Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"A primary osteosarcoma of the mandibular articular process with long-term follow-up: A case report","authors":"Tomomi Sakuma ,&nbsp;Hiroyuki Yoshitake ,&nbsp;Namiaki Takahara ,&nbsp;Tohru Ikeda ,&nbsp;Tetsuya Yoda","doi":"10.1016/j.ajoms.2025.05.005","DOIUrl":"10.1016/j.ajoms.2025.05.005","url":null,"abstract":"<div><div><span>Primary neoplastic lesions of the temporomandibular joint<span><span> (TMJ) are rare, with malignant tumors in this region being even more uncommon. The prognosis of maxillofacial malignancies is often poor due to challenges in achieving an adequate surgical margin. Heein, we report a case of TMJ </span>osteosarcoma<span> with an exceptional 34-year disease-free survival following surgery. A 26-year-old patient underwent preoperative chemotherapy and radiation therapy, followed by surgical resection and adjuvant postoperative radiation therapy. Despite significant postoperative cheek deformity, the patient remained free of recurrence or </span></span></span>metastasis<span>. We propose that the favorable outcome may be attributed to complete tumor resection facilitated by the TMJ joint capsule, which may have acted as a barrier to tumor spread. This case highlights the potential protective role of the joint capsule in achieving successful outcomes in TMJ osteosarcoma.</span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1226-1231"},"PeriodicalIF":0.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteopontin derived from tumor-associated macrophages modulates radiosensitivity of oral squamous cell carcinoma via reactive oxygen species production","authors":"Hikaru Nakashima ,&nbsp;Keisuke Yamana ,&nbsp;Ryoji Yoshida ,&nbsp;Yuichiro Matsuoka ,&nbsp;Hidetaka Arita ,&nbsp;Shunsuke Gohara ,&nbsp;Masatoshi Hirayama ,&nbsp;Kenta Kawahara ,&nbsp;Akiyuki Hirosue ,&nbsp;Yoshikazu Kuwahara ,&nbsp;Tomohiko Wakayama ,&nbsp;Hideki Nakayama","doi":"10.1016/j.ajoms.2025.05.008","DOIUrl":"10.1016/j.ajoms.2025.05.008","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the role of osteopontin (OPN), a secreted phosphoglycoprotein, in radioresistance in oral squamous cell carcinoma (OSCC).</div></div><div><h3>Methods</h3><div>Samples were collected from 66 patients with OSCC. Immunohistochemistry and double staining were performed on tissue sections to assess OPN levels in stromal and tumor cells and OPN and CD163 colocalization, respectively. Cell lines were treated to simulate cancer-associated environments. Macrophage and fibroblast differentiation were induced; enzyme-linked immunosorbent assays, in situ hybridization, and western blotting were performed; and reactive oxygen species (ROS) were detected to evaluate protein levels and cell responses. Cells were also irradiated for survival analysis.</div></div><div><h3>Results</h3><div>Immunohistochemical analysis of OSCC tissue samples revealed OPN localization predominantly in the tumor stroma, particularly in tumor-associated macrophages (TAMs). In vitro experiments demonstrated that TAM-like cells differentiated from THP-1 monocytes secreted higher OPN levels compared with cancer-associated fibroblast-like cells. Clinicopathological analysis revealed a significant correlation between high OPN expression and poor chemoradiotherapy response. The addition of recombinant OPN to OSCC cell lines decreased radiosensitivity, which was reversed by blocking OPN signaling using anti-CD44 and anti-integrin αVβ3 antibodies. Furthermore, OPN treatment reduced radiation-induced DNA double-strand breaks and ROS production and increased glutathione levels, which were inhibited by blocking OPN-CD44 and OPN-integrin αVβ3 pathways.</div></div><div><h3>Conclusions</h3><div>OPN secreted by the tumor stroma, particularly TAMs, contributes to OSCC radioresistance by regulating ROS and GSH levels via the OPN-CD44 and OPN-integrin αVβ3 axes. Therefore, targeting OPN signaling may represent a novel therapeutic strategy for overcoming radioresistance in OSCC.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1186-1195"},"PeriodicalIF":0.