Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Spindle cell variant of ameloblastic carcinoma of mandible","authors":"Kiran Jot ,&nbsp;Rahul Yadav ,&nbsp;Aanchal Kakkar ,&nbsp;Deepika Mishra","doi":"10.1016/j.ajoms.2024.04.017","DOIUrl":"10.1016/j.ajoms.2024.04.017","url":null,"abstract":"<div><div>Ameloblastic carcinoma (AC) is an aggressive odontogenic tumor. Spindle cell variant of AC (SCAC) is a rare entity and only sixteen cases of SCACs have been reported in the literature till date. We reported a case of 42-years-old male presented with swelling in right lower posterior region for 3 years. Radiology revealed multilocular osteolytic with cortical thinning and rarefaction showing internal non-enhancing areas. Histologically, the tumor revealed areas characteristic of ameloblastoma along with hypercellular areas of monomorphic spindle shaped cells merging into the stroma displaying cytological atypia, suggestive of AC with spindle cell variant. The purpose of this case report is to document an unusual case of spindle cell variant of AC, which can mimic other oral spindle cell lesions. Additionally, proliferative marker along with histological parameters like cytological atypia, mitoses and cell morphology is emphasized.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 243-247"},"PeriodicalIF":0.4,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma ex pleomorphic adenoma primarily composed of squamous cell carcinoma in buccal region – Case report","authors":"Takako Naruse ,&nbsp;Kouji Ohta ,&nbsp;Hideo Shigeishi ,&nbsp;Toshinori Ando ,&nbsp;Takayuki Nakagawa ,&nbsp;Nao Yamakado ,&nbsp;Yoshiaki Ninomiya ,&nbsp;Shinichi Sakamoto ,&nbsp;Yoko Ishida ,&nbsp;Tomonao Aikawa","doi":"10.1016/j.ajoms.2024.04.014","DOIUrl":"10.1016/j.ajoms.2024.04.014","url":null,"abstract":"<div><div>Carcinoma ex pleomorphic adenoma (CXPA) is a tumor arising from a pleomorphic adenoma and classified as an independent type in the 2005 WHO classification. These tumors mainly occur in the parotid gland or palate, though rarely in the buccal region. The carcinoma component is most often a salivary duct carcinoma, while findings of a squamous cell carcinoma (SCC) are rare. Here, we report a case of carcinoma of pleomorphic adenoma origin with SCC as the main component occurring in the buccal region. A 77-year-old woman was referred to our department because of swelling in the right buccal mucosa. An elastic hard mass was found in the right buccal subcutaneous region and induration in the right buccal mucosa due to the mass was noted by palpation. Biopsy results from an obtained specimen led to a diagnosis of SCC. The patient underwent excision of a right-sided buccal malignant tumor in combination with skin resection and partial right-sided maxillary resection. Histopathological examination findings of the excised tumor indicated CXPA primarily composed of SCC with lymph node metastasis. Thereafter, multiple sites of distant metastasis were found. The patient died at two years six months after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 99-103"},"PeriodicalIF":0.4,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141046580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"General anesthesia with remimazolam for tooth extraction in a patient with Noonan syndrome and hypertrophic obstructive cardiomyopathy: A case report","authors":"Hisanobu Kamio ,&nbsp;Kana Oue ,&nbsp;Yasuyuki Asada ,&nbsp;Nanako Ito ,&nbsp;Serika Imamura ,&nbsp;Mitsuru Doi ,&nbsp;Yoshitaka Shimizu ,&nbsp;Mitsuhiro Yoshida ,&nbsp;Souichi Yanamoto ,&nbsp;Hiroshi Hanamoto","doi":"10.1016/j.ajoms.2024.04.016","DOIUrl":"10.1016/j.ajoms.2024.04.016","url":null,"abstract":"<div><div>Noonan syndrome (NS) is characterized by various abnormalities and is complicated with cardiac diseases, such as hypertrophic cardiomyopathy, in &gt; 80% of cases. Minimum hemodynamic changes are a crucial factor during general anesthesia in such patients. We report the case of a patient with NS and hypertrophic obstructive cardiomyopathy (HOCM) who underwent general anesthesia using remimazolam, a new ultrashort-acting benzodiazepine anesthetic, which is expected to cause less circulatory depression. A 19-year-old woman with NS complicated with HOCM was scheduled to undergo extraction of the wisdom teeth and second molar under general anesthesia. Preoperative evaluation revealed HOCM with left ventricular outflow tract obstruction and the patient had chronic heart failure. After the placement of an arterial line under moderate sedation with remimazolam, general anesthesia was induced with remimazolam, fentanyl, and rocuronium, followed by anesthesia maintenance with remimazolam and remifentanil. Tracheal intubation was performed using videolaryngoscopy. Local anesthesia and inferior alveolar nerve block were performed using adrenaline-free local anesthetics. Intraoperatively, low-dose phenylephrine was administered continuously to maintain peripheral vascular resistance. At the end of surgery, the endotracheal tube was replaced with an i-gel® supraglottic airway device before emergence from general anesthesia. After full recovery from anesthesia, the i-gel® was removed, and the patient was transferred to the hospital ward. The perioperative blood pressure and heart rate were maintained within normal ranges, and no cardiovascular events occurred during anesthesia. Anesthesia management using remimazolam and low-dose phenylephrine with reduction in perioperative stress may provide an appropriate circulatory condition for noncardiac surgery in patients with HOCM.