Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

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Evaluation of bone-to-implant contact area in patients with reduced residual bone height in the posterior maxilla: A virtual simulation study 后上颌骨残骨高度降低患者骨与种植体接触面积的评估:一项虚拟模拟研究
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-15 DOI: 10.1016/j.ajoms.2025.09.007
Artem Artemchuk, Bekir Osmanov, Yurii Chepurnyi
{"title":"Evaluation of bone-to-implant contact area in patients with reduced residual bone height in the posterior maxilla: A virtual simulation study","authors":"Artem Artemchuk,&nbsp;Bekir Osmanov,&nbsp;Yurii Chepurnyi","doi":"10.1016/j.ajoms.2025.09.007","DOIUrl":"10.1016/j.ajoms.2025.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between implant diameter and potential bone to implant contact area (pBIC) under varying residual bone heights in the posterior maxilla using virtual modeling techniques.</div></div><div><h3>Methods</h3><div>A total of 444 virtual implant placements were simulated using CBCT data from partially edentulous patients with residual alveolar ridge heights ranging from ≤ 2 mm to &lt; 7 mm. Three conical implant models (3.5, 4.0, and 4.5 mm diameter, 10 mm length) were virtually positioned with identical angulation. pBIC was calculated based on Boolean operations and segmentation in a CAD environment. Residual bone height was categorized into three groups: ≤ 2 mm, &gt; 2–4 mm, and &gt; 4–&lt; 7 mm. Statistical analysis included non‑parametric and parametric tests as appropriate, with p &lt; 0.05 as the significance threshold.</div></div><div><h3>Results</h3><div>Implants of 4.0 mm diameter showed pBIC values comparable to both 3.5 mm and 4.5 mm, representing a possible optimal diameter. Each 0.5 mm increase in implant diameter corresponded to a 16–18 % increase in pBIC. However, under minimal bone conditions (≤2 mm), differences among diameters were not statistically significant; with increasing bone height, differences became more pronounced, reaching up to ∼30 % disparity and growing proportionally with bone height.</div></div><div><h3>Conclusions</h3><div>Implant diameter significantly influences pBIC, particularly with adequate residual bone height. When bone availability is limited, the impact diminishes. These findings emphasize the need for individualized implant selection and further clinical studies exploring the interactions between bone microarchitecture, biomechanical properties, implant design, and insertion torque.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 209-214"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of salivary duct cyst arising from the accessory parotid gland 副腮腺引起的唾液管囊肿1例
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-05 DOI: 10.1016/j.ajoms.2025.08.009
Yudai Shimizu , Taiki Suzuki , Yoshihiro Ohashi , Reo Aoki , Kenichi Kumagai , Takanori Eguchi , Yoshiki Hamada
{"title":"A case of salivary duct cyst arising from the accessory parotid gland","authors":"Yudai Shimizu ,&nbsp;Taiki Suzuki ,&nbsp;Yoshihiro Ohashi ,&nbsp;Reo Aoki ,&nbsp;Kenichi Kumagai ,&nbsp;Takanori Eguchi ,&nbsp;Yoshiki Hamada","doi":"10.1016/j.ajoms.2025.08.009","DOIUrl":"10.1016/j.ajoms.2025.08.009","url":null,"abstract":"<div><div>The accessory parotid gland is an anatomical variation of the salivary gland system, is typically unilateral and located anterior to the main parotid gland, connected to it via an independent ductal system. It may be misidentified as a buccal mass and has been implicated in the development of parotid tumors. Salivary duct cysts, also known as mucous retention cysts, are non-neoplastic cystic lesions that account for approximately 2–5 % of all salivary gland pathologies. Although generally benign, rare cases of malignant transformation have been reported. To the best of our knowledge, this is the first documented case of a salivary duct cysts arising from the accessory parotid gland. The patient was a 63-year-old man who presented with left buccal pain that had persisted for six months, followed by a rapid swelling in the same region. Based on imaging and fine-needle aspiration findings, a benign tumor or cystic lesion arising from the accessory parotid gland was suspected, and surgical excision was performed. Histopathological examination confirmed the diagnosis of a salivary duct cyst arising from the accessory parotid gland. Although rare, both lesion of accessory parotid gland and salivary duct cyst have been associated with malignant transformation. Therefore, careful diagnostic evaluation and treatment planning with malignancy in mind are essential.