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Single-cell proteomics: When individual cells tell population stories 单细胞蛋白质组学：当单个细胞讲述群体故事时。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 Epub Date: 2026-06-16 DOI: 10.1016/j.tibs.2026.05.007
Aline M.A. Martins, John R. Yates III, Alysson R. Muotri, Paulo C. Carvalho
{"title":"Single-cell proteomics: When individual cells tell population stories","authors":"Aline M.A. Martins, John R. Yates III, Alysson R. Muotri, Paulo C. Carvalho","doi":"10.1016/j.tibs.2026.05.007","DOIUrl":"10.1016/j.tibs.2026.05.007","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages 1079-1080"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 DOI: 10.1016/S0968-0004(26)00288-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(26)00288-4","DOIUrl":"10.1016/S0968-0004(26)00288-4","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages i-ii"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HAT trick: how histones open the door to gene expression 帽子戏法：组蛋白如何打开基因表达的大门
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 DOI: 10.1016/j.tibs.2026.07.007
Divya Rana
{"title":"HAT trick: how histones open the door to gene expression","authors":"Divya Rana","doi":"10.1016/j.tibs.2026.07.007","DOIUrl":"10.1016/j.tibs.2026.07.007","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Page 1081"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advisory Board and Contents 咨询委员会及内容
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 DOI: 10.1016/S0968-0004(26)00288-4
{"title":"Advisory Board and Contents","authors":"","doi":"10.1016/S0968-0004(26)00288-4","DOIUrl":"10.1016/S0968-0004(26)00288-4","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages i-ii"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A phylogenomic analysis of ancient transition metal biochemistry 古代过渡金属生物化学的系统基因组分析。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 Epub Date: 2026-08-26 DOI: 10.1016/j.tibs.2026.08.003
Kshitiza M. Dhyani, Ahmed H. Badran
{"title":"A phylogenomic analysis of ancient transition metal biochemistry","authors":"Kshitiza M. Dhyani,&nbsp;Ahmed H. Badran","doi":"10.1016/j.tibs.2026.08.003","DOIUrl":"10.1016/j.tibs.2026.08.003","url":null,"abstract":"<div><div>Despite seemingly low levels of molybdenum (Mo)/tungsten (W) in the Earth’s ancient oceans, these metals play central roles in driving modern biogeochemical cycles. <span><span>Klos <em>et al</em>.</span><svg><path></path></svg></span> used phylogenomic approaches to reconstruct the Mo/W biochemical repertoire over approximately 3.4 billion years, showing that ancient organisms used these metals early in Earth’s history.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages 984-985"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inside the RNA world, 40 years on 在RNA世界里，40年过去了。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 Epub Date: 2026-07-25 DOI: 10.1016/j.tibs.2026.07.002
Alberto Vázquez-Salazar
{"title":"Inside the RNA world, 40 years on","authors":"Alberto Vázquez-Salazar","doi":"10.1016/j.tibs.2026.07.002","DOIUrl":"10.1016/j.tibs.2026.07.002","url":null,"abstract":"<div><div>Forty years after the term ‘RNA world’ was coined, the RNA world hypothesis is best framed as an RNA-centered evolutionary phase rather than as an RNA-only biosphere. Recent advances in systems chemistry now turn several long-standing objections into experimentally measurable constraints. These include linking nucleotide activation with template copying, quantifying how wet–dry cycling and freeze–thaw cycles alter polymer growth, and testing how compartments change retention, exchange, and parasite control. In parallel, polymerase ribozymes now connect structure, processivity, fidelity, and sustained RNA-catalyzed evolution. Peptide ligation in water, thioester-mediated aminoacyl-RNA chemistry, peptidyl-RNA synthesis, and peptide effects on RNA folding support ribonucleoprotein models in which peptides are integrated partners in a coevolutionary process. Remaining bottlenecks define testable benchmarks in chemically heterogeneous RNA-centered systems.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages 1026-1037"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The expanding functional landscape of alternative splicing in plants 植物选择性剪接功能景观的扩展。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 Epub Date: 2026-08-19 DOI: 10.1016/j.tibs.2026.07.014
María J. Iglesias, Yamila C. Agrofoglio, Łukasz Szewc, Julieta L. Mateos
