Audiology Research最新文献

筛选
英文 中文
Normative Data of Extended High Frequency Audiometry in Normal Hearing Subjects with Different Aged Groups. 不同年龄组正常听力受试者扩展高频测听的规范性数据。
IF 2.1
Audiology Research Pub Date : 2024-12-09 DOI: 10.3390/audiolres14060089
Kittiphorn Luengrungrus, Panida Thanawirattananit, Watchareporn Teeramatwanich
{"title":"Normative Data of Extended High Frequency Audiometry in Normal Hearing Subjects with Different Aged Groups.","authors":"Kittiphorn Luengrungrus, Panida Thanawirattananit, Watchareporn Teeramatwanich","doi":"10.3390/audiolres14060089","DOIUrl":"10.3390/audiolres14060089","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Conventional audiometry assesses hearing in the frequency range of 250-8000 Hz, while humans can detect sounds from 20 to 20,000 Hz. Hearing sensitivity above 8000 Hz can be assessed through \"Extended high-frequency audiometry (EHFA)\", which is useful for early detection and monitoring of hearing loss and counseling for tinnitus patients. Despite its usefulness, age significantly affects hearing sensitivity. Currently, there are no standard hearing thresholds in the EHF range categorized by age groups in Thailand. In this study, the aim was to determine normative EHFA data across different age groups in a healthy Thai population. <b>Methods</b>: This study included 134 participants aged 18-70 years, categorized into five age groups. All participants had normal hearing thresholds and type A tympanograms bilaterally. Following this, EHFA measurement was performed. <b>Results</b>: Across all age groups, there was an observed increase in median hearing thresholds as age increased. In comparison, no significant difference in median hearing thresholds was found between individuals aged 18-30 and >30-40 years. However, those over 40 years had significantly higher median thresholds across all frequencies compared to those under 40 years (<i>p</i> < 0.05). Based on these findings, we propose two new subgroups of 18-40 years and >40-70 years. Median hearing thresholds for those aged 18-40 was ≤20 dB HL across most frequencies, except at 16,000 Hz (30 dB HL). In the >40-70 age group, thresholds ranged from 20 dB HL at 9000 Hz to 70 dB HL at 14,000 and 16,000 Hz. However, no significant differences were found in hearing thresholds between sexes and ear sides. <b>Conclusions</b>: In this study, normative EHFA data were established for healthy Thai adults, appropriately divided into two groups (18-40 and >40-70 years) for clinical use. Further studies with more participants per age group are also needed to validate the results.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1084-1092"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary Cortisol Concentration Is an Objective Measure of the Physiological Response to Loud Music. 唾液皮质醇浓度是对大声音乐生理反应的客观测量。
IF 2.1
Audiology Research Pub Date : 2024-12-09 DOI: 10.3390/audiolres14060090
Robert Tomljenović, Andro Košec, Livije Kalogjera, Ivana Ćelap, Domagoj Marijančević, Davor Vagić
{"title":"Salivary Cortisol Concentration Is an Objective Measure of the Physiological Response to Loud Music.","authors":"Robert Tomljenović, Andro Košec, Livije Kalogjera, Ivana Ćelap, Domagoj Marijančević, Davor Vagić","doi":"10.3390/audiolres14060090","DOIUrl":"10.3390/audiolres14060090","url":null,"abstract":"<p><p><b>Purpose</b>: This study examines the potential associations between salivary cortisol concentrations and subjective stress test scores in healthy individuals subjected to sound-related, psychological, and physical stressors. <b>Methods</b>: This study employed a single-center observational cross-sectional design, with a sample size of 36 subjects recruited from a tertiary referral audiology center. Between 2023 and 2024, the study recruited subjects with normal hearing, baseline salivary cortisol levels, and subjective stress levels. The participants were requested to complete an STAI-Y1 questionnaire and provide salivary cortisol samples before and following exposure to sound-related, psychological, and physical stress tests. <b>Results</b>: Exposure to psychological and physical stressors significantly increased STAI-Y1 scores (Friedman's test, χ<sup>2</sup> = 57.118, df = 2, <i>p</i> = 0.377). This increase was greater than that observed in response to loud, favorite music (Friedman's test, χ<sup>2</sup> = 57.118, df = 2, <i>p</i> < 0.0001). The salivary cortisol concentration significantly increased in all three provocation tests (Friedman's