Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第2页

The use of ubiquinone to improve the healing of soft and hard jaw tissues – A systematic review 使用泛醌改善颌骨软组织和硬组织的愈合--系统综述

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-19 DOI: 10.1016/j.ajoms.2024.07.008

Alini Cardoso Soares , Camila Barcellos Calderipe , Rafael dos Santos Giorgis , Luisa Quevedo Grave , Antonio Cesar Manentti Fogaça , Marcos Antonio Torriani , Ana Carolina Uchoa Vasconcelos , Lauren Frenzel Schuch

{"title":"The use of ubiquinone to improve the healing of soft and hard jaw tissues – A systematic review","authors":"Alini Cardoso Soares , Camila Barcellos Calderipe , Rafael dos Santos Giorgis , Luisa Quevedo Grave , Antonio Cesar Manentti Fogaça , Marcos Antonio Torriani , Ana Carolina Uchoa Vasconcelos , Lauren Frenzel Schuch","doi":"10.1016/j.ajoms.2024.07.008","DOIUrl":"10.1016/j.ajoms.2024.07.008","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of the present study was to survey the scientific literature for conclusive evidence about the capacity of ubiquinone to improve the healing process of soft and hard jaw tissue.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to the PRISMA 2020 statement. An electronic search was undertaken in six databases and in the gray literature<strong>.</strong></div></div><div><h3>Results</h3><div>Eight studies were identified, four of them <em>in vitro,</em> three <em>in vivo,</em> and one clinical. All articles demonstrated that ubiquinone accelerates the repair of soft tissue, whereas one study found little effect on the remodeling of bone tissue. Despite the possibility that ubiquinone application may be beneficial, the limited knowledge about the action of this coenzyme on oral tissue repair requires further preclinical studies before the development of human clinical trials.</div></div><div><h3>Conclusion</h3><div>This systematic review provides valuable information about potential new medications that could help the healing of oral tissues, especially for oral and maxillofacial surgeons.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 157-166"},"PeriodicalIF":0.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of lichen planus in the oral cavity and laryngopharynx 两例口腔和喉咽部扁平苔藓病例

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-06 DOI: 10.1016/j.ajoms.2024.06.009

Atsushi Tsurumi , Masaki Minabe , Sari Ueno , Yuria Akira , Nana Morita , Kazuhiko Hashimoto , Nobuyuki Matsuura , Takeshi Nomura , Michiyoshi Kouno

{"title":"Two cases of lichen planus in the oral cavity and laryngopharynx","authors":"Atsushi Tsurumi , Masaki Minabe , Sari Ueno , Yuria Akira , Nana Morita , Kazuhiko Hashimoto , Nobuyuki Matsuura , Takeshi Nomura , Michiyoshi Kouno","doi":"10.1016/j.ajoms.2024.06.009","DOIUrl":"10.1016/j.ajoms.2024.06.009","url":null,"abstract":"<div><div>Lichen planus (LP) is a chronic inflammatory disease that frequently occurs in the oral mucosa and skin; however, it rarely occurs in the laryngopharynx. Here, we describe the cases of an 83-year-old woman (Case 1) and a 77-year-old man (Case 2) who presented with LP in the oral cavity and laryngopharynx. Both patients had erythema and erosion of the palate, pharynx, and epiglottis as well as pain during swallowing. Case 1 had airway stenosis caused by laryngopharyngeal mucosa scarring. Mucosal pemphigoid was clinically suspected in both cases; however, direct immunofluorescence findings of specimens obtained from the oral cavity and pharynx were negative. Together with the histopathological findings, we diagnosed the patients with LP. We administered topical therapy with tacrolimus (Case 1) and steroids (Case 2) for intraoral lesions. Inhaled corticosteroids were administered to the laryngopharynx by an otorhinolaryngologist at our hospital. Consequently, the patient’s symptoms alleviated. In both cases, odynophagia, erythema, erosion of the palate, and the histopathological findings of bullous LP were observed. If such findings are observed, it is necessary to consider the possibility that oral LP that is accompanied by laryngopharyngeal LP.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 221-227"},"PeriodicalIF":0.4,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclooxygenase upregulation in cytomegalovirus-infected gingival fibroblasts: Implications for periodontal disease 受巨细胞病毒感染的牙龈成纤维细胞中环氧化酶的上调：对牙周病的影响

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-02 DOI: 10.1016/j.ajoms.2024.07.004

Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos

{"title":"Cyclooxygenase upregulation in cytomegalovirus-infected gingival fibroblasts: Implications for periodontal disease","authors":"Sara Delgadillo-Barrera , Lilia J. Bernal-Cepeda , Sigrid Camacho-Ortega , Sonia P. Bohórquez-Avila , Jaime E. Castellanos","doi":"10.1016/j.ajoms.2024.07.004","DOIUrl":"10.1016/j.ajoms.2024.07.004","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the changes in the expression of COX-1 and COX-2 in primary gingival fibroblasts upon infection with two strains of human cytomegalovirus (CMV).</div></div><div><h3>Methods</h3><div>Primary human gingival fibroblasts (HGFs) were cultured and infected with two strains of human CMV the laboratory strain (Towne) and a clinical isolate (B52) at a multiplicity of infection of 0.5. The relative mRNA levels of COX-1 and COX-2 were evaluated using multiplex reverse transcriptase quantitative polymerase chain reaction with specific hydrolysis probes. Additionally, immunofluorescence was performed for COX-2, IE1, and IE2 viral proteins.</div></div><div><h3>Results</h3><div>At 24 h post infection, CMV infection of HGFs resulted in a decrease in COX-1 transcripts in cells infected with both the Towne strain and B52 clinical isolate, and in non-infected cells. Conversely, COX-2 transcripts increased in infected cells (Towne and B52); they were significantly higher in B52 infected cells, similar to the immunofluorescence detection results for COX-2.</div></div><div><h3>Conclusions</h3><div>Infection of HGFs with CMV increased in both mRNA and protein expression of COX-2. Furthermore, the B52 isolate induced higher COX-2 expression than the Towne laboratory strain. This study provides a basis for understanding the putative relationships between CMV infection and inflammatory responses in gingival diseases.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 188-194"},"PeriodicalIF":0.4,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141690466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review COVID-19患者口腔病变的形态学和组织分子特征：在世系统综述的更新

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-28 DOI: 10.1016/j.ajoms.2024.06.010

Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos

{"title":"Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: An update of a living systematic review","authors":"Felipe Martins Silveira , Laura Borges Kirschnick , Camila Barcellos Calderipe , Lauren Frenzel Schuch , Manoela Domingues Martins , Ronell Bologna-Molina , Alan Roger Santos-Silva , Ana Carolina Uchoa Vasconcelos","doi":"10.1016/j.ajoms.2024.06.010","DOIUrl":"10.1016/j.ajoms.2024.06.010","url":null,"abstract":"<div><h3>Objective</h3><div>This is the update of the previously published living systematic review that integrated the morphological and tissue-based molecular characterization of oral lesions occurring in individuals infected with COVID-19 (OLICs).</div></div><div><h3>Methods</h3><div>This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data.</div></div><div><h3>Results</h3><div>Six studies, reporting nineteen cases of OLICs, were included. Of the patients, 73.7 % were males with a mean age of 54.8 (± 18.8) years. The most commonly observed clinical presentation was ulcers (42.9 %), primarily in the palate (52 %). Histopathologically, the most frequently reported features in the mesenchymal layer were thrombi/microvascular thrombosis (36.6 %), inflammation (24.4 %), and hemorrhage (14.7 %). Immunohistochemistry for SARS-CoV-2 or Spike Protein was conducted in 15 cases, revealing 86.7 % positivity. In one study, RT-PCR yielded a negative result, which was further confirmed by negative immunohistochemistry.</div></div><div><h3>Conclusion</h3><div>The occurrence of thrombotic events associated with the presence of the spike protein could explain the etiopathogenesis of some cases of OLICs, probably also associated with other etiological factors.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 151-156"},"PeriodicalIF":0.4,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dentoalveolar distraction osteogenesis combined with surgical orthodonthic treatment for a patient with jaw deformity and ankylosed maxillary canine – A case report 牙槽骨牵引成骨联合外科正畸治疗一名下颌畸形和上颌犬牙强直的患者--病例报告

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-24 DOI: 10.1016/j.ajoms.2024.06.007

Zhuoyang Zheng, Ryoko Takeuchi, Daisuke Suda, Daisuke Saito, Daichi Hasebe, Tadaharu Kobayashi

