Audiology Research最新文献

{"title":"Individual Noise-Tolerance Profiles and Neural Signal-to-Noise Ratio: Insights into Predicting Speech-in-Noise Performance and Noise-Reduction Outcomes.","authors":"Subong Kim, Susan Arzac, Natalie Dokic, Jenn Donnelly, Nicole Genser, Kristen Nortwich, Alexis Rooney","doi":"10.3390/audiolres15040078","DOIUrl":"10.3390/audiolres15040078","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Individuals with similar hearing sensitivity exhibit varying levels of tolerance to background noise, a trait tied to unique individual characteristics that affect their responsiveness to noise reduction (NR) processing in hearing aids. The present study aimed to capture such individual characteristics by employing electrophysiological measures and subjective noise-tolerance profiles, and both were analyzed in relation to speech-in-noise performance and NR outcomes. <b>Methods</b>: From a sample of 42 participants with normal hearing, the neural signal-to-noise ratio (SNR)-a cortical index comparing the amplitude ratio between auditory evoked responses to target speech onset versus noise onset-was calculated, and individual noise-tolerance profiles were also derived using k-means cluster analysis to classify participants into distinct subgroups. <b>Results</b>: The neural SNR showed significant correlations with speech-in-noise performance and NR outcomes with varying strength. In contrast, noise-tolerance subgroups did not show meaningful group-level differences in either speech-in-noise or NR outcomes. The neural SNR and noise-tolerance profiles were found to be statistically independent. <b>Conclusions</b>: While the neural SNR reliably predicted perceptual performance in background noise and NR outcomes, our noise-tolerance profiles lacked sufficient sensitivity. Still, subjective ratings of individual noise tolerance are clinically accessible, and thus, integrating both physiology and subjective measures in the same cohort is a valuable strategy.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear Implants and the Aided Audiogram: A Retrospective Study Comparing Performance Across Device Manufacturers.","authors":"Nicole Hope Capach, Noam Zigdon, Taylor A Payne, Jonathan D Neukam, Yeonjoo Choi, Hong Ju Park, William H Shapiro, Mario A Svirsky","doi":"10.3390/audiolres15040079","DOIUrl":"10.3390/audiolres15040079","url":null,"abstract":"<p><p><b>Background/Objectives</b>: We investigated: (1) differences in CI-aided thresholds and speech perception scores among cochlear implant manufacturers and (2) the relationship between CI-aided thresholds and speech perception. <b>Methods</b>: We analyzed exploratory data from NYU and a confirmatory data set of 120 CI-aided audiograms from the ASAN clinic. CI-aided soundfield evaluations were compared between manufacturers (Cochlear, Advanced Bionics, MED-EL) using 5- and 6-pure-tone average thresholds; percentage of patients with average thresholds above 35 dB HL; speech perception scores; and correlations between thresholds and speech perception. <b>Results</b>: Compared to Cochlear users, MED-EL and Advanced Bionics users had significantly higher (poorer) pure-tone averages (26.7 dB HL for Cochlear vs. 30.0 dB HL for AB and 34.6 dB HL for MED-EL at NYU; 29.0 dB HL for Cochlear vs. 36.5 dB HL for MED-EL at ASAN), and higher incidence of 5- or 6-PTAs above 35 dB HL (1.6% vs. 23.4%/47.1% at NYU; 11.2% vs. 60.0% at ASAN). Word and sentence scores were significantly higher for the Cochlear group when compared to the MED-EL group. Speech scores were higher for manufacturers that recommend the use of behaviorally-measured T-levels (Cochlear) rather than estimated T-levels (AB and MED-EL). Significant negative correlations existed between CI-aided thresholds and speech scores. <b>Conclusions</b>: Significant differences in CI-aided thresholds and speech perception were observed between manufacturers, potentially related to brand-specific T-level programming approaches.