test, χ<sup>2</sup> = 95.264, df = 5, <i>p</i> < 0.0001). Furthermore, there is no significant difference in salivary cortisol concentrations between the three pre-test and post-test measurement intervals, indicating a comparable stress-inducing pattern regardless of the nature of the stimulus (Friedman's test, χ<sup>2</sup> = 95.264, df = 5, <i>p</i> > 0.05). <b>Conclusions</b>: Exposure to loud favorite music increases salivary cortisol concentrations, as does acute physical and psychological stress. Interestingly, unlike psychological and physical stress, loud music was not objectively perceived as stress, which may mask the physiological signs of stress, potentially increasing the risk of both acute and chronic stress-related health outcomes.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1093-1104"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multicenter Study on the Impact of the Masker Babble Spectrum on the Acceptable Noise Level (ANL) Test. 掩蔽语谱对可接受噪声级(ANL)测试影响的多中心研究。
IF 2.1
Audiology Research Pub Date : 2024-12-07 DOI: 10.3390/audiolres14060088
Mark Laureyns, Giorgia Pugliese, Melinda Freyaldenhoven Bryan, Marieke Willekens, Anna Maria Gasbarre, Diego Zanetti, Julien Gilson, Paul Van Doren, Federica Di Berardino
{"title":"Multicenter Study on the Impact of the Masker Babble Spectrum on the Acceptable Noise Level (ANL) Test.","authors":"Mark Laureyns, Giorgia Pugliese, Melinda Freyaldenhoven Bryan, Marieke Willekens, Anna Maria Gasbarre, Diego Zanetti, Julien Gilson, Paul Van Doren, Federica Di Berardino","doi":"10.3390/audiolres14060088","DOIUrl":"10.3390/audiolres14060088","url":null,"abstract":"<p><strong>Introduction: </strong>Acceptable Noise Level (ANL) is defined as the most comfortable level (MCL) intensity for speech and is calculated by subtracting the maximum noise tolerable by an individual. The ANL test has been used over time to predict hearing aid use and the impact of digital noise reduction. This study analyzes this impact by using different masker babble spectra when performing the ANL test in both hearing-impaired and healthy subjects in three different languages (Dutch, French, and Italian).</p><p><strong>Materials and methods: </strong>A total of 198 patients underwent the ANL test in their native language using a standardized protocol. The babble file was speech-weighted to match the long-term spectrum of the specific ANL language version. ANL was proposed in three different masking conditions: with multitalker Matched babble speech noise, with the same masking signal with the spectrum reduced from 2 kHz onwards (High Cut), and with the spectrum increased from 2 kHz onwards (High Boost).</p><p><strong>Results: </strong>In all of the comparisons among the three languages, ANL with High Boost noise gave significantly higher (worse) scores than ANL with Matched noise (<i>p</i>-value S1: <0.0001, S2: <0.0001, S3: 0.0003) and ANL with High Cut noise (<i>p</i>-value S1: 0.0002, S2: <0.0001, S3: <0.0001). The ANL values did not show any significant correlation with age and gender. In French, a weak correlation was found between ANL with High Cut noise and the Fletcher index of the worst ear. In Italian, a weak correlation was found between both ANL with Matched and High Boost noise and the Fletcher index of the best ear.</p><p><strong>Conclusions: </strong>ANL with High Boost added to noise stimuli was less acceptable for all patients in all of the languages. The ANL results did not vary in relation to the patients' characteristics. This study confirms that the ANL test has potential application for clinical use regardless of the native language spoken.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1075-1083"},"PeriodicalIF":2.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward Alleviating the Stigma of Hearing Aids: A Review. 减轻助听器耻辱感:综述。
IF 2.1
Audiology Research Pub Date : 2024-12-04 DOI: 10.3390/audiolres14060087
Edward Madara, Achintya K Bhowmik