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid growth of a melanotic neuroectodermal tumor after biopsy in a 3-month-old infant","authors":"Hideki Ichikawa ,&nbsp;Junko Yagisawa ,&nbsp;Junichi Tanaka ,&nbsp;Hiroyuki Kato ,&nbsp;Aki Ito","doi":"10.1016/j.ajoms.2025.05.006","DOIUrl":"10.1016/j.ajoms.2025.05.006","url":null,"abstract":"<div><div>Melanotic neuroectodermal tumor of infancy<span><span><span> (MNTI) is a rare pigmented tumor of neural crest origin, commonly occurring in the head and neck region. Despite being a </span>benign tumor<span><span>, MNTI is characterized by high cell proliferation activity and can sometimes enlarge while destroying surrounding tissues. Herein, we report a case of MNTI in a 3-month-old girl who exhibited rapid tumor growth following a biopsy; we have included a discussion of the case and review of the relevant literature. Upon initial examination, a 20-mm (long axis) elastic hard mass was observed in the left upper alveolar region extending to the oral </span>vestibule<span>. The mucosal surface was smooth, and submucosal blue-gray tissue was visible. A biopsy was performed under </span></span></span>general anesthesia<span>, but the lesion rapidly enlarged into a grayish-white, irregular mass within a few days. Subsequently, a diagnosis of MNTI was made, and 14 days after the biopsy, the patient underwent a left maxillary tumor<span><span><span> resection and surrounding bone removal under general anesthesia. Following the surgery, a pediatric<span> prosthesis was timely fabricated by the Department of Pediatric Dentistry, resulting in both morphological and functional recovery. Treatment options should carefully consider factors related to </span></span>quality of life to address potential </span>facial deformities that may become more prominent with the subsequent growth of the child.</span></span></span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1232-1238"},"PeriodicalIF":0.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gradient boosting based prediction of gender based on gonial angle measurements","authors":"S. Sowmya ,&nbsp;R. Sangavi ,&nbsp;Pradeep kumar yadalam","doi":"10.1016/j.ajoms.2025.04.003","DOIUrl":"10.1016/j.ajoms.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>Forensic odontology is a field of dentistry that applies dental science to the legal system, examining and analyzing dental evidence in criminal investigations, civil litigation, and other legal proceedings. It plays a crucial role in determining the gender of individuals whose bones have been significantly deformed in a catastrophic event. Forensic dentists use morphological and genetic studies to determine an individual's gender, relying on sexual dimorphism and remnants. The mandible and gonial angle, formed by the lower mandible and ramus, aid in gender determination and age estimation. The study aimed to assess the comparison of neural networks and gradient boosting in the prediction of gender based on gonial angle measurements.</div></div><div><h3>Methods</h3><div>Two hundred CBCT and 200 OPG images were retrieved from Oral and Maxillofacial Radiology archives, involving 100 males and 100 females. Before evaluation, CBCT scans underwent manual reorientation for standardization. The coronal view was adjusted by aligning the software's vertical reference line with the median sagittal plane. The axial reconstruction line was aligned with the mandibular body. The sagittal reconstruction image thickness was increased to 35 millimeters, with two lines for demarcation of the Gonion point. After obtaining the dataset, outliers were removed and normalized, and data were split into 80 % percent and 20 % percent test data and subjected to gradient boosting and neural networks.</div></div><div><h3>Result</h3><div>The study compares Neural Networks' and gradient-boosting models' performance on a task, finding that the Neural Network outperformed the latter with an Area Under the Curve (AUC) of 0.922 and a higher F1 score (Harmonic mean of Precision and Recall).</div></div><div><h3>Conclusion</h3><div>The study demonstrates that the gonial angle, a mandibular measure, can accurately determine gender, with conventional statistical methods and machine learning models predicting it, but with limitations</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 921-928"},"PeriodicalIF":0.