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Tandem repeats matter for the functional versatility of giant proteins 串联重复序列对巨蛋白的多功能性至关重要。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-03-26 DOI: 10.1016/j.tibs.2026.02.010
Zarifa Osmanli , Alexander Miguel Monzon , Silvio C.E. Tosatto
{"title":"Tandem repeats matter for the functional versatility of giant proteins","authors":"Zarifa Osmanli ,&nbsp;Alexander Miguel Monzon ,&nbsp;Silvio C.E. Tosatto","doi":"10.1016/j.tibs.2026.02.010","DOIUrl":"10.1016/j.tibs.2026.02.010","url":null,"abstract":"<div><div>Giant proteins play essential cellular roles but remain structurally challenging. Recent advances in structure determination and modeling reveal that tandem repeats are widespread in large proteins, providing modularity, adaptability, and multifunctionality. Examples including apolipoprotein B100, teneurins, and ryanodine receptors illustrate how repetition drives structural flexibility, regulatory precision, and evolutionary innovation.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages 423-426"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voices across Africa: from local challenges to global impact 非洲各地的声音：从地方挑战到全球影响
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-05-07 DOI: 10.1016/j.tibs.2026.03.004
Victoria Patten , Olorunfemi R. Molehin , Aishatu M. Malami
{"title":"Voices across Africa: from local challenges to global impact","authors":"Victoria Patten ,&nbsp;Olorunfemi R. Molehin ,&nbsp;Aishatu M. Malami","doi":"10.1016/j.tibs.2026.03.004","DOIUrl":"10.1016/j.tibs.2026.03.004","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages 414-417"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147828214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenosine illuminates nobility 腺苷彰显高贵
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-05-07 DOI: 10.1016/j.tibs.2026.04.001
Tereza Dolejšková
{"title":"Adenosine illuminates nobility","authors":"Tereza Dolejšková","doi":"10.1016/j.tibs.2026.04.001","DOIUrl":"10.1016/j.tibs.2026.04.001","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Page 524"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147828218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms of PINK1/Parkin-mediated mitochondrial quality control PINK1/ parkin介导的线粒体质量控制的分子机制
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-04-16 DOI: 10.1016/j.tibs.2026.02.014
Andrew N. Bayne , Jean-François Trempe
{"title":"Molecular mechanisms of PINK1/Parkin-mediated mitochondrial quality control","authors":"Andrew N. Bayne ,&nbsp;Jean-François Trempe","doi":"10.1016/j.tibs.2026.02.014","DOIUrl":"10.1016/j.tibs.2026.02.014","url":null,"abstract":"<div><div>PINK1/Parkin-mediated mitophagy and other related mitochondrial quality control pathways are critical to maintaining cellular homeostasis and neuronal health, and indeed, mutations in <em>PINK1</em> and <em>PRKN</em> that disrupt this pathway cause early-onset Parkinson’s disease. While PINK1-dependent Parkin recruitment to damaged mitochondria has been established for over a decade, recent structural and biochemical advances have illuminated the mechanisms governing their allosteric activation and integration into broader cellular signaling networks. This review synthesizes these insights, focusing on the molecular determinants of PINK1/Parkin activation and the regulatory crosstalk that integrates mitophagy with other cellular stress responses. These mechanistic advances position the PINK1/Parkin pathway as a promising, tractable therapeutic target for Parkinson’s disease and related pathologies.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages 474-490"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular and structural mechanisms of nutrient sensing in the mTORC1 pathway mTORC1通路中营养感知的分子和结构机制。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-03-30 DOI: 10.1016/j.tibs.2026.02.009
Serim Yang , Tong Bian , Roberto Zoncu
{"title":"Molecular and structural mechanisms of nutrient sensing in the mTORC1 pathway","authors":"Serim Yang ,&nbsp;Tong Bian ,&nbsp;Roberto Zoncu","doi":"10.1016/j.tibs.2026.02.009","DOIUrl":"10.1016/j.tibs.2026.02.009","url":null,"abstract":"<div><div>Primary nutrient sensors directly bind metabolites and undergo conformational changes that signal through core pathways to coordinate metabolic and cellular outcomes. Sensing of amino acids, lipids, sugars, and nucleotides is critical for the master growth regulatory Ser/Thr kinase, mechanistic target of rapamycin complex 1 (mTORC1), to promote growth and proliferation. Systematic proteomic and bioinformatic studies have accelerated the discovery of primary nutrient sensors upstream of mTORC1, whereas structural biology has shed light on how binding to their cognate metabolites triggers mTORC1-dependent signaling responses. This review focuses on recently reported amino acid and lipid sensors upstream of mTORC1 and highlights structural and functional features of these sensors that illuminate fundamental principles of nutrient detection and signal transduction.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages 457-473"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulation of circadian clocks by chromatin dynamics from fungi to mammals 从真菌到哺乳动物的染色质动力学对生物钟的表观遗传调控。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-03-25 DOI: 10.1016/j.tibs.2026.02.002
Xiao-Lan Liu , Muqun Yu , Zeyu Duan , Xiao Liu
