Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Mandibular single-system Langerhans cell histiocytosis with repeated recurrences at other sites, and a brief literature review","authors":"Kenichi Kume ,&nbsp;Mahiro Beppu ,&nbsp;Hiroshi Hijioka ,&nbsp;Takurou Nishikawa ,&nbsp;Yuuichi Goto ,&nbsp;Kouta Yamashiro ,&nbsp;Maya Nakamura ,&nbsp;Yuusaku Noma ,&nbsp;Keitaro Nishi ,&nbsp;Tatsuo Okui","doi":"10.1016/j.ajoms.2024.10.006","DOIUrl":"10.1016/j.ajoms.2024.10.006","url":null,"abstract":"<div><div>Langerhans cell histiocytosis (LCH) is rare disease that has a very diverse course, ranging from spontaneous recovery to fatal disease. We report the case of a 2-year-old Japanese boy who visited our department with the chief complaint of a mass formation in the molar region of his right mandible. Odontogenic infection was suspected for the mass, and the patient had been receiving antibiotics at a nearby pediatrician’s clinic for about 1 month before visiting our department, but the lesion had increased in size. The patient was admitted to the hospital and an excisional biopsy was performed with general anesthesia. Based on the pathological test results, we diagnosed mandibular single-system LCH. Chemotherapy was performed our hospital’s pediatric department. Thereafter, recurrence occurred four times in the mandible and skull, and chemotherapy was administered each time. Over the 4.5 years since the initial diagnosis, there have been no further signs of recurrence or any effects on the growth of the patient’s jawbone or eruption of teeth.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 524-529"},"PeriodicalIF":0.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden dangers of e-cigarettes on oral health in conjunction with dental implants: A narrative review","authors":"Vorapol Pianjitlertkajorn ,&nbsp;Napatsorn Imerb","doi":"10.1016/j.ajoms.2024.10.007","DOIUrl":"10.1016/j.ajoms.2024.10.007","url":null,"abstract":"<div><div>The use of electronic cigarettes (e-cigarettes) has gained significant popularity in recent years, apparently as a safer alternative to conventional tobacco smoking. However, emerging evidence suggests potential adverse effects on oral health and dental implant outcomes. This review aims to explore the intricate interplay between e-cigarette usage, oral health, and dental implant success. The search strategy utilized pubmed.gov to identify articles pertinent to the mechanisms underlying the impact of e-cigarettes on osseointegration, peri-implant tissue health, and inflammatory responses within the oral environment. Studies reveal that e-cigarette aerosols contain various harmful compounds that may disrupt the delicate balance required for optimal dental implant integration. Furthermore, investigations into the immunomodulatory effects of e-cigarettes highlight their potential to exacerbate inflammatory responses, posing challenges to successful osseointegration. Despite some conflicting findings, evidence suggests an association between e-cigarette use and increased risk of peri-implant diseases and compromised healing processes. Additionally, comparisons with traditional cigarette smoking underscore the need for further research to elucidate the unique risks posed by e-cigarettes in the context of dental implantology. Understanding the multifaceted impact of e-cigarettes on oral health and dental implants is imperative for clinicians to make informed decisions and tailor treatment strategies accordingly. Future research directions should focus on longitudinal studies and mechanistic investigations to unravel the hidden dangers of e-cigarettes and optimize dental implant outcomes in e-cigarette users.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 406-413"},"PeriodicalIF":0.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and severity of temporomandibular disorders in a group of iranian musicians","authors":"Farnaz Bagheri Taddi ,&nbsp;Ali Azadi ,&nbsp;Mahshid Namdari ,&nbsp;Hamed Mortazavi","doi":"10.1016/j.ajoms.2024.10.003","DOIUrl":"10.1016/j.ajoms.2024.10.003","url":null,"abstract":"<div><h3>Objective</h3><div>Allegedly playing a musical instrument is a contributing factor to developing TMD signs and symptoms, but the literature is incoherent. The main aim of this study was to evaluate the prevalence of TMD among amateur musicians for the first time in the Iranian population.</div></div><div><h3>Methods</h3><div>This is a descriptive questionnaire-based cross-sectional study that includes 140 amateur musicians (35 international wind instrumentalists, 35 traditional wind instrumentalists, 35 international string instrumentalists, and 35 traditional string instrumentalists). Forty-eight violinists were studied separately from other study groups. The Fonseca questionnaire was used to evaluate TMD in this sample. A P-value of 0.05 was considered significant.