Journal of Oral and Maxillofacial Surgery Medicine and Pathology最新文献

{"title":"Tube feeding in patients with head and neck cancer undergoing chemoradio-/radio therapy: A systematic review and meta-analysis based on the GRADE approach","authors":"Taiki Suzuki ,&nbsp;Souichi Yanamoto ,&nbsp;Daisuke Takeda ,&nbsp;Hirokazu Saito ,&nbsp;Haruki Sato ,&nbsp;Seiji Asoda ,&nbsp;Masatoshi Adachi ,&nbsp;Hidemichi Yuasa ,&nbsp;Narikazu Uzawa ,&nbsp;Hiroshi Kurita","doi":"10.1016/j.ajoms.2024.08.015","DOIUrl":"10.1016/j.ajoms.2024.08.015","url":null,"abstract":"<div><h3>Scope</h3><div>The scope of this systematic review (SR) was to determine whether a nasogastric tube (NGT) or percutaneous endoscopic gastrostomy (PEG) is a more useful supportive therapy in patients with oral cancer undergoing chemoradio-/radio therapy.</div></div><div><h3>Methods</h3><div>For the review, two authors searched MEDLINE, Cochrane CENTRAL and Ichushi-Web to identify clinical practice guidelines, SRs and randomised controlled trials (RCTs) according to pre-determined criteria. RevMan Web was used to combine trials and analyse the data. We evaluated the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation system approach.</div></div><div><h3>Results</h3><div>It was not possible to perform a meta-analysis of only treatment completion based on the included RCTs; therefore, we performed a meta-analysis of treatment breaks as a surrogate outcome. A meta-analysis of potential treatment breaks, including treatment discontinuation, revealed no superiority between PEG and NGT (risk ratio=0.64 [0.23, 1.79]). A meta-analysis was conducted on two RCTs regarding the harms of infection. There does not appear to be a significant increase in the risk of infection with either PEG or NGT (risk ratio=1.18 [0.45, 3.08]). The certainty of the evidence for two outcomes was judged to be very low. Further, meta-analyses of quality of life and nutritional status were not possible because of differences in assessment methods.</div></div><div><h3>Conclusion</h3><div>We could not determine the superiority of NGT or PEG in the supportive care of oral cancer patients who received chemoradio-/radio therapy. The effect of PEG feeding is uncertain, and it is necessary to consider indications for each case.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 92-98"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor budding and complete epithelial mesenchymal transition correlate with late nodal metastasis in early-stage tongue squamous cell carcinoma","authors":"Takayoshi Kikuchi ,&nbsp;Kinue Kurihara ,&nbsp;Homare Kawachi ,&nbsp;Satoru Ogane ,&nbsp;Kazuhiko Hashimoto ,&nbsp;Takahiko Shibahara ,&nbsp;Takeshi Nomura","doi":"10.1016/j.ajoms.2024.08.012","DOIUrl":"10.1016/j.ajoms.2024.08.012","url":null,"abstract":"<div><h3>Background</h3><div>Late nodal metastasis is a poor prognostic factor for early-stage tongue squamous cell carcinoma. However, for most early-stage patients, there is a low risk for late nodal metastasis, which currently lacks a diagnostic marker. Tumor budding is a nodal metastasis risk factor in other human cancers. Here, we evaluated tumor budding by partial or complete epithelial-mesenchymal transition and Ovol2 expression, a transcription factor that directly suppresses epithelial-mesenchymal transition.</div></div><div><h3>Methods</h3><div>Sixty-six T1–2N0 patients were enrolled in this retrospective study. Tumor expressions of E-cadherin and vimentin (epithelial-mesenchymal transition markers) and Ovol2 were assessed by immunohistochemistry. Tumor histopathological and immunohistochemical features, mode of invasion, and tumor budding were assessed. Correlations between these potential predictive factors and late nodal metastasis were determined statistically.