Audiology Research最新文献

{"title":"Impact of Cochlear Trauma Degree and Localization on Intracochlear Electrocochleographic Recordings.","authors":"David Bächinger, Merlin Schär, Ahmet Kunut, Rahel Bertschinger, Ivo Dobrev, Leanne Sijgers, Andreas H Eckhard, Adrian Dalbert","doi":"10.3390/audiolres15030074","DOIUrl":"10.3390/audiolres15030074","url":null,"abstract":"<p><strong>Background/objectives: </strong>Electrocochleography (ECochG) is a promising tool to monitor preservation of cochlear structures and function during cochlear implant (CI) surgery. However, the interpretation of ECochG signal changes during insertion of the CI electrode array remains controversial. This study investigates the influence of the degree and localization of cochlear trauma on ECochG signal changes using a mouse model.</p><p><strong>Methods: </strong>C57BL/6J-Crl1 mice underwent intracochlear ECochG recordings during the insertion of a platinum-iridium electrode.</p><p><strong>Results: </strong>In case of grade 1 and 2 cochlear trauma, as determined by post-mortem histological analysis, we found that a reduction in intracochlear cochlear microphonic (CM) amplitude correlates more significantly with the location of the trauma than with its severity. The more basally a trauma is located, the larger the CM amplitude drop. Furthermore, the results revealed that grade 1 or 2 trauma was detectable through ECochG before more severe trauma developed.</p><p><strong>Conclusions: </strong>These findings suggest that intracochlear ECochG can serve as a reliable intraoperative tool for detecting early and possibly reversible cochlear trauma, preventing more severe damage and aiding hearing preservation. The results emphasize the need for a nuanced interpretation of CM signal drops, considering trauma location and cochlear structure integrity at the site of trauma and apical to it.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Accuracy of Self-Administered Web- and App-Based Tools for Audiometric Tests-A Systematic Review.","authors":"Sahuur Abdullahi Ahmed Sheikh Hassan, Uffe Kock Wiil, Ali Ebrahimi","doi":"10.3390/audiolres15030073","DOIUrl":"10.3390/audiolres15030073","url":null,"abstract":"<p><p><b>Objectives:</b> This systematic review aimed to evaluate the diagnostic accuracy of self-administered web- and app-based tools for audiometric testing compared to pure-tone audiometry (PTA), the clinical gold standard. <b>Methods:</b> Studies were eligible if they involved human participants, evaluated self-administered digital tools for audiometric testing, reported diagnostic accuracy metrics (e.g., sensitivity, specificity, and accuracy), were published between 2014 and 2024, and were written in English. Studies were excluded if they did not compare to PTA, were reviews, or did not assess self-administered tools. MEDLINE, Web of Science, Scopus, and EMBASE were systematically searched throughout November 2024. Study quality was assessed using the QUADAS-2 tool, evaluating four domains: patient selection, index test, reference standard, and flow and timing. Most studies showed some concern for a risk of bias. <b>Results:</b> Twelve studies, including a total of 2453 participants and evaluating 15 applications, met the inclusion criteria. The studies reported wide variability in diagnostic accuracy. Sensitivity ranged from 18% to 100%, specificity from 35.5% to 99.1%, and accuracy from 14% to 97.4%. SHOEBOX and Screenout demonstrated high diagnostic accuracy, while other apps showed inconsistent results across studies and settings. Heterogeneity in definitions of hearing loss, test environments, device and headphone types and a lack of standardized reporting limited comparability. Most studies were conducted in non-soundproof environments, and some had unclear or a high risk of bias. <b>Conclusions:</b> Self-administered audiometric apps and web tools show promise for remote hearing screening but require further validation and methodological standardization. Clinicians should interpret the results cautiously given the current variability in performance.