Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献_第4页

Identification of clinical, prognostic and immunological impact of replication factor C subunit 5 (RFC5) expression in head and neck squamous cell carcinoma 复制因子C亚单位5 （RFC5）在头颈部鳞状细胞癌中表达的临床、预后和免疫学影响的鉴定

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-27 DOI: 10.1016/j.ajoms.2025.04.014

Dakshitha Sankar , Anitha Pandi , Palati Sinduja , Vijayashree Priyadharsini Jayaseelan , Paramasivam Arumugam

{"title":"Identification of clinical, prognostic and immunological impact of replication factor C subunit 5 (RFC5) expression in head and neck squamous cell carcinoma","authors":"Dakshitha Sankar , Anitha Pandi , Palati Sinduja , Vijayashree Priyadharsini Jayaseelan , Paramasivam Arumugam","doi":"10.1016/j.ajoms.2025.04.014","DOIUrl":"10.1016/j.ajoms.2025.04.014","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to identify and validate replication factor C subunit 5 (RFC5) mRNA and protein expression in head and neck squamous cell carcinoma (HNSCC) patients, analyzing its association with clinicopathological features, prognosis, and immune signatures.</div></div><div><h3>Methods</h3><div>The study primarily relied on the cancer genome atlas (TCGA-HNSCC) dataset and additionally recruited 32 OSCC patients, a common type of cancer in HNSCC. RFC5 mRNA and protein expression were analyzed in oral squamous cell carcinoma (OSCC) and adjacent normal tissues using methods such as real time-qPCR and Western blot. The implications of RFC5 expression in clinicopathological features, survival, immune regulation, and functional enrichment analysis were analyzed using the TCGA-HNSCC dataset.</div></div><div><h3>Results</h3><div>RFC5 mRNA and protein are significantly altered in multiple cancers, particularly upregulated in HNSCC/OSCC. <em>RFC5</em> mRNA expression is associated with cancer stage, grade, nodal metastasis, HPV status, and poor prognosis, suggesting its potential as a biomarker. Protein network analysis identified an interaction between RFC5 and various well-known oncoproteins involved in DNA replication and cancer pathways. Functional enrichment analysis showed a strong association between RFC5 and HNSCC development and progression.</div></div><div><h3>Conclusions</h3><div>RFC5 is a key player in HNSCC, and its overexpression is associated with aggressive clinical features and poor outcomes. Its role in oncogenic pathways and interaction with key proteins suggest its potential as a biomarker and therapeutic target.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1115-1122"},"PeriodicalIF":0.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant transformation of oral leukoplakia and associated risk factors: A retrospective clinical study from a single institution 口腔白斑恶性转化及相关危险因素：一项来自单一机构的回顾性临床研究

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-25 DOI: 10.1016/j.ajoms.2025.04.005

Sanako Nakaya , Kensuke Naganawa , Reika Hasegawa , Mai Tomimatsu , Fumitaka Terasawa , Satoru Miyabe , Satoshi Watanabe , Shogo Hasegawa , Hitoshi Miyachi , Mitsuo Goto

{"title":"Malignant transformation of oral leukoplakia and associated risk factors: A retrospective clinical study from a single institution","authors":"Sanako Nakaya , Kensuke Naganawa , Reika Hasegawa , Mai Tomimatsu , Fumitaka Terasawa , Satoru Miyabe , Satoshi Watanabe , Shogo Hasegawa , Hitoshi Miyachi , Mitsuo Goto","doi":"10.1016/j.ajoms.2025.04.005","DOIUrl":"10.1016/j.ajoms.2025.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the clinical features of oral leukoplakia (OL) and its rate of progression to oral squamous cell carcinoma (OSCC) in a Japanese population. We also investigated the impact of clinical risk factors on the rate of malignant transformation (MT).</div></div><div><h3>Methods</h3><div>This retrospective study included 308 patients diagnosed with OL between 1989 and 2020. Of these, 231 patients with 6 months follow-up were enrolled. The Kaplan−Meier method was employed to analyze 5- and 10-year risks of developing OSCC. Chi-square test and nominal logistic regression analysis were used to investigate predictors of progression to OSCC.</div></div><div><h3>Results</h3><div>The mean age of the patients was 62.6 years (range 20 −89), and 45.9 % were female. The most common site of OL was the tongue (36.4 %). Twenty patients (8.7 %) experienced MT to OSCC. The predominant clinical type was the homogenous type (66.7 %), with no patient developing OSCC. Univariate analyses showed that the risk of progression to OSCC was significantly higher in patients aged < 64 years, those with OL of the tongue, nonhomogeneous type, and biopsied cases. In the multivariate analyses, the statistically significant predictor was clinical type. The numbers of female nonsmokers and nondrinkers were significantly higher among the MT cases (p = 0.0016, p = 0.0373, respectively).</div></div><div><h3>Conclusions</h3><div>OL increases the risk of MT due to a combination of clinical risk factors. Therefore, high-risk cases require shorter follow-up intervals, and we suggest that multiple examiners share their findings. Performing biopsies to identify histopathological factors and make a definitive diagnosis should be considered.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 929-934"},"PeriodicalIF":0.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of immune-related hub genes as prognostic biomarkers in HPV-positive oropharyngeal cancer hpv阳性口咽癌中免疫相关中枢基因作为预后生物标志物的研究

