Juo Lee;Sungmin Lee;Iksong Byun;Myung Chul Lee;Jungsil Kim;Hoon Seonwoo
{"title":"Pulsed Electromagnetic Field-Assisting Reduced Graphene Oxide-Incorporated Nanofibers for Osteogenic Differentiation of Human Dental Pulp Stem Cells","authors":"Juo Lee;Sungmin Lee;Iksong Byun;Myung Chul Lee;Jungsil Kim;Hoon Seonwoo","doi":"10.1109/OJNANO.2024.3494770","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3494770","url":null,"abstract":"In bone tissue engineering, various approaches have been investigated to enhance osteogenic regeneration. Previous studies have predominantly employed scaffolds with aligned structures or reduced graphene oxide (RGO) to facilitate bone regeneration. However, current scaffold designs face limitations in combining structural guidance with effective electromagnetic stimulation. Additionally, delivering localized stimulation within scaffolds remains a challenge in maximizing the potential of these materials for bone regeneration. To address these limitations and strengthen previous approaches, this study presents a novel strategy in tissue engineering for enhanced osteogenic differentiation. RGO-incorporated nanofibers (RGO-NFs) were fabricated via electrospinning a 10% polycaprolactone (PCL) solution with RGO concentrations varying. The random fibers were deposited on a planar surface, while the aligned fibers were deposited on a rotating drum. The morphology and orientation of the fibers were confirmed through electron microscopy. X-ray diffraction spectrometry was employed to confirm the integration of RGO and PCL. All groups demonstrated optimal cell adhesion and viability. RGO-NFs exhibited higher osteogenesis-related protein expression than PCL-only scaffolds, further enhanced by pulsed electromagnetic field (PEMF) application. The application of PEMF stimulation within aligned RGO-NFs presents a potentially more efficient alternative to existing methods, offering a novel, non-invasive therapeutic strategy for bone defect regeneration.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"124-133"},"PeriodicalIF":1.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10769987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142736342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utilizing MRAMs With Low Resistance and Limited Dynamic Range for Efficient MAC Accelerator","authors":"Sateesh;Kaustubh Chakarwar;Shubham Sahay","doi":"10.1109/OJNANO.2024.3501293","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3501293","url":null,"abstract":"The recent advancements in data mining, machine learning algorithms and cognitive systems have necessitated the development of neuromorphic processing engines which may enable resource and computationally intensive applications on the internet-of-Things (IoT) edge devices with unprecedented energy efficiency. Spintronics based magnetic memory devices can emulate synaptic behavior efficiently and are hailed as one of the most promising candidates for realizing compact and ultra-energy efficient neural network accelerators. Although ultra-dense magnetic memories with multi-bit capability (MLC) were proposed recently, their application in hybrid CMOS-non-volatile memory accelerators is limited due to their low dynamic range (memory window) and high cell currents (ON/OFF-state resistance in ∼kΩ). In this work, we propose a novel supercell to enable the use of MLC MRAMs for neuromorphic multiply-accumulate (MAC) accelerators. For proof-of-concept demonstration, we exploit an MLC MRAM based on c-MTJ for realizing a highly scalable 2-FinFET-1-MRAM supercell with large dynamic range, low supercell currents and high endurance. Furthermore, we perform a comprehensive design exploration of a time-domain MAC accelerator utilizing the proposed supercell. Our detailed analysis using the ASAP7 PDK from ARM for FinFETs and an experimentally calibrated compact model for c-MTJ-based MRAM indicates the possibility of realizing a significantly high energy-efficiency of 87.4 TOPS/W and a throughput of 2.5 TOPS for a 200×200 MAC operation with 4-bit precision.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"141-148"},"PeriodicalIF":1.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10756528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vasileios P. Karkanis;Nikolaos I. Dourvas;Andrew Adamatzky;Panagiotis Dimitrakis;Georgios Ch. Sirakoulis