{"title":"Epigenetic regulation of circadian clocks by chromatin dynamics from fungi to mammals","authors":"Xiao-Lan Liu ,&nbsp;Muqun Yu ,&nbsp;Zeyu Duan ,&nbsp;Xiao Liu","doi":"10.1016/j.tibs.2026.02.002","DOIUrl":"10.1016/j.tibs.2026.02.002","url":null,"abstract":"<div><div>Circadian clocks allow eukaryotes to adapt to the daily cycles caused by the Earth’s rotation. At the molecular level, circadian oscillators consist of transcriptional–translational negative feedback loops that drive circadian rhythms. Epigenetic regulators coordinate with transcription factors to modulate the rhythmic transcription of circadian clock genes, ensuring proper circadian clock function. In this review, we first provide a brief overview of the epigenetic regulation of circadian clock genes and the conserved circadian oscillators in <em>Neurospora</em>, <em>Drosophila</em>, and mammals. Then, we summarize recent advances in understanding the role of epigenetic regulation in circadian rhythms and how chromatin modifiers interact with core clock proteins to regulate clock gene expression. Finally, we discuss what remains unknown about how chromatin states influence circadian clocks.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages 491-506"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-05-07 DOI: 10.1016/S0968-0004(26)00114-3
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(26)00114-3","DOIUrl":"10.1016/S0968-0004(26)00114-3","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages i-ii"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147828215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenosine signals an imbalance between activity and supply in privileged cells 腺苷标志着特权细胞活动和供应之间的不平衡。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-05-01 Epub Date: 2026-03-31 DOI: 10.1016/j.tibs.2026.02.007
Pavla Nedbalova , Tomas Dolezal
{"title":"Adenosine signals an imbalance between activity and supply in privileged cells","authors":"Pavla Nedbalova ,&nbsp;Tomas Dolezal","doi":"10.1016/j.tibs.2026.02.007","DOIUrl":"10.1016/j.tibs.2026.02.007","url":null,"abstract":"<div><div>Extracellular adenosine (e-Ado) is a critical signaling molecule, yet its origin beyond energy stress and inflammation is underexplored. Herein, we propose that Ado is ubiquitously generated in the S-adenosylmethionine transmethylation pathway and integrate this source with the concept of cellular privilege in nutrient acquisition. In this model, less privileged cells convert Ado to adenosine monophosphate (AMP) under nutrient scarcity, activating AMP-activated protein kinase, while privileged cells release Ado to signal for resources. We define Ado as a sensor of the balance between cellular activity, reflected in methylation, and nutrient supply, reflected in ATP recycling. This framework redefines Ado’s role in immunity, brain function, and aging and highlights transmethylation-derived Ado as a key factor in the tumor microenvironment and immunotherapeutic strategies.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 5","pages":"Pages 427-438"},"PeriodicalIF":11.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science is always unfinished: rethinking the demand for complete stories. 科学总是未完成的：重新考虑对完整故事的需求。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-29 DOI: 10.1016/j.tibs.2026.04.010
Roberto Munita
{"title":"Science is always unfinished: rethinking the demand for complete stories.","authors":"Roberto Munita","doi":"10.1016/j.tibs.2026.04.010","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.04.010","url":null,"abstract":"<p><p>The 'complete story' has become the standard in top journals. Narrative structure helps communicate science, but requiring mechanistic completeness for publication can exclude important discoveries, delay their dissemination, and push researchers to overfit their data to a narrative. This essay makes the case for making room for rigorous, unfinished stories.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic encoding of multiple distinct noncanonical amino acids. 多种不同的非规范氨基酸的遗传编码。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-24 DOI: 10.1016/j.tibs.2026.03.006
Wei Yu, Yu Fang, Shixian Lin, Wenlong Ding
{"title":"Genetic encoding of multiple distinct noncanonical amino acids.","authors":"Wei Yu, Yu Fang, Shixian Lin, Wenlong Ding","doi":"10.1016/j.tibs.2026.03.006","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.03.006","url":null,"abstract":"<p><p>The site-specific incorporation of noncanonical amino acids (ncAAs) has revolutionized protein research. However, synthesizing multifunctional biopolymers demands moving beyond single-type ncAA incorporation to simultaneously encoding multiple distinct ncAAs. This review summarizes transformative progress in the genetic encoding of multiple distinct ncAAs, including the development of mutually orthogonal translation systems and the expansion of codon repertoires. We highlight recent breakthroughs that have achieved the incorporation of multiple distinct ncAAs. Notably, integrating rare codon recoding with stop codon suppression in mammalian systems has recently enabled the genetic encoding of five distinct ncAAs. These innovations establish a robust platform for advanced biosensors, next-generation therapeutics, and synthetic biology with expanded chemical repertoires.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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