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Assessment in Patients with Inner Ear Functional Disorders: A Prospective Cohort Study Investigating Sleep Quality Through Polygraphy Recordings.","authors":"Dorota Kuryga, Artur Niedzielski","doi":"10.3390/audiolres15040076","DOIUrl":"10.3390/audiolres15040076","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The vestibulo-respiratory reflex regulates the tension of the respiratory muscles, which prevents apneas and awakenings during sleep. This study aimed to determine whether functional deficits in the inner ear disturb sleep quality. <b>Methods</b>: We compared sleep parameters in patients with their first episode of acute inner ear deficit (Group A: sudden idiopathic vertigo attack, sudden sensorineural hearing loss), chronic functional inner ear impairment (Group B: chronic peripheral vertigo, permanent hearing loss), and in healthy individuals (Group C). Polygraphy recordings were performed twice, in Group A at the onset of acute otoneurological symptoms and the second time after their withdrawal with an interval of 1 to 13 days, in Group B after 1 to 6 days, and in Group C after 1 to 8 days. <b>Results</b>: In Group A during the symptomatic night, overall and central apnea-hypopnea indices were significantly higher and snoring time was longer. Group A also had higher central apnea-hypopnea index on the first night compared to healthy individuals. In chronic disorders, sleep recordings showed lower autonomic arousal index than in controls or symptomatic nights in Group A. <b>Conclusions</b>: These findings highlight the severity of sleep apnea indicators in Group A. Our results suggest that acute dysfunction of the inner ear substantially impacts central neuronal signaling responsible for regulating normal sleep-related breathing and leads to a deterioration in sleep quality in contrast to individuals with chronic inner ear impairments. It can also be assumed that people with chronic vertigo or hearing loss experience less interrupted sleep than healthy individuals.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audiovisual Perception of Sentence Stress in Cochlear Implant Recipients.","authors":"Hartmut Meister, Moritz Wächtler, Pascale Sandmann, Ruth Lang-Roth, Khaled H A Abdel-Latif","doi":"10.3390/audiolres15040077","DOIUrl":"10.3390/audiolres15040077","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Sentence stress as part of linguistic prosody plays an important role for verbal communication. It emphasizes particularly important words in a phrase and is reflected by acoustic cues such as the voice fundamental frequency. However, visual cues, especially facial movements, are also important for sentence stress perception. Since cochlear implant (CI) recipients are limited in their use of acoustic prosody cues, the question arises as to what extent they are able to exploit visual features. <b>Methods:</b> Virtual characters were used to provide highly realistic but controllable stimuli for investigating sentence stress in groups of experienced CI recipients and typical-hearing (TH) peers. In addition to the proportion of correctly identified stressed words, task load was assessed via reaction times (RTs) and task-evoked pupil dilation (TEPD), and visual attention was estimated via eye tracking. Experiment 1 considered congruent combinations of auditory and visual cues, while Experiment 2 presented incongruent stimuli. <b>Results:</b> In Experiment 1, CI users and TH participants performed similarly in the congruent audiovisual condition, while the former were better at using visual cues. RTs were generally faster in the AV condition, whereas TEPD revealed a more detailed picture, with TH subjects showing greater pupil dilation in the visual condition. The incongruent stimuli in Experiment 2 showed that modality use varied individually among CI recipients, while TH participants relied primarily on auditory cues. <b>Conclusions:</b> Visual cues are generally useful for perceiving sentence stress. As a group, CI users are better at using facial cues than their TH peers. However, CI users show individual differences in the reliability of the various cues.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kolliker's Organ and Its Functional Role in the Development of Corti's Organ and Auditory Systems.","authors":"Valeria Caragli, Valerio M Di Pasquale Fiasca, Elisabetta Genovese, Alessandro Martini","doi":"10.3390/audiolres15040075","DOIUrl":"10.3390/audiolres15040075","url":null,"abstract":"<p><p><b>Background</b>: Kölliker's organ (KO), a transient structure in the cochlea, plays a critical role in the auditory maturation of mammals, particularly during embryonic and early postnatal development. This organ is essential for the proper differentiation and function of cochlear cells, acting as a pivotal source of signalling molecules