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 312-316"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of quality of life related to oral health after orthognathic surgery and polymorphisms in the COMT, HTR2A and MTNR1A genes 正颌手术后与口腔健康相关的生活质量演变及COMT、HTR2A和MTNR1A基因多态性
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-12 DOI: 10.1016/j.ajoms.2025.09.002
Katheleen Miranda dos Santos , Michelle Nascimento Meger , Mainara Bassetto , João Armando Brancher , Aline Monise Sebastiani , Rafaela Scariot
{"title":"Evolution of quality of life related to oral health after orthognathic surgery and polymorphisms in the COMT, HTR2A and MTNR1A genes","authors":"Katheleen Miranda dos Santos ,&nbsp;Michelle Nascimento Meger ,&nbsp;Mainara Bassetto ,&nbsp;João Armando Brancher ,&nbsp;Aline Monise Sebastiani ,&nbsp;Rafaela Scariot","doi":"10.1016/j.ajoms.2025.09.002","DOIUrl":"10.1016/j.ajoms.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between the improvement in perception of OHRQoL after orthognathic surgery with genetic polymorphisms.</div></div><div><h3>Materials and methods</h3><div>This study included 112 patients with dentofacial deformity (DFD) who underwent orthognathic surgery. All patients were assessed preoperatively and 6 months after surgery. The Oral Health Impact Profile (OHIP-14) was applied and oral mucosa cells were collected for DNA extraction. The <em>COMT</em> (rs165656 and rs174675), <em>HTR2A</em> (rs6313 and rs4941573) and <em>MTNR1A</em> (rs13140012, rs6553010 and rs6847693) <em>genes</em> were genotyped with real-time PCR. Evolution in perception of QoL was classified into improvement, same and worsening. Results obtained were submitted to statistical analysis (CI 95 %).</div></div><div><h3>Results</h3><div>There was an association of <em>COMT</em> with the psychological disability domain in the rs165656 polymorphism (<em>p</em> = 0.042). <em>HTR2A gene</em> in the rs6313 and rs4941573 polymorphism was associated with the social disability domain (<em>p</em> &lt; 0.019; <em>p</em> &lt; 0.038 respectively). There was an association between <em>MTNR1A</em> and the social handicap domain in the recessive G model of rs165656 (<em>p</em> &lt; 0.042).</div></div><div><h3>Conclusion</h3><div>Genetic factors are involved on the evolution OHRQoL. The <em>COMT</em>, <em>HTR2A</em> and <em>MTNR1A genes</em> are associated with the perception of OHRQoL in the domains related to psychological disability, social disability and social handicap.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 196-200"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dentinogenic ghost cell tumor invading the maxillary sinus: A rare case report with a review of the literature 牙本质源性鬼细胞瘤侵袭上颌窦:一例罕见病例报告并复习文献
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-08-22 DOI: 10.1016/j.ajoms.2025.08.012
Pawat Sripodok , Pornpattra Chulamanee , Atsumu Kouketsu , Yutaro Higashi , Tomonari Kajita , Tsuyoshi Kurobane , Yuta Yanagisawa , Tsuyoshi Sugiura , Hiroyuki Kumamoto
