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The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes. 多功能，应激敏感核糖核酸酶血管生成素交叉调节不同的基因表达过程。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-22 DOI: 10.1016/j.tibs.2026.03.005
Ana C de A P Schwarzer, Markus T Bohnsack, Katherine E Bohnsack
{"title":"The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes.","authors":"Ana C de A P Schwarzer, Markus T Bohnsack, Katherine E Bohnsack","doi":"10.1016/j.tibs.2026.03.005","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.03.005","url":null,"abstract":"<p><p>Ribonucleases shape gene expression by mediating RNA processing and degradation. Angiogenin (ANG) is a prominent ribonuclease implicated in several pathophysiologies that contributes to multiple cellular processes by targeting different RNA substrates in a context-dependent manner. ANG has emerged as a key regulator of ribosomal DNA transcription and a direct modulator of translation. Upon cellular stress, ANG is responsible for the cleavage of tRNAs into fragments that are now recognized as important regulators of different aspects of gene expression, including mRNA stability and translation. In this review, we provide updated perspectives on the mechanisms of gene expression regulation by ANG and highlight the potential of multifunctional ribonucleases for mediating crosstalk between different aspects of gene expression.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repurposing nanopore sequencing platforms for high-throughput peptide profiling. 利用纳米孔测序平台进行高通量肽谱分析。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-22 DOI: 10.1016/j.tibs.2026.04.005
Ji Wang, Junyi Chen, Xun Xu
{"title":"Repurposing nanopore sequencing platforms for high-throughput peptide profiling.","authors":"Ji Wang, Junyi Chen, Xun Xu","doi":"10.1016/j.tibs.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.04.005","url":null,"abstract":"","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity. 丙酮酰化：连接代谢紊乱和抗病毒免疫受损的纽带。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-20 DOI: 10.1016/j.tibs.2026.04.004
Song Yang, Lili Gong, Lihong Liu
{"title":"Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity.","authors":"Song Yang, Lili Gong, Lihong Liu","doi":"10.1016/j.tibs.2026.04.004","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.04.004","url":null,"abstract":"<p><p>Zuo et al. identified a novel post-translational modification-protein pyruvylation-and revealed that pyruvate, a glycolysis metabolite, induces STAT1 pyruvylation at Lys201, which blocks signal transducer and activator of transcription 1 (STAT1)-signal transducer and activator of transcription 2 (STAT2) binding to suppress type I interferon signaling and antiviral immunity. This study provides new insights into antiviral therapy for patients with metabolic diseases.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transglutaminase 2 drives histone monoaminylation as an epigenetic mechanism in health and disease. 转谷氨酰胺酶2驱动组蛋白单胺化作为健康和疾病的表观遗传机制。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-20 DOI: 10.1016/j.tibs.2026.04.003
Anne A Leaman, Zeng Lin, Qingfei Zheng
{"title":"Transglutaminase 2 drives histone monoaminylation as an epigenetic mechanism in health and disease.","authors":"Anne A Leaman, Zeng Lin, Qingfei Zheng","doi":"10.1016/j.tibs.2026.04.003","DOIUrl":"10.1016/j.tibs.2026.04.003","url":null,"abstract":"<p><p>Transglutaminases (TGs) were originally discovered to catalyze protein-protein crosslinking by forming isopeptide bonds between the side chains of lysine and glutamine. Recently, TGs have been found to mediate the bioconjugation between protein glutamines and monoamine metabolites (such as serotonin, dopamine, and histamine), which is termed 'monoaminylation'. Monoaminylation on core histones, installed by human transglutaminase 2 (TG2), is an emerging epigenetic mark that plays a significant role in regulating cellular gene transcription. Unlike other histone post-translational modifications, the dynamics of monoaminylation (including its installation, removal, and replacement) are solely regulated by TG2. Here, we review the most recent advances in TG2-mediated histone monoaminylation (including serotonylation, dopaminylation, and histaminylation), focusing on its novel biochemical basis and epigenetic functions in pathophysiology.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic secrets in a ubiquitous enzyme. 一种无处不在的酶的代谢秘密。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-16 DOI: 10.1016/j.tibs.2026.04.002
Dan Kehila, Paola Laurino
{"title":"Metabolic secrets in a ubiquitous enzyme.","authors":"Dan Kehila, Paola Laurino","doi":"10.1016/j.tibs.2026.04.002","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.04.002","url":null,"abstract":"<p><p>Recent work by Sakuma et al. shows that the ubiquitous enzyme alkaline phosphatase (PhoA) can oxidize phosphite, revealing a new metabolic role for a classic catalytic generalist. Despite its relatively low efficiency, PhoA's global distribution and conservation indicate that it may substantially influence phosphite turnover and highlight the significance of enzymatic multifunctionality.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Powerful polymerases synthesize labeled RNA better, faster, stronger. 强大的聚合酶能更好、更快、更强地合成标记RNA。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-08 DOI: 10.1016/j.tibs.2026.03.001
Aria A Khalique, Aaron M Leconte
{"title":"Powerful polymerases synthesize labeled RNA better, faster, stronger.","authors":"Aria A Khalique, Aaron M Leconte","doi":"10.1016/j.tibs.2026.03.001","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.03.001","url":null,"abstract":"<p><p>Engineered DNA polymerases capable of synthesizing RNA have the potential to make the synthesis of site-specifically labeled RNA faster, cheaper, and more user-friendly. After many years of trying, two recent reports, by Chen et al. and Medina et al., have identified new DNA polymerase mutants, which may unlock the promise of these enzymes for RNA production and research.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms and therapeutic potential of proton-sensing GPCRs. 质子传感gpcr的分子机制和治疗潜力。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-03 DOI: 10.1016/j.tibs.2026.02.015