{"title":"Colloidal Spin Ice Cellular Automata for Logic Design","authors":"Vasileios P. Karkanis;Nikolaos I. Dourvas;Andrew Adamatzky;Panagiotis Dimitrakis;Georgios Ch. Sirakoulis","doi":"10.1109/OJNANO.2024.3499974","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3499974","url":null,"abstract":"An engineered system that exhibits a variety of interesting properties, such as collective dynamics that are not inherited in their building blocks, is the artificial spin ice (ASI) meta-materials. The building block of such a system is a dipolar nanomagnet with sub-micrometer dimensions. These nanomagnets are arranged in specific designs usually in square or kagome shape and are coupled together by their magnetic interactions. With external magnetic fields, it is possible to create magnetic moments or monopoles that cause a frustration to the system. Because of the local interactions, those moments travel through the topology. The observation of such structures is a very challenging procedure, because of the extremely fast flipping process of the spins. This is why the researchers use mesoscopic systems with materials such as colloids or spheres of nanomagnets which are placed inside of islands in periodic lattices that generate frustration by design. The interactions between those nanomagnets are based on Coulomb forces and are usually modeled by Brownian equations. In this paper, we propose a simple yet effective Cellular Automata (CA) model that can describe effectively the dynamics between nanomagnets in a square lattice structure. The manipulation of the initial positions of nanomagnets via an external magnetic field and the movement of magnetic moments from one site to another are capable to create Boolean logic. Using the CA model we propose the design of logic gates, computing structures such as half adders and rewritable memory elements.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"163-172"},"PeriodicalIF":1.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10755125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-Performance Dielectric Modulated Epitaxial Tunnel Layer Tunnel FET for Label-Free Detection of Biomolecules","authors":"Kunal Aggarwal;Avinash Lahgere","doi":"10.1109/OJNANO.2024.3494714","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3494714","url":null,"abstract":"In this paper, using calibrated simulation we have reported a dielectric modulated epitaxial tunnel layer TFET (DM ETL-TFET) for the label-free detection of biomolecules. We have shown that due to vertical tunneling direction, the ETL-TFET exhibits \u0000<inline-formula><tex-math>$sim$</tex-math></inline-formula>\u00003 orders of improvement in the ON-state current in comparison to its counterpart conventional TFET. In addition, the proposed DM ETL-TFET biosensor shows \u0000<inline-formula><tex-math>$sim$</tex-math></inline-formula>\u00004 orders, and \u0000<inline-formula><tex-math>$sim$</tex-math></inline-formula>\u00001 order higher ON-state current sensitivity than the past reported core-shell junctionless NT-TFET, and DM NT-TFET biosensors, respectively. Moreover, in comparison to the lateral DM TFET, the proposed DM ETL-TFET shows \u0000<inline-formula><tex-math>$sim$</tex-math></inline-formula>\u0000310 mV higher threshold voltage sensitivity. Also, the subthreshold swing sensitivity of the proposed biosensor is found to be \u0000<inline-formula><tex-math>$sim$</tex-math></inline-formula>\u00000.63 for the keratin biomolecule. Although the proposed biosensor shows almost the same selectivity, the proposed DM ETL-TFET biosensor does not need a complex fabrication process flow, hence, reducing the fabrication cost. Our findings that the proposed biosensor is a lucrative alternative to the FET-based biosensors.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"116-123"},"PeriodicalIF":1.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10747756","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142672185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multitask Learning for Estimation of Magnetic Parameters Using Pattern Recognition","authors":"Anubha Sehgal;Shipra Saini;Hemkant Nehete;Kunal Kranti Das;Sourajeet Roy;Brajesh Kumar Kaushik","doi":"10.1109/OJNANO.2024.3494836","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3494836","url":null,"abstract":"Machine learning (ML) approaches present an effective technique for accurately and efficiently predicting device parameters. Using these techniques, we introduce a multi-task convolutional neural network (CNN) model and support vector regression (SVR) model that is intended to precisely estimate two important parameters of magnetic systems such as the Dzyaloshinskii-Moriya interaction (DMI) constant and the exchange constant (A\u0000<sub>ex</sub>\u0000). The magnetic Hamiltonian encapsulates various energy components, including exchange energy, DMI, Zeeman energy, and anisotropy energy, wherein factors such as saturation magnetization, DMI strength, exchange stiffness, and anisotropy constants influence their magnitudes. Conventionally, the estimation of these parameters has been computationally intensive and time-consuming. The CNN and SVR models can simultaneously estimate both the DMI constant and the exchange constant, making it a versatile tool for magnetic system characterization. The custom CNN model performs best for the DMI constant and A\u0000<sub>ex</sub>\u0000 with R\u0000<sup>2</sup>\u0000 scores of 0.991 and 0.998 respectively. The SVR model achieves R\u0000<sup>2</sup>\u0000 scores of 0.927 and 0.989 for DMI constant and A\u0000<sub>ex</sub>\u0000 respectively. The estimated values are in good agreement with true values, thus emphasizing the potential of ML methods for pattern recognition.