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 108-111"},"PeriodicalIF":0.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141032474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreign body in infant hard palate: A report of a rare case and literature review","authors":"Shohei Takaoka ,&nbsp;Kenji Yamagata ,&nbsp;Satoshi Fukuzawa ,&nbsp;Fumihiko Uchida ,&nbsp;Naomi Ishibashi-Kanno ,&nbsp;Hiroki Bukawa","doi":"10.1016/j.ajoms.2024.04.015","DOIUrl":"10.1016/j.ajoms.2024.04.015","url":null,"abstract":"<div><div>Infants tend to place anything in their mouths; however, foreign bodies embedded in the hard palate of infants are extremely rare in clinical practice. Infants are often difficult to examine, and foreign bodies in the hard palate are misdiagnosed as neoplastic or inflammatory lesions in some cases. We present a rare case of a foreign body that was not diagnosed until its removal from the hard palate of an infant under general anesthesia. A healthy 12-month-old girl with a protruding foreign body on the hard palate was referred for close investigation. A white-yellow protruding foreign body measuring approximately 10 mm was found on the palate. Computed tomography revealed a radiopaque foreign body at the border. It was decided to examine and performed biopsy under general anesthesia, and the foreign body removed easily was an obviously plastic object with a semicircular shape and a brim around it. The histopathological examination of the abnormal gingiva under the foreign body revealed inflammatory granulation tissue. This report highlights the difficulty in diagnosing an infant with a foreign body in the hard palate and the safety of its removal under general anesthesia. Clinicians must consider the possibility of foreign bodies causing lesions on an infant’s hard palate. Therefore, careful examination and safe removal are necessary to prevent serious aspiration complications.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 104-107"},"PeriodicalIF":0.4,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141051016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-BP230 type mucous membrane pemphigoid with desquamative gingivitis: A case report","authors":"Seiichiro Oda ,&nbsp;Hirofumi Okada ,&nbsp;Atsushi Kihara ,&nbsp;Norito Ishii ,&nbsp;Hiroshi Koga ,&nbsp;Yoshiyuki Mori ,&nbsp;Tadahide Noguchi","doi":"10.1016/j.ajoms.2024.04.013","DOIUrl":"10.1016/j.ajoms.2024.04.013","url":null,"abstract":"<div><div>Mucous membrane pemphigoid (MMP) is an autoimmune subepithelial/subepidermal blistering disease characterized by linear deposition of immunoglobulin G (IgG), IgA, and/or C3 in the basement membrane zone (BMZ) and predominant mucosal lesions involving the oral cavity and conjunctivae. Here, we describe a case of a 58-year-old Japanese man with MMP. Intraoral examination revealed desquamative gingivitis in the upper and lower gingivae. No conjunctival or cutaneous lesions were observed. Histopathological examination revealed a subepithelial split with inflammatory cell infiltration of the epithelial and connective tissues. Direct immunofluorescence revealed a linear deposition of C3 in the BMZ. IgG autoantibodies against BP230 were detected using an enzyme-linked immunosorbent assay. Indirect immunofluorescence using 1 mol/L NaCl-split skin sections revealed no reactivity for serum IgG or IgA. Immunoblotting using normal human epidermal extract as a substrate did not detect IgG reactivity against the 230-kDa antigen. Based on the above results, the definitive diagnosis of MMP with anti-BP230 antibody alone was established. Our case was categorized as low-risk MMP. The patient was treated with 0.1% triamcinolone acetonide ointment, oral minocycline, and oral nicotinamide, which improved the oral erosions. However, the mechanism underlying IgG autoantibody production against intracellular BP230 remains unclear. Further research and more such case studies are necessary to elucidate the mechanism of anti-BP230 antibody production and the clinical feature of anti-BP230 type MMP.