Use of the FLEX 28 Dexamethasone-Eluting Cochlear Implant Electrode in Electric-Acoustic Stimulation: A Case Report.

IF 1.8 Q1 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Audiology Research Pub Date : 2025-09-08 DOI:10.3390/audiolres15050112

Shin-Ichi Usami, Yutaka Takumi, Hidekane Yoshimura, Shin-Ya Nishio

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引用次数: 0

Abstract

Background/Objectives: During and after electric-acoustic stimulation (EAS) surgery (as well as regular cochlear implant surgery), the oral and/or intravenous administration of steroids is recommended to prevent acute inflammatory reactions and subsequent fibrosis. However, the effect does not last long. Therefore, with the hope of providing a sustained effect, a new dexamethasone (DEX)-eluting electrode (FLEX28 DEX) has recently been developed. Methods: A case study was performed at Shinshu University in February 2024 in which a DEX-eluting electrode array was utilized for a patient presenting with high-frequency hearing loss with a defined etiology (hearing loss due to a mitochondrial m.1555A > G variant). Results: Residual hearing was well preserved after EAS surgery, and post-operative impedance field telemetry was maintained at a very low level in contrast with a historical/retrospective control group (FLEX28 electrodes without DEX); therefore, it is expected that post-operative fibrosis will be minimized. Further, it was shown that the DEX-eluting electrode can also be applied to EAS. Conclusions: The DEX-eluting electrode was useful in maintaining post-operative impedance at a very low level, indicating that post-operative fibrosis could be minimized even after EAS surgery.

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FLEX 28地塞米松洗脱人工耳蜗电极在电声刺激中的应用：1例报告。

背景/目的：在电声刺激（EAS）手术（以及常规人工耳蜗手术）期间和之后，推荐口服和/或静脉注射类固醇以预防急性炎症反应和随后的纤维化。然而，这种效果不会持续太久。因此，为了提供持续的效果，最近开发了一种新的地塞米松（DEX）洗脱电极（FLEX28 DEX）。方法：2024年2月，在日本新州大学进行了一项病例研究，该研究使用dex洗脱电极阵列治疗一名病因明确的高频听力损失患者（由线粒体m.1555A > G变异引起的听力损失）。结果：与历史/回顾性对照组（无DEX的FLEX28电极组）相比，EAS术后残余听力保存良好，术后阻抗场遥测维持在非常低的水平；因此，预计术后纤维化将减少到最低程度。此外，dex洗脱电极也可以应用于EAS。结论：dex洗脱电极有助于将术后阻抗维持在非常低的水平，这表明即使在EAS手术后，术后纤维化也可以最小化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Audiology Research AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-

CiteScore

2.30

自引率

23.50%

发文量

审稿时长

11 weeks

期刊介绍： The mission of Audiology Research is to publish contemporary, ethical, clinically relevant scientific researches related to the basic science and clinical aspects of the auditory and vestibular system and diseases of the ear that can be used by clinicians, scientists and specialists to improve understanding and treatment of patients with audiological and neurotological disorders.