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniofacial growth patterns of female patients with cleft lip and/or palate: A longitudinal study from infancy to adolescence","authors":"Akira Suzuki ,&nbsp;Naoko Tamura ,&nbsp;Masaaki Sasaguri ,&nbsp;Takeshi Mitsuyasu ,&nbsp;Seiji Nakamura","doi":"10.1016/j.ajoms.2025.05.004","DOIUrl":"10.1016/j.ajoms.2025.05.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Abnormal craniofacial morphology<span><span> in patients with cleft lip and/or palate has been attributed to defects in craniofacial growth potential and to the effects of surgical and </span>orthodontic treatment. The influence of these factors was examined by analyzing craniofacial growth patterns throughout the growth process from infancy to adulthood.</span></div></div><div><h3>Design</h3><div>Retrospective longitudinal study</div></div><div><h3>Participants</h3><div>The subjects were 46 Japanese female CL/P patients who underwent surgical lip and/or palatal repairs and orthodontic treatment at the Kyushu University Dental Hospital, Fukuoka, Japan.</div></div><div><h3>Methods</h3><div>Using serial cephalometric<span> radiographs from 4 months to 15 + years of age, growth patterns of craniofacial morphology were compared for three cleft types (12 patients with UCLA, 13 CP, and 21 UCLP) using repeated measures ANOVA.</span></div></div><div><h3>Results</h3><div><span>The growth patterns of the patients with UCLP differed from those of the patients with UCLA in the maxillofacial angle (S-N-A), maxillary basal length (A’-Ptm’), posterior maxillary height (S-Ptm’), maxillofacial widths (NC-NC’ and Mx-Mx’), and three maxillofacial ratios (Cd-Go/S-N, Pog-Go/S-N, N-PP/Cd-Go). The growth patterns of the patients with UCLP differed from those of the patients with CP in cranial </span>base lengths (N-Ba and S-Ba), the maxillary basal length, maxillofacial angle, maxillofacial width, and the ratio S-Ptm'/N-PP.</div></div><div><h3>Conclusion</h3><div>Craniofacial growth patterns varied by the cleft types, the presence of both cleft lip and cleft palate inhibited forward and downward growth of the posterior maxillofacial complex, and surgical intervention on the lips, alveolar bone, and palate had a cumulative inhibitory effect on maxillofacial growth.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1167-1180"},"PeriodicalIF":0.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of osteocartilaginous choristoma at the floor of the oral cavity","authors":"Takasuke Usuki ,&nbsp;Soju Seki ,&nbsp;Toshihiro Uchihashi ,&nbsp;Tomonori Sasahira ,&nbsp;Shingo Kodama ,&nbsp;Kohei Kawamura ,&nbsp;Susumu Tanaka ,&nbsp;Syoichiro Ishii ,&nbsp;Munehiro Hamaguchi","doi":"10.1016/j.ajoms.2025.05.003","DOIUrl":"10.1016/j.ajoms.2025.05.003","url":null,"abstract":"<div><div><span>Osteocartilaginous choristomas<span><span> are benign bone lesion<span> composed of hyaline cartilage that undergo ossification and arise when osteochondral cells proliferate into surrounding tissues. In the oral and maxillofacial regions, these lesions usually occur on the dorsum of the </span></span>tongue<span>, with no reported cases of osteocartilaginous choristomas occurring on the oral floor. We report the case of a 57-year-old Japanese male referred to our hospital in late November 2021 with the chief complaint of tongue hypoaesthesia and a mass on the right side of the oral floor. Clinical examination revealed that the lesion was a 22 × 13 mm elastic hard mass with an ulcer at the centre of the lesion on the right side of the oral floor behind Walton's canal orifice. Computed tomography images showed an opaque mass with a major diameter of 20 mm, internal heterogeneity, and a well-defined border located slightly to the right of the floor of the </span></span></span>oral cavity<span>. Surgical resection was performed through an intraoral incision<span> under local anaesthesia. The imaging and surgical findings at our hospital showed a 22 × 15 mm lesion with clear boundaries, which could be removed as a single mass from the surrounding connective tissue. Histological investigation revealed that lesion has the characteristics of hyaline cartilage with some areas showing ossification, leading to a diagnosis of osteocartilaginous choristoma of the oral floor. The patient has progressed well and remains recurrence-free 2 years postoperatively.