</div></div><div><h3>Results</h3><div>The Prevalence of the study sample was 72.8 %. The prevalence of TMD and the mean severity score among musicians of international wind instruments, traditional wind instruments, international string instruments, and traditional string instruments were 77.1 %, 67.6 %, 82.8 %, and 62.8 %, and 30.00 ± 15.52, 32.42 ± 14.92, 30.71 ± 18.75, and 28.57 ± 19.87, respectively. The study groups did not show any significant differences regarding the TMD severity score. The prevalence of TMD was higher among women (<em>P</em> = 0.000017) and wind instrumentalists (<em>P</em> = 0.009). The prevalence of TMD and the mean severity score among violinists were 62.85 % and 26.85 ± 20.68, respectively.</div></div><div><h3>Conclusions</h3><div>Regardless of class or category, the prevalence of TMD is high among musicians compared to the available statistics reported previously on the Iranian population in the literature. Moreover, TMD prevalence is higher among wind instrumentalists than string instrumentalists.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 435-439"},"PeriodicalIF":0.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of biomechanical strength of titanium versus unsintered-hydroxyapatite/poly-L-lactic acid (u-HA/PLLA) osteosynthesis screws in bilateral sagittal split ramus osteotomy","authors":"Ankhtsetseg Shijirbold,&nbsp;Mrunalini Ramanathan,&nbsp;Yuhei Matsuda,&nbsp;Nithish Sankepally,&nbsp;Masako Fujioka-Kobayashi,&nbsp;Takahiro Kanno","doi":"10.1016/j.ajoms.2024.10.004","DOIUrl":"10.1016/j.ajoms.2024.10.004","url":null,"abstract":"<div><div>Titanium osteosynthesis is considered to be stable for the bilateral sagittal split ramus osteotomy (BSSRO) procedure in orthognathic surgery but is disregarded owing to a multitude of complications, the most significant necessitating a secondary surgery for removal. Bioresorbable osteofixation devices, especially third-generation unsintered-hydroxyapatite/poly-L-lactic acid (u-HA/PLLA), are increasingly used in the mandibular region because of their strength and bioactive/osteoconductivity. To date, three titanium bicortical screws has been the standard for the rigid fixation of BSSRO. As data on the use of u-HA/PLLA bicortical screws are limited, we conducted an in vitro biomechanical strength test to evaluate the performance of 12-mm bicortical u-HA/PLLA screws in comparison with titanium screws using mandibular bone models. BSSRO was performed on all specimens, followed by fixation with either three titanium screws or three, four, or five u-HA/PLLA screws, and loading was performed using a clinically presumed occlusal force. Displacement forces (measured in newton ‘N′) of 50 N, 130 N, and 220 N were applied. Our results showed that the use of three u-HA/PLLA screws was unstable, that of four u-HA/PLLA screws was comparable, and that of five u-HA/PLLA screws provided stability equal to that of the three titanium bicortical screws. Although further clinical assessment is needed, our study demonstrated that the five u-HA/PLLA bicortical screws are viable alternatives to titanium in BSSRO osteofixation.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 440-445"},"PeriodicalIF":0.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on direct metastasis to levels III, IV in oral tongue squamous cell carcinoma","authors":"Yu Oikawa,&nbsp;Rika Noji,&nbsp;Hiroaki Shimono,&nbsp;Rikuka Shimizu,&nbsp;Naoya Kinoshita,&nbsp;Naoto Nishii,&nbsp;Takuma Kugimoto,&nbsp;Takeshi Kuroshima,&nbsp;Hiroyuki Harada","doi":"10.1016/j.ajoms.2024.10.005","DOIUrl":"10.1016/j.ajoms.2024.10.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to determine the frequency and specific metastatic patterns of direct metastasis to levels III and IV in oral tongue squamous cell carcinoma (OTSCC) among Japanese individuals.</div></div><div><h3>Methods</h3><div>We conducted neck dissections on 319 patients at our department from January 2001 to December 2020. Of these, 220 patients with histopathological evidence of lymph node metastasis were included in the study. Lymph node metastases were categorized by level to elucidate the metastatic patterns. Additionally, metastatic sites within level III were identified as either anterior or posterior to the internal jugular vein, and these findings were compared between the direct metastatic group and the non-direct metastatic group.</div></div><div><h3>Results</h3><div>Among the patients, 13 experienced direct metastases to level III or IV. Specifically, 12 patients had metastases at level III, and one patient had metastases at both levels III and IV, constituting 5.9 % (13/220) of those with cervical lymph node metastasis in OTSCC. No patients exhibited direct metastases solely to level IV. Within level III, the direct metastasis group showed a significantly higher incidence of metastasis anterior to the internal jugular vein (<em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>Direct metastasis to levels III and/or IV occurred in 5.9 % of the cases. Although elective neck dissection up to level III is generally sufficient, metastasis to level IV, while infrequent, can occur. Therefore, vigilant follow-up with attention to the lower neck regions is crucial.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 446-449"},"PeriodicalIF":0.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of greater palatine artery hemodynamics in Le Fort I osteotomy","authors":"Kentarou Muramatsu,&nbsp;Shuji Yoshida,&nbsp;Masato Narita,&nbsp;Masayuki Takano,&nbsp;Akira Watanabe","doi":"10.1016/j.ajoms.2024.10.002","DOIUrl":"10.1016/j.ajoms.