</div></div><div><h3>Results</h3><div>Univariate analysis demonstrated lymphoid infiltrate, perineural invasion, infiltrative growth pattern, tumor budding, vimentin positive, and complete epithelial-mesenchymal transition were significant factors of late nodal metastasis (all P &lt; 0.05), observed in 25.8 % of patients. Multivariate analysis identified tumor budding and vimentin positive were independent prognostic factors (both P &lt; 0.025). Ovol2 expression was significantly decreased in partial and complete epithelial-mesenchymal transition cells (both P &lt; 0.01) compared with normal epithelia. Univariate analysis, but not multivariate analysis, showed Ovol2 correlated with depth of invasion and tumor budding (both P &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Tumor budding and vimentin expression are risk factors for late nodal metastasis in T1–2N0 tongue squamous cell carcinoma. Ovol2 might be involved in the early stages of epithelial-mesenchymal transition. Evaluation of these factors might identify patients susceptible to late nodal metastasis who require elective neck dissection.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 201-209"},"PeriodicalIF":0.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of mantle cell lymphoma (MCL) detected with initial symptoms in the oral region","authors":"Shingo Hara,&nbsp;Shohei Domae,&nbsp;Hideka Kanemoto,&nbsp;Yoshihisa Tateishi,&nbsp;Yukihiro Tatemoto","doi":"10.1016/j.ajoms.2024.08.016","DOIUrl":"10.1016/j.ajoms.2024.08.016","url":null,"abstract":"<div><div>We encountered a case of mantle cell lymphoma (MCL) located in the oral cavity, diagnosed through the analysis of a biopsy sample from a palatal mass. The patient was an 85-year-old female who was referred to our department due to a palatal mass. Contrast-enhanced computed tomography (CT) showed a shadow of a mass in the palate and several enlarged lymph nodes on both sides of the neck. Magnetic resonance imaging revealed diffuse enlargement of the palatal soft tissue, with a faint and uniform signal on T2-weighted imaging. The signal was markedly hyperintense on diffusion-weighted imaging, with multiple lymph node enlargements in the bilateral parotid glands, neck, submental area, and clavicular fossa. Histopathological findings showed dense infiltration of small lymphocyte-like tumor cells beneath the epithelium. Immunostaining was positive for CD20, CD5, and cyclinD1, confirming the diagnosis of MCL. Fluorescence in situ hybridization using a bone marrow aspirate showed positive BCL translocation and negative p53 deletion. Positron emission tomography-CT indicated higher fluorine-18-deoxyglucose accumulation in the palate, as well as in the bilateral cervical, axillary, mesenteric, iliac, and enlarged inguinal lymph nodes, compared to the liver. The Lugano classification was advanced Stage IV, and the patient underwent six courses of combination therapy of bendamustine and rituximab, resulting in complete remission.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 323-330"},"PeriodicalIF":0.4,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical assessment of stem cell-related Sox2 and Klf4 in ameloblastomas","authors":"Kanako Kuroda ,&nbsp;Atsumu Kouketsu ,&nbsp;Haruka Saito ,&nbsp;Tetsu Takahashi ,&nbsp;Kensuke Yamauchi ,&nbsp;Tsuyoshi Sugiura ,&nbsp;Hiroyuki Kumamoto","doi":"10.1016/j.ajoms.2024.08.014","DOIUrl":"10.1016/j.ajoms.2024.08.014","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to investigate the potential roles of sex-determining region Y-related high mobility group-box 2 (Sox2) and Krüppel-like factor 4 (Klf4), two stem cell-related molecules, in odontogenic tissues.</div></div><div><h3>Methods</h3><div>Immunohistochemical reactivity to Sox2 and Klf4 was examined in 10 dental follicle and 54 ameloblastoma specimens. The association between these molecules and clinical variables was analyzed in ameloblastoma cases.</div></div><div><h3>Results</h3><div>Dental follicles showed immunoreactivity to Sox2 and Klf4 predominantly in the dental lamina. In ameloblastomas, Sox2 and Klf4 expression was detected in 48 of the 54 cases, and was predominantly localized in neoplastic cells adjacent to the basement membrane. Sox2 showed substantially higher expression in dental follicles than in ameloblastomas. Granular cell ameloblastomas presented lower levels of Sox2 and Klf4 than acanthomatous ameloblastomas. Moreover, immunoreactivity of ameloblastomas to Sox2 and Klf4 was slightly higher in recurrent cases than in non-recurrent cases.