that influence hair cell development and synaptic connectivity. <b>Methods</b>: This study systematically analyses the literature according to the PRISMA statement in order to evaluate the function roles of KO during cochlea development, reporting the molecular mechanisms and signalling pathways involved. <b>Results</b>: From our study, it emerged that KO supporting cells release adenosine triphosphate (ATP) through connexin hemichannels, initiating a cascade of intracellular calcium (Ca²⁺) signalling in adjacent inner hair cells (IHCs). This signalling promotes the release of glutamate, facilitating synaptic excitation of afferent nerve fibres and enhancing auditory neuron maturation prior to the onset of hearing. Additionally, the spontaneous electrical activity generated within KO supports the establishment of essential neural connections in the auditory pathway. The dynamic interplay between ATP release, Ca²⁺ signalling, and morphological changes in KO is crucial for cochlear compartmentalisation and fluid regulation, contributing to the formation of endolymph and perilymph. Furthermore, KO supports cellular plasticity and may provide a reservoir of precursor cells capable of trans-differentiating into hair cells under specific conditions. <b>Conclusions</b>: Dysregulation of KO function or delayed degeneration of its supporting cells has been implicated in auditory disorders, underscoring the importance of this organ in normal cochlear development and auditory function. Despite its identification over a century ago, further investigation is necessary to elucidate the molecular mechanisms underlying KO's contributions to auditory maturation, particularly in human physiology.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 4","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Cochlear Trauma Degree and Localization on Intracochlear Electrocochleographic Recordings.","authors":"David Bächinger, Merlin Schär, Ahmet Kunut, Rahel Bertschinger, Ivo Dobrev, Leanne Sijgers, Andreas H Eckhard, Adrian Dalbert","doi":"10.3390/audiolres15030074","DOIUrl":"10.3390/audiolres15030074","url":null,"abstract":"<p><strong>Background/objectives: </strong>Electrocochleography (ECochG) is a promising tool to monitor preservation of cochlear structures and function during cochlear implant (CI) surgery. However, the interpretation of ECochG signal changes during insertion of the CI electrode array remains controversial. This study investigates the influence of the degree and localization of cochlear trauma on ECochG signal changes using a mouse model.</p><p><strong>Methods: </strong>C57BL/6J-Crl1 mice underwent intracochlear ECochG recordings during the insertion of a platinum-iridium electrode.</p><p><strong>Results: </strong>In case of grade 1 and 2 cochlear trauma, as determined by post-mortem histological analysis, we found that a reduction in intracochlear cochlear microphonic (CM) amplitude correlates more significantly with the location of the trauma than with its severity. The more basally a trauma is located, the larger the CM amplitude drop. Furthermore, the results revealed that grade 1 or 2 trauma was detectable through ECochG before more severe trauma developed.</p><p><strong>Conclusions: </strong>These findings suggest that intracochlear ECochG can serve as a reliable intraoperative tool for detecting early and possibly reversible cochlear trauma, preventing more severe damage and aiding hearing preservation. The results emphasize the need for a nuanced interpretation of CM signal drops, considering trauma location and cochlear structure integrity at the site of trauma and apical to it.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Accuracy of Self-Administered Web- and App-Based Tools for Audiometric Tests-A Systematic Review.","authors":"Sahuur Abdullahi Ahmed Sheikh Hassan, Uffe Kock Wiil, Ali Ebrahimi","doi":"10.3390/audiolres15030073","DOIUrl":"10.3390/audiolres15030073","url":null,"abstract":"<p><p><b>Objectives:</b> This systematic review aimed to evaluate the diagnostic accuracy of self-administered web- and app-based tools for audiometric testing compared to pure-tone audiometry (PTA), the clinical gold standard. <b>Methods:</b> Studies were eligible if they involved human participants, evaluated self-administered digital tools for audiometric testing, reported diagnostic accuracy metrics (e.g., sensitivity, specificity, and accuracy), were published