A case of multiple minor salivary gland tumors with synchronous carcinoma ex pleomorphic adenoma and pleomorphic adenoma

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE
Akio Shibata , Kou Kawahara , Yutaro Kondo , Kumiko Hatsukawa , Yuki Tange , Satoru Miyabe
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Abstract

Multiple salivary gland tumors (MSGTs) are very rare, and can be categorized as unilateral or bilateral by topographic distribution and synchronous or metachronous by chronologic appearance. Intraoral MSGTs are extremely rare, and only very few cases have been reported. To our knowledge, the synchronous occurrence of a carcinoma ex pleomorphic adenoma (Ca-ex-PA) and a pleomorphic adenoma (PA) of minor salivary glands has not been reported in the literature. A 72-year-old woman presented with a 15 mm, firm, nontender, well-circumscribed nodule on the left side of the upper lip for > 10 years and presented with an asymptomatic 18-mm, elastic mass of the right palate.
Magnetic resonance imaging detected an upper lip mass, T2-weighted imaging (T2WI) revealed a 15-mm mass in a well-demarcated area of heterogeneous intensity, and diffusion-weighted (DW) imaging and apparent diffusion coefficient (ADC) mapping revealed low-intensity medial components. Fat-saturated T2WI showed a 20-mm palate mass of homogeneous high intensity in a well-demarcated area, DW and ADC mapping indicated high intensity of the medial components. An excisional biopsy was performed with a safety margin. Histopathological examination revealed the palate tumor was PA, and the lip tumor was Ca-ex-PA, with salivary gland carcinoma not otherwise specified component accounting for approximately half of the central region of the tumor. Because the patient had noninvasive Ca-ex-PA, a wait-and-see approach without postoperative treatment was selected. No evidence of recurrence or metastasis was noted 3 years after surgery.
多发性小涎腺肿瘤合并癌外多形性腺瘤及多形性腺瘤1例
多发性唾液腺肿瘤(MSGTs)非常罕见,根据地形分布可分为单侧或双侧,根据时间表现可分为同步或异时性。口内msgt极为罕见,只有极少数病例被报道。据我们所知,文献中尚未报道同时发生癌前多形性腺瘤(Ca-ex-PA)和小唾液腺多形性腺瘤(PA)。一位72岁的女性,在左侧上唇出现了一个15 毫米,坚固,不触痛,边界清楚的结节,持续了 10年,并在右侧上颚出现了一个无症状的18毫米弹性肿块。磁共振成像发现上唇肿块,t2加权成像(T2WI)显示15毫米肿块,分布均匀,扩散加权成像(DW)和表观扩散系数(ADC)成像显示低强度内侧成分。脂肪饱和T2WI显示20 mm腭部均匀高强度肿块,边界清晰,DW和ADC图显示内侧部分高强度。切除活检在安全范围内进行。组织病理学检查显示:上颚肿瘤为PA,唇部肿瘤为Ca-ex-PA,涎腺癌无特殊成分,约占肿瘤中心区域的一半。由于患者无创Ca-ex-PA,因此选择了不进行术后治疗的观望方法。术后3年无复发或转移迹象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
129
审稿时长
83 days
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