</div></div><div><h3>Conclusions</h3><div>The differential expression patterns of Sox2 and Klf4 in dental follicles and ameloblastomas indicate that these transcription factors may be involved in the regulation of odontogenic tissues. As these transcription factors are associated with cell proliferation and differentiation in the odontogenic epithelium, they may contribute to tumorigenesis or disease prognosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 228-233"},"PeriodicalIF":0.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of tongue granuloma requiring differentiation of Langerhans cell histiocytosis and Erdheim–Chester disease","authors":"Katsuhisa Sekido ,&nbsp;Takashi Kawane ,&nbsp;Yoshinobu Maeda ,&nbsp;Danki Takatsuka ,&nbsp;Koji Takii ,&nbsp;Ryo Ouchi","doi":"10.1016/j.ajoms.2024.08.008","DOIUrl":"10.1016/j.ajoms.2024.08.008","url":null,"abstract":"<div><div>Granulomatous lesions in the head and neck include Langerhans cell histiocytosis (LCH) and Erdheim–Chester disease (ECD). ECD is a rare non-LCH characterised by histiocytic infiltration of multiple organ systems. In the head and neck region, there are some reports of its occurrence in the bony skeleton; however, it is extremely rare in soft tissues. Herein, we report a case of tongue granuloma requiring the differentiation of LCH and ECD. A 64-year-old man was referred to our hospital for swelling of the tongue and oral floor. We performed a biopsy and diagnosed ECD pathologically. However, as no bone lesions were identified in other parts of the body, a diagnosis of tongue granuloma was made. Following systemic administration of corticosteroids, the swelling of the tongue and oral floor completely disappeared. Steroids were gradually decreased, and there were no signs of recurrence of the disease. This case underscores the importance of considering ECD in the differential diagnosis of granulomatous lesions in the head and neck, even in soft tissues, and highlights the efficacy of corticosteroid therapy in managing associated symptoms.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 385-390"},"PeriodicalIF":0.4,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143151375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of lymphoproliferative disease of the palate while receiving infliximab and azathioprine for Crohn's disease","authors":"Nanako Ito ,&nbsp;Tomoaki Hamana ,&nbsp;Hisako Furusho ,&nbsp;Natsuki Eboshida ,&nbsp;Yasuyuki Asada ,&nbsp;Fumitaka Obayashi ,&nbsp;Mirai Higaki ,&nbsp;Atsuko Hamada ,&nbsp;Sachiko Yamasaki ,&nbsp;Toshinori Ando ,&nbsp;Koichi Koizumi ,&nbsp;Souichi Yanamoto","doi":"10.1016/j.ajoms.2024.08.010","DOIUrl":"10.1016/j.ajoms.2024.08.010","url":null,"abstract":"<div><div>Methotrexate (MTX)-associated lymphoproliferative diseases (LPD) have been reported to occur in the oral cavity. However, there are no reports of LPD in the oral cavity caused by anti-TNF-α inhibitors. A 37-year-old man was initially treated for diffuse large B-cell lymphoma (DLBCL) after prolonged treatment with infliximab (IFX) and azathioprine (AZA) for Crohn’s disease (CD). The patient was aware of an abnormal right upper molar and was transferred to our hospital. DLBCL was diagnosed based on biopsy specimens of the mass in the right upper molar region. Six courses of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone were administered. After chemotherapy, the lymphoma showed complete remission for two years.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 365-370"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evaluation of pathologic fracture risk and residual bone height in unicortical and bicortical mandibular corpus defects: A 3D finite analysis","authors":"Arzum Yilmaz ,&nbsp;Sedat Çeti̇ner ,&nbsp;Ilgin Ari","doi":"10.1016/j.ajoms.2024.08.013","DOIUrl":"10.1016/j.ajoms.2024.08.013","url":null,"abstract":"<div><h3>Objective</h3><div>Mandibular bone defects are a common problem and difficult to manage. A defected area mostly left to heal spontaneously. It doesn’t have a definite protocol in the literature, when the area will be left to heal spontaneously or when supported with materials such as plates, screws, grafts, especially in intermediate-sized defects. In this study, it was aimed to determine by examining the areas where the stresses due to chewing forces are concentrated on the mandible bone and the risk of fracture in intermediate size unicortical and bicortical defects.