{"title":"Toward Alleviating the Stigma of Hearing Aids: A Review.","authors":"Edward Madara, Achintya K Bhowmik","doi":"10.3390/audiolres14060087","DOIUrl":"10.3390/audiolres14060087","url":null,"abstract":"<p><p>Despite the significant advancements in hearing aid technology, their adoption rates remain low, with stigma continuing to be a major barrier for many. This review aims to assess the origins and current state of hearing aid stigma, as well as explore potential strategies for alleviating it. This review examines the societal perceptions, psychological impacts, and recent technological advancements that can influence hearing aid adoption and reduce stigma. <b>Methods:</b> A narrative-focused review of the literature from peer-reviewed journals and reputable sources was conducted, analyzing papers on hearing aid stigma, adoption rates, and technological solutions. The research works were categorized based on their focus on the drivers and alleviation strategies for the stigma of hearing aids. <b>Results:</b> This review identifies stigma as a complex, multifaceted issue driven primarily by ageism, disability perception, and the association of hearing aids with aging and incapability. Despite technological improvements, the studies surveyed listed stigma as a major factor in non-adoption. Technological advancements such as artificial intelligence in sound processing, multifunctional features, and innovative design have shown potential in reducing stigma and improving user experience. <b>Conclusions:</b> Alleviating the stigma of hearing aids requires a multi-pronged approach, combining improvements in technology with changes in societal perceptions. Multifunctional devices including both health and communications functions, advanced signal processing, and esthetic improvements can drive their adoption, but broader public health awareness and education are also essential to changing societal attitudes and fostering greater acceptance of hearing aids.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1058-1074"},"PeriodicalIF":2.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142898962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 3D-Printed Educational Model for First-Line Management of BPPV in Emergency Departments. 急诊科BPPV一线管理的3d打印教学模型
IF 2.1
Audiology Research Pub Date : 2024-12-02 DOI: 10.3390/audiolres14060086
Pietro Canzi, Elena Carlotto, Stefania Marconi, Silvia Quaglieri, Giuseppe Attanasio, Francesca Yoshie Russo, Ilaria Ottoboni, Silvia Ponzo, Andrea Scribante, Stefano Perlini, Marco Benazzo
{"title":"A 3D-Printed Educational Model for First-Line Management of BPPV in Emergency Departments.","authors":"Pietro Canzi, Elena Carlotto, Stefania Marconi, Silvia Quaglieri, Giuseppe Attanasio, Francesca Yoshie Russo, Ilaria Ottoboni, Silvia Ponzo, Andrea Scribante, Stefano Perlini, Marco Benazzo","doi":"10.3390/audiolres14060086","DOIUrl":"10.3390/audiolres14060086","url":null,"abstract":"<p><strong>Background: </strong>We present a feasibility study on the development of a 3D-printed (3DP) model of benign paroxysmal positional vertigo (BPPV) and its validation as an educational tool for training in therapeutic maneuvers.</p><p><strong>Methods: </strong>A 1.5:1 3DP model of the human labyrinth, supplemented by a 1:1 3DP model of the skull, was obtained from a computed tomography scan. We presented the model to 15 Emergency Medicine residents, 15 medical students, 15 Otolaryngology residents, and 15 Otolaryngology practitioners from two academic referral centers. Participants performed the Semont and Epley maneuvers on the model twice, once before and once after observing the biomechanics of BPPV using this tool. A specific survey was then administered to assess both performance improvement and satisfaction.</p><p><strong>Results: </strong>All the trainees demonstrated an improving trend on the second attempt. The medical students ameliorated significantly after the training in both Epley (<i>p</i> = 0.007) and Semont maneuvers (<i>p</i> = 0.0134). The Emergency Medicine residents improved significantly in Semont maneuvers (<i>p</i> = 0.0134). Self-reported understanding of the BPPV mechanics improved significantly after training in all the groups (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The preliminary data highlighted the potential benefits of training on the 3DP model for practitioners involved in the first-line management of BPPV.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1045-1057"},"PeriodicalIF":2.1,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring Speech Intelligibility with Romanian Synthetic Unpredictable Sentences in Normal Hearing. 用正常听力罗马尼亚语合成不可预知句子测量语音可理解性。
IF 2.1
Audiology Research Pub Date : 2024-12-01 DOI: 10.3390/audiolres14060085
Oana Astefanei, Sebastian Cozma, Cristian Martu, Roxana Serban, Corina Butnaru, Petronela Moraru, Gabriela Musat, Luminita Radulescu
