Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第4页

Inverted ductal papilloma of the lower lip: A diminutive lesion with no surface mucosal change

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-11 DOI: 10.1016/j.ajoms.2024.09.007

Ayuko Moriyama , Saya Imaoka , Hiroshi Shiratsuchi , Tatsuaki Fujiki , Machi Hosaka , Masatake Asano

引用次数: 0

Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-10 DOI: 10.1016/j.ajoms.2024.09.003

Kumiko Kamada , Naito Kurio , Yasuhiro Mouri , Yasusei Kudo

{"title":"Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro","authors":"Kumiko Kamada , Naito Kurio , Yasuhiro Mouri , Yasusei Kudo","doi":"10.1016/j.ajoms.2024.09.003","DOIUrl":"10.1016/j.ajoms.2024.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>Hyaluronic acid (HA) is a major glycosaminoglycan in the extracellular matrix and plays a vital role in cancer progression. HA interacts with cell membrane receptors, such as receptor for HA-mediated motility (RHAMM), to regulate the cell cycle and cell division. 4-Methylumbelliferone (4-MU) is a well-known HA synthesis inhibitor and a promising cancer therapy alternative. 4-MU is a coumarin derivative with no obvious side effects and has been studied in several cancers. However, little is known about its use in oral squamous cell carcinoma (OSCC). In this study, we evaluated the antitumor effects of 4-MU on OSCC cells.</div></div><div><h3>Methods</h3><div>The effects of 4-MU on HAS gene and HA-related protein expression were evaluated with RT-qPCR and Western blotting. The effects on HA secretion was confirmed by ELISA. The effects on cell proliferation were confirmed by MTS assay. Trypan blue exclusion assay was used for cell viability assay. Cell cycle analysis, cell-clock cell cycle assay, and apoptosis assay were used to determine the effects on cell cycle and apoptosis. SA-β-gal staining was used to evaluate senescence.</div></div><div><h3>Results</h3><div>4-MU induced senescence change in OSCC cells by overexpression of the anti-apoptotic protein Bcl-2 and markedly suppressed their proliferation. Furthermore, following administration of Bcl-2 inhibitor, ABT-263 known as a senescent cell eliminator can specifically induce apoptosis and eliminate the senescent OSCC cells.</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential use of 4-MU in OSCC chemotherapy as a senescence-inducing agent that not only potently suppresses OSCC cell proliferation but also enhances the efficacy of Bcl-2 inhibitor.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 289-296"},"PeriodicalIF":0.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case report of apexification using mineral trioxide aggregate

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-10 DOI: 10.1016/j.ajoms.2024.09.006

Yuka Miyamoto , Kazuki Kiho , Daisuke Yokokawa , Tomoya Hasegawa , Chinami Sakai , Michiko Ehara , Takanaga Ochiai , Satoshi Kawano , Motohiko Nagayama

{"title":"A case report of apexification using mineral trioxide aggregate","authors":"Yuka Miyamoto , Kazuki Kiho , Daisuke Yokokawa , Tomoya Hasegawa , Chinami Sakai , Michiko Ehara , Takanaga Ochiai , Satoshi Kawano , Motohiko Nagayama","doi":"10.1016/j.ajoms.2024.09.006","DOIUrl":"10.1016/j.ajoms.2024.09.006","url":null,"abstract":"<div><div>Mineral trioxide aggregate (MTA) is an excellent biocompatible material that can seal intra- and extra-root canal spaces via hard tissue formation. However, the biological mechanism of hard tissue formation is still unclear. This study aims to investigate the biological mechanism of hard tissue formation by MTA in apexification. A 9-year-old boy visited to Asahi University medical dental center complaining of spontaneous pain in tooth #7. #7 was immature tooth and dens invaginatus. At first, we tried to performe apexogenesis because we diagnosed pulpitis, but 2 days after the treatment, dental pulp necrosis later occurred, so we performed apexification using MTA. Unfortunately, the tooth was extracted because of external root resorption after apexification. We explored the potential for MTA to conduct hard tissue formation from apical periodontal tissue into the root canal. The formalin-fixed tooth was subjected to volume of mineral density (VMD) analysis by micro-computed tomography (µCT). After decalcification, the specimen was embedded in paraffin and sliced into thin sections. VMD and histological analyses revealed regions of moderate-/high-mineral-density bony hard tissue and bone marrow tissue, along with vacuolar cell clusters. Immunohistochemical analyses of bony-like hard tissue revealed immunopositivity for osterix and dentin matrix acidic phosphoprotein 1 (DMP1). Moreover, vacuolated cells were immunopositive for CD68 and CD163, but immunonegative for DMP1, osterix, and negative staining for TRAP. Our findings suggested that apical closure was caused by MTA with osteoconduction via CD68-positive/CD163-negative M1-like macrophages (foreign body response) and CD163-positive M2 macrophages (tissue repair and regeneration) derived from apical periodontal tissue.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 562-566"},"PeriodicalIF":0.4,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant oral epidermoid cyst emptying as an emergency maneuver: Case report and literature review

