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RNA processing in innate immunity: regulation by RNA-binding proteins 先天免疫中的RNA加工：RNA结合蛋白的调控。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.004
Asmita Panthi , Kristen W. Lynch
{"title":"RNA processing in innate immunity: regulation by RNA-binding proteins","authors":"Asmita Panthi ,&nbsp;Kristen W. Lynch","doi":"10.1016/j.tibs.2025.04.004","DOIUrl":"10.1016/j.tibs.2025.04.004","url":null,"abstract":"<div><div>RNA processing is an important but often overlooked process in determining protein expression. Alternative polyadenylation and regulated mRNA stability control the amount and duration of protein expression, while alternative splicing also controls protein identity and function. Much work in innate immunity has focused on the activation of transcription factors and the downstream consequences in gene expression. However, there is increasing evidence indicating that regulation of RNA processing by RNA-binding proteins (RBPs) contributes significantly to tuning the innate immune response. Herein we review work highlighting the impact of RNA processing in innate immunity and describe the RBPs and mechanisms driving this regulation. We conclude with a discussion of unanswered questions to motivate continued research in this important and understudied field.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 610-621"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅及版权资料
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/S0968-0004(25)00146-X
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(25)00146-X","DOIUrl":"10.1016/S0968-0004(25)00146-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/S0968-0004(25)00143-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(25)00143-4","DOIUrl":"10.1016/S0968-0004(25)00143-4","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diverse lineages and adaptations of oxygen-adapted hydrogenases 适应氧的氢化酶的不同谱系和适应性。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.006
Marion Jespersen , Chris Greening , Leonard Ernst , Pok Man Leung , Hannah S. Shafaat , Rhys Grinter
{"title":"Diverse lineages and adaptations of oxygen-adapted hydrogenases","authors":"Marion Jespersen ,&nbsp;Chris Greening ,&nbsp;Leonard Ernst ,&nbsp;Pok Man Leung ,&nbsp;Hannah S. Shafaat ,&nbsp;Rhys Grinter","doi":"10.1016/j.tibs.2025.04.006","DOIUrl":"10.1016/j.tibs.2025.04.006","url":null,"abstract":"<div><div>Hydrogenases allow microorganisms to consume and produce hydrogen gas (H<sub>2</sub>). Although most hydrogenases are oxygen (O<sub>2</sub>)-sensitive, recent studies show that bacteria and archaea produce diverse nickel–iron [NiFe]-hydrogenases that function in oxic environments and often support aerobic respiration. As we describe herein, these hydrogenases have independently evolved multiple strategies to withstand O<sub>2</sub>, not only by reversing inhibition through reduction of bound O<sub>2</sub> to water using a unique [4Fe3S] cluster but also by preventing O<sub>2</sub> binding through narrow gas channels and active-site rearrangements. We further propose that [NiFe]-hydrogenases originated on an anoxic Earth, but diversified after the Great Oxygenation Event to tolerate and exploit redox coupling with O<sub>2</sub>. Hydrogenases may be more adaptable to O<sub>2</sub> than was previously thought, and this has implications for synthetic biology and biomimetics.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 596-609"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial heat production: the elephant in the lab… 线粒体产热：实验室里的大象....
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.002
Pierre Rustin , Howard T. Jacobs , Mügen Terzioglu , Paule Bénit
{"title":"Mitochondrial heat production: the elephant in the lab…","authors":"Pierre Rustin ,&nbsp;Howard T. Jacobs ,&nbsp;Mügen Terzioglu ,&nbsp;Paule Bénit","doi":"10.1016/j.tibs.2025.03.002","DOIUrl":"10.1016/j.tibs.2025.03.002","url":null,"abstract":"<div><div>It has long been established that heat represents a major part of the energy released during the oxidation of mitochondrial substrates. However, with a few exceptions, the release of heat is rarely mentioned other than as being produced at the expense of ATP, without having any specific function. Here, after briefly surveying the literature on mitochondrial heat production, we argue for its cellular and organismal importance, sharing our opinions as to what could account for this unbalanced portrayal of mitochondrial energy transactions.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 559-565"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging mechanisms of human mitochondrial translation regulation 人类线粒体翻译调控的新机制。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.007
Michele Brischigliaro , Ahram Ahn , Seungwoo Hong , Flavia Fontanesi , Antoni Barrientos