{"title":"Measuring Speech Intelligibility with Romanian Synthetic Unpredictable Sentences in Normal Hearing.","authors":"Oana Astefanei, Sebastian Cozma, Cristian Martu, Roxana Serban, Corina Butnaru, Petronela Moraru, Gabriela Musat, Luminita Radulescu","doi":"10.3390/audiolres14060085","DOIUrl":"10.3390/audiolres14060085","url":null,"abstract":"<p><strong>Background/objectives: </strong>Understanding speech in background noise is a challenging task for listeners with normal hearing and even more so for individuals with hearing impairments. The primary objective of this study was to develop Romanian speech material in noise to assess speech perception in diverse auditory populations, including individuals with normal hearing and those with various types of hearing loss. The goal was to create a versatile tool that can be used in different configurations and expanded for future studies examining auditory performance across various populations and rehabilitation methods.</p><p><strong>Methods: </strong>This study outlines the development of Romanian speech material for speech-in-noise testing, initially presented to normal-hearing listeners to establish baseline data. The material consisted of unpredictable sentences, each with a fixed syntactic structure, generated using speech synthesis from all Romanian phonemes. A total of 50 words were selected and organized into 15 lists, each containing 10 sentences, with five words per sentence. Two evaluation methods were applied in two sessions to 20 normal-hearing volunteers. The first method was an adaptive speech-in-noise recognition test designed to assess the speech recognition threshold (SRT) by adjusting the signal-to-noise ratio (SNR) based on individual performance. The intelligibility of the lists was further assessed at the sentence level to evaluate the training effect. The second method was used to obtain normative data for the SRT, defined as the SNR at which a subject correctly recognizes 50% of the speech material, as well as for the slope, which refers to the steepness of the psychometric function derived from threshold recognition scores measured at three fixed SNRs (-10 dB, -7 dB, and -4 dB) during the measurement phase.</p><p><strong>Results: </strong>The adaptive method showed that the training effect was established after two lists and remained consistent across both sessions. During the measurement phase, the fixed SNR method yielded a mean SRT50 of -7.38 dB with a slope of 11.39%. These results provide reliable and comparable data, supporting the validity of the material for both general population testing and future clinical applications.</p><p><strong>Conclusions: </strong>This study demonstrates that the newly developed Romanian speech material is effective for evaluating speech recognition abilities in noise. The training phase successfully mitigated initial unfamiliarity with the material, ensuring that the results reflect realistic auditory performance. The obtained SRT and slope values provide valuable normative data for future auditory assessments. Due to its flexible design, the material can be further developed and extended to accommodate various auditory rehabilitation methods and diverse populations in future studies.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1028-1044"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Hearing Loss Type on Linguistic Development in Children: A Cross-Sectional Study. 听力损失类型对儿童语言发展影响的横断面研究。
IF 2.1
Audiology Research Pub Date : 2024-11-27 DOI: 10.3390/audiolres14060084
Nadia Porcar-Gozalbo, Miguel López-Zamora, Beatriz Valles-González, Alejandro Cano-Villagrasa
{"title":"Impact of Hearing Loss Type on Linguistic Development in Children: A Cross-Sectional Study.","authors":"Nadia Porcar-Gozalbo, Miguel López-Zamora, Beatriz Valles-González, Alejandro Cano-Villagrasa","doi":"10.3390/audiolres14060084","DOIUrl":"10.3390/audiolres14060084","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Hearing loss in childhood is associated with significant challenges in linguistic and cognitive development, particularly affecting language skills such as syntax, semantics, and pragmatics, which are essential for effective communication and social integration. This study aimed to analyze how different types and degrees of hearing loss impact linguistic development in children, and to identify clinical factors-such as age at diagnosis and years of language intervention-that may predict language performance. <b>Methods:</b> This study included a sample of 140 children aged 6 to 12, categorized into seven groups based on their hearing