivary gland cancers account for a relatively small proportion, accounting for 3–5 %, among head and neck cancers. The range of antibody drugs available for head and neck cancers, including salivary gland cancers, has been expanding in recent years. However, reports indicated insufficient clinical efficacy despite high target expression. Our research has been investigating methods to improve the cytotoxic effects of antibody drugs in head and neck cancers, using immunotoxins (ITs), which are antibodies conjugated with toxins. Our studies on squamous cell carcinoma, which constitutes the majority of head and neck cancers, indicated that promoting endosomal escape of ITs improves their cytotoxic effects. Therefore, the current study aimed to confirm the antitumor effects of IT-Cetuximab (Cmab), which is cetuximab conjugated with a toxin, targeting salivary gland cancers—a type of cancer with limited effective treatment options aside from surgery.</div></div><div><h3>Methods</h3><div>We confirmed protein and mRNA expression of epidermal growth factor receptor (EGFR) in the human salivary duct carcinoma cell line, A253. We analyzed the cytotoxicity of saporin-conjugated anti-EGFR antibody (IT-Cmab).</div></div><div><h3>Results</h3><div>EGFR expression in A253 was comparably higher than in epidermoid carcinoma cell line A431 which highly expresses EGFR. Cmab alone exhibited no cytotoxic effects, but IT-Cmab demonstrated concentration-dependent cytotoxic effects in A253. We revealed the promising cytotoxic effects of IT-Cmab in salivary gland cancer cells.</div></div><div><h3>Conclusion</h3><div>We first demonstrate the cytotoxic effects of IT in salivary gland cancers in vitro. The IT we used, cetuximab toxin conjugated antibody may be a remarkable treatment option for salivary gland cancers.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 450-454"},"PeriodicalIF":0.4,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifocal viral epithelial hyperplasia in the elderly with identification of high-risk human papillomavirus

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-02 DOI: 10.1016/j.ajoms.2024.11.002

Cynthia Marina Urias-Barreras , Alberto Rodríguez-Archilla , Rogelio Lagarde-Guerrero , José Guadalupe Rendón-Maldonado

引用次数: 0

A rare case of Ameloblastic Fibro-Odontoma in Child

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-11-01 DOI: 10.1016/j.ajoms.2024.11.001

Mariana Rodrigues Santos , Milla Gontijo Costa , Isadora Moreira Aquino , Carlos Alberto Ribeiro , Vladimir Reimar Augusto de Souza Noronha

{"title":"A rare case of Ameloblastic Fibro-Odontoma in Child","authors":"Mariana Rodrigues Santos , Milla Gontijo Costa , Isadora Moreira Aquino , Carlos Alberto Ribeiro , Vladimir Reimar Augusto de Souza Noronha","doi":"10.1016/j.ajoms.2024.11.001","DOIUrl":"10.1016/j.ajoms.2024.11.001","url":null,"abstract":"<div><div>Ameloblastic Fibro-Odontoma (AFO) is a rare benign tumor, constituting 1–3 % of odontogenic tumors, and is of mixed origin, involving both ectomesenchymal and epithelial components. It predominantly affects males and typically manifests in individuals within their first two decades of life. The posterior jaw and maxilla are the most affected regions, in that order. Often asymptomatic, this tumor is usually discovered during routine imaging examinations or investigations into delayed tooth eruption. Histopathological examination reveals fragments of immature mineralized tissue resembling dental structures such as enamel, dentin, and cementum. The optimal treatment involves enucleation and curettage. This study aims to present a case of AFO in a five-year-old patient, detailing its oral, radiographic, and histopathological manifestations, along with differential diagnoses and treatment. A literature review will be conducted, correlating the case with existing knowledge in major scientific databases such as PubMed and Scielo.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 576-580"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of oral mucosal tuberculosis resembling a malignancy in an immunocompromised patient

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-10-31 DOI: 10.1016/j.ajoms.2024.10.008

Daisuke Ueda , Soichi Hirashima , Toshiyuki Akimori , Yawaka Shitozawa , Kiko Takano , Konomi Sennari , Akihiko Miyawaki

{"title":"A case of oral mucosal tuberculosis resembling a malignancy in an immunocompromised patient","authors":"Daisuke Ueda , Soichi Hirashima , Toshiyuki Akimori , Yawaka Shitozawa , Kiko Takano , Konomi Sennari , Akihiko Miyawaki","doi":"10.1016/j.ajoms.2024.10.008","DOIUrl":"10.1016/j.ajoms.2024.10.008","url":null,"abstract":"<div><div>Tuberculosis of the oral cavity is rare and is usually secondary to pulmonary Tuberculosis. The lungs are the most common sites of involvement. However, any organ may exhibit extrapulmonary involvement. We report a case of oral mucosal tuberculosis in an elderly man with oral mucosal ulcers. A man in his 80 s, with pemphigoid and renal dysfunction, was admitted to our department with intractable contact pain. Ulcers were undermined and had a saw-tooth appearance with granulation tissue formation in the left lower buccal gingiva. No abnormal bone resorption was observed on the panoramic graphs. A biopsy of the same area showed positive Ziehl-Neelsen staining, suggesting gingival inflammation due to tuberculosis. Upon consultation with the Department of Respiratory Medicine at our hospital, tuberculosis was diagnosed based on positive results of the sputum loop-mediated isothermal amplification method. The patient had a history of pulmonary tuberculosis and was taking steroids to treat pemphigoid. Tuberculosis recurrence is likely due to immunosuppression resulting from aging, underlying diseases, and steroid therapy. Care is required when diagnosing these patients. Oral mucosal tuberculosis should be considered in patients with refractory oral ulcers, contact pain, or a history of pulmonary tuberculosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 530-534"},"PeriodicalIF":0.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0