{"title":"Emerging mechanisms of human mitochondrial translation regulation","authors":"Michele Brischigliaro ,&nbsp;Ahram Ahn ,&nbsp;Seungwoo Hong ,&nbsp;Flavia Fontanesi ,&nbsp;Antoni Barrientos","doi":"10.1016/j.tibs.2025.03.007","DOIUrl":"10.1016/j.tibs.2025.03.007","url":null,"abstract":"<div><div>Mitochondrial translation regulation enables precise control over the synthesis of hydrophobic proteins encoded by the organellar genome, orchestrating their membrane insertion, accumulation, and assembly into oxidative phosphorylation (OXPHOS) complexes. Recent research highlights regulation across all translation stages (initiation, elongation, termination, and recycling) through a complex interplay of mRNA structures, specialized translation factors, and unique regulatory mechanisms that adjust protein levels for stoichiometric assembly. Key discoveries include mRNA-programmed ribosomal pausing, frameshifting, and termination-dependent re-initiation, which fine-tune protein synthesis and promote translation of overlapping open reading frames (ORFs) in bicistronic transcripts. In this review, we examine these advances, which are significantly enhancing our understanding of mitochondrial gene expression.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 566-584"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitivity to chirality correlates in a continuum with protein disorder 对手性的敏感性与蛋白质紊乱连续相关。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.003
Lucía Álvarez , Lucía Beatriz Chemes
{"title":"Sensitivity to chirality correlates in a continuum with protein disorder","authors":"Lucía Álvarez ,&nbsp;Lucía Beatriz Chemes","doi":"10.1016/j.tibs.2025.04.003","DOIUrl":"10.1016/j.tibs.2025.04.003","url":null,"abstract":"<div><div>Intrinsically disordered proteins (IDPs) exist as dynamic conformational ensembles the behavior of which challenges the tenets of the protein structure–function paradigm. In a new study, Newcombe, <span><span>Due <em>et al</em></span><svg><path></path></svg></span>. reveal a striking continuum in sensitivity to chirality: while folded complexes are under strong chiral constraints, progressively disordered complexes show decreased sensitivity to chirality.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 553-555"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discussing the future of mitochondrial biochemistry 讨论线粒体生物化学的未来。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.05.010
Antoni Barrientos , Flavia Fontanesi , Pierre Rustin , Agnieszka Chacinska
{"title":"Discussing the future of mitochondrial biochemistry","authors":"Antoni Barrientos ,&nbsp;Flavia Fontanesi ,&nbsp;Pierre Rustin ,&nbsp;Agnieszka Chacinska","doi":"10.1016/j.tibs.2025.05.010","DOIUrl":"10.1016/j.tibs.2025.05.010","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 547-549"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding mitochondrial protein import: a revised model of the presequence translocase 理解线粒体蛋白的输入：一个修正的前序转位酶模型。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.03.001
Naintara Jain , Agnieszka Chacinska , Peter Rehling
{"title":"Understanding mitochondrial protein import: a revised model of the presequence translocase","authors":"Naintara Jain ,&nbsp;Agnieszka Chacinska ,&nbsp;Peter Rehling","doi":"10.1016/j.tibs.2025.03.001","DOIUrl":"10.1016/j.tibs.2025.03.001","url":null,"abstract":"<div><div>Mitochondrial function relies on the precise targeting and import of cytosolic proteins into mitochondrial subcompartments. Most matrix-targeted proteins follow the presequence pathway, which directs precursor proteins across the outer mitochondrial membrane (OMM) via the Translocase of the Outer Membrane (TOM) complex and into the matrix or inner mitochondrial membrane (IMM) via the Translocase of the Inner Membrane 23 (TIM23) complex. While classical biochemical studies provided detailed mechanistic insights into the composition and mechanism of the TIM23 complex, recent cryogenic-electron microscopy (cryo-EM) data challenge these established models and propose a revised model of translocation in which the TIM17 subunit acts as a ‘slide’ for precursor proteins, with Tim23 acting as a structural element. In this review, we summarize existing models, highlighting the questions and data needed to reconcile these perspectives, and enhance our understanding of TIM23 complex function.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 585-595"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerating the stride toward functional glycoproteomics 加速向功能性糖蛋白组学迈进。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2025-07-01 DOI: 10.1016/j.tibs.2025.04.002
Tim S. Veth , Nicholas M. Riley
{"title":"Accelerating the stride toward functional glycoproteomics","authors":"Tim S. Veth ,&nbsp;Nicholas M. Riley","doi":"10.1016/j.tibs.2025.04.002","DOIUrl":"10.1016/j.tibs.2025.04.002","url":null,"abstract":"<div><div>The heterogeneity of the glycoproteome and the challenges associated with quantifying its regulation in complex biological systems have hindered functional glycoproteomics. The deep quantitative glycoprofiling (DQGlyco) method recently developed by <span><span>Potel, Burtscher, and Garrido-Rodriguez <em>et al.</em></span><svg><path></path></svg></span> significantly improves the glycoproteomic depth compared with existing methods, aiding our ability to interrogate the functional implications of glycoproteins.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"50 7","pages":"Pages 550-552"},"PeriodicalIF":11.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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