发布求助
文献互助 智能选刊 最新文献

Trends in Biochemical Sciences最新文献

筛选
英文 中文
Two hearts beat as one: the debate over RAS dimers continues 两心相印：关于 RAS 二聚体的争论仍在继续。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.09.005
Andrew G. Stephen
{"title":"Two hearts beat as one: the debate over RAS dimers continues","authors":"Andrew G. Stephen","doi":"10.1016/j.tibs.2024.09.005","DOIUrl":"10.1016/j.tibs.2024.09.005","url":null,"abstract":"<div><div>A recent report by <span><span>Yun <em>et al.</em></span><svg><path></path></svg></span> describes the detection of RAS dimers using intact mass spectrometry and investigates the role that membrane lipids, nucleotide state, and binding partners have in their formation.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 933-935"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing sustainable biotechnology through protein engineering 通过蛋白质工程推进可持续生物技术。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.07.006
Amelia R. Bergeson , Hal S. Alper
{"title":"Advancing sustainable biotechnology through protein engineering","authors":"Amelia R. Bergeson ,&nbsp;Hal S. Alper","doi":"10.1016/j.tibs.2024.07.006","DOIUrl":"10.1016/j.tibs.2024.07.006","url":null,"abstract":"<div><div>The push for industrial sustainability benefits from the use of enzymes as a replacement for traditional chemistry. Biological catalysts, especially those that have been engineered for increased activity, stability, or novel function, and are often greener than alternative chemical approaches. This Review highlights the role of engineered enzymes (and identifies directions for further engineering efforts) in the application areas of greenhouse gas sequestration, fuel production, bioremediation, and degradation of plastic wastes.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 955-968"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会和内容
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/S0968-0004(24)00238-X
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(24)00238-X","DOIUrl":"10.1016/S0968-0004(24)00238-X","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages i-ii"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142651063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The inositol phosphate signalling network in physiology and disease 生理和疾病中的磷酸肌醇信号网络。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.08.005
Seyun Kim , Rashna Bhandari , Charles A. Brearley , Adolfo Saiardi
{"title":"The inositol phosphate signalling network in physiology and disease","authors":"Seyun Kim ,&nbsp;Rashna Bhandari ,&nbsp;Charles A. Brearley ,&nbsp;Adolfo Saiardi","doi":"10.1016/j.tibs.2024.08.005","DOIUrl":"10.1016/j.tibs.2024.08.005","url":null,"abstract":"<div><div>Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules constitute an elaborate metabolic and signalling network that influences nearly every cellular function. This review delves into the knowledge accumulated over the past decades regarding the biochemical principles and significance of InsP metabolism. We focus on the biological actions of InsPs in mammals, with an emphasis on recent findings regarding specific target proteins. We further discuss the roles of InsP metabolism in contributing to physiological homeostasis and pathological conditions. A deeper understanding of InsPs and their metabolic pathways holds the potential to address unresolved questions and propel advances towards therapeutic applications.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 969-985"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them 克服 T 细胞功能障碍的新机遇：转录因子的作用及其靶向方法。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.08.002
Bocheng Wu , Angela N. Koehler , Peter M.K. Westcott
{"title":"New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them","authors":"Bocheng Wu ,&nbsp;Angela N. Koehler ,&nbsp;Peter M.K. Westcott","doi":"10.1016/j.tibs.2024.08.002","DOIUrl":"10.1016/j.tibs.2024.08.002","url":null,"abstract":"<div><div>Immune checkpoint blockade (ICB) therapies, which block inhibitory receptors on T cells, can be efficacious in reinvigorating dysfunctional T cell responses. However, most cancers do not respond to these therapies and even in those that respond, tumors can acquire resistance. New strategies are needed to rescue and recruit T cell responses across patient populations and disease states. In this review, we define mechanisms of T cell dysfunction, focusing on key transcription factor (TF) networks. We discuss the complex and sometimes contradictory roles of core TFs in both T cell function and dysfunction. Finally, we review strategies to target TFs using small molecule modulators, which represent a challenging but highly promising opportunity to tune the T cell response toward sustained immunity.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 1014-1029"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging brain insulin resistance to Alzheimer’s pathogenesis 将大脑胰岛素抵抗与阿尔茨海默氏症发病机制联系起来。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.09.004
Wenqiang Chen , Valdemar Brimnes Ingemann Johansen , Cristina Legido-Quigley