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study.","authors":"Stefani Maihoub, Panayiota Mavrogeni, Gábor Dénes Répássy, András Molnár","doi":"10.3390/audiolres15030072","DOIUrl":"10.3390/audiolres15030072","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to analyse the haematological parameters in relation to subjective tinnitus. We hypothesise that abnormal haematological findings may correlate with increased severity and chronicity of tinnitus. This research could lead to improved diagnostic methods and more targeted treatments. <b>Material and Methods:</b> A total of 439 patients with primary subjective tinnitus and 274 individuals without tinnitus were enrolled. These participants underwent comprehensive laboratory testing, which included haematological parameters. <b>Results:</b> When comparing the white blood cell levels between the tinnitus group and the control group, no statistically significant differences were found (<i>p</i> = 0.743). Similarly, comparisons of red blood cell levels (<i>p</i> = 0.250), haemoglobin levels (<i>p</i> = 0.087), and haematocrit levels (<i>p</i> = 0.066) also revealed no significant differences. The platelet levels showed no significant difference between the two groups (<i>p</i> = 0.782). According to a logistic regression model, lower levels of haemoglobin (<i>p</i> = 0.000) and platelets (<i>p</i> = 0.000) significantly predicted higher scores on the Tinnitus Handicap Inventory, indicating self-reported tinnitus severity. Furthermore, lower haemoglobin levels were significant predictors (<i>p</i> = 0.04) of developing bilateral tinnitus. Using Spearman's correlation test, a statistically significant negative correlation (<i>p</i> = 0.029) was observed between red blood cell levels and the onset of tinnitus. The frequency of tinnitus demonstrated a significant positive correlation with haemoglobin levels (<i>p</i> = 0.04) and haematocrit levels (<i>p</i> = 0.043). Conversely, platelet levels showed a significant negative correlation with both tinnitus intensity (<i>p</i> = 0.002) and the onset of tinnitus (<i>p</i> = 0.033). <b>Conclusions:</b> While the haematological parameters showed no significant differences between the tinnitus and control groups, further analyses indicated that certain parameters, such as haemoglobin and haematocrit levels, could potentially influence tinnitus, necessitating further investigation.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Instrumental Evaluation of Vestibular Function Before and After Cochlear Implantation in Adults.","authors":"Pasqualina Maria Picciotti, Tiziana Di Cesare, Daniela Rodolico, Walter Di Nardo, Jacopo Galli","doi":"10.3390/audiolres15030071","DOIUrl":"10.3390/audiolres15030071","url":null,"abstract":"<p><strong>Background/objectives: </strong>Vestibular dysfunction is one of the main complications after cochlear implant (CI) surgery, and there are currently no standardized protocols for vestibular assessment in CI candidates. Our objectives were to investigate the incidence of vestibular impairment after CI surgery, anamnestic (age, known systemic pathologies and cause of deafness) and surgical (intraoperative complications, malposition of the CI) risk factors, and the role of vestibular assessment in the selection of the suitable ear for implantation.</p><p><strong>Methods: </strong>We included 68 adult patients (80 ears) affected by moderate-to-profound SNHL undergoing CI. The dizziness handicap inventory (DHI), the video head impulse test (VHIT), the caloric test, and dynamic posturography (DP) were used to study the vestibular function and balance before and one month after CI. The DHI was also administered 24 h after surgery.</p><p><strong>Results: </strong>Despite significative impairment 24 h after surgery (29.6 ± 30), the mean DHI score returned to preoperative values (17.9 ± 26) after one month. Dizziness persisted in case of age ≥ 65 years old, surgical difficulties, simultaneous bilateral CI, Meniere's disease and otosclerosis, comorbidities ≥ 3, anxiety/depression, and neurological diseases. The VHIT significantly worsened in 25% of ears, while the caloric test SPV nystagmus significantly decreased in 30% of ears. In cases of preoperative unilateral weakness, the implantation of the better ear was significantly related to higher DHI scores. Only 4/68 patients had a significant persistent reduction in the postural composite score after surgery, with an increased risk of falls.</p><p><strong>Conclusions: </strong>Medical history and vestibular assessment predict the risk of vestibular damage and help to choose the CI's side and to manage vertigo after surgery.