{"title":"Dentoalveolar distraction osteogenesis combined with surgical orthodonthic treatment for a patient with jaw deformity and ankylosed maxillary canine – A case report","authors":"Zhuoyang Zheng, Ryoko Takeuchi, Daisuke Suda, Daisuke Saito, Daichi Hasebe, Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2024.06.007","DOIUrl":"10.1016/j.ajoms.2024.06.007","url":null,"abstract":"<div><div>In surgical orthodontic treatment, the presence of an ankylosed tooth makes it difficult to achieve the desired dental arch morphology. Single tooth osteotomy and dentoalveolar distraction osteogenesis (DO) combined with surgical orthodontic treatment for a patient with jaw deformity and an ankylosed maxillary canine is described in this report. A 37-year-old female was referred to our clinic with a chief complaint of anterior crossbite and was diagnosed with skeletal mandibular protrusion. During preoperative orthodontic treatment for surgical orthodontic treatment, her upper right canine did not move and was diagnosed as an ankylosed tooth. Therefore, we decided to perform a single tooth osteotomy and dentoalveolar DO of the right maxillary canine. Instead of using a commercially available distractor, the dentoalveolar DO in this case was performed using a homemade device with orthodontic biomechanics to move the ankylosed tooth with its supporting alveolar bone and soft tissue into the correct position. After preoperative orthodontic treatment, orthognathic surgery with Le Fort I osteotomy and bilateral sagittal split osteotomies was performed. However, root resorption of the right upper canine continued, and the resorption area was therefore restored with composite resin 10 months after orthognathic surgery to improve the function and esthetics of the maxillofacial region. One and a half years have passed since the orthognathic surgery, and the skeletal stability is good, and the patient is progressing well.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 130-134"},"PeriodicalIF":0.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological study on diameter of extranodal extension of cervical metastatic lymph nodes in the prognosis of oral cancer 口腔癌预后中宫颈转移淋巴结外延直径的临床病理学研究

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-21 DOI: 10.1016/j.ajoms.2024.06.008

Daigo Yoshiga , Naomi Yada , Kazuya Haraguchi , Hironori Fujita , Kenichiro Katsuno , Sho Mitsugi , Norihiko Furuta , Manabu Habu , Masaaki Sasaguri , Kazuhiro Tominaga , Izumi Yoshioka

{"title":"Clinicopathological study on diameter of extranodal extension of cervical metastatic lymph nodes in the prognosis of oral cancer","authors":"Daigo Yoshiga , Naomi Yada , Kazuya Haraguchi , Hironori Fujita , Kenichiro Katsuno , Sho Mitsugi , Norihiko Furuta , Manabu Habu , Masaaki Sasaguri , Kazuhiro Tominaga , Izumi Yoshioka","doi":"10.1016/j.ajoms.2024.06.008","DOIUrl":"10.1016/j.ajoms.2024.06.008","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the relationship between the degree of destruction of the cervical lymph node capsule, extranodal invasion distance, and the prognosis of extranodal extension (ENE)-positive patients</div></div><div><h3>Study design</h3><div>We retrospectively examined microscopic slides from neck dissection specimens of ENE-positive patients of our hospital. The ENE distance was measured by a pathologist who set up a virtual lymph node and measured the maximum extranodal invasion distance. The maximum distance was used for multiple ENEs. Forty patients with ENE were enrolled in this study. The Kaplan–Meier method was used to estimate survival.</div></div><div><h3>Results</h3><div>Among the ENE-positive cases, the capsule was completely destroyed and partially destroyed in seven and 33 cases, respectively. Disease-specific survival (DSS) was 1251 days (range 156–3009 days). The median distance of extranodal invasion was 2500 µm (392–8500 µm) in the 33 ENE-positive cases in which the capsule was not completely destroyed. Receiver operating characteristic curve analysis of these 33 cases showed that the cutoff value of extranodal invasion distance for progression-free survival was 2241 µm.</div></div><div><h3>Conclusions</h3><div>ENE is a prognostic predictor of oral cancer; ENE was an independent prognostic factor; and ENE size cutoff of 2241 µm was a significant prognostic factor.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 64-69"},"PeriodicalIF":0.4,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maxillary osteonecrosis related to post-COVID-19: A report of case series and 6-month follow-up 与后COVID-19相关的上颌骨骨坏死：系列病例和 6 个月随访报告

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-18 DOI: 10.1016/j.ajoms.2024.06.005

Duong Van Huynh , Dung Kim Nguyen , Tuan Van Nguyen , Thanh Van Bui , Chanh Trung Le