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-24 DOI: 10.1016/j.ajoms.2025.03.012

Chin-Hsuan Yeh , Tsung-Ming Chang , Chia-Yu Wu , Ju-Fang Liu

{"title":"Investigation of immune-related hub genes as prognostic biomarkers in HPV-positive oropharyngeal cancer","authors":"Chin-Hsuan Yeh , Tsung-Ming Chang , Chia-Yu Wu , Ju-Fang Liu","doi":"10.1016/j.ajoms.2025.03.012","DOIUrl":"10.1016/j.ajoms.2025.03.012","url":null,"abstract":"<div><div>Human papillomavirus (HPV) infection is a significant risk factor for head and neck squamous cell carcinoma (HNSCC), with oropharyngeal cancer being predominantly attributed to HPV. Clinical studies have consistently demonstrated that patients with HPV-positive oropharyngeal cancer exhibit a markedly better prognosis compared to those with HPV-negative oropharyngeal cancer. Consequently, understanding the key genes that influence the prognosis of HPV-positive patients is critical. This study aimed to identify the essential genes contributing to the prognostic differences observed between HPV-positive and HPV-negative oropharyngeal cancer patients. Utilizing GSE72536 and GSE55544 datasets obtained from the Gene Expression Omnibus (GEO), we conducted a comprehensive analysis and identified ten hub genes (IFNG, CD19, CD27, CD2, CD247, PDCD1, KLRK1, LAG3, FASLG, and KLRB1) that are significantly overexpressed in HPV-positive oropharyngeal cancer tissues. These genes strongly correlate with improved prognosis and are closely associated with immune cell activation and infiltration, contributing to a potent antitumor immune response. The enhanced immune response observed in HPV-positive cancers, mediated by these hub genes, explains the better prognosis and longer overall survival (OS) associated with HPV-positive oropharyngeal cancer patients. These findings indicate that the identified hub genes could be valuable prognostic biomarkers and potential therapeutic targets. This underscores the importance of personalized treatment strategies in improving clinical outcomes for HPV-positive oropharyngeal cancer patients.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1103-1114"},"PeriodicalIF":0.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of oral reactions of immune-related adverse events caused by immune checkpoint inhibitors 免疫检查点抑制剂引起的免疫相关不良事件的口服反应发生率

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-24 DOI: 10.1016/j.ajoms.2025.04.011

Akira Kurokawa , Kanae Niimi , Hiroko Kanemaru , Marie Soga , Moe Yamashita , Hidenobu Sakuma , Kei Tomihara , Kensuke Yoshida , Tadaharu Kobayashi , Akitugu Ohuchi

{"title":"Incidence of oral reactions of immune-related adverse events caused by immune checkpoint inhibitors","authors":"Akira Kurokawa , Kanae Niimi , Hiroko Kanemaru , Marie Soga , Moe Yamashita , Hidenobu Sakuma , Kei Tomihara , Kensuke Yoshida , Tadaharu Kobayashi , Akitugu Ohuchi","doi":"10.1016/j.ajoms.2025.04.011","DOIUrl":"10.1016/j.ajoms.2025.04.011","url":null,"abstract":"<div><h3>Objective</h3><div>Immune-related adverse events (irAEs) are side effects caused by the persistence of autoantigen-specific T cells in normal cells and organs that are not eliminated after immune checkpoint inhibitors (ICI) administration. Oral irAEs include xerostomia, oral mucositis, and lichen planus-like lesions; however, only a few studies have reported oral irAEs during ICI therapy. This study aimed to examine the incidence of oral irAEs in our hospital and the effect of oral care.</div></div><div><h3>Methods</h3><div>The study enrolled 165 patients who underwent oral hygiene management during ICI administration, and did not undergo radiotherapy to the head and neck region, and 63 patients (38.2 %) presented with oral mucositis and/or xerostomia, which appears to be oral irAE. Although most of the patients who suffered from these oral reactions were using anti-Programmed cell Death-1 antibodies, severe oral mucositis was observed in patients who treated with multiple ICIs. Symptoms of patients with grade 1 and 2 mucositis were improved with oral care, and ICI were continued in most of them. However, all patients with grade 3 oral mucositis also showed improvement in symptoms, ICI therapy was discontinued in three patients, systemic steroids were administered in two patients, and ICI therapy was not restarted during the study period.</div></div><div><h3>Conclusion</h3><div>The incidence of oral irAEs is high in patients on ICI therapy, and continuous oral hygiene management by experts appears to be important for continuity of the treatment.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1051-1055"},"PeriodicalIF":0.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative management of acquired von Willebrand syndrome associated with monoclonal gammopathy of undetermined significance: A case report and review of literature 意义不明的单克隆γ病合并获得性血管性血友病的围手术期治疗：1例报告及文献复习