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation and Extension of a Cochlear Implant Performance Prediction Model: Analysis of the Oldenburg Cohort.","authors":"Rieke Ollermann, Robert Böscke, John Neidhardt, Andreas Radeloff","doi":"10.3390/audiolres15030069","DOIUrl":"10.3390/audiolres15030069","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Rehabilitation success with a cochlear implant (CI) varies considerably and identifying predictive factors for the reliable prediction of speech understanding with CI remains a challenge. Hoppe and colleagues have recently described a predictive model, which was specifically based on Cochlear™ recipients with a four-frequency pure tone average (4FPTA) ≤ 80 dB HL. The aim of this retrospective study is to test the applicability to an independent patient cohort with extended inclusion criteria. <b>Methods</b>: The Hoppe et al. model was applied to CI recipients with varying degrees of hearing loss. Model performance was analyzed for Cochlear™ recipients with 4FPTA ≤ 80 dB HL and for all recipients regardless of 4FPTA. Subgroup analyses were conducted by <i>WRS_max</i> and CI manufacturer. <b>Results</b>: The model yielded comparable results in our patient cohort when the original inclusion criteria were met (n = 24). Extending the model to patients with profound hearing loss (4FPTA > 80 dB HL; n = 238) resulted in a weaker but significant correlation (r = 0.273; <i>p</i> < 0.0001) between predicted and measured word recognition score at 65 dB with CI (<i>WRS</i>₆₅(<i>CI</i>)). Also, a higher percentage of data points deviated by more than 20 pp, either better or worse. When patients provided with CIs from different manufacturers were enrolled, the prediction error was also higher than in the original cohort. In Cochlear™ recipients with a maximum word recognition score (<i>WRS_max</i>) > 0% (n = 83), we found a moderate correlation between measured and predicted scores (r = 0.3274; <i>p</i> = 0.0025). <b>Conclusions</b>: In conclusion, as long as the same inclusion criteria are used, the Hoppe et al. (2021) prediction model results in similar prediction success in our cohort, and thus seems applicable independently of the cohort used. Nevertheless, it has limitations when applied to a broader and more diverse patient cohort. Our data suggest that the model would benefit from adaptations for broader clinical use, as the model lacks sufficient sensitivity in identifying poor performers.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postural Balance in Italian Air Force Pilots: Development of Specific Normative Values.","authors":"Vincenzo Fiorillo, Barbara Martino, Valeria Castelli, Eliana Filipponi, Leonardo Braga, Alessandro Randolfi, Emanuele Garzia, Federica Di Berardino","doi":"10.3390/audiolres15030070","DOIUrl":"10.3390/audiolres15030070","url":null,"abstract":"<p><p><b>Objectives</b>: Assessing balance in highly trained individuals, such as military pilots, poses challenges, as deficits may be underestimated when compared to general population norms. To address this, several studies have proposed tailored databases providing reference values for specific populations. This study retrospectively analyzed balance characteristics in active-duty military pilots of the Italian Air Force. <b>Methods</b>: We enrolled 106 subjects split into two groups: 53 military pilots from the Italian Air Force and 53 civilians without flight experience or exposure to specific vestibular stimuli. All participants underwent ENT examinations with audiometric testing to exclude related pathologies, followed by a personal history collection. Subsequently, they completed the EquiTest protocol across six standard conditions. <b>Results</b>: Significant differences were observed between Army Aviators and Non-Aviators. The PREF variable showed the most consistent distinction, with military pilots demonstrating a superior performance (<i>p</i> < 0.01). Additionally, borderline differences were noted in Condition 6 of the equilibrium scores (<i>p</i> = 0.056), and in the Centre of Gravity (COG) analysis along the X-axis for Conditions 1 and 5 (<i>p</i> = 0.090), and for Condition 2 (<i>p</i> = 0.050). These findings suggest enhanced postural control strategies among Army Aviators under conditions of sensory conflict. <b>Conclusions</b>: These findings suggest that normative balance values specific to military pilots should be used when evaluating aviators recovering from balance deficits. Such tailored benchmarks can help determine the need for rehabilitation before returning to duty, ensuring optimal performance under demanding conditions. Further research is necessary to explore the underlying mechanisms responsible for these adaptations and to identify the specific stimuli that contribute to the enhanced balance capabilities observed in this highly trained population.