{"title":"Maxillary osteonecrosis related to post-COVID-19: A report of case series and 6-month follow-up","authors":"Duong Van Huynh , Dung Kim Nguyen , Tuan Van Nguyen , Thanh Van Bui , Chanh Trung Le","doi":"10.1016/j.ajoms.2024.06.005","DOIUrl":"10.1016/j.ajoms.2024.06.005","url":null,"abstract":"<div><h3>Objective</h3><div>Post-COVID-19-related osteonecrosis of jaws (PCRONJ) has emerged as a complication observed in patients recovered from COVID-19 infection, but PCRONJ has been understudied in the literature. We aimed to report a case series of PCRONJ, including diagnosis, treatment procedures, and discussion about related factors.</div></div><div><h3>Methods</h3><div>We prospectively evaluated PCRONJ patients at the National Hospital of Odonto-Stomatology in Ho Chi Minh, Vietnam. Patients’ demographics, medical history, COVID-19 treatment, clinical and preclinical features, and clinical outcomes were reported.</div></div><div><h3>Results</h3><div>During a six-month period, nine patients were included in this study. The mean age was 53.7 years and 56 % of patients were male. All patients were diagnosed with PCRONJ at the maxillary, diabetic and administered corticosteroids to manage COVID-19 prior to this infection. The mean time from COVID-19 recovery to the onset of symptoms was 4.6 weeks. 89 % of patients underwent tooth extractions following tooth mobility examination. Clinically, mobility of dentoalveolar maxillae, in combination with necrotic bone exposure and/or inflammatory signs were observed in all cases. Radiographically, bone destruction located in maxillae and surrounding structures reflected the extension of lesions. Surgical treatment was applied for all cases to debride the necrotic bone. All patients exhibited well-healing, and an improved quality of life after discharge.</div></div><div><h3>Conclusions</h3><div>PCRONJ should be distinguished from other forms of osteonecrosis of the jaws due to its distinct features. Multiple risk factors complicate the refinement of the likelihood of PCRONJ but warrant awareness for clinicians. An early diagnosis would help to plan a timely treatment and for optimal clinical outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 180-187"},"PeriodicalIF":0.4,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative three-dimensional maxillary stability assessment: Bioresorbable miniplate vs. titanium miniplate systems in Le Fort I osteotomy 上颌骨三维稳定性对比评估：勒堡 I 型截骨术中的生物可吸收小板与钛小板系统

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-16 DOI: 10.1016/j.ajoms.2024.06.003

Koki Takamatsu , Sunao Shiogama , Yosuke Ikehata , Arisa Yasuda , Yuji Kurihara , Tatsuo Shirota

{"title":"Comparative three-dimensional maxillary stability assessment: Bioresorbable miniplate vs. titanium miniplate systems in Le Fort I osteotomy","authors":"Koki Takamatsu , Sunao Shiogama , Yosuke Ikehata , Arisa Yasuda , Yuji Kurihara , Tatsuo Shirota","doi":"10.1016/j.ajoms.2024.06.003","DOIUrl":"10.1016/j.ajoms.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the usefulness of bioresorbable miniplates by comparing the three-dimensional maxillary stability of poly L-lactic acid and titanium miniplate systems in Le Fort I osteotomy.</div></div><div><h3>Methods</h3><div>Fifty patients with jaw deformities underwent Le Fort I or bilateral sagittal split osteotomies. The patients were divided into two groups: the first group received the polylactic acid miniplate system for bone fixation, while the second group received the titanium miniplate system. Cone-beam computed tomography (CBCT) was performed before surgery and at 1 and 6 months after surgery. The acquired images were overlapped to quantify the extent of maxillary relapse by calculating the difference in the distance moved between 1 and 6 months after surgery.</div></div><div><h3>Results</h3><div>There was no significant difference in maxillary stability between the two groups 6 months after surgery.</div></div><div><h3>Conclusions</h3><div>The postoperative stability achieved using the poly L-lactic acid miniplate system for maxillary fixation was comparable to that achieved using the titanium miniplate system.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 56-63"},"PeriodicalIF":0.4,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Segmental mandibular resection and reconstruction using a multidisciplinary approach in adolescent and young adult patients: A case of Ewing sarcoma with a eight-year follow-up 采用多学科方法对青少年和年轻成人患者进行下颌骨节段切除和重建：一例随访八年的尤文肉瘤病例

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-15 DOI: 10.1016/j.ajoms.2024.06.002

Sumitaka Hagiwara , Ikuo Hyodo , Daisuke Nishikawa , Masashi Ando , Naoko Maeda , Shogo Ozawa , Yasuhisa Hasegawa , Nobuhiro Hanai