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-20 DOI: 10.1016/j.ajoms.2025.04.010

Ryouji Tani , Tadayoshi Nobumoto , Kosei Okamoto , Taeko Fukutani , Sugru Hirota , Kento Okamoto , Koichi Koizumi , Souichi Yanamoto

{"title":"Perioperative management of acquired von Willebrand syndrome associated with monoclonal gammopathy of undetermined significance: A case report and review of literature","authors":"Ryouji Tani , Tadayoshi Nobumoto , Kosei Okamoto , Taeko Fukutani , Sugru Hirota , Kento Okamoto , Koichi Koizumi , Souichi Yanamoto","doi":"10.1016/j.ajoms.2025.04.010","DOIUrl":"10.1016/j.ajoms.2025.04.010","url":null,"abstract":"<div><div>Acquired von Willebrand syndrome (AvWS) is a bleeding disorder characterized by symptoms resulting from a decrease in the von Willebrand factor (vWF) due to an underlying disease or medication. We report our experience in managing tooth extraction in a patient with AvWS who had bleeding gums. A 90-year-old woman was admitted to a nearby hospital for gastrointestinal bleeding treatment, wherein bleeding gums were observed. Suspecting AvWS, she was referred to the hematology department for further evaluation and subsequently to our department for oral cavity treatment. Following a comprehensive evaluation by the hematology department, a diagnosis of AvWS with a background of monoclonal gammopathy was made. Upon initial presentation to our department, the residual root of the right maxillary first premolar was considered the bleeding source and thus indicated for extraction. Following Factor VIII/vWF concentrate administration during hospitalization, the tooth was extracted under local anesthesia. A local hemostatic agent was inserted into the extraction socket; a hemostatic splint was applied after suturing and closing the wound. Postoperative bleeding from the wound was absent; after Factor VIII/vWF concentrate administration, the patient was discharged the following day. However, upon sutures removal nine days after the procedure, rebleeding occurred, requiring reapplication of a hemostatic splint. Two weeks after surgery, the splint was removed and hemostasis was achieved. In such cases, collaborating with the hematology department is necessary to formulate a customized treatment plan for each case.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1081-1085"},"PeriodicalIF":0.4,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An in-silico comparison of success rate of different methods for inferior alveolar nerve blockade 下肺泡神经阻滞不同方法成功率的计算机比较

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-19 DOI: 10.1016/j.ajoms.2025.04.007

Ákos Bicsák , Leandra Esser , Stefan Hassfeld , Lars Bonitz

{"title":"An in-silico comparison of success rate of different methods for inferior alveolar nerve blockade","authors":"Ákos Bicsák , Leandra Esser , Stefan Hassfeld , Lars Bonitz","doi":"10.1016/j.ajoms.2025.04.007","DOIUrl":"10.1016/j.ajoms.2025.04.007","url":null,"abstract":"<div><h3>Objective</h3><div>We present a comparison of five methods for inferior alveolar nerve blockade (Halsted’s, Fischer’s, Laguardia’s, Szokolóczy-Syllaba’s and Gow-Gates method -as control group) in our three-dimensional virtual model based on the radiological database of our Department.</div></div><div><h3>Methods</h3><div>The injection canula was modelled as a vector in a coordinate system applied to the skull, a spherical model projected to the mandibular foramen was defined as target zone. The parallelism of these vectors and the targeting accuracy around the mandibular foramen was compared by independent statistician with Fisher’s test with a significance level of α= 5 %.</div></div><div><h3>Results</h3><div>100 mandibular sides (50 left and 50 right mandibles) were measured in virtual model. There were no significant gender or age differences. In case of the Laguardia method the administration lines deviated in average 10°, in case of the other methods 5° in average. The hit rate at different target radius was worst with the Laguardia’s method than with the others, the results were statistically significant (p < 0.001).</div></div><div><h3>Conclusions</h3><div>This in-silico model reproduced the literature results of the clinical accuracy (70 %-100 %) of inferior alveolar nerve blockade. Further anatomical studies of the pterygomandibular space are necessary to improve clinical accuracy.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 935-940"},"PeriodicalIF":0.4,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyostomatitis vegetans associated with ulcerative colitis: A case report 植物性化脓性口炎合并溃疡性结肠炎1例报告

