克罗恩病接受英夫利昔单抗和硫唑嘌呤治疗时发生上颚淋巴细胞增生性疾病1例

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-08-16 DOI:10.1016/j.ajoms.2024.08.010

Nanako Ito , Tomoaki Hamana , Hisako Furusho , Natsuki Eboshida , Yasuyuki Asada , Fumitaka Obayashi , Mirai Higaki , Atsuko Hamada , Sachiko Yamasaki , Toshinori Ando , Koichi Koizumi , Souichi Yanamoto

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引用次数: 0

摘要

甲氨蝶呤（MTX）相关淋巴细胞增生性疾病（LPD）已报道发生在口腔。然而，尚无抗tnf -α抑制剂引起的口腔LPD的报道。一名37岁男性在长期使用英夫利昔单抗（IFX）和硫唑嘌呤（AZA）治疗克罗恩病（CD）后，最初治疗弥漫性大b细胞淋巴瘤（DLBCL）。患者意识到右上磨牙异常并被转移到我们医院。DLBCL是根据右上磨牙区肿块的活检标本诊断的。给予6个疗程的利妥昔单抗联合环磷酰胺、阿霉素、长春新碱和强的松龙。化疗后，淋巴瘤完全缓解两年。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A case of lymphoproliferative disease of the palate while receiving infliximab and azathioprine for Crohn's disease

Methotrexate (MTX)-associated lymphoproliferative diseases (LPD) have been reported to occur in the oral cavity. However, there are no reports of LPD in the oral cavity caused by anti-TNF-α inhibitors. A 37-year-old man was initially treated for diffuse large B-cell lymphoma (DLBCL) after prolonged treatment with infliximab (IFX) and azathioprine (AZA) for Crohn’s disease (CD). The patient was aware of an abnormal right upper molar and was transferred to our hospital. DLBCL was diagnosed based on biopsy specimens of the mass in the right upper molar region. Six courses of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone were administered. After chemotherapy, the lymphoma showed complete remission for two years.

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