between 2014 and 2024, and were written in English. Studies were excluded if they did not compare to PTA, were reviews, or did not assess self-administered tools. MEDLINE, Web of Science, Scopus, and EMBASE were systematically searched throughout November 2024. Study quality was assessed using the QUADAS-2 tool, evaluating four domains: patient selection, index test, reference standard, and flow and timing. Most studies showed some concern for a risk of bias. <b>Results:</b> Twelve studies, including a total of 2453 participants and evaluating 15 applications, met the inclusion criteria. The studies reported wide variability in diagnostic accuracy. Sensitivity ranged from 18% to 100%, specificity from 35.5% to 99.1%, and accuracy from 14% to 97.4%. SHOEBOX and Screenout demonstrated high diagnostic accuracy, while other apps showed inconsistent results across studies and settings. Heterogeneity in definitions of hearing loss, test environments, device and headphone types and a lack of standardized reporting limited comparability. Most studies were conducted in non-soundproof environments, and some had unclear or a high risk of bias. <b>Conclusions:</b> Self-administered audiometric apps and web tools show promise for remote hearing screening but require further validation and methodological standardization. Clinicians should interpret the results cautiously given the current variability in performance.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study.","authors":"Stefani Maihoub, Panayiota Mavrogeni, Gábor Dénes Répássy, András Molnár","doi":"10.3390/audiolres15030072","DOIUrl":"10.3390/audiolres15030072","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to analyse the haematological parameters in relation to subjective tinnitus. We hypothesise that abnormal haematological findings may correlate with increased severity and chronicity of tinnitus. This research could lead to improved diagnostic methods and more targeted treatments. <b>Material and Methods:</b> A total of 439 patients with primary subjective tinnitus and 274 individuals without tinnitus were enrolled. These participants underwent comprehensive laboratory testing, which included haematological parameters. <b>Results:</b> When comparing the white blood cell levels between the tinnitus group and the control group, no statistically significant differences were found (<i>p</i> = 0.743). Similarly, comparisons of red blood cell levels (<i>p</i> = 0.250), haemoglobin levels (<i>p</i> = 0.087), and haematocrit levels (<i>p</i> = 0.066) also revealed no significant differences. The platelet levels showed no significant difference between the two groups (<i>p</i> = 0.782). According to a logistic regression model, lower levels of haemoglobin (<i>p</i> = 0.000) and platelets (<i>p</i> = 0.000) significantly predicted higher scores on the Tinnitus Handicap Inventory, indicating self-reported tinnitus severity. Furthermore, lower haemoglobin levels were significant predictors (<i>p</i> = 0.04) of developing bilateral tinnitus. Using Spearman's correlation test, a statistically significant negative correlation (<i>p</i> = 0.029) was observed between red blood cell levels and the onset of tinnitus. The frequency of tinnitus demonstrated a significant positive correlation with haemoglobin levels (<i>p</i> = 0.04) and haematocrit levels (<i>p</i> = 0.043). Conversely, platelet levels showed a significant negative correlation with both tinnitus intensity (<i>p</i> = 0.002) and the onset of tinnitus (<i>p</i> = 0.033). <b>Conclusions:</b> While the haematological parameters showed no significant differences between the tinnitus and control groups, further analyses indicated that certain parameters, such as haemoglobin and haematocrit levels, could potentially influence tinnitus, necessitating further investigation.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12190120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Instrumental Evaluation of Vestibular Function Before and After Cochlear Implantation in Adults.","authors":"Pasqualina Maria Picciotti, Tiziana Di Cesare, Daniela Rodolico, Walter Di Nardo, Jacopo Galli","doi":"10.3390/audiolres15030071","DOIUrl":"10.3390/audiolres15030071","url":null,"abstract":"<p><strong>Background/objectives: </strong>Vestibular dysfunction is one of the main complications after cochlear implant (CI) surgery, and there are currently no standardized protocols for vestibular assessment in CI candidates. Our objectives were to investigate the incidence of vestibular impairment after CI surgery, anamnestic (age, known systemic pathologies and cause of deafness) and surgical (intraoperative complications, malposition of the CI) risk factors, and the role of vestibular assessment in the selection of the suitable ear for implantation.