{"title":"Dentinogenic ghost cell tumor invading the maxillary sinus: A rare case report with a review of the literature","authors":"Pawat Sripodok ,&nbsp;Pornpattra Chulamanee ,&nbsp;Atsumu Kouketsu ,&nbsp;Yutaro Higashi ,&nbsp;Tomonari Kajita ,&nbsp;Tsuyoshi Kurobane ,&nbsp;Yuta Yanagisawa ,&nbsp;Tsuyoshi Sugiura ,&nbsp;Hiroyuki Kumamoto","doi":"10.1016/j.ajoms.2025.08.012","DOIUrl":"10.1016/j.ajoms.2025.08.012","url":null,"abstract":"<div><div>Dentinogenic ghost cell tumor (DGCT) is a rare, locally aggressive odontogenic neoplasm. This report presents the case of an 80-year-old female with DGCT involving the left maxilla and maxillary sinus. Orthopantomography radiography revealed a well-defined radiopaque lesion in the left posterior maxilla, while Waters’ view demonstrated an irregular radiopaque mass with mixed radiolucent and radiopaque features in the maxillary sinus. Advanced imaging, including CT, confirmed the mass extending into the maxillary sinus and adjacent structures. Histopathological examination of the biopsy indicated DGCT, characterized by ameloblastoma-like epithelium, ghost cells, and dentinoid formation. The patient underwent partial resection of the left maxilla. Immunohistochemistry revealed positive staining for β-catenin, bcl-2, and p63, with a 15 % Ki-67 expression. At 26 months postoperatively, the patient showed no signs of recurrence. A review of the literature identified 13 cases of DGCT with maxillary sinus involvement since 2000, revealing a recurrence rate of approximately 60 % and a potential risk of malignant transformation into ghost cell odontogenic carcinoma. Recurrence was commonly observed in cases treated conservatively, likely due to initial misdiagnosis as a calcifying odontogenic cyst based on incisional biopsy findings, along with challenges related to maxillary sinus involvement. Given the aggressive nature of DGCT, we advocate for surgical resection with long-term follow-up to reduce the risk of recurrence and malignant transformation.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 324-330"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Injectable platelet rich fibrin with microneedling in enhancing peri-implant mucosal phenotype - A prospective clinical trial 微针注射富血小板纤维蛋白增强种植体周围粘膜表型的前瞻性临床试验
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-13 DOI: 10.1016/j.ajoms.2025.09.008
Poornima chittabathina , Sruthima NVS Gottumukkala , Gautami S. Penmetsa , Satyanarayana Raju Mantena , Konathala SV Ramesh , Mohan Kumar Pasupuleti , Anil Kumar Kanakamedala
{"title":"Injectable platelet rich fibrin with microneedling in enhancing peri-implant mucosal phenotype - A prospective clinical trial","authors":"Poornima chittabathina ,&nbsp;Sruthima NVS Gottumukkala ,&nbsp;Gautami S. Penmetsa ,&nbsp;Satyanarayana Raju Mantena ,&nbsp;Konathala SV Ramesh ,&nbsp;Mohan Kumar Pasupuleti ,&nbsp;Anil Kumar Kanakamedala","doi":"10.1016/j.ajoms.2025.09.008","DOIUrl":"10.1016/j.ajoms.2025.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>Enhancing the peri-implant phenotype increases the possibility of long-term favourable outcomes by offering stable peri-implant tissue support, which is essential for the restoration's aesthetic and functional value. The current study aims to investigate the effect non-invasive method of using injectable platelet rich fibrin (iPRF) with micro-needling (MN) on peri-implant mucosal thickness (PIMT) and keratinized mucosal width (KMW) in participants with thin per-implant phenotype.</div></div><div><h3>Methods</h3><div>This prospective clinical trial included 15 endosseous dental implants with thin peri-implant phenotype(&lt;0.8 mm). iPRF injection with microneedling was done during three sessions ten days apart. PIMT and KMW were measured at baseline, 3- and 6-months post-treatment. Pink Esthetic Score(PES) and Patient Esthetic Score(VAS) were assessed at Baseline, 3- and 6-Months. Pain Score(VAS) was assessed at Baseline, 1-and 2- Weeks.Inferential statistical analyses were done using repeated measures of ANOVA followed by Bonferroni post hoc test.</div></div><div><h3>Results</h3><div>The intra group comparison of PIMT at 2, 4 mm showed a statistically significant improvement from baseline (0.56 ± 0.06, 0.72 ± 0.07) to 6 Months (1.31 ± 0.26, 1.48 ± 0.32) (p = &lt;0.001).The KMW showed significant increase from baseline (1.66 ± 0.25) to 3months (1.92 ± 0.12) and 6 months(1.98 ± 0.07)(p = &lt;0.001). Patient reported outcomes showed significant improvement by the end of study period.</div></div><div><h3>Conclusions</h3><div>iPRF + MN is a potentially effective non-surgical, minimally invasive technique to enhance PIMT.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 215-221"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weber–Fergusson incision with triangular flaps to improve postoperative upper lip morphology: A report of five cases 三角形皮瓣Weber-Fergusson切口改善术后上唇形态5例报告