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sound Preference on Loudness Tolerance and Preferred Listening Levels Using Personal Listening Devices.","authors":"Yula C Serpanos, Thomas DiBlasi, Jasmin Butler","doi":"10.3390/audiolres15030068","DOIUrl":"10.3390/audiolres15030068","url":null,"abstract":"<p><p><b>Background/Objectives:</b> This study examined the effect of sound preference on loudness tolerance (LTLs) and preferred listening levels (PLLs) using personal listening devices (PLDs). The implication of this relationship on hearing health promotion counseling and practices using PLDs is discussed. <b>Methods:</b> Participants were 50 individuals, aged 21 to 90 years, with normal hearing or hearing loss. Listeners rated several sound samples (i.e., music, running speech, and machinery noise) played through a PLD using earphones according to their sound preference (i.e., enjoyable, acceptable, and unpleasant) and then self-adjusted the volume setting to their LTL and PLL for a sound sample in each sound preference category. <b>Results:</b> Most listeners judged music (70%) as <i>enjoyable</i>, running speech (54%) as <i>acceptable</i>, and machinery noise (84%) as <i>unpleasant.</i> No significant differences were found in LTLs according to sound preference, but PLLs for enjoyable sounds occurred at significantly higher levels compared with those deemed acceptable or unpleasant. <b>Conclusions:</b> Listeners using PLDs perceived LTLs and PLLs differently according to their sound preferences. PLLs occurred at significantly higher volumes for sounds deemed enjoyable when using PLDs. The implication is that hearing health counseling should include information to PLD users on the potential of altered loudness perception with enjoyable sounds, which may lead to higher and riskier PLD listening levels.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Early Vestibular Screening and Developmental Changes in Air- and Bone-Conducted Cervical Vestibular Evoked Myogenic Potentials in Infants and Children with Normal Hearing.","authors":"Jiali Shen, Xiaobao Ma, Lu Wang, Wei Wang, Jianyong Chen, Qing Zhang, Maoli Duan, Yulian Jin, Jun Yang","doi":"10.3390/audiolres15030067","DOIUrl":"10.3390/audiolres15030067","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the feasibility of vestibular screening in infants and investigate age-related changes in the characteristics of air-conducted sound cervical vestibular evoked myogenic potential (ACS-cVEMP) and bone-conducted vibration cervical vestibular evoked myogenic potential (BCV-cVEMP) in infants and children with normal hearing, aiming to provide new insights into the developmental trajectory of vestibular function during early childhood. <b>Methods:</b> A total of 159 subjects aged 3 months to 17 years old were divided into seven age groups. Additionally, 20 adults aged 18-30 years were included as controls to explore developmental changes in the sacculocollic reflex pathway. <b>Results:</b> The response rates of BCV-cVEMP in 3-month-olds were significantly higher than that of ACS-cVEMP (<i>p</i> = 0.048), while no significant difference was observed in other age groups (<i>p</i> > 0.05). Age-related changes were found in both latencies and amplitudes of ACS-cVEMP and BCV-cVEMP. ACS-cVEMP latencies reached adult levels at 13-17 years, while BCV-cVEMP latencies normalized by 7-12 years. ACS-cVEMP amplitudes increased with age, stabilizing at 4 years, whereas BCV-cVEMP amplitudes peaked at 4-6 years before gradually decreasing. <b>Conclusions:</b> This study demonstrates that cVEMP is not only a viable tool for vestibular screening in infants but also reveals crucial age-related developmental changes in the vestibular system. These findings contribute new insights into the maturation of the vestibular reflex pathways and provide normative data that can be used to guide early vestibular screening practices.