</span></span></div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1299-1303"},"PeriodicalIF":0.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternation of salivary microbiome and Lautropia dominancy after allogenic hematopoietic stem cell transplantation","authors":"Osamu Imataki ,&nbsp;Akihiro Takeuchi ,&nbsp;Tomoya Ishida ,&nbsp;Makiko Uemura ,&nbsp;Minoru Miyake ,&nbsp;Yumiko Ohbayashi","doi":"10.1016/j.ajoms.2025.05.001","DOIUrl":"10.1016/j.ajoms.2025.05.001","url":null,"abstract":"<div><h3>Objective</h3><div><span>In a patient with hematological malignancy<span>, oral microbiome is disturbed during chemotherapy including </span></span>hematopoietic stem cell transplantation<span> (HSCT). A critical role of salivary microbiota has not been fully investigated.</span></div></div><div><h3>Methods</h3><div><span>We collected saliva of 6 HSCT recipients before and after (around 30 day) transplantation, and characterized patterns of oral microbiota<span>. We set up a healthy control cohort (N = 6) as a normal reference. A two-step PCR protocol was used to amplify a 16S rDNA<span> in the V3-V4 region. Sequencing of the amplicons was performed on an </span></span></span>Illumina MiSeq<span> (Illumina). A significance of alpha and beta diversity of microbiota, and taxonomic composition were investigated.</span></div></div><div><h3>Results</h3><div><span>The patients’ characteristics were median age 43 years old (range 39–58) and 4 female patients. The diversity of microorganisms in saliva were significantly decreased after HSCT. Shannon index (t-test, P = 0.03) and Simpson index (P = 0.06) were significantly lower in recipients after HSCT comparing to before HSCT. In recipients experienced severe (&gt;grade 2) oral mucositis<span>, alpha index was less diverse compared to recipients with mild or moderate oral mucositis, and in whose saliva genus </span></span><em>Lautropia</em> were predominant after HSCT. A common observation of salivary microbiota after HSCT were significant increase of phylum <em>Actinomycetacea</em> and genus <span><span>Actinomyces</span><em>.</em></span> Genus <span><span>Neisseria</span></span> was significantly decreased after HSCT.</div></div><div><h3>Conclusions</h3><div><span>We observed substantial decreases in the number and diversity of salivary microbiota through HSCT in recipient with hematological malignancy. </span><em>Lautropia</em> is newly found microorganism, which is possible to linked to mitigation of severe oral mucositis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1251-1256"},"PeriodicalIF":0.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile xanthogranuloma of the tongue: A case report","authors":"Ayumi Yamamoto,&nbsp;Sho Ishida,&nbsp;Yasuo Hanazawa","doi":"10.1016/j.ajoms.2025.05.002","DOIUrl":"10.1016/j.ajoms.2025.05.002","url":null,"abstract":"<div><div><span>Juvenile xanthogranuloma<span> (JXG) is a rare non-Langerhans cell histiocytosis that typically presents as a self-limiting dermatological condition<span> in young children, and oral mucosal involvement is exceedingly rare. We report the case of a 2-year-old boy, in whom a pink exophytic nodule gradually enlarged for 3 months and subsequently changed to an orange submucosal mass in approximately 1 month. Excisional biopsy was performed to obtain a definitive diagnosis. Histopathological examination revealed diffuse proliferation of foamy </span></span></span>histiocytes and Touton giant cells within the lesion. Based on these results, the patient was diagnosed with JXG. Herein, we present an uncommon case of oral JXG to increase awareness about this lesion. The patient is currently healthy, and no recurrence has been observed 2 years after surgical excision.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1294-1298"},"PeriodicalIF":0.