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-08 DOI: 10.1016/j.ajoms.2024.09.005

Ana Cláudia Oliveira Teles , Larissa Doalla de Almeida e Silva , Cássio Roberto Rocha dos Santos, Ana Terezinha Marques Mesquita

{"title":"Giant oral epidermoid cyst emptying as an emergency maneuver: Case report and literature review","authors":"Ana Cláudia Oliveira Teles , Larissa Doalla de Almeida e Silva , Cássio Roberto Rocha dos Santos, Ana Terezinha Marques Mesquita","doi":"10.1016/j.ajoms.2024.09.005","DOIUrl":"10.1016/j.ajoms.2024.09.005","url":null,"abstract":"<div><div>The aim of this case report was to present a giant epidermoid cyst (giant EC) in the floor of the mouth measuring 7.1 × 6.0 × 9.2 cm in a 21-year-old black male treated through an incision and marsupialization as an emergency maneuver, restoring vital functions, including breathing and eating. Additionally, a literature review was conducted in PubMed and Web of Science including case reports describing patients with a giant EC measuring 3.5 cm or larger in the intraoral region. The qualitative analysis included demographic data, clinical characteristics, and treatment modalities. In this review, we found 16 cases of giant EC, more prevalent in males with a mean age of 32.62 years, predominantly located on the floor of the mouth, and with an average of 4.48 × 6.64 cm. The complications most frequently reported were dysphagia, dysarthria, dyspnea, and tongue displacement. Magnetic Resonance Imaging was commonly used as a complementary exam. The main treatment was surgical excision with intraoral access, and postoperative complications were reported in two cases. Emptying and marsupialization of giant EC can be useful techniques for reducing the size and restoring the patient's basic functions in emergencies.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 3","pages":"Pages 484-490"},"PeriodicalIF":0.4,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and diagnostic features of salivary glands disease related to COVID-19 infection: A systematic review of the literature 与COVID-19感染相关的唾液腺疾病的临床和诊断特征：文献系统回顾

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-07 DOI: 10.1016/j.ajoms.2024.08.011

Pierre Guarino , Francesco Chiari , Claudio Donadio Caporale , Livio Presutti , Gabriele Molteni

{"title":"Clinical and diagnostic features of salivary glands disease related to COVID-19 infection: A systematic review of the literature","authors":"Pierre Guarino , Francesco Chiari , Claudio Donadio Caporale , Livio Presutti , Gabriele Molteni","doi":"10.1016/j.ajoms.2024.08.011","DOIUrl":"10.1016/j.ajoms.2024.08.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Coronavirus disease 2019 (COVID-19) results from primary infection by severe acute respiratory syndrome coronavirus 2 (Sars COV-2). The transmission thereof is based on mucosal inoculation of infected droplets or direct contact from carriers. However, coronavirus viral loads can be found in throat wash and saliva specimens. The aim of this work is to make an overview about clinical and diagnostic information of patients affected by sialadenitis related to Sars COV-2 infection.</div></div><div><h3>Methods</h3><div>A systematic literature review has been performed following PRISMA 2020 checklist statement. A computerized search has been carried on by an extensive set of queries on the Embase/Pubmed, Scopus and Cochrane databases, relating to articles published from January 2020 to February 2024.</div></div><div><h3>Results</h3><div>Information reported within ten papers has been processed in this review. The total amount of patients included was 27 (55 % females), with a mean age of 35.6 years. All patients showed a parotid gland infection, which was described bilaterally in 45 % of cases. However, submandibular and sublingual gland infections were reported only as of a single patient. Sialadenitis diagnosis was made through clinical examination, radiological tools and laboratory tests. The diagnosis of parotitis was contextual or delayed to COVID-19 detection in 78 % and 22 % of cases, respectively. The therapeutic management thereof consisted of symptomatic therapies as in Sars COV-2 infection. Antibiotics were reserved in a few cases (12 %).</div></div><div><h3>Conclusions</h3><div>Sialadenitis in patients affected by Sars COV-2 is an uncommon manifestation of COVID-19 infection. Its treatment and prognosis do not differ from those used to treat patients affected by Sars COV-2.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 167-174"},"PeriodicalIF":0.4,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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High-dose-rate brachytherapy radiation carrier with tongue depressing prosthesis – A case report

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-05 DOI: 10.1016/j.ajoms.2024.09.004

Karkala Sayed Suhaim, Zahra Harmain, Rajesh Shetty, Savita Dandekeri

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Psammomatoid and trabecular variants of juvenile ossifying fibroma - Two case reports

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-05 DOI: 10.1016/j.ajoms.2024.09.001

S. Anjana , R. Rajeev , Manju M. Stephen , Deepak Kammath

引用次数: 0

Dendritic cells and vascular endothelial growth factor-C in human oral squamous cell carcinoma