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-18 DOI: 10.1016/j.ajoms.2025.04.009

Hiroyuki Kano , Yusuke Kato , Naoyuki Sato , Mai Nozawa‑Kobayashi , Tadaharu Kobayashi

{"title":"Pyostomatitis vegetans associated with ulcerative colitis: A case report","authors":"Hiroyuki Kano , Yusuke Kato , Naoyuki Sato , Mai Nozawa‑Kobayashi , Tadaharu Kobayashi","doi":"10.1016/j.ajoms.2025.04.009","DOIUrl":"10.1016/j.ajoms.2025.04.009","url":null,"abstract":"<div><div>Pyostomatitis vegetans (PV) is a rare, benign, and chronic disorder of the oral mucosa characterized by the presence of multiple pustules with an erythematous base and is an unusual oral expression of inflammatory bowel disease, such as ulcerative colitis (UC) or Crohn’s disease. Herein, a case of successful treatment for PV associated with UC is described. A 62-year-old male exhibited numerous tiny pustules and shallow erosions fusing to form characteristic “snail track” appearances were noted extensively on the gingiva. He had been diagnosed with UC five years previously and had been treated with steroid suppositories and other medications. Histological examination of a biopsy specimen of the upper left gingiva revealed a diagnosis of PV. Treatment for PV and UC was initiated with ATM therapy in which three antibiotics (amoxicillin, tetracycline and metronidazole) should be co-administered simultaneously three times a day, for two weeks. Then, the patient administered prednisolone at 30 mg/day. Two weeks later, significant improvement of oral mucosal lesions was observed. Although prednisolone was reduced gradually to 5 mg⁄ day after that, the erosions and ulcers of the rectalmucosa were not found endoscopically four months after the administration of systemic corticosteroids. Thereafter, treatment and management of UC was continued by his attending gastroenterologist, and no recurrence of PV has been observed for more than five years after the PV was cured.PV may accompany or precede active UC despite the absence of intestinal symptoms and can be used as a good mucocutaneous sign to determine the occurrence of active UC at an early stage.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1077-1080"},"PeriodicalIF":0.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique presentation of spongiotic hyperplasia at the mucogingival junction 牙龈粘膜交界处海绵状增生的独特表现

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-16 DOI: 10.1016/j.ajoms.2025.04.008

Karanbir Sidhu , Kale Wudrich , Matheus de Castro Costa , Amanda Gruza , Marina Lara de Carli , Felipe Fornias Sperandio

{"title":"A unique presentation of spongiotic hyperplasia at the mucogingival junction","authors":"Karanbir Sidhu , Kale Wudrich , Matheus de Castro Costa , Amanda Gruza , Marina Lara de Carli , Felipe Fornias Sperandio","doi":"10.1016/j.ajoms.2025.04.008","DOIUrl":"10.1016/j.ajoms.2025.04.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Spongiotic Gingival Hyperplasia (SGH), previously known as Localized Juvenile Spongiotic Gingival Hyperplasia (LJSGH), has been a subject of nomenclature debate due to its presentation in patients of all ages. SGH is characterized by erythematous, slightly raised plaques or nodules, often localized in the marginal gingiva. This case report presents a unique clinical presentation of Spongiotic Hyperplasia of the Mucogingival Junction (SHMJ), further elucidating SGH's clinical variability, with a particular focus on its differential diagnosis and management, followed by long-term clinical monitoring.</div></div><div><h3>Case Report</h3><div>A 67-year-old female presented with an asymptomatic, erythematous patch at the mucogingival junction between teeth #21 and #22. Clinical and radiographic examination revealed no signs of periodontal or pulpal infection/necrosis. An excisional biopsy of the lesion revealed marked spongiosis and exocytosis of a diffusely CK19-positive overlying mucosal epithelium. Histological findings were consistent with spongiotic hyperplasia. The lesion showed complete healing at a 9-month follow-up without recurrence.</div></div><div><h3>Conclusion</h3><div>This case represents a peculiar instance of SHMJ, highlighting the need for heightened clinical awareness of SGH’s atypical presentations. Surgical excision remains the treatment of choice, as conservative periodontal treatments are ineffective. Histological and immunohistochemical analysis aid in definitive diagnosis; long-term follow-up is essential to exclude recurrence.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1153-1157"},"PeriodicalIF":0.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of primary squamous cell carcinoma of the submandibular gland responding to chemoradiotherapy 原发性颌下腺鳞状细胞癌放化疗的疗效分析