condition: unilateral and bilateral conductive, unilateral and bilateral sensorineural, unilateral and bilateral mixed hearing loss, and a control group with no hearing loss. Linguistic development was assessed using the Clinical Evaluation of Language Fundamentals-5 (CELF-5), a validated tool for diagnosing language disorders. Statistical analyses, including MANOVA and multiple regression, were conducted to evaluate differences in linguistic skills across groups and to determine the predictive value of clinical variables on total language performance. <b>Results:</b> The analysis revealed statistically significant differences across groups in all assessed linguistic domains (<i>p</i> < 0.001), with children with severe or bilateral hearing loss exhibiting notably lower scores compared to normohearing peers. The multiple regression analysis indicated that type of hearing loss was the strongest predictor of total linguistic performance (β = -0.674), followed by age at diagnosis (β = -0.285) and age of hearing device adaptation (β = -0.220). Years of language intervention also contributed significantly (β = 0.198) but to a lesser extent. <b>Conclusions:</b> This study highlights the critical impact of early and comprehensive auditory and language intervention on linguistic outcomes for children with hearing impairments. Early diagnosis and timely adaptation of hearing aids or cochlear implants are essential in mitigating language deficits, particularly in areas like syntax and pragmatic skills. These findings support the need for specialized, long-term interventions tailored to the severity and type of hearing loss to improve language development in this population.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1014-1027"},"PeriodicalIF":2.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11673131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lack of Amino Acid Alterations Within the Cochlear Nucleus and the Auditory Cortex in Acoustic Trauma-Induced Tinnitus Rats Using In Vivo Microdialysis. 利用体内微透析技术发现声创伤诱发耳鸣的大鼠耳蜗核和听皮层内缺乏氨基酸变化
IF 2.1
Audiology Research Pub Date : 2024-11-17 DOI: 10.3390/audiolres14060083
Shanshan Yuan, Huey Tieng Tan, Paul F Smith, Yiwen Zheng
{"title":"Lack of Amino Acid Alterations Within the Cochlear Nucleus and the Auditory Cortex in Acoustic Trauma-Induced Tinnitus Rats Using In Vivo Microdialysis.","authors":"Shanshan Yuan, Huey Tieng Tan, Paul F Smith, Yiwen Zheng","doi":"10.3390/audiolres14060083","DOIUrl":"10.3390/audiolres14060083","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Tinnitus is a debilitating auditory disorder commonly described as a ringing in the ears in the absence of an external sound source. Sound trauma is considered a primary cause. Neuronal hyperactivity is one potential mechanism for the genesis of tinnitus and has been identified in the cochlear nucleus (CN) and the auditory cortex (AC), where there may be an imbalance of excitatory and inhibitory neurotransmissions. However, no study has directly correlated tinnitus with the extracellular levels of amino acids in the CN and the AC using microdialysis, which reflects the functions of these neurochemicals. In the present study, rats were exposed to acoustic trauma and then subjected to behavioural confirmation of tinnitus after one month, followed by microdialysis. <b>Methods:</b> Rats were divided into sham (aged, <i>n</i> = 6; young, <i>n</i> = 6); tinnitus-positive (aged, <i>n</i> = 7; young, <i>n</i> = 7); and tinnitus-negative (aged, <i>n</i> = 3; young, <i>n</i> = 3) groups. In vivo microdialysis was utilized to collect samples from the CN and the AC, simultaneously, in the same rat. Extracellular levels of amino acids were quantified using high-performance liquid chromatography (HPLC) coupled with an electrochemical detector (ECD). The effects of sound stimulation and age on neurochemical changes associated with tinnitus were also examined. <b>Results:</b> There were no significant differences in either the basal levels or the sound stimulation-evoked changes of any of the amino acids examined in the CN and the AC between the sham and tinnitus animals. However, the basal levels of serine and threonine exhibited age-related alterations in the AC, and significant differences in threonine and glycine levels were observed in the responses to 4 kHz and 16 kHz stimuli in the CN. <b>Conclusions:</b> These results demonstrate the lack of a direct link between extracellular levels of amino acids in the CN and the AC and tinnitus perception in a rat model of tinnitus.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"1000-1013"},"PeriodicalIF":2.1,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revisiting Diagnostic Criteria for Bilateral Vestibulopathy: A New Comprehensive Instrumental Model. 重新审视双侧前庭病的诊断标准:新的综合工具模型