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"149-155"},"PeriodicalIF":1.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10748362","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142777687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Portable and Cost-Effective Handheld Ultrasound System Utilizing FPGA-Based Synthetic Aperture Imaging","authors":"Wenping Wang;Ziliang Feng","doi":"10.1109/OJNANO.2024.3494544","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3494544","url":null,"abstract":"The handheld ultrasound has been widely applied in various clinical applications due to its high portability and cost-effectiveness advantages. The smaller hardware architecture can expand its range of application scenarios. However, miniaturized ultrasound devices face the challenges in terms of image quality, frame rate, and power consumption. The achievement of high-quality and high-frame-rate imaging depends on numerous channels and higher pulse repetition frequency (PRF) at the cost of power consumption. The proposed work aims to design a field-programmable gate array (FPGA)-based prototype with synthetic aperture method for portable and cost-effective handheld ultrasound system. The prototype supports 8 transmit and receive channels and forms up to 8 synthetic apertures. In addition, to optimize the FPGA resources, the auto delay calculation and segmented apodizations are employed for 4 parallel beamforming lines. To evaluate the performance of our proposed prototype, scan sequences of B-mode, C-mode, and D-mode are implemented for image construction. The results show that the proposed prototype can provide a lateral resolution of 0.30 mm, a contrast-to-noise ratio (CNR) of 7.58 dB, and a frame rate of 22 frames per second (FPS) in dual-mode imaging. Moreover, it is remarkable that the memory and logic resources in the FPGA (EP4CE55) account for 73.7% and 66.2%, respectively, which makes the FPGA's power consumption only about 530 mW. The proposed prototype is suitable for handheld and other miniaturized ultrasound imaging systems.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"107-115"},"PeriodicalIF":1.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10747270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142672082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microfluidic Microreactor Device With Integrated Heaters for Temperature Assisted Synthesis of Gold Nanoparticles and Alkene","authors":"Tinku Naik Banavathi;Mukesh Kumar Sivakumar;Aniket Balapure;Sohan Dudala;Satish Kumar Dubey;Sanket Goel","doi":"10.1109/OJNANO.2024.3492116","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3492116","url":null,"abstract":"Thermal synthesis is an essential process in most chemical formulations. While several well-established methods exist for synthesizing materials in large quantities, synthesizing materials on a small scale is challenging and costly. This work delves into the design and functionality of microfluidic-based thermal synthesis microreactors, which are highly customizable and cost-effective. Instead of conventional electrothermal heaters, Laser-Induced Graphene (LIG) heaters are leveraged over traditional electrothermal heaters due to their cost-effectiveness, simplified fabrication process, and high level of customization. The parameters for developing these LIG heaters were optimized by tuning the speed and power of the CO\u0000<sub>2</sub>\u0000 laser to obtain both the desired electrical conductivity and mechanical strength. The developed heaters were integrated with microfluidic devices fabricated using the soft-lithography technique. The functionality of these devices was demonstrated by performing gold nanoparticles (inorganic) and alkene (organic) synthesis. The synthesized gold nanoparticles (AuNPs) and alkene solution were analyzed using UV-visible spectroscopy, Fourier Transform Infrared (FTIR) spectroscopy, and Nuclear Magnetic Resonance (NMR) techniques to evaluate the quality of the end products. The functionality of synthesized solutions can be utilized as catalyst in electrochemical applications and as precursors in downstream chemical syntheses.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"134-140"},"PeriodicalIF":1.8,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10742960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142736590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Electronic Slime-Based Epidermal Electrode Using Carbon Nanocomposites for Biosignal Sensing","authors":"Yu Feng;Hui Sun;Meng Chen;Cong Wu;Jiankun Li;Zhi Li;Kremena Makasheva;Na Liu;Guanglie Zhang;Wen Jung Li","doi":"10.1109/OJNANO.2024.3488720","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3488720","url":null,"abstract":"Epidermal sensing electrodes, a key type of advanced wearable device, play a crucial role in biosignal sensing. Recent advancements in functional nanomaterials have propelled the development of these