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary intra-osseous squamous cell carcinoma arising from dentigerous cysts: A systematic review of the published case reports","authors":"Esam Halboub ,&nbsp;Gamilah Al-Qadhi ,&nbsp;Layla Hafed ,&nbsp;Faisal Mehsen Alali","doi":"10.1016/j.ajoms.2025.04.013","DOIUrl":"10.1016/j.ajoms.2025.04.013","url":null,"abstract":"<div><h3>Objectives</h3><div>Primary Intraosseous Squamous Cell Carcinoma (PIOSCC) may develop from the dentigerous cyst (DC). The present systematic review aimed at characterizing and analyzing the so-far-published cases of PIOSCC arising from DC.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted utilizing PubMed, Web of Science, and Google Scholar for all relevant studies using a variety of relevant keywords. All studies that reported PIOSCC arising from DC were eligible for inclusion. The quality of the included studies was assessed using the JBI Critical Appraisal Tools for case reports.</div></div><div><h3>Results</h3><div>Twenty-seven case report studies including 29 patients with DC were analyzed. Approximately 79 % of the patients were males, with a mean age of 54 years. One case involved a child who was just 1.4-year-old. The mandible was the most frequently affected jaw, and associated with impacted lower third molars. Two crucial criteria for diagnosis of PIOSCC originating from DC was the transition from normal to abnormal cyst epithelium, and the absence of cystic ameloblastoma, and they were reported in 28 cases (96.6 %). Other two criteria, exclusion of the presence of primary carcinoma elsewhere, and communication with the oral mucosa, were reported less frequently (6 and 18 cases, respectively). Several studies incorporated additional evaluation methods such as immunohistochemical, CT, MRI, and PET-CT. In terms of treatment, surgery alone was the first choice, followed by radiation therapy.</div></div><div><h3>Conclusions</h3><div>Despite its rarity, PIOSCC can arise from DC. Once DC is suspected, a prompt surgical excision with robust serial microscopic examination of the whole excised lesion should be done.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1089-1095"},"PeriodicalIF":0.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of cerebral infarction in which a carotid artery stent was fractured by an elongated styloid process(eagle syndrome)","authors":"Nobuhiro Yoshimi ,&nbsp;Hiromitsu Hatakeyama ,&nbsp;Kazuo Matsui ,&nbsp;Noriyuki Katsumata ,&nbsp;Satoshi Yamada ,&nbsp;Kiyoshi Misawa","doi":"10.1016/j.ajoms.2025.04.012","DOIUrl":"10.1016/j.ajoms.2025.04.012","url":null,"abstract":"<div><div>Eagle’s syndrome is characterized by laryngopharyngeal hypersensitivity, such as sore throat and dysphagia in otorhinolaryngology. It is caused by mechanical pressure from the styloid process that extends to ≥ 25 mm. In most cases, the symptoms appear unilaterally. There are two primary symptoms as follows: (i) classic stylohyoid syndrome, which occurs after tonsillectomy; (ii) stylo-carotid artery syndrome, which involves compression of the carotid artery or sympathetic nerve. We experienced a case of repeated cerebral infarctions due to stylo-carotid artery syndrome. Details of the case are shown below. An elongated styloid process caused three times cerebral infarctions due to internal carotid artery dissection. Internal carotid artery dissection treated with carotid artery stent. But after that, the carotid artery stent was fractured by the styloid process compression. As a result, he suffered a fourth cerebral infarction due to embolization caused by the stent fragments. Using CT angiography and angiography, we diagnosed carotid artery dissection and carotid stent fracture due to an elongated styloid process. In addition to medical therapy for cerebral infarction, we surgically resected the styloid process to prevent recurrence. The scattered stent fragments in the cerebral artery were difficult to remove and were left behind. However, he has not had a recurrence two and a half years. In order to prevent repeated or iatrogenic cerebral infarction, we believe that an elongated styloid process should be resected before stent treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1027-1030"},"PeriodicalIF":0.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}