</div></div><div><h3>Material and Methods</h3><div>The all defect models which was the residual bone heights were 6, 8, 10 mm in mandibular corpus region were created. Two different loading scenarios were applied anterior and defected premolar side. Von Mises, Pmax and Pmin stresses in models were evaluated by three-dimensional finite element analysis method.</div></div><div><h3>Results</h3><div>The study found higher stress accumulation on the buccal anterior side of defects in both unicortical and bicortical models, with the most stress concentrated at the buccal corners. Under Loading 1, bicortical defects with 10 mm residual bone height showed slightly higher stress accumulations than unicortical defects, while bicortical defects with 8 and 6 mm residual bone height exhibited significantly higher stress values. Under Loading 2, stress accumulations in bicortical defects were higher than in unicortical defects, with bicortical defects at 6 mm residual bone height showing almost double the stress values. Pmax stress values were higher in bicortical defects under both loadings, especially when the residual bone height decreased. Pmin stress values were comparable in unicortical defects but were higher in bicortical defects, particularly at 6 mm residual bone height, under both loading conditions.</div></div><div><h3>Conclusion</h3><div>This study was presented that mandibular resistance decreases significantly when residual bone height is less than 10 mm for bicortical defects and less than 8 mm at unicortical defects. In these conditions it may need supported with materials to prevent fractures. However, in vivo and in vitro studies are necessary for definitive conclusions.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 84-91"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of periodontal tissue regeneration using octacalcium phosphate and collagen composite","authors":"Keiko Matsui ,&nbsp;Shinji Kamakura ,&nbsp;Atsumu Kouketsu ,&nbsp;Yushi Ezoe ,&nbsp;Kei-ichiro Miura ,&nbsp;Kensuke Yamauchi","doi":"10.1016/j.ajoms.2024.08.009","DOIUrl":"10.1016/j.ajoms.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate periodontal tissue regenerative potential of octacalcium phosphate (OCP) and collagen composite (OCPcol), recognized as excellent bone-regenerative materials, in artificial bone defect models using beagle dogs. This study specifically assessed the efficacy of OCPcol in periodontal soft-tissue regeneration.</div></div><div><h3>Methods</h3><div>OCPcol was implanted in bone defects adjacent to the roots of the left mandibular third and fourth premolars in six beagle dogs (OCP group), while five dogs did not receive OCPcol (control group). The dogs were observed for 3 months. The specimens were evaluated radiologically and histologically.</div></div><div><h3>Results</h3><div>Microcomputed tomography revealed bone regeneration originating from the lateral cortical bone surface adjacent to the created defect. The superficial layer of the regenerated bone was cortical bone-like and continuous with the upper and lower alveolar bone. The bone was regenerated by maintaining a continuous void in the periodontal ligament space above and below the dentinal defect. Dental defects of roots were not regenerated. The control group did not exhibit sufficient bone regeneration. Histologically, in the OCP group, formation of new cementum was observed on the outer surface of the root dentin, with connective tissue attachment and an oblique-running periodontal ligament in the space between the new bone and dentin. However, the dentinal defects were not regenerated．</div></div><div><h3>Conclusions</h3><div>Alveolar bone and periodontal ligament regenerated when OCPcol was implanted into a bone and dentinal defect created around a natural tooth root. These results suggest that OCPcol effectively regenerates periodontal tissue, without ankylosis.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 76-83"},"PeriodicalIF":0.