{"title":"Bridging brain insulin resistance to Alzheimer’s pathogenesis","authors":"Wenqiang Chen ,&nbsp;Valdemar Brimnes Ingemann Johansen ,&nbsp;Cristina Legido-Quigley","doi":"10.1016/j.tibs.2024.09.004","DOIUrl":"10.1016/j.tibs.2024.09.004","url":null,"abstract":"<div><div>Emerging evidence links type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD), with brain insulin resistance (BIR) as a key factor. In a recent study, <span><span>Lanzillotta <em>et al.</em></span><svg><path></path></svg></span> reveal that reduced biliverdin reductase-A (BVR-A) impairs glycogen synthase kinase 3β (GSK3β) phosphorylation, causing mitochondrial dysfunction and exacerbating brain insulin resistance in the progression of both T2DM and AD.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 939-941"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The quest to identify ADP-ribosylation readers: methodological advances 鉴别 ADP 核糖基化阅读器的探索：方法学上的进步。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.08.006
Suzanne A. Weijers , Michiel Vermeulen , Katarzyna W. Kliza
{"title":"The quest to identify ADP-ribosylation readers: methodological advances","authors":"Suzanne A. Weijers ,&nbsp;Michiel Vermeulen ,&nbsp;Katarzyna W. Kliza","doi":"10.1016/j.tibs.2024.08.006","DOIUrl":"10.1016/j.tibs.2024.08.006","url":null,"abstract":"<div><div>ADP-ribosylation regulates numerous fundamental cellular processes in health and disease. However, the limited availability of suitable tools and methods prevents the identification and characterization of certain components of the ADP-ribosylation signaling network and, consequently, efficient utilization of their biomedical potential. Identification of ADP-ribose (ADPr) readers has been particularly impeded by challenges associated with the development of ADPr-based enrichment probes. These difficulties were finally overcome in several recent studies describing various approaches to identifying ADPr readers in an unbiased, proteome-wide manner. In this review we discuss these different strategies and their limitations, benefits and drawbacks, and summarize how these technologies contribute to a dissection of ADP-ribosylation signaling networks. We also address unmet technological needs and future directions to investigate interactions with ADPr linkages.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 1000-1013"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expanding landscape of canonical and non-canonical protein phosphorylation 规范和非规范蛋白质磷酸化的不断扩展。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.08.004
Thibault Houles , Sang-Oh Yoon , Philippe P. Roux
{"title":"The expanding landscape of canonical and non-canonical protein phosphorylation","authors":"Thibault Houles ,&nbsp;Sang-Oh Yoon ,&nbsp;Philippe P. Roux","doi":"10.1016/j.tibs.2024.08.004","DOIUrl":"10.1016/j.tibs.2024.08.004","url":null,"abstract":"<div><div>Protein phosphorylation is a crucial regulatory mechanism in cell signaling, acting as a molecular switch that modulates protein function. Catalyzed by protein kinases and reversed by phosphoprotein phosphatases, it is essential in both normal physiological and pathological states. Recent advances have uncovered a vast and intricate landscape of protein phosphorylation that include histidine phosphorylation and more unconventional events, such as pyrophosphorylation and polyphosphorylation. Many questions remain about the true size of the phosphoproteome and, more importantly, its site-specific functional relevance. The involvement of unconventional actors such as pseudokinases and pseudophosphatases adds further complexity to be resolved. This review explores recent discoveries and ongoing challenges, highlighting the need for continued research to fully elucidate the roles and regulation of protein phosphorylation.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 986-999"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanobody-assisted cryoEM structural determination for challenging proteins 纳米体辅助低温电子显微镜结构测定具有挑战性的蛋白质。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.06.002
Xudong Wu
{"title":"Nanobody-assisted cryoEM structural determination for challenging proteins","authors":"Xudong Wu","doi":"10.1016/j.tibs.2024.06.002","DOIUrl":"10.1016/j.tibs.2024.06.002","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 1030-1031"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141436529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surfaces as frameworks for intracellular organization 作为细胞内组织框架的表面。
IF 11.6 1区 生物学
Trends in Biochemical Sciences Pub Date : 2024-11-01 DOI: 10.1016/j.tibs.2024.07.007
Germán Rivas , Allen P. Minton
{"title":"Surfaces as frameworks for intracellular organization","authors":"Germán Rivas ,&nbsp;Allen P. Minton","doi":"10.1016/j.tibs.2024.07.007","DOIUrl":"10.1016/j.tibs.2024.07.007","url":null,"abstract":"<div><div>A large fraction of soluble protein within the interior of living cells may reversibly associate with structural elements, including proteinaceous fibers and phospholipid membranes. In this opinion, we present theoretical and experimental evidence that many of these associations are due to nonspecific attraction between the protein and the surface of the fiber or membrane, and that such associations may lead to substantial changes in the association state of the adsorbed proteins, the biological function of the adsorbed proteins, and the distribution of these proteins between the many microenvironments existing within the cell.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"49 11","pages":"Pages 942-954"},"PeriodicalIF":11.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信