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>Le Fort I osteotomy (LIO) is a widely known standard orthognathic surgical treatment. However, complications such as osteonecrosis of the jaw due to poor postoperative blood flow to tissues of the maxilla have been reported. This study measured the hemodynamics of the greater palatine artery (GPA) in patients who underwent LIO to explore the factors that affect postoperative blood flow.</div></div><div><h3>Methods</h3><div>We included 15 patients who underwent LIO and sagittal split ramus osteotomy (SSRO), and 8 patients, who only underwent SSRO, were included as controls. Preoperative, intraoperative, and postoperative blood flow in the oral mucosa anterior to the foramen magnum was measured with a laser Doppler blood flow meter.</div></div><div><h3>Results</h3><div>On average blood flow at immediately after downfracture in LIO patients reduced to 24.8 % of baseline blood flow and patients who underwent anterior maxillary movement had a lower recovery rate at any time. Multiple regression analysis showed that the greater the maxillary anterior shift and the longer the time from maxillary disarticulation to fixation (mandibular fracture time: DFT), the more delayed was the blood flow recovery.</div></div><div><h3>Conclusions</h3><div>Since blood flow decreased after downfracture and recovered only to around 85.4 % of baseline after 6 months in LⅠO, preserving blood vessels is important. Furthermore, the recovery rate was lower in patients who underwent anterior movement, and blood flow reduced more in patients with longer DFT, suggesting the importance of determining the direction and distance of movement preoperatively, and repositioning and fixing the maxilla as quickly as possible during surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 427-434"},"PeriodicalIF":0.4,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction questionnaire survey after surgical orthodontic treatment in patients with jaw deformities","authors":"Rika Hayakawa,&nbsp;Daichi Hasebe ,&nbsp;Masaki Kasahara,&nbsp;Kenta Haga,&nbsp;Eri Asami,&nbsp;Ryoko Takeuchi,&nbsp;Naoaki Saito,&nbsp;Daisuke Saito,&nbsp;Hidenobu Sakuma,&nbsp;Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2024.10.001","DOIUrl":"10.1016/j.ajoms.2024.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>Surgical orthodontic treatment leads to morphological, functional and psychological changes in patients with jaw deformities. For the evaluation of outcomes of surgical orthodontic treatment from the patient's point of view, a questionnaire survey was performed after treatment and factors affecting patient satisfaction were examined.</div></div><div><h3>Methods</h3><div>A survey by mailing questionnaires that each consisted of 30 items was conducted in 250 patients with jaw deformities who underwent orthognathic surgery in our department during the period from January 2015 to December 2020. Eighty-four patients responded (response rate of 34.0 %). The patients who responded included 24 males and 60 females. The mean age at the time of surgery was 26 years.</div></div><div><h3>Results</h3><div>Fifty-four patients complained of morphological abnormalities such as facial appearance and malocclusion, and 30 patients complained of functional disturbances such as masticatory disabilities. Eighty-two patients were satisfied with the outcome of surgery, but there were two patients with postoperative paresthesia and residual facial asymmetry who were not satisfied with the outcome. Improvements were observed in mastication and pronunciation in 74 and 46 patients, respectively. Psychologically, 26 patients showed positive personality changes postoperatively. Thirty-three patients had TMJ symptoms before surgery, and the symptoms were resolved after surgery in 24 of those patients. Two patients developed snoring during sleep after surgery.</div></div><div><h3>Conclusions</h3><div>This survey showed that most patients with jaw deformities were satisfied with the results of surgical orthodontic treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 420-426"},"PeriodicalIF":0.4,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is elective neck dissection effective for clinical cervical node-negative oral squamous cell carcinoma? A systematic review and meta-analysis for the update of the 2019 Japanese Oral Cancer Clinical Practice Guidelines","authors":"Daisuke Takeda ,&nbsp;Nobuhiro Ueda ,&nbsp;Shintaro Sukegawa ,&nbsp;Masatoshi Adachi ,&nbsp;Hidemichi Yuasa ,&nbsp;Taiki Suzuki ,&nbsp;Narikazu Uzawa ,&nbsp;Hiroshi Kurita","doi":"10.1016/j.ajoms.2024.09.012","DOIUrl":"10.1016/j.ajoms.2024.09.012","url":null,"abstract":"<div><h3>Objective</h3><div>There is no consensus on whether elective neck dissection should be performed for potential cervical lymph node metastases in patients with clinical cervical node-negative oral cancer. The aim of the present updated systematic review was to clarify the efficacy of elective neck dissection concurrently with resection of the primary tumor in patients with clinical cervical node-negative oral cancer.