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing and Listening Difficulties in High Schools and Universities: The Results of an Exploratory Survey of a Large Number of Students and Teachers in the Friuli-Venezia Giulia and Umbria Regions, Italy.","authors":"Valeria Gambacorta, Davide Stivalini, Niccolò Granieri, Raffaella Marchi, Alessia Fabbri, Pasquale Viola, Alessia Astorina, Ambra Fastelli, Giampietro Ricci, Eva Orzan","doi":"10.3390/audiolres15030066","DOIUrl":"10.3390/audiolres15030066","url":null,"abstract":"<p><strong>Background/objectives: </strong>with the aim of describing how students and their teachers perceive and define their hearing and auditory experience in the classroom, we present the results of a questionnaire that examined the listening challenges faced by students and teachers at the University of Perugia and in four secondary schools in Friuli-Venezia Giulia, Italy.</p><p><strong>Methods: </strong>A survey was developed as part of the A.Ba.Co. project (Overcoming Communication Barriers). Closed or open-ended questions were used to analyze the responses of students and teachers regarding diagnosed or only perceived hearing difficulties in daily life and the quality of listening in school classes.</p><p><strong>Results: </strong>Hearing difficulties, either clinically diagnosed or only perceived, were reported by 8-9% of students. Between teachers, the reported hearing difficulties were 27.1% in high school and 12% at university (<i>p</i> < 0.001). The most frequent reason for less-than-optimal ease of listening in class differed between the two educational levels; 45.8% of high school students blamed it on the noise in the room compared to 18.2% of university students (<i>p</i> < 0.001). Inversely, 40.9% of university students connected listening difficulty with their place in class compared to 9.5% (101/1065) of high school students (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Although the minimum acoustic requirements for educational facilities have been established by the UNI 11532-2 standard, it is speculated that the majority of high school and university classrooms in Italy do not meet optimal listening conditions. Furthermore, the reasons for students' poor listening quality appear to not be fully understood, neither by students nor by teachers. In addition to the need for greater attention to physical learning spaces (advocating the universal design principles), effective change will also need to involve a greater awareness of what the barriers to listening are and how much they influence both teaching and learning quality and effectiveness.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium Channel Blockers for Vestibular Paroxysmia in Children.","authors":"Pierre Reynard, Hung Thai-Van, Eugenia Mustea, Alexandra Neagu, Samar A Idriss, Eugen C Ionescu","doi":"10.3390/audiolres15030065","DOIUrl":"10.3390/audiolres15030065","url":null,"abstract":"<p><p><b>Background/Objectives:</b> As vestibular paroxysmia (VP) has recently been described in children, with an incidence of up to 4% of vertigo, and a promising therapeutic response to sodium-channel-blocking drugs has also been reported, the aim of this paper is to review the available literature on this topic and to provide the best possible guidance for diagnosis and treatment. <b>Methods</b>: PubMed, Medline, Cochrane, and Crossref databases were searched, and all studies on VP in children and sodium channel blockers were selected. <b>Results</b>: Only five articles reporting small case series or single case reports were identified. To date, oxcarbazepine (OXC) and carbamazepine (CBZ) are the only two molecules prescribed. The recommended doses were 300 to 360 mg/day and 50 to 200 mg/day for OXC and CBZ, respectively, for a total duration of 6 weeks. Fast efficacy (one week) was reported. <b>Conclusions</b>: VP has been identified in pediatric patients and appears to respond to sodium channel blockers in a manner similar to adults. Only a limited number of cases have been reported to date; thus, there is a need to raise awareness about this treatable cause of episodic vertigo in children.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}