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-16 DOI: 10.1016/j.ajoms.2025.09.011
Norika Funayama, Kazuhide Matsunaga, Akinori Takeshita, Yoshihiro Morita, Himeka Satake, Takafumi Kashiwagi, Emiko Ogasa, Narikazu Uzawa
{"title":"Weber–Fergusson incision with triangular flaps to improve postoperative upper lip morphology: A report of five cases","authors":"Norika Funayama,&nbsp;Kazuhide Matsunaga,&nbsp;Akinori Takeshita,&nbsp;Yoshihiro Morita,&nbsp;Himeka Satake,&nbsp;Takafumi Kashiwagi,&nbsp;Emiko Ogasa,&nbsp;Narikazu Uzawa","doi":"10.1016/j.ajoms.2025.09.011","DOIUrl":"10.1016/j.ajoms.2025.09.011","url":null,"abstract":"<div><div>A Weber–Fergusson incision is used to resect extensive tumors in the maxilla. Some reports have described postoperative scarring and upper lip asymmetry in cases in which a Weber–Fergusson incision was used. In this study, a Weber–Fergusson incision with two triangular flaps was applied to prevent postoperative scarring and upper lip asymmetry. Here, we present details of this surgical procedure and the postoperative outcomes in patients treated using it.</div><div>Five patients having a maxillary malignant tumor underwent resection of the maxilla using a Weber–Fergusson incision, with the raw surface of the buccal mucosa undergoing skin grafting. For the upper lip incision, a 6 mm triangular flap was set 5 mm above the vermilion border within the philtrum on the white lip and a 6 mm triangular flap was set on the vermilion-mucosal junction of the red lip. The upper lip morphology was evaluated one year postoperatively. In all patients, postoperative scarring of the white lip and depression of the red lip were not noticeable, and both patient and observer assessments favorable. Our Weber–Fergusson incision method might be useful for obtaining good postoperative upper lip morphology in adult patients with a maxillary malignant tumor.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 267-272"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current status of patients with maxillofacial fractures in high-energy trauma in our hospital: Usefulness and limitations of conventional classifications 我院高能外伤颌面部骨折的现状:常规分类的有效性和局限性
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-23 DOI: 10.1016/j.ajoms.2025.09.010
Yoshiaki Kitsukawa , Ryo Shiraishi , Aya Koike , Toshiki Hyodo , Yosuke Kunitomi , Shuma Yagisawa , Tomonori Hasegawa , Yasuhiro Tsubura , Yuske Komiyama , Chonji Fukumoto , Takahiro Wakui , Hitoshi Kawamata
{"title":"Current status of patients with maxillofacial fractures in high-energy trauma in our hospital: Usefulness and limitations of conventional classifications","authors":"Yoshiaki Kitsukawa ,&nbsp;Ryo Shiraishi ,&nbsp;Aya Koike ,&nbsp;Toshiki Hyodo ,&nbsp;Yosuke Kunitomi ,&nbsp;Shuma Yagisawa ,&nbsp;Tomonori Hasegawa ,&nbsp;Yasuhiro Tsubura ,&nbsp;Yuske Komiyama ,&nbsp;Chonji Fukumoto ,&nbsp;Takahiro Wakui ,&nbsp;Hitoshi Kawamata","doi":"10.1016/j.ajoms.2025.09.010","DOIUrl":"10.1016/j.ajoms.2025.09.010","url":null,"abstract":"<div><h3>Objective</h3><div>In order to evaluated the usefulness and limitations of conventional classifications for maxillofacial fracture in high-energy trauma, we analyzed the current status of maxillofacial fractures in our hospital.</div></div><div><h3>Methods</h3><div>One hundred nineteen patients with maxillofacial fractures who were treated at our hospital from January 2014 to August 2022 were subjected to this study. We retrospectively searched the electronic medical records of the patients for gender, age, cause of trauma, consultation route, fracture site, fracture pattern, complicating other serious injury, treatment details, and period before surgery if surgery was performed.