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-16 DOI: 10.1016/j.ajoms.2025.04.006

Akihiko Nakamura , Tomohiro Hamada , Mizuki Yanagida , Toshiaki Tanaka , Masashi Oe , Tsuguo Sano

{"title":"A case of primary squamous cell carcinoma of the submandibular gland responding to chemoradiotherapy","authors":"Akihiko Nakamura , Tomohiro Hamada , Mizuki Yanagida , Toshiaki Tanaka , Masashi Oe , Tsuguo Sano","doi":"10.1016/j.ajoms.2025.04.006","DOIUrl":"10.1016/j.ajoms.2025.04.006","url":null,"abstract":"<div><div>Primary squamous cell carcinoma of the submandibular gland is extremely rare. Although surgical resection is recommended for the initial treatment of primary squamous cell carcinoma of the submandibular gland, postoperative loss of oral and maxillofacial function with tumor growth represents a significant concern. We report the case of a patient with primary squamous cell carcinoma of the submandibular gland that responded to chemoradiotherapy. A 72-year-old man was referred to our department with swelling in the right submandibular region. Tissue biopsy resulted in a histopathological diagnosis of squamous cell carcinoma. The patient declined surgery and selected chemoradiotherapy, which proved effective. However, salvage surgery was performed for residual tumor at the primary site. Negative results were obtained for <em>CRTC1/MAML2</em> fusion, so the diagnosis was primary squamous cell carcinoma of the submandibular gland. Careful follow-up is important because patients with primary squamous cell carcinoma of the submandibular gland has a poor prognosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1022-1026"},"PeriodicalIF":0.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metachronous occurrence of Epstein-Barr virus-positive mucocutaneous ulcers suspected to be related to periodontitis: A case report 怀疑与牙周炎有关的eb病毒阳性皮肤粘膜溃疡同时发生1例

IF 0.4

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2025-04-11 DOI: 10.1016/j.ajoms.2025.04.001

Yukiko Kusuyama , Rie Irie , Atsuko Niki-Yonekawa , Yoshio Ueno , Nobuo Morita , Yoshihiro Morita , Shinya Takahashi , Kenshin Ohara , Yumi Ito

{"title":"Metachronous occurrence of Epstein-Barr virus-positive mucocutaneous ulcers suspected to be related to periodontitis: A case report","authors":"Yukiko Kusuyama , Rie Irie , Atsuko Niki-Yonekawa , Yoshio Ueno , Nobuo Morita , Yoshihiro Morita , Shinya Takahashi , Kenshin Ohara , Yumi Ito","doi":"10.1016/j.ajoms.2025.04.001","DOIUrl":"10.1016/j.ajoms.2025.04.001","url":null,"abstract":"<div><div>Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is an Epstein-Barr virus-associated B-cell lymphoproliferative disorder that usually occurs in immunosuppressed patients. In this report, we describe the case of a 75-year-old man who repeatedly developed EBVMCUs at different gingival sites. He had a history of B-cell lymphoma and had achieved remission with chemotherapy 2 years before visiting our hospital. In all three EBVMCUs, radiographic examination revealed alveolar bone resorption beneath the EBVMCUs, and the ulcers regressed after spontaneous loss or extraction of adjacent teeth. Four years after the third appearance, no new lesions emerged, and the periodontal disease was controlled. Histopathological features showed that ulcers in the first and third instances were classical Hodgkin lymphoma-like and that in the second instance was a diffuse large B-cell lymphoma-like EBVMCU. Programmed death-ligand 1 (PD-L1) expression was examined using a PD-L1 antibody (SP142); only the ulcer in the third instance was positive. This case suggests a possible association between EBVMCU and periodontitis and that the past history of chemotherapy can be a risk factor for systemic immunosuppression causing EBVMCU.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 5","pages":"Pages 1141-1146"},"PeriodicalIF":0.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0