</div></div><div><h3>Methods</h3><div>The MEDLINE, Cochrane Central Register of Controlled Trials, and Ichushi-Web databases were searched to identify relevant randomized controlled trials (RCTs). We performed a statistical analysis using the Review Manager 5.4 computer program and assessed the certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation approach.</div></div><div><h3>Results</h3><div>Five RCTs were included. The meta-analysis revealed that the hazard ratios for overall survival, disease-free survival, and locoregional control were significantly in favor of elective neck dissection concurrently with resection of the primary tumor. Additionally, the risk difference for shoulder dysfunction after neck dissection was significantly in favor of resection of the primary tumor alone, although this outcome was only investigated in one RCT. The certainty of evidence was low for overall survival, disease-free survival, locoregional control, and shoulder dysfunction after neck dissection.</div></div><div><h3>Conclusion</h3><div>The present updated systematic review suggests that elective neck dissection should be performed concurrently with resection of the primary tumor in patients with clinical cervical node-negative oral cancer; however, the certainty of evidence was low. Future systematic reviews, including RCTs with larger samples, are expected to confirm the present findings.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 263-271"},"PeriodicalIF":0.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of plasma cell leukemia with initial symptoms in the oral cavity","authors":"Kohei Okinaga ,&nbsp;Hiromasa Yoshikawa ,&nbsp;Kiyoshi Nagai ,&nbsp;Ryo Akase ,&nbsp;Kanae Yamate","doi":"10.1016/j.ajoms.2024.09.011","DOIUrl":"10.1016/j.ajoms.2024.09.011","url":null,"abstract":"<div><div>Plasma cell leukemia (PCL) is a type of plasma cell neoplasm (PCN) and is very rare, accounting for 1–4 % of PCNs. PCL progresses rapidly and has a very poor prognosis. Extramedullary lesions in the oral cavity are extremely rare. We herein report a case in which a mass in the oral cavity was the initial symptom, with PCL subsequently identified. The patient was a 72-year-old woman. Mass formation was observed on the palatal side of upper left first molar, and the tooth was extracted at another hospital. The patient was referred to our department for a close examination and treatment because the mass had increased. At the time of the initial examination, a 20 × 15 mm, smooth, elastic, slightly hard mass was observed in the area corresponding to the extraction socket of the upper left first molar. A biopsy was performed under local anesthesia and an interim report suggested malignancy tumor. Blood tests were performed and the white blood cell count had increased to 45,800 /µL, and plasma cells accounted for 50.5 % of the total. The patient was referred to a hematologist and was diagnosis with PCL. The final diagnosis of the biopsy was invasion of PCL. After chemotherapy, the oral mass disappeared, but the patient died five months after the start of treatment. When a mass formation is observed in the oral cavity, it is necessary to examine the patient with hematological diseases in mind, and it is important to perform blood tests as appropriate.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 518-523"},"PeriodicalIF":0.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized median tongue AL amyloidosis accompanied with chondroid metaplasia: the possible etiology and relationship to median rhomboid glossitis","authors":"Yuki Oikawa ,&nbsp;Yuki Fukawa ,&nbsp;Kenichiro Suzuki ,&nbsp;Akiteru Goto ,&nbsp;Yusoon Kim ,&nbsp;Hiroyuki Yoshitake ,&nbsp;Tetsuya Yoda ,&nbsp;Tohru Ikeda","doi":"10.1016/j.ajoms.2024.09.009","DOIUrl":"10.1016/j.ajoms.2024.09.009","url":null,"abstract":"<div><div>In the oral cavity, amyloidosis is rare and predominantly occurs in the tongue. We report a case of extremely rare AL amyloidosis accompanied with chondroid metaplasia in the tongue. Patient was a 66-year-old man with elastic hard mass on dorsum of the tongue in the median. The tongue papillae of the surface mucosa were atrophic, and candida was detected by microbial test. Biopsy was performed, and histological specimen showed a mass lesion consisted of subepithelial deposition of amorphous eosinophilic material admixed with focal chondroid areas. The deposits were positive for Congo red staining with apple-green birefringence under polarized light. Immunohistochemically, the deposits were positive for amyloid-kappa, and chondroid lesion was positive for SOX9 antibody. Finally, we diagnosed this lesion as AL amyloidosis with chondroid metaplasia. After the histological diagnosis, systemic examination was performed. The amyloid deposition was only observed in the tongue, and there was no hematopoietic disease or other diseases that could cause systemic amyloidosis. This was the first report of localized amyloidosis of the mobile tongue accompanied with chondroid metaplasia. The etiology of this case might be associated with median rhomboid glossitis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 571-575"},"PeriodicalIF":0.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}