{"title":"A case of multiple minor salivary gland tumors with synchronous carcinoma ex pleomorphic adenoma and pleomorphic adenoma","authors":"Akio Shibata , Kou Kawahara , Yutaro Kondo , Kumiko Hatsukawa , Yuki Tange , Satoru Miyabe","doi":"10.1016/j.ajoms.2025.05.009","DOIUrl":null,"url":null,"abstract":"<div><div>Multiple salivary gland tumors<span><span> (MSGTs) are very rare, and can be categorized as unilateral or bilateral by topographic distribution and synchronous or metachronous by chronologic appearance. Intraoral MSGTs are extremely rare, and only very few cases have been reported. To our knowledge, the synchronous occurrence of a carcinoma ex pleomorphic adenoma (Ca-ex-PA) and a pleomorphic adenoma (PA) of minor </span>salivary glands<span> has not been reported in the literature. A 72-year-old woman presented with a 15 mm, firm, nontender, well-circumscribed nodule on the left side of the upper lip for > 10 years and presented with an asymptomatic 18-mm, elastic mass of the right palate.</span></span></div><div><span>Magnetic resonance imaging detected an upper lip mass, T2-weighted imaging (T2WI) revealed a 15-mm mass in a well-demarcated area of heterogeneous intensity, and diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping revealed low-intensity medial components. Fat-saturated T2WI showed a 20-mm palate mass of homogeneous high intensity in a well-demarcated area, DW and ADC mapping indicated high intensity of the medial components. An excisional biopsy was performed with a safety margin. Histopathological examination revealed the palate tumor was PA, and the lip tumor was Ca-ex-PA, with salivary gland carcinoma not otherwise specified component accounting for approximately half of the central region of the tumor. Because the patient had noninvasive Ca-ex-PA, a wait-and-see approach without postoperative treatment was selected. No evidence of recurrence or </span>metastasis was noted 3 years after surgery.</div></div>","PeriodicalId":45034,"journal":{"name":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","volume":"37 6","pages":"Pages 1304-1308"},"PeriodicalIF":0.4000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Surgery Medicine and Pathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212555825000961","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Multiple salivary gland tumors (MSGTs) are very rare, and can be categorized as unilateral or bilateral by topographic distribution and synchronous or metachronous by chronologic appearance. Intraoral MSGTs are extremely rare, and only very few cases have been reported. To our knowledge, the synchronous occurrence of a carcinoma ex pleomorphic adenoma (Ca-ex-PA) and a pleomorphic adenoma (PA) of minor salivary glands has not been reported in the literature. A 72-year-old woman presented with a 15 mm, firm, nontender, well-circumscribed nodule on the left side of the upper lip for > 10 years and presented with an asymptomatic 18-mm, elastic mass of the right palate.
Magnetic resonance imaging detected an upper lip mass, T2-weighted imaging (T2WI) revealed a 15-mm mass in a well-demarcated area of heterogeneous intensity, and diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping revealed low-intensity medial components. Fat-saturated T2WI showed a 20-mm palate mass of homogeneous high intensity in a well-demarcated area, DW and ADC mapping indicated high intensity of the medial components. An excisional biopsy was performed with a safety margin. Histopathological examination revealed the palate tumor was PA, and the lip tumor was Ca-ex-PA, with salivary gland carcinoma not otherwise specified component accounting for approximately half of the central region of the tumor. Because the patient had noninvasive Ca-ex-PA, a wait-and-see approach without postoperative treatment was selected. No evidence of recurrence or metastasis was noted 3 years after surgery.