electrodes; however, their fabrication often involves complex processes and expensive raw materials. While significant progress has been made in enhancing the biocompatibility of electrodes through the use of human-friendly materials, improvements in flexibility and conductivity are still needed to ensure optimal skin conformability and compliance. In this study, we present an innovative epidermal sensing electrode constructed from electronic slime (E-slime), which is synthesized through a simple one-step, one-pot method utilizing widely available and cost-effective carbon nanocomposites. The E-slime electrode exhibits exceptional deformability, flexibility, and self-healing properties, ensuring mechanical compliance and effective skin adherence for epidermal applications. Our results demonstrate the electrode's capability in biosignal sensing, including electrocardiogram (ECG) monitoring with a high signal-to-noise ratio (SNR) of 46dB and electromyogram (EMG) monitoring for real-time human-robot interaction. This work introduces a novel strategy for the design and fabrication of epidermal electrodes, offering high conformability, low impedance, and superior signal quality, which holds significant promise for applications in intelligent healthcare monitoring and human-machine interfaces.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"156-162"},"PeriodicalIF":1.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10739952","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142810339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polarization and Strain in Piezoelectric Nanomaterials: Advancing Sensing Applications in Biomedical Technology","authors":"Anmol Garg;Sajal Agarwal;Deepak Punetha","doi":"10.1109/OJNANO.2024.3488787","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3488787","url":null,"abstract":"This paper reports the comparative analysis of different piezoelectric materials through a MEMS-based piezoelectric actuator model, emphasizing their potential for sensing applications. The polarization and electrostrictive strain tensor capabilities have been extensively studied for different piezoelectric materials such as PZT, LiNbO\u0000<sub>3</sub>\u0000, PVDF, etc. The simulation results obtained at varying voltages and mechanical stress demonstrate that LiNbO\u0000<sub>3</sub>\u0000 exhibits superior performance among the tested materials, with a polarization value of 0.5163 C/m\u0000<sup>2</sup>\u0000 at 800 volts and an electrostrictive strain tensor of 0.01 at an applied mechanical stress of 25 MPa. These findings will assist scientists in selecting the most suitable piezoelectric materials for sensing applications in biomedical fields.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"89-97"},"PeriodicalIF":1.8,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10739969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142636309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Manipulation of 2D and 3D Magnetic Solitons Under the Influence of DMI Gradients","authors":"Rayan Moukhader;Davi Rodrigues;Eleonora Raimondo;Vito Puliafito;Bruno Azzerboni;Mario Carpentieri;Abbass Hamadeh;Giovanni Finocchio;Riccardo Tomasello","doi":"10.1109/OJNANO.2024.3484568","DOIUrl":"https://doi.org/10.1109/OJNANO.2024.3484568","url":null,"abstract":"Magnetic solitons hold great promise for token-based computing applications due to their intrinsic properties, including small size, topological stability, ultra-low power manipulation, and potentially ultra-fast operation. In particular, they have been proposed as reliable memory units that enable the execution of various logic tasks with in-situ memory. A critical challenge remains the identification of optimal soliton and efficient manipulation techniques. Previous research has primarily focused on the manipulation of two-dimensional solitons, such as skyrmions, domain walls, and vortices, by applied currents. The discovery of novel methods to control magnetic parameters, such as the interfacial Dzyaloshinskii-Moriya interaction, through strain, temperature gradients, and applied voltages offers new avenues for energetically efficient manipulation of magnetic structures. In this work, we present a comprehensive study using numerical and analytical methods to investigate the stability and motion of various magnetic textures under the influence of DMI gradients. Our results show that Néel and Bloch-type skyrmions, as well as radial vortices, exhibit motion characterized by finite skyrmion Hall angles, while circular vortices undergo expulsion dynamics. This study provides a deeper and crucial understanding of the stability and gradient-driven dynamics of magnetic solitons, paving the way for the design of scalable spintronics token-based computing devices.","PeriodicalId":446,"journal":{"name":"IEEE Open Journal of Nanotechnology","volume":"5 ","pages":"68-79"},"PeriodicalIF":1.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10726665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}