{"title":"The expanding functional landscape of alternative splicing in plants","authors":"María J. Iglesias,&nbsp;Yamila C. Agrofoglio,&nbsp;Łukasz Szewc,&nbsp;Julieta L. Mateos","doi":"10.1016/j.tibs.2026.07.014","DOIUrl":"10.1016/j.tibs.2026.07.014","url":null,"abstract":"<div><div>Alternative splicing (AS) massively expands transcriptome diversity but does so within a densely interconnected regulatory network that challenges simple, linear models of gene expression. Despite its pervasiveness, principles governing AS choices and their functional outcomes are only beginning to emerge. Recent work in plants places AS at the interface of transcriptional dynamics, RNA fate, and protein output, raising fundamental questions about how transcript diversity translates into function. In parallel, splicing factors are increasingly recognized as multifunctional regulators with ‘moonlighting’ roles beyond pre-mRNA processing, including roles in chromatin, transcription, silencing, and stress responses. Here, we discuss how splicing-dependent and splicing-independent activities are integrated and propose a framework in which splicing factors act as regulatory hubs coordinating gene expression across multiple layers.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages 1010-1025"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telomeres and telomerase: revealing the end game 端粒和端粒酶：揭示终极游戏。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 Epub Date: 2026-08-13 DOI: 10.1016/j.tibs.2026.07.010
Julieta Rivosecchi, Guanhui Wu, Thomas R. Cech
{"title":"Telomeres and telomerase: revealing the end game","authors":"Julieta Rivosecchi,&nbsp;Guanhui Wu,&nbsp;Thomas R. Cech","doi":"10.1016/j.tibs.2026.07.010","DOIUrl":"10.1016/j.tibs.2026.07.010","url":null,"abstract":"<div><div>Because eukaryotic chromosomes are composed of linear DNA molecules, specialized mechanisms are required to ensure their protection and replication. Telomeres, consisting of multiple repeats of a simple DNA sequence and associated proteins, cap these chromosome ends. Telomeric DNA replication requires telomerase, a reverse transcriptase with an intrinsic RNA subunit that provides a template for synthesizing the DNA repeats. New technologies, including cryogenic electron microscopy and long-read DNA sequencing, have provided insights into telomere biology that motivate this review. Furthermore, mutations that impair the machinery responsible for the replication and protection of telomeres lead to telomere biology disorders, and activation of telomerase is a driver of diverse cancers. In this review, we describe how basic science is now informing therapeutic approaches to these diseases.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Pages 990-1009"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HAT trick: how histones open the door to gene expression 帽子戏法：组蛋白如何打开基因表达的大门
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-10-01 DOI: 10.1016/j.tibs.2026.07.007
Divya Rana
{"title":"HAT trick: how histones open the door to gene expression","authors":"Divya Rana","doi":"10.1016/j.tibs.2026.07.007","DOIUrl":"10.1016/j.tibs.2026.07.007","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 10","pages":"Page 1081"},"PeriodicalIF":14.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinesins as dynamic drug targets: structural insights and emerging therapeutic strategies. 动力蛋白作为动态药物靶点：结构洞察和新兴治疗策略。
IF 14.4 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-09-22 DOI: 10.1016/j.tibs.2026.09.002
John S Allingham, Benjamin H Kwok, Hernando Sosa
{"title":"Kinesins as dynamic drug targets: structural insights and emerging therapeutic strategies.","authors":"John S Allingham, Benjamin H Kwok, Hernando Sosa","doi":"10.1016/j.tibs.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.09.002","url":null,"abstract":"<p><p>Kinesins are essential for intracellular organization and cell division, and their involvement in disease has generated interest in their therapeutic potential. However, pharmacological studies have focused on a limited subset of kinesins and have mainly targeted the conserved motor domain. Advances in cryogenic electron microscopy and artificial intelligence-based structure prediction are revealing new opportunities for selective modulation. These approaches show that specific kinesin families may be inhibited by targeting conformational states induced by nucleotide and microtubule binding. They have also identified regulatory sites outside the motor domain, including stalk and tail interfaces that control autoinhibition, cargo binding, and localization. These insights redefine kinesins as dynamic, multidomain machines and highlight opportunities for selective, mechanism-guided therapeutic strategies.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":14.4,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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