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 210-214"},"PeriodicalIF":0.4,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the changes in trabecular bone density of angle and condyle regions of the mandible before and after COVID-19 contraction using fractal analysis","authors":"Farzad Esmaeili ,&nbsp;Narges Bayat ,&nbsp;Amir Ebrahimpour Tolouei ,&nbsp;Mohammad Azimzadeh ,&nbsp;Mehrdad Nateghi ,&nbsp;Kasra Rahimipour","doi":"10.1016/j.ajoms.2024.04.011","DOIUrl":"10.1016/j.ajoms.2024.04.011","url":null,"abstract":"<div><div>This study aimed to investigate the impact of COVID-19 on the trabecular bone thickness in the mandible using fractal analysis. The researchers selected 82 healthy patients who had previously been infected with COVID-19 and had dental panoramic radiographs (DPRs) prior to contracting the virus. DPRs were obtained again after infection, and the trabecular thickness was analyzed before and after COVID-19 using statistical tests. The results revealed that the average trabecular thickness of the mandible at the angle and condyle regions decreased significantly after contracting COVID-19. The mean thickness before infection was 1.479 ± 0.128 at the angle point and 1.469 ± 0.124 at the condylar region, while after infection, it decreased to 1.200 ± 0.123 and 1.159 ± 0.114, respectively. The reduction in trabecular thickness was found to be statistically significant. This study underscores the importance of monitoring bone density in COVID-19 patients. The findings suggest that COVID-19 can have extrapulmonary effects on skeletal health, specifically the mandibular bone. The results highlight the need for preventive interventions to mitigate pathological bone loss in individuals affected by COVID-19. Overall, this research emphasizes the significance of considering skeletal manifestations and implementing appropriate measures for COVID-19 patients to safeguard their bone health.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 175-179"},"PeriodicalIF":0.4,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maroteaux-lamy syndrome (mucopolysaccharidosis VI) with abnormal coronoid and condylar processes of the mandible: Report of a case with surgical intervention","authors":"","doi":"10.1016/j.ajoms.2024.04.012","DOIUrl":"10.1016/j.ajoms.2024.04.012","url":null,"abstract":"<div><p>Maroteaux-Lamy syndrome (mucopolysaccharidoses VI) is a rare genetic disease results in functional deficiency of arylsulfatase B<span><span> and accumulation of dermatan sulfate<span><span> within lysosomes in various tissues. Here we present an 8-year-old male who was referred for treatment of limited mouth opening. The patient had been diagnosed with </span>mucopolysaccharidoses<span> VI at age of 6 months. He had received bone marrow transplantation at age of 3.5 years, developed graft-versus-host disease and subsequent vitiligo-like changes. The patient presented with short stature, and some </span></span></span>skeletal anomalies<span><span>. In radiographic images bilateral hyperplasia of the coronoid process, underdeveloped condyles, and dentigerous cyst-like follicles in the jaws were noted. Bilateral coronoidectomy was performed to improve the maximum opening of the mouth. Post-op follow-up examinations in 5 years showed moderate improvement. Abnormal coronoid and </span>condylar processes are unusual in MPS VI. Proper management is needed to improve patients’ oral and general health for the remainder of their lives.</span></span></p></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"36 6","pages":"Pages 872-877"},"PeriodicalIF":0.4,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in dentistry — A scoping review","authors":"Ruchi Vashisht ,&nbsp;Aaina Sharma ,&nbsp;Tanvi Kiran ,&nbsp;Satnam Singh Jolly ,&nbsp;Prabhleen Kaur Brar ,&nbsp;Jay Veer Puri","doi":"10.1016/j.ajoms.2024.04.009","DOIUrl":"10.1016/j.ajoms.2024.04.009","url":null,"abstract":"<div><h3>Introduction</h3><p>In dentistry, AI technologies are revolutionizing diagnosis, treatment planning, and patient care. From image analysis for detecting cavities and fractures to personalized treatment recommendations based on patient data, AI is enhancing efficiency and accuracy in dental practices, leading to improved outcomes and patient satisfaction.</p></div><div><h3>Objectives</h3><p>This scoping review was done to assess the use of artificial intelligence in various fields of dentistry.</p></div><div><h3>Methods</h3><p>The electronic databases were searched for scientific research articles in electronic search engines like PubMed, Scopus, Web of science etc. and 87 articles fulfilled the eligibility criteria. Various artificial intelligence, machine learning and deep learning tools and techniques used in various fields of dentistry were studied and their accuracy and precision were noted.</p></div><div><h3>Results</h3><p>We have various artificial intelligence models being used in various fields of dentistry with high accuracy, sensitivity and specificity.