IF 2.1
Audiology Research Pub Date : 2024-11-16 DOI: 10.3390/audiolres14060082
Leonardo Manzari, Nicola Ferri, Marco Tramontano
{"title":"Revisiting Diagnostic Criteria for Bilateral Vestibulopathy: A New Comprehensive Instrumental Model.","authors":"Leonardo Manzari, Nicola Ferri, Marco Tramontano","doi":"10.3390/audiolres14060082","DOIUrl":"10.3390/audiolres14060082","url":null,"abstract":"<p><p><b>Background:</b> Bilateral vestibulopathy (BVP) is a disabling condition characterized by a deficit in vestibular function on both sides. Current diagnostic criteria consider instrumental data only from horizontal canals, excluding vertical canals and otolithic function, with the possibility of not including some variants of BVP. This study aims to evaluate vestibular functions in people with chronic vestibular syndrome through a comprehensive battery of tests. <b>Methods:</b> This diagnostic accuracy study included patients who met criteria for probable BVP. The index test included a thorough evaluation of the vestibular system, using the video Head Impulse Test (vHIT) to measure the gain of the angular vestibulo-ocular reflex (aVOR) in all six semicircular canals and the cervical and ocular vestibular-evoked myogenic potentials (VEMPs) to assess otolith function. The diagnostic criteria established by the Barany Society were considered the standard reference, including only the horizontal vHIT as an instrumental assessment. <b>Results:</b> 78 patients (41 male, age 61.40 ± 12.99) were enrolled. The Barany criteria showed a low ability to rule out BPV (sensitivity = 46%). The median Dizziness Handicap Inventory (DHI) varied from 66 to 69 among the models studied, and a significant difference in DHI scores between positive and negative tests was observed for the Barany criteria and the six-canals vHIT model. <b>Conclusions:</b> Our findings highlight the potential to transform BPV diagnostic criteria. The identification of new bilateral vestibular dysfunction variants through improved diagnostic tools calls for revising current criteria, with promising implications for patient care and understanding of etiological and prognostic aspects.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"991-999"},"PeriodicalIF":2.1,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air-Bone Gap in Meniere's Disease: A Case Series and Literature Review. 梅尼埃病中的气骨间隙:病例系列和文献综述
IF 2.1
Audiology Research Pub Date : 2024-11-08 DOI: 10.3390/audiolres14060081
Arun Pajaniappane, Nilesh Parekh, Anita Wong
{"title":"Air-Bone Gap in Meniere's Disease: A Case Series and Literature Review.","authors":"Arun Pajaniappane, Nilesh Parekh, Anita Wong","doi":"10.3390/audiolres14060081","DOIUrl":"10.3390/audiolres14060081","url":null,"abstract":"<p><strong>Background/objectives: </strong>An air-bone gap (ABG) on audiometry is usually secondary to a conductive hearing loss. However, persistent and repeatable ABGs on audiometry in the absence of external or middle ear pathology is thought to arise from inner ear disorders including Meniere's Disease (MD). In this paper, we aim to showcase this interesting finding occurring in MD with an associated literature review.</p><p><strong>Methods: </strong>Using retrospective review and analysis of case notes, we describe eight cases of persistent ABG on audiometry in MD. All other causes for the ABG were explored and excluded with the aid of objective audiological testing.</p><p><strong>Results: </strong>ABG can occur in a small sub-set of the MD population. In our case series, the ABG was typically found to affect the low frequencies. Higher frequencies appear to be spared. However, a detailed history, examination and battery of objective tests are required to ensure that all other causes of the ABG are reliably considered and excluded prior to attributing it to the inner ear. The finding of an ABG in MD may be dependent on the stage of the disease. Further research is required to determine the underlying cause of the ABG and its potential applications to help guide treatment.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"14 6","pages":"983-990"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信