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The role of hydrolysis in perceiving and degrading the plant hormone strigolactones. 水解作用在感知和降解植物激素绞股蓝内酯中的作用。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1016/j.tibs.2024.09.006
Kawthar F Alashoor, Jian You Wang, Salim Al-Babili
{"title":"The role of hydrolysis in perceiving and degrading the plant hormone strigolactones.","authors":"Kawthar F Alashoor, Jian You Wang, Salim Al-Babili","doi":"10.1016/j.tibs.2024.09.006","DOIUrl":"10.1016/j.tibs.2024.09.006","url":null,"abstract":"<p><p>Strigolactones (SLs) perform versatile functions in plants. The different members of the α/β-hydrolase superfamily bind and hydrolyze SLs at varying rates to transduce their signal or maintain SL homeostasis. Recent work by Palayam et al. on SL-degrading carboxylesterases (CXEs) uncovers structural elements that determine the mechanism, efficiency of SL hydrolysis, and biological functions.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":"1039-1041"},"PeriodicalIF":11.6,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From algae to plants: understanding pyrenoid-based CO2-concentrating mechanisms. 从藻类到植物：了解基于类肾上腺素的二氧化碳浓缩机制。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-25 DOI: 10.1016/j.tibs.2024.10.010
Ella Catherall, Sabina Musial, Nicky Atkinson, Charlotte E Walker, Luke C M Mackinder, Alistair J McCormick
{"title":"From algae to plants: understanding pyrenoid-based CO<sub>2</sub>-concentrating mechanisms.","authors":"Ella Catherall, Sabina Musial, Nicky Atkinson, Charlotte E Walker, Luke C M Mackinder, Alistair J McCormick","doi":"10.1016/j.tibs.2024.10.010","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.010","url":null,"abstract":"<p><p>Pyrenoids are the key component of one of the most abundant biological CO<sub>2</sub> concentration mechanisms found in nature. Pyrenoid-based CO<sub>2</sub>-concentrating mechanisms (pCCMs) are estimated to account for one third of global photosynthetic CO<sub>2</sub> capture. Our molecular understanding of how pyrenoids work is based largely on work in the green algae Chlamydomonas reinhardtii. Here, we review recent advances in our fundamental knowledge of the biogenesis, architecture, and function of pyrenoids in Chlamydomonas and ongoing engineering biology efforts to introduce a functional pCCM into chloroplasts of vascular plants, which, if successful, has the potential to enhance crop productivity and resilience to climate change.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142724555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diseases caused by altered specificity of a protein kinase for its allosteric activators. 蛋白激酶对其异位激活剂的特异性改变导致的疾病。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-22 DOI: 10.1016/j.tibs.2024.10.008
Philip Cohen, Tom Snelling
{"title":"Diseases caused by altered specificity of a protein kinase for its allosteric activators.","authors":"Philip Cohen, Tom Snelling","doi":"10.1016/j.tibs.2024.10.008","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.008","url":null,"abstract":"<p><p>Protein kinases regulate many intracellular processes, and their dysregulation causes cancers and other diseases. This review focuses on the atypical alpha-kinase 1 (ALPK1), which is activated in mammalian cells by nucleoside diphosphate heptoses (ADP-heptose, UDP-heptose, and CDP-heptose) produced by microbial pathogens but not by mammalian cells. Mutations in human ALPK1 cause ROSAH syndrome and spiradenoma, which result from an alteration in its specificity for nucleoside diphosphate heptoses, causing aberrant activation by mammalian nucleoside diphosphate sugars without microbial infection. These may be the first diseases caused by altered specificity of an enzyme for its allosteric activators and has suggested ways in which selective drugs could be developed to treat them without compromising the innate immune system.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Textbook oxidative phosphorylation needs to be rewritten. 教科书中的氧化磷酸化需要重写。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-21 DOI: 10.1016/j.tibs.2024.11.002
Alicia J Kowaltowski, Fernando Abdulkader
{"title":"Textbook oxidative phosphorylation needs to be rewritten.","authors":"Alicia J Kowaltowski, Fernando Abdulkader","doi":"10.1016/j.tibs.2024.11.002","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.11.002","url":null,"abstract":"<p><p>Oxidative phosphorylation (OxPhos) is the energy-transfer process that generates most of our ATP, fueled by proton and electrical gradients across the inner mitochondrial membrane. A new surprising finding by Hernansanz-Agustín et al. demonstrates that between one-third and half of this gradient is attributable to Na<sup>+</sup>, transported in exchange for protons within complex I.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How does p53 work? Regulation by the intrinsically disordered domains. p53 如何工作？内在无序结构域的调控。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-21 DOI: 10.1016/j.tibs.2024.10.009