Xiaolei Yue, Shenyuan Gao, Zhi-Jie Liu, Tian Hua
{"title":"Molecular mechanisms and therapeutic potential of proton-sensing GPCRs.","authors":"Xiaolei Yue, Shenyuan Gao, Zhi-Jie Liu, Tian Hua","doi":"10.1016/j.tibs.2026.02.015","DOIUrl":"https://doi.org/10.1016/j.tibs.2026.02.015","url":null,"abstract":"<p><p>Extracellular acidification is a defining feature of many pathological microenvironments and is sensed by G protein-coupled receptors (GPCRs)-GPR4, GPR65, and GPR68. These proton-sensing receptors regulate vascular, immune, and neural responses and are increasingly implicated in inflammation, cancer, fibrosis, and ischemic injury. Recent cryo-electron microscopy structures have revealed the molecular basis of proton detection, highlighting dynamic extracellular loop rearrangements, pH-sensitive histidine networks, and a stepwise activation mechanism that tunes G protein coupling and signaling bias. Emerging structural evidence also shows lipid modulation and species-specific adaptations that shape receptor responsiveness. These advances provide a structural and mechanistic framework for developing selective modulators of proton-sensing GPCRs as therapeutic targets in acidic disease environments.</p>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parallels and crosstalk of ADP-ribosylation and ubiquitination adp核糖基化和泛素化的平行和串扰。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI: 10.1016/j.tibs.2026.02.008
Carlos Vela-Rodríguez , Albert Galera-Prat , Jonathan N. Pruneda , Michael S. Cohen , Lari Lehtiö
{"title":"Parallels and crosstalk of ADP-ribosylation and ubiquitination","authors":"Carlos Vela-Rodríguez ,&nbsp;Albert Galera-Prat ,&nbsp;Jonathan N. Pruneda ,&nbsp;Michael S. Cohen ,&nbsp;Lari Lehtiö","doi":"10.1016/j.tibs.2026.02.008","DOIUrl":"10.1016/j.tibs.2026.02.008","url":null,"abstract":"<div><div>Post-translational modifications (PTMs) can regulate the localization, function, and activity of proteins. Different PTMs can influence each other to create complex regulatory networks with significant implications for cellular signaling and protein homeostasis; an interplay known as crosstalk. Here, we highlight recent studies revealing crosstalk between ubiquitination and ADP-ribosylation, two PTMs that, while chemically distinct, share notable mechanistic similarities. We discuss how their enzymes, substrates, and resulting adducts are similar and distinct. We describe the different levels at which one PTM impacts the other and, ultimately, how they build on each other to create a hybrid modification. Both ADP-ribosylation and ubiquitination are targeted by drugs, and understanding this crosstalk is also important for translational research, opening potentially innovative strategies for new therapies.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 4","pages":"Pages 342-353"},"PeriodicalIF":11.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magical moments in protease biology: proteasome autocatalytic activation and PI31-mediated inhibition 蛋白酶生物学中的神奇时刻：蛋白酶体自催化激活和pi31介导的抑制。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-01 Epub Date: 2026-03-07 DOI: 10.1016/j.tibs.2026.02.003
Tamayanthi Rajakumar , Erignacio Fermin Perez , Darlene Fung , Shaun Rawson , Richard M. Walsh Jr , John Hanna
{"title":"Magical moments in protease biology: proteasome autocatalytic activation and PI31-mediated inhibition","authors":"Tamayanthi Rajakumar ,&nbsp;Erignacio Fermin Perez ,&nbsp;Darlene Fung ,&nbsp;Shaun Rawson ,&nbsp;Richard M. Walsh Jr ,&nbsp;John Hanna","doi":"10.1016/j.tibs.2026.02.003","DOIUrl":"10.1016/j.tibs.2026.02.003","url":null,"abstract":"<div><div>Proteases regulate nearly every aspect of cellular function. Spatial and temporal control of protease activity contributes to this functional versatility and includes both zymogen activation mechanisms and the existence of dedicated protease inhibitors. Unlike conventional proteases, the proteasome harbors six individual proteases within a single macromolecular complex. This unique arrangement poses formidable challenges by requiring simultaneous activation or inhibition of all six active sites. Recent work from multiple labs has uncovered key aspects of assembly-coupled autocatalytic activation as well as the mechanism of proteasome inhibition by the endogenous inhibitor PI31 (proteasome inhibitor 31 kDa). These elegant mechanisms highlight and expand the remarkable complexity and beauty of protease biology.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 4","pages":"Pages 367-378"},"PeriodicalIF":11.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease 线粒体坏死：免疫代谢和疾病中禁食诱导的细胞死亡。
IF 11 1区 生物学
Trends in Biochemical Sciences Pub Date : 2026-04-01 Epub Date: 2026-03-18 DOI: 10.1016/j.tibs.2026.01.005
Radhwan Al-Zidan , Manjul Gautam , Si Ming Man
{"title":"Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease","authors":"Radhwan Al-Zidan ,&nbsp;Manjul Gautam ,&nbsp;Si Ming Man","doi":"10.1016/j.tibs.2026.01.005","DOIUrl":"10.1016/j.tibs.2026.01.005","url":null,"abstract":"<div><div>Recent work by <span><span>Wang and colleagues</span><svg><path></path></svg></span> reveals a unique mode of cell death called mitoxyperilysis, driven by mitochondrial proximity-dependent rupture of the plasma cell membrane. This lytic cell death is triggered by immune agonists combined with fasting or nutrient starvation, offering therapeutic implications in sepsis and cancer.</div></div>","PeriodicalId":440,"journal":{"name":"Trends in Biochemical Sciences","volume":"51 4","pages":"Pages 313-315"},"PeriodicalIF":11.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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