</div></div><div><h3>Results</h3><div>There were 29 patients in the high-energy trauma group and 90 patients in the non-high-energy trauma group. Regarding midface fractures, fracture patterns in high-energy trauma group did not apply to the Le Fort classification than those in non-high-energy trauma group. Mandibular fractures in non-high-energy trauma group, fractures were more frequent at common sites, including the mandibular angle, mandibular median, and condylar process neck, whereas those in high-energy trauma group were more frequent at sites other than those previously reported as common sites. Complicating other serious injuries at sites other than maxillofacial region were significantly more common in high-energy trauma group than in non-high-energy trauma group.</div></div><div><h3>Conclusions</h3><div>The majority of patients with maxillofacial fractures in high-energy trauma were difficult to classify according to conventional classifications of maxillofacial fractures. There is a need to develop a simple and appropriate diagnostic classification that can guide treatment plans and prognosis for patients with maxillofacial fracture in high-energy trauma.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 222-228"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between immune-related adverse events and treatment efficacy in patients with oral squamous cell carcinoma receiving immune checkpoint inhibitors 接受免疫检查点抑制剂的口腔鳞状细胞癌患者免疫相关不良事件与治疗疗效之间的关系
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-10-02 DOI: 10.1016/j.ajoms.2025.09.015
Kotaro Sakurai , Shuichi Imaue , Atsushi Ikeda , Akinari Sakurai , Hidetake Tachinami , Danki Takatsuka , Mitsuna Fujiki , Shin-ichi Yamada
{"title":"Association between immune-related adverse events and treatment efficacy in patients with oral squamous cell carcinoma receiving immune checkpoint inhibitors","authors":"Kotaro Sakurai ,&nbsp;Shuichi Imaue ,&nbsp;Atsushi Ikeda ,&nbsp;Akinari Sakurai ,&nbsp;Hidetake Tachinami ,&nbsp;Danki Takatsuka ,&nbsp;Mitsuna Fujiki ,&nbsp;Shin-ichi Yamada","doi":"10.1016/j.ajoms.2025.09.015","DOIUrl":"10.1016/j.ajoms.2025.09.015","url":null,"abstract":"<div><h3>Objective</h3><div>This retrospective study examined the relationship between the efficacy of immune checkpoint inhibitors (ICIs) and immune-related adverse events (irAEs) in patients with recurrent or metastatic oral squamous cell carcinoma (OSCC).</div></div><div><h3>Methods</h3><div>Forty patients who received ICIs as their initial treatment were included in the analysis, which utilized medical records. The severity of irAEs was evaluated according to the Common Terminology Criteria for Adverse Events version 5.0. Treatment outcomes were evaluated based on the overall response rate (ORR), disease control rate (DCR), overall survival (OS), and progression-free survival (PFS).</div></div><div><h3>Results</h3><div>Twenty-two irAEs were observed in 15 patients, after a median follow-up period of 15.5 months. Treatment response was significantly higher in irAE+ patients for ORR (66.7 %) and DCR (93.3 %) compared to irAE- patients (28.0 %, 48.0 %). The median OS was 36 months for irAE+ patients and 12 months for irAE- patients (<em>P</em> &lt; 0.01). Similarly, the median PFS was 10 months for irAE+ patients and 2 months for irAE- patients (<em>P</em> &lt; 0.05). Multivariate analysis identified irAE occurrence (hazard ratio [HR]: 0.3; 95 % confidence interval [CI]: 0.07–0.9; <em>P</em> &lt; 0.05) as independent factors for prolonged OS.</div></div><div><h3>Conclusions</h3><div>These results revealed a significant correlation between irAE occurrence and improved clinical outcomes. IrAEs could potentially serve as biomarkers for predicting ICI efficacy in patients with OSCC.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 229-233"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Zataria multiflora on oral bacterial and periodontal indices in fixed orthodontic patients: A double-blind, randomized, controlled, clinical trial 扎连对固定正畸患者口腔细菌和牙周指标的影响:一项双盲、随机、对照的临床试验