H Jane Dyson, Peter E Wright
{"title":"How does p53 work? Regulation by the intrinsically disordered domains.","authors":"H Jane Dyson, Peter E Wright","doi":"10.1016/j.tibs.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.009","url":null,"abstract":"<p><p>Defects in the tumor suppressor protein p53 are found in the majority of cancers. The p53 protein (393 amino acids long) contains the folded DNA-binding domain (DBD) and tetramerization domain (TET), with the remainder of the sequence being intrinsically disordered. Since cancer-causing mutations occur primarily in the DBD, this has been the focus of most of the research on p53. However, recent reports show that the disordered N-terminal activation domain (NTAD) and C-terminal regulatory domain (CTD) function synergistically with the DBD to regulate p53 activity. We propose a mechanistic model in which intermolecular and intramolecular interactions of the disordered regions, modulated by post-translational modifications, perform a central role in the regulation and activation of p53 in response to cellular stress.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising. KRAS 突变癌症中 ERK 依赖性蛋白磷酸化：意料之中与意料之外的混合。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-16 DOI: 10.1016/j.tibs.2024.10.011
Kevin Huang, Yubao Wang, Thomas M Roberts
{"title":"ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising.","authors":"Kevin Huang, Yubao Wang, Thomas M Roberts","doi":"10.1016/j.tibs.2024.10.011","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.011","url":null,"abstract":"<p><p>Recently developed KRAS inhibitors have delivered clinical benefits but their antitumor efficacy remains limited. A recent study by Klomp et al. reports an unprecedentedly comprehensive profiling of protein phosphorylation dependent on the KRAS pathway and generates new insights and directions to improve the efficacy of KRAS-targeted therapies.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TEX264-mediated selective autophagy directs DNA damage repair. TEX264 介导的选择性自噬可引导 DNA 损伤修复。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-15 DOI: 10.1016/j.tibs.2024.10.012
Yuxia Qi, Sho W Suzuki
{"title":"TEX264-mediated selective autophagy directs DNA damage repair.","authors":"Yuxia Qi, Sho W Suzuki","doi":"10.1016/j.tibs.2024.10.012","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.012","url":null,"abstract":"<p><p>DNA is constantly subject to damage from endogenous and exogenous factors, leading to mutations and disease. While DNA is traditionally repaired in the nucleus, Lascaux et al. reveal a novel role for the lysosome in DNA repair, demonstrating that topoisomerase 1 (TOP1) cleavage complex (TOP1cc) DNA lesions are degraded via TEX264-mediated selective autophagy.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endomembrane GPCR signaling: 15 years on, the quest continues. 内膜 GPCR 信号传导：15 年过去了，探索仍在继续。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-11 DOI: 10.1016/j.tibs.2024.10.006
Davide Calebiro, Tamara Miljus, Shannon O'Brien
{"title":"Endomembrane GPCR signaling: 15 years on, the quest continues.","authors":"Davide Calebiro, Tamara Miljus, Shannon O'Brien","doi":"10.1016/j.tibs.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.006","url":null,"abstract":"<p><p>G-protein-coupled receptors (GPCRs) are the largest family of cell receptors. They mediate the effects of a multitude of endogenous and exogenous cues, are deeply involved in human physiology and disease, and are major pharmacological targets. Whereas GPCRs were long thought to signal exclusively at the plasma membrane, research over the past 15 years has revealed that they also signal via classical G-protein-mediated pathways on membranes of intracellular organelles such as endosomes and the Golgi complex. This review provides an overview of recent advances and emerging concepts related to endomembrane GPCR signaling, as well as ongoing research aimed at a better understanding of its mechanisms, physiological relevance, and potential therapeutic applications.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NMR spectroscopy reveals insights into mechanisms of GPCR signaling. 核磁共振光谱揭示了 GPCR 信号传导机制。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-09 DOI: 10.1016/j.tibs.2024.10.007
Larissa O Silva, Anuradha V Wijesekara, Matthew T Eddy
{"title":"NMR spectroscopy reveals insights into mechanisms of GPCR signaling.","authors":"Larissa O Silva, Anuradha V Wijesekara, Matthew T Eddy","doi":"10.1016/j.tibs.2024.10.007","DOIUrl":"https://doi.org/10.1016/j.tibs.2024.10.007","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscription and Copyright Information 订阅和版权信息
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/S0968-0004(24)00241-X
{"title":"Subscription and Copyright Information","authors":"","doi":"10.1016/S0968-0004(24)00241-X","DOIUrl":"10.1016/S0968-0004(24)00241-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Page e1"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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