</p><p><strong>Methods: </strong>We included 68 adult patients (80 ears) affected by moderate-to-profound SNHL undergoing CI. The dizziness handicap inventory (DHI), the video head impulse test (VHIT), the caloric test, and dynamic posturography (DP) were used to study the vestibular function and balance before and one month after CI. The DHI was also administered 24 h after surgery.</p><p><strong>Results: </strong>Despite significative impairment 24 h after surgery (29.6 ± 30), the mean DHI score returned to preoperative values (17.9 ± 26) after one month. Dizziness persisted in case of age ≥ 65 years old, surgical difficulties, simultaneous bilateral CI, Meniere's disease and otosclerosis, comorbidities ≥ 3, anxiety/depression, and neurological diseases. The VHIT significantly worsened in 25% of ears, while the caloric test SPV nystagmus significantly decreased in 30% of ears. In cases of preoperative unilateral weakness, the implantation of the better ear was significantly related to higher DHI scores. Only 4/68 patients had a significant persistent reduction in the postural composite score after surgery, with an increased risk of falls.</p><p><strong>Conclusions: </strong>Medical history and vestibular assessment predict the risk of vestibular damage and help to choose the CI's side and to manage vertigo after surgery.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation and Extension of a Cochlear Implant Performance Prediction Model: Analysis of the Oldenburg Cohort.","authors":"Rieke Ollermann, Robert Böscke, John Neidhardt, Andreas Radeloff","doi":"10.3390/audiolres15030069","DOIUrl":"10.3390/audiolres15030069","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Rehabilitation success with a cochlear implant (CI) varies considerably and identifying predictive factors for the reliable prediction of speech understanding with CI remains a challenge. Hoppe and colleagues have recently described a predictive model, which was specifically based on Cochlear™ recipients with a four-frequency pure tone average (4FPTA) ≤ 80 dB HL. The aim of this retrospective study is to test the applicability to an independent patient cohort with extended inclusion criteria. <b>Methods</b>: The Hoppe et al. model was applied to CI recipients with varying degrees of hearing loss. Model performance was analyzed for Cochlear™ recipients with 4FPTA ≤ 80 dB HL and for all recipients regardless of 4FPTA. Subgroup analyses were conducted by <i>WRS_max</i> and CI manufacturer. <b>Results</b>: The model yielded comparable results in our patient cohort when the original inclusion criteria were met (n = 24). Extending the model to patients with profound hearing loss (4FPTA > 80 dB HL; n = 238) resulted in a weaker but significant correlation (r = 0.273; <i>p</i> < 0.0001) between predicted and measured word recognition score at 65 dB with CI (<i>WRS</i>₆₅(<i>CI</i>)). Also, a higher percentage of data points deviated by more than 20 pp, either better or worse. When patients provided with CIs from different manufacturers were enrolled, the prediction error was also higher than in the original cohort. In Cochlear™ recipients with a maximum word recognition score (<i>WRS_max</i>) > 0% (n = 83), we found a moderate correlation between measured and predicted scores (r = 0.3274; <i>p</i> = 0.0025). <b>Conclusions</b>: In conclusion, as long as the same inclusion criteria are used, the Hoppe et al. (2021) prediction model results in similar prediction success in our cohort, and thus seems applicable independently of the cohort used. Nevertheless, it has limitations when applied to a broader and more diverse patient cohort. Our data suggest that the model would benefit from adaptations for broader clinical use, as the model lacks sufficient sensitivity in identifying poor performers.</p>","PeriodicalId":44133,"journal":{"name":"Audiology Research","volume":"15 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12189566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144486504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}