</p></div><div><h3>Conclusion</h3><p>This data would be helpful for dental practitioners in reducing their workload and improve precision and accuracy in various treatments.</p></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"36 4","pages":"Pages 579-592"},"PeriodicalIF":0.4,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-calcifying/Langerhans cell-rich variant of calcifying epithelial odontogenic tumor: A case report and review","authors":"Reo Fukushima ,&nbsp;Dai Nakashima ,&nbsp;Shusaku Yoshimura ,&nbsp;Yutaro Kase ,&nbsp;Ryunosuke Nozaki ,&nbsp;Tomoaki Saito ,&nbsp;Atsushi Kasamatsu ,&nbsp;Katsuhiro Uzawa","doi":"10.1016/j.ajoms.2024.04.010","DOIUrl":"10.1016/j.ajoms.2024.04.010","url":null,"abstract":"<div><div>A calcifying epithelial odontogenic tumor (CEOT) is a rare benign epithelial odontogenic tumor. Histologically, CEOTs are commonly composed of polygonal epithelial cells, eosinophilic amyloid deposits, and calcifications. The non-calcifying/Langerhans cell-rich variant, one of the three variants of CEOTs according to the 2022 World Health Organization classification of head and neck tumors, is rare with few cases reported to date. We present an additional case of a non-calcifying/Langerhans cell-rich CEOT. A 76-year-old woman was referred to our department for painless swelling of the mandibular incisor. Computed tomography showed a 33 × 10 × 18 mm well-defined bone resorption lesion without distention, radiopaque spots, or unerupted teeth in the mandible. Tissue biopsy showed that the tumor was composed of atypical cells with oval nuclei and eosinophilic cytoplasm and many amorphous eosinophilic amyloid-like deposits, which led to the diagnosis of CEOT. Marginal mandibulectomy was performed under general anesthesia from the right mandibular first premolar to the left mandibular canine. The tumor was composed of small nests and strands of odontogenic epithelial cells and many amorphous eosinophilic amyloid-like deposits; however, there was no area of calcification in any tissue section. Immunohistochemical examination showed that the tumor epithelial cells were positive for S-100 protein. Based on these histopathological and immunohistochemical findings, the tumor was diagnosed as a non-calcifying/Langerhans cell-rich CEOT. No local recurrence was detected over the 4 years of follow up.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 234-238"},"PeriodicalIF":0.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140784663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of treatment-related myelodysplastic syndrome in the early stage after radiotherapy in a patient with cancer of the oral floor","authors":"","doi":"10.1016/j.ajoms.2024.04.004","DOIUrl":"10.1016/j.ajoms.2024.04.004","url":null,"abstract":"<div><p><span>Therapy-related myelodysplastic syndrome<span><span> (t-MDS) is a rare but potentially fatal adverse event caused by chemotherapy or radiotherapy. We report a case of t-MDS diagnosed 8 months after radiotherapy for </span>recurrent carcinoma<span><span><span> of the floor of the mouth and cervical lymph node metastases<span> after surgical treatment. A 74-year-old man visited our department with the chief complaint of pain in the lower part of the tongue. Tumor resection and right </span></span>radical neck dissection<span><span> (RND) were performed based on the diagnosis of carcinoma of the floor of the mouth (cT1N2bM0). A </span>computed tomography scan<span><span> at 10 months postoperatively showed metastatic lymph nodes in the left neck, right </span>hyoid bone<span><span>, right parotid subpolar, and anterior trachea. Therefore, the patient underwent left RND and excision of the right hyoid bone, subpolar right parotid and anterior tracheal metastatic lymph nodes. Postoperative radiation therapy (70 Gy) was administered to the neck bilaterally. An upper gastrointestinal examination revealed a </span>carcinoma in situ<span> in the lower esophagus, and endoscopic submucosal dissection of the esophagus was performed. He had </span></span></span></span></span>pancytopenia preoperatively, which progressed postoperatively; therefore, a </span></span></span>bone marrow examination<span> was performed to rule out a hematological malignancy<span>. Bone marrow smear<span> and flow cytometric analyses indicated the development of t-MDS. He received supportive transfusion therapy but died 8 months after the diagnosis of t-MDS. During post-treatment follow-up, clinicians should be aware of t-MSD, in addition to cancer recurrence and metastasis.</span></span></span></p></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"36 6","pages":"Pages 860-865"},"PeriodicalIF":0.4,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140787117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}