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-10 DOI: 10.1016/j.ajoms.2025.09.005
Maryam Fatemipour , Zeinab Naghshvarian Jahromi , Fatemeh Amin , Ebrahim Rezazadeh Zarandi , Bahareh Fatemipour , Seyed Mehdi Vahedi , Amir Hossein Fatehi Marj
{"title":"Efficacy of Zataria multiflora on oral bacterial and periodontal indices in fixed orthodontic patients: A double-blind, randomized, controlled, clinical trial","authors":"Maryam Fatemipour ,&nbsp;Zeinab Naghshvarian Jahromi ,&nbsp;Fatemeh Amin ,&nbsp;Ebrahim Rezazadeh Zarandi ,&nbsp;Bahareh Fatemipour ,&nbsp;Seyed Mehdi Vahedi ,&nbsp;Amir Hossein Fatehi Marj","doi":"10.1016/j.ajoms.2025.09.005","DOIUrl":"10.1016/j.ajoms.2025.09.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients undergoing fixed orthodontic treatment are at high risk of gingivitis and periodontal problems; therefore, regular disinfection of orthodontic appliances and rims is necessary to maintain oral health. As common chemical mouthwashes often lead to sensitivity and mucosal lesions, the present study aimed to evaluate the effect of Protact mouthwash containing the extract of Zataria multiflora (ZM) on <em>Streptococcus mutans</em> and <em>Lactobacillus</em> bacteria, and the assessment of gingival indices in orthodontic patients.</div></div><div><h3>Methods</h3><div>In this double-blind clinical trial, 60 fixed orthodontic patients were randomly assigned to three groups: Protact mouthwash, 0.12 % chlorhexidine (CHX), and placebo (Normal saline; NS). Patients were given the necessary training on correct brushing, use of mouthwash, and dental floss. Gingival indices, including papillary bleeding index (PBI) and modified gingival index (MGI), as well as bacterial colony counts of <em>Streptococcus mutans</em> and <em>Lactobacillus</em>, were assessed at baseline and 21 days after mouthwash application. Data were analyzed using SPSS version 20.</div></div><div><h3>Results</h3><div>After 21 days, the colony counts of both <em>Streptococcus mutans</em> and <em>Lactobacillus</em> decreased significantly in the CHX and Protact mouthwash groups, whereas an increase in colony counts was observed in the NS group, which showed an 11 % increase. Moreover, reductions in both MGI and PBI were significantly greater in the CHX and Protact groups compared to the NS group (P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that Protact mouthwash containing Zataria multiflora extract effectively reduces the colony counts of <em>Streptococcus mutans</em> and <em>Lactobacillus</em> and improves the gingival indices in patients receiving fixed orthodontic treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 286-290"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervicofacial necrotizing fasciitis – Patterns of spread: Case report and review of literature 颈面坏死性筋膜炎-传播模式:病例报告及文献回顾
IF 0.4
Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2026-03-01 Epub Date: 2025-09-16 DOI: 10.1016/j.ajoms.2025.09.009
Clarence Tang , Aidan McKinlay, James Buckley
{"title":"Cervicofacial necrotizing fasciitis – Patterns of spread: Case report and review of literature","authors":"Clarence Tang ,&nbsp;Aidan McKinlay,&nbsp;James Buckley","doi":"10.1016/j.ajoms.2025.09.009","DOIUrl":"10.1016/j.ajoms.2025.09.009","url":null,"abstract":"<div><div>This report describes a rare case of an ascending cervicofacial necrotizing fasciitis in an otherwise healthy 24-year-old after routine third molar extractions. Cervicofacial necrotizing fasciitis is typically odontogenic and spreads in a descending pattern through the anterior neck toward the mediastinum, but other pathways of spread are possible, including ascending and periorbital spread.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"38 2","pages":"Pages 291-295"},"PeriodicalIF":0.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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