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteonecrosis of the jaw in a patient treated with alendronate and then denosumab: A case of dramatic amelioration by minocycline and then etidronate","authors":"Takefumi Oizumi ,&nbsp;Kazuhiro Imoto ,&nbsp;Kanan Bando ,&nbsp;Yukinori Tanaka ,&nbsp;Hiromi Funayama ,&nbsp;Kensuke Yamauchi ,&nbsp;Hiroyuki Kumamoto ,&nbsp;Tetsu Takahashi ,&nbsp;Yasuo Endo","doi":"10.1016/j.ajoms.2024.07.012","DOIUrl":"10.1016/j.ajoms.2024.07.012","url":null,"abstract":"<div><div>Nitrogen-containing bisphosphonates (NBPs) and denosumab are widely-used anti-bone-resorptive agents. However, osteonecrosis of the jaw (ONJ) is a known side effect with each of them (called BRONJ or DRONJ, respectively). BRONJ and DRONJ are intractable, and no sound/solid treatments have been established. Some reports note that denosumab carries a greater risk of ONJ than NBPs, and that they mutually augment the risk. Our previous animal and in vitro studies led us to suppose that etidronate (a bisphosphonate not containing nitrogen) may be effective against BRONJ, and we reported that etidronate ameliorated BRONJ in all 13 of the patients we tested. Here, we add a case in which etidronate healed stage 3 ONJ caused by alendronate (an NBP) followed by denosumab. We first treated her with minocycline (a bacteriostatic antibiotic) and then etidronate. Pain and drainage disappeared with minocycline. Within 3 weeks after the start of etidronate, bone exposure was markedly reduced and it had disappeared within 6 months, being followed by osteogenesis in the injured area and fracture-line disappearance. These results suggest that (i) in the present patient, the major cause of ONJ might have been alendronate, with denosumab possibly promoting its progress, (ii) etidronate is effective against BRONJ caused not only by NBPs, but also by NBPs + denosumab, and (iii) minocycline is suitable as a combination drug with etidronate, because in addition to its bacteriostatic effect, minocycline has various effects helping to ameliorate ONJ, including analgesic, anti-inflammatory, and bone-forming effects together with its high affinity for bone.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 2","pages":"Pages 348-355"},"PeriodicalIF":0.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143150328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using texture analysis of ultrasonography images of neck lymph nodes to differentiate metastasis to non-metastasis in oral maxillary gingival squamous cell carcinoma","authors":"Yusuke Kawashima ,&nbsp;Aya Hagimoto ,&nbsp;Hiroshi Abe ,&nbsp;Masaaki Miyakoshi ,&nbsp;Yoshihiro Kawabata ,&nbsp;Hiroko Indo ,&nbsp;Tatsurou Tanaka","doi":"10.1016/j.ajoms.2024.07.013","DOIUrl":"10.1016/j.ajoms.2024.07.013","url":null,"abstract":"<div><h3>Object</h3><div>To differentiate between metastatic neck nodes and non-metastatic neck nodes in oral maxillary gingival squamous cell carcinoma, textural analysis of these lymph nodes in ultrasound images was performed in this study.</div></div><div><h3>Methods</h3><div>Twenty five metastatic neck nodes and 28 non-metastatic neck nodes were enrolled in this study. Seventy eight texture characteristics were retrieved from the US images using the LIFEx software.</div><div>The Mann Whitney U test was measurably utilized to survey on the off chance that there was a measurably noteworthy distinction within the textural characteristics between metastatic neck nodes and non-metastatic neck nodes. The capacity of the surface highlights to recognize between metastatic neck nodes and non-metastatic neck nodes was illustrated utilizing the Receiver Operating Characteristic analysis curves (ROC). Youden's J statistic was used to determine the cut-off positions in each ROC curve that maximized sensitivity and specificity.</div></div><div><h3>Results</h3><div>Zone size non uniformity (ZSNU) highlight appeared the foremost noteworthy contrast between these nodes (p &lt; 0.001).</div><div>Strength had Area Under the Curve (AUC) of 0.811, specificity of 0.821 and sensitivity of 0.8, when measured at the cutoff value of 896.344.</div></div><div><h3>Conclusions</h3><div>Our results come about uncovered that quality highlight may be the finest surface highlight to distinguish from non-metastatic neck nodes and to anticipate metastatic neck nodes in oral maxillary gingival squamous cell carcinoma.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 1","pages":"Pages 70-75"},"PeriodicalIF":0.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}