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-09-05 DOI: 10.1016/j.ajoms.2024.09.002

Ayako Okuyama , Kenko Okamoto , Miki Haruyama , Shinnichi Sakamoto , Miyako Hoshino , Michiko Nishimura , Yuji Miyazaki , Takahiko Furuya , Nobuharu Yamamoto , Kentaro Kikuchi

{"title":"Dendritic cells and vascular endothelial growth factor-C in human oral squamous cell carcinoma","authors":"Ayako Okuyama , Kenko Okamoto , Miki Haruyama , Shinnichi Sakamoto , Miyako Hoshino , Michiko Nishimura , Yuji Miyazaki , Takahiko Furuya , Nobuharu Yamamoto , Kentaro Kikuchi","doi":"10.1016/j.ajoms.2024.09.002","DOIUrl":"10.1016/j.ajoms.2024.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>Dendritic cells (DCs) are antigen-presenting cells that can activate naive T cells and thus play a role in tumor immunity. Vascular endothelial growth factors (VEGFs) produced and secreted by various cancers have been reported to inhibit DC differentiation from progenitor cells. However, the relationship between VEGF-C and DCs in oral squamous cell carcinoma (OSCC) remains unclear.</div></div><div><h3>Methods</h3><div>Formalin-fixed paraffin-embedded samples of 172 OSCCs were studied. Immunohistological staining was performed to determine the density of S100- and CD1a- positive DCs, D2–40-positive lymphatic vessels, and the grade of VEGF-C expression in OSCCs. OSCC cell lines were cultured and examined for VEGF-C secretion using ELISA.</div></div><div><h3>Results</h3><div>In comparison to pathological lymph node-negative (PN-) cases, the density of DCs in cancer tissues was significantly lower in PN-positive (PN+) cases, whereas the lymphatic vessel density of cancer tissues was significantly higher in PN+ cases. The density of DCs decreased significantly with increasing VEGF-C expression, indicating a weak inverse relationship. There was a strong positive correlation between VEGF-C expression and lymphatic vessel density. ELISA revealed VEGF-C secretion in various OSCC cell lines, particularly HSC-3, and this increased over time.</div></div><div><h3>Conclusions</h3><div>These results indicate that VEGF-C expressed by OSCC may increase lymphangiogenesis and create an environment that promotes lymph node metastasis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 278-288"},"PeriodicalIF":0.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chondrolipoma arising in the tongue and related literature review: A report of two cases

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.017

Takashi Baba , Yu Yamaguma , Takehito Fukui , Takeshi Kaneuji , Koji Kashima , Yoshihiro Yamashita

引用次数: 0

Open reduction internal fixation versus closed reduction for the management of mandibular intra-capsular fractures in adult patients: A systematic review and meta-analysis

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Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-08-30 DOI: 10.1016/j.ajoms.2024.08.018

Sameer Pandey , Saurabh S. Simre , Srinivedha CV , Ram Sundar Chaulagain , Akansha Vyas , Abiskar Basnet

{"title":"Open reduction internal fixation versus closed reduction for the management of mandibular intra-capsular fractures in adult patients: A systematic review and meta-analysis","authors":"Sameer Pandey , Saurabh S. Simre , Srinivedha CV , Ram Sundar Chaulagain , Akansha Vyas , Abiskar Basnet","doi":"10.1016/j.ajoms.2024.08.018","DOIUrl":"10.1016/j.ajoms.2024.08.018","url":null,"abstract":"<div><h3>Purpose</h3><div>The management of mandibular condylar head/intra-capsular fractures is a controversial subject. Many centres still prescribe closed/ conservative management of this fracture based upon reasonably good functional rehabilitation and fear of surgical complications. The study aims to generate evidence for the selection of the best treatment (open reduction internal fixation, or closed reduction).</div></div><div><h3>Material and methods</h3><div>A systematic review of the literature was performed by searching four electronic databases. The protocol was registered in Prospero (CRD42022365919). Using well-defined PICOS criteria, all randomised and non-randomised studies comparing Open reduction internal fixation to a closed reduction of mandible condylar head fracture were included in the study. Eight were selected for final data analysis. The two treatment methods were compared using post-treatment TMJ dysfunction, malocclusion, facial nerve weakness and condylar resorption as outcomes. The statistical analysis was done using Revman 5.4 and MedCalc software.</div></div><div><h3>Results</h3><div>The meta-analysis results suggested better clinical TMJ function and less malocclusion with open reduction. Better mouth opening associated with closed reduction group. The proportional meta-analysis revealed a 3 % incidence of temporary facial nerve weakness and 47 % condylar resorption associated with open reduction internal fixation.</div></div><div><h3>Conclusion</h3><div>Open reduction internal fixation of mandible condylar head/intra-capsular fractures are associated with less clinical TMJ dysfunction and malocclusion than the closed reduction/conservative treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 255-262"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0