{"title":"Segmental mandibular resection and reconstruction using a multidisciplinary approach in adolescent and young adult patients: A case of Ewing sarcoma with a eight-year follow-up","authors":"Sumitaka Hagiwara , Ikuo Hyodo , Daisuke Nishikawa , Masashi Ando , Naoko Maeda , Shogo Ozawa , Yasuhisa Hasegawa , Nobuhiro Hanai","doi":"10.1016/j.ajoms.2024.06.002","DOIUrl":"10.1016/j.ajoms.2024.06.002","url":null,"abstract":"<div><div>Ewing sarcoma (ES) is a rare malignant tumor, particularly in the head and neck region. Its incidence tends to be higher in pediatric patients than in adults. Occasionally, curative treatment of ES requires extensive resection of the primary lesion, which can result in postoperative aesthetic or functional disorders. In recent years, advances have been made in reconstructive surgery of the maxillofacial region. Broad mandibular defects are a prime indication for several types of vascularized free bone grafts. Similarly, the treatment of ES has progressed in the field of systemic chemotherapy. We report a multidisciplinary surgical case of ES in the mandible of a 12-year-old patient who underwent extensive mandibular resection and fibula free flap (FFF) reconstruction with preoperative and postoperative chemotherapy. In brief, after conducting a multidisciplinary clinical conference, perioperative chemotherapy was planned by pediatric oncologists, and the operation was performed by a head and neck cancer team consisting of head and neck, oral and maxillofacial, and plastic surgeons. Five months after the operation, prosthodontists applied an intraoral prosthesis. The reconstructed mandible demonstrated good development, and the quality of life was maintained both aesthetically and functionally for eight years after treatment. Our efficient multidisciplinary medical collaboration demonstrated that mandibular reconstruction using FFF is a suitable method for treating pediatric patients and leads to long-term survival with satisfactory outcomes.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 123-129"},"PeriodicalIF":0.4,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of postoperative radiotherapy combined with or without chemotherapy for locally advanced oral cancer: A systematic review and meta-analysis 局部晚期口腔癌术后放疗联合或不联合化疗的疗效：系统综述和荟萃分析

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-06-14 DOI: 10.1016/j.ajoms.2024.06.001

Hu Longfei, Zhou Shangyin, Zhang Ju

{"title":"Outcomes of postoperative radiotherapy combined with or without chemotherapy for locally advanced oral cancer: A systematic review and meta-analysis","authors":"Hu Longfei, Zhou Shangyin, Zhang Ju","doi":"10.1016/j.ajoms.2024.06.001","DOIUrl":"10.1016/j.ajoms.2024.06.001","url":null,"abstract":"<div><h3>Objective</h3><div>Radiotherapy combined with chemotherapy or radiotherapy alone is an important treatment for locally advanced oral squamous cell carcinoma. We performed a meta-analysis of published reports about these two treatments.</div></div><div><h3>Methods</h3><div>We performed an extensive exploration of various databases, such as Embase, PubMed, and the Cochrane Library. The study included research on the comparison between postoperative chemoradiotherapy (POCRT) and postoperative radiotherapy (PORT) for oral cancer, with a restriction on the search language to English. The included endpoints consisted of disease-free survival (DFS), overall survival (OS), locoregional control (LRC), and distant metastasis-free survival (DMFS).</div></div><div><h3>Results</h3><div>Sixteen studies were included, including 3 prospective studies and 13 retrospective studies, with 3364 patients. For patients with locally advanced oral cancer, compared with PORT, POCRT had better DFS (HR 0.64; 95 % confidence interval [CI],0.48–0.84; P = 0.001), OS (HR 0.76;95 %CI 0.65–0.89; P = 0.0005), and LRC (HR 0.65;95 %CI 0.44–0.95; P = 0.02). There was a tendency for DMFS (RR 0.95;95 %CI 0.90–1.01; P = 0.09) to exhibit a marginal statistical distinction. The risks of grade 3 or higher acute toxicity, such as oral mucositis (RR 1.36; p = 0.44), dysphagia (RR 1.57; p = 0.13), and severe skin (RR 0.71; p = 0.17), were more frequent in the POCRT group, but the difference was not statistically significant.</div></div><div><h3>Conclusions</h3><div>For patients with oral squamous cell carcinoma, POCRT is beneficial in terms of DFS, OS, and LRC, but there is no significant benefit in DMFS. The group receiving POCRT exhibited a slightly increased likelihood of experiencing oral mucositis and dysphagia, although the disparity did